The relation between brain iron and NMR relaxation times: An in vitro study

Magnetic Resonance in Medicine

Volumn 35, Issue 1, 1996, Pages 56-61

  Vymazal, Josef ^a   Brooks, Rodney A ^a,b   Baumgarner, Charles ^a   Tran, Vu ^a   Katz, David ^b,c   Bulte, Jeff W M ^a   Bauminger, E Rivka ^d   Di Chiro, Giovanni ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

brain iron; ferritin; T1; T2 shortening

Indexed keywords

ELECTROMAGNETIC FIELD EFFECTS; NUCLEAR MAGNETIC RESONANCE; RELAXATION TIME;

BRAIN IRON; DIFFERENT EFFECTS; FERRIC OXYHYDROXIDE; FERRITIN; FERRITIN SOLUTIONS; FIELD INDEPENDENTS; IRON CONCENTRATIONS; T2 SHORTENING;

IRON;

FERRITIN; HEMOSIDERIN;

ADULT; ANIMAL TISSUE; ARTICLE; BRAIN; CAVERNOUS HEMANGIOMA; FEMALE; GRAY MATTER; HUMAN; HUMAN TISSUE; MAGNETIC FIELD; MALE; MONKEY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING;

EID: 0030022886     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.1910350108     Document Type: Article

References (15)

1. B. P. Drayer, P. Burger, R. Darwin, S. Riederer, R. Herfkens, G. A. Johnson, MRI of brain iron. AJR 147, 103-110 (1986).
2. W. Kucharczyk, R. M. Henkelman, J. Chen, Brain iron and T2 signal. AJNR 15, 1795-1796 (1994).
3. G. Bartzokis, M. Aravagiri, W. H. Oldendorf, J. Mintz, S. R. Marder, Field-dependent transverse relaxation rate increase may be a specific measure of tissue iron stores. Magn. Reson. Med. 29, 459-464 (1993).
4. F. Q. Ye, W. R. W. Martin, J. Hodder, P. S. Allen, Brain iron imaging exploiting heterogeneous-susceptibility-enhanced proton relaxation, in "Proc., SMR, 2nd Annual Meeting, San Francisco, 1994," p. 5.
5. J. Vymazal, M. Hajek, N. Patronas, J. N. Giedd, J. W. M. Bulte, R. A. Brooks, The quantitative relation between T 1-and T2-weighted MRI of normal gray matter and iron concentration. J. Magn. Reson. Imaging 5, 554-560 (1995).
6. S. H. Koenig, R. D. I. I. I. Brown, J. F. Gibson, R. J. Ward, T. J. Peters. Relaxometry of ferritin solutions and the influence of the Fe3+ core ions. Magn. Reson. Med. 3, 755-767 (1986).
7. J. Vymazal, R. A. Brooks, O. Zak, C. McRill, C. Shen, G. Di Chiro, T1 and T2 of ferritin at different field strengths: effect on MRI. Magn. Reson. Med. 27, 368-372 (1992).
8. E. R. Bauminger, S. G. Cohen, S. Ofer, E. A. Rachmilewitz, Quantitative studies of ferrtin-like iron in erythrocytes of thalassemia, sickle cell anemia and hemoglobin Hammersmith with Mossbauer spectroscopy. Proc. Natl. Acad. Sci. (USA) 76, 939-945 (1979).
9. A. Bizzi, R. A. Brooks, A. Brunetti, J. M. Hill, J. R. Alger, R. S. Miletich, T. L. Francavilla, G. Di Chiro, Role of iron and ferritin in MR imaging of the brain: a study in primates at different field strengths. Radiology 177, 59-65 (1990).
10. J. W. M. Bulte, J. Vymazal, R. A. Brooks, C. Pierpaoli, J. A. Frank. Frequency dependence of NMR relaxation times. II. Iron oxides. J. Magn. Reson. Imaging 3, 641-648 (1993).
11. J. M. Hill, in "Brain Iron - Neurochemical and Behavioural Aspects" (M.B.H. Youdim, Ed.), pp. 14-19, Taylor & Francis, London. 1988.
12. J. M. Gomori, R. I. Grossman, H. R. Drott, MR relaxation times and iron content of thalassemic spleens: an in vitro study. AJR 150, 567-559 (1988).
13. J. C. Chen, P. A. Hardy, W. Kucharczyk, M. Clauberg, J. G. Joshi, A. Vourlas, M. Dhar, R. M. Henkelman, MR of human postmortem brain tissue: Correlative study between T2 and assays of iron and ferritin in Parkinson and Huntington disease. AJNR 14, 275-281 (1993)
14. R. A. Brooks, J. Vymazal, J. W. M. Bulte, C. D. Baumgarner, V. Tran, Comparison of T2 relaxation in blood, brain and ferritin. J. Magn. Reson. Imaging 5, 446-450 (1995).
15. J. W. M. Bulte, G. F. Miller, J. Vymazal, R. A. Brooks, J. A. Frank. Idiopathic hemochromatosis in primates: quantification of liver iron using field-dependent T2 proton relaxation enhancement, in "Proc., SMR, 3rd Annual Meeting, Nice. France, 1995," p. 512.