Expression of type 2 orexin receptor in human endometrium and its epigenetic silencing in endometrial cancer

Journal of Clinical Endocrinology and Metabolism

Volumn 98, Issue 4, 2013, Pages 1549-1557

  Dehan, P ^a   Canon, C ^a   Trooskens, G ^b   Rehli, M ^c   Munaut, C ^a   Van Criekinge, W ^b   Delvenne, P ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b MDxHealth   (Belgium)

^c UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; OREXIN 2 RECEPTOR;

ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; ENDOMETRIUM CANCER; ENDOMETRIUM CELL; EPIGENETICS; EXON; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ONCOGENE; OX2R GENE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, ENDOMETRIOID; CASE-CONTROL STUDIES; CELL LINE, TUMOR; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; MIDDLE AGED; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; VALIDATION STUDIES AS TOPIC;

EID: 84876240469     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-3263     Document Type: Article

References (37)

1. de Lecea L, Kilduff TS, Peyron C, et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA. 1998; 95: 322-327.
2. Sakurai T, Amemiya A, Ishii M, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998; 92: 573-585.
3. Heinonen MV, Purhonen AK, Makela KA, Herzig KH. Functions of orexins in peripheral tissues. Acta Physiol (Oxf). 2008; 192: 471-485.
4. Kirchgessner AL, Liu M. Orexin synthesis and response in the gut. Neuron. 1999; 24: 941-951.
5. Mitsuma T, Hirooka Y, Kayma M, et al. Radioimmunoassay for hypocretin-2. Endocr Regul. 2000; 34: 23-27.
6. Mitsuma T, Hirooka Y, Kayama M, et al. Radioimmunoassay for orexin A. Life Sci. 2000; 66: 897-904.
7. Karteris E, Chen J, Randeva HS. Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system. J Clin Endocrinol Metab. 2004; 89: 1957-1962.
8. Tafuri S, Muto RL, Pavone LM, et al. Novel localization of orexin A in the tubular cytotypes of the rat testis. Regul Pept. 2010; 164: 53-57.
9. Silveyra P, Lux-Lantos V, Libertun C. Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation. Am J Physiol Endocrinol Metab. 2007; 293: E977-E985.
10. Laburthe M, Voisin T, El Firar A. Orexins/hypocretins and orexin receptors in apoptosis: a mini-review. Acta Physiol (Oxf). 2010; 198: 393-402.
11. Rouet-Benzineb P, Rouyer-Fessard C, Jarry A, et al. Orexins acting at native OX(1) receptor in colon cancer and neuroblastoma cells or at recombinant OX(1) receptor suppress cell growth by inducing apoptosis. J Biol Chem. 2004; 279: 45875-45886.
12. Nakabayashi M, Suzuki T, Takahashi K, et al. Orexin-A expression in human peripheral tissues. Mol Cell Endocrinol. 2003; 205: 43-50.
13. Hecht JL, Mutter GL. Molecular and pathologic aspects of endometrial carcinogenesis. J Clin Oncol. 2006; 24: 4783-4791.
14. You JS, Jones PA. Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell. 2012; 22: 9-20.
15. Tao MH, Freudenheim JL. DNA methylation in endometrial cancer. Epigenetics. 2010; 5: 491-498.
16. Esteller M. Epigenetics in cancer. N Engl J Med. 2008; 358: 1148-1159.
17. Sharma S, Kelly TK, Jones PA. Epigenetics in cancer. Carcinogenesis. 2010; 31: 27-36.
18. Laird PW. The power and the promise of DNA methylation markers. Nat Rev Cancer. 2003; 3: 253-266.
19. Eckhardt F, Lewin J, Cortese R, et al. DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet. 2006; 38: 1378-1385.
20. Mo B, Vendrov AE, Palomino WA, DuPont BR, Apparao KB, Lessey BA. ECC-1 cells: a well-differentiated steroid-responsive endometrial cell line with characteristics of luminal epithelium. Biol Reprod. 2006; 75: 387-394.
21. Hackenberg R, Loos S, Nia AH, Kunzmann R, Schulz KD. Expression of placental protein 14 by the new endometrial cancer cell line MFE-280 in vitro and by endometrial carcinomas in vivo. Anticancer Res. 1998; 18: 1153-1158.
22. Rohde C, Zhang Y, Reinhardt R, Jeltsch A. BISMA-fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences. BMC Bioinformatics. 2010; 11: 230.
23. Randeva HS, Karteris E, Grammatopoulos D, Hillhouse EW. Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis. J Clin Endocrinol Metab. 2001; 86: 4808-4813.
24. Nagasaka T, Goel A, Notohara K, et al. Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis. Int J Cancer. 2008; 122: 2429-2436.
25. Jass JR, Whitehall VL, Young J, Leggett BA. DNA methylation in colorectal cancer. In: Szyf M, ed. DNA Methylation and Cancer Therapy. Georgetown and New York: Kluwer Academic/Plenum and Landes Biosciences/Eurekah.com Publishers; 2005: 59-68.
26. Rashid A, Shen L, Morris JS, Issa JP, Hamilton SR. CpG island methylation in colorectal adenomas. Am J Pathol. 2001; 159: 1129-1135.
27. Chen J, Randeva HS. Genomic organization and regulation of the human orexin (hypocretin) receptor 2 gene: identification of alternative promoters. Biochem J. 2010; 427: 377-390.
28. Brenet F, Moh M, Funk P, et al. DNA methylation of the first exon is tightly linked to transcriptional silencing. PloS One. 2011; 6: e14524.
29. Meaburn EL, Schalkwyk LC, Mill J. Allele-specific methylation in the human genome: implications for genetic studies of complex disease. Epigenetics. 2010; 5: 578-582.
30. Luedi PP, Dietrich FS, Weidman JR, Bosko JM, Jirtle RL, Hartemink AJ. Computational and experimental identification of novel human imprinted genes. Genome Res. 2007; 17: 1723-1730.
31. Faquin WC, Fitzgerald JT, Boynton KA, Mutter GL. Intratumoral genetic heterogeneity and progression of endometrioid type endometrial adenocarcinomas. Gynecol Oncol. 2000; 78: 152-157.
32. Feng YZ, Shiozawa T, Horiuchi A, et al. Intratumoral heterogeneous expression of p53 correlates with p53 mutation, Ki-67, and cyclin A expression in endometrioid-type endometrial adenocarcinomas. Virchows Archiv. 2005; 447: 816-822.
33. Mikeska T, Candiloro IL, Dobrovic A. The implications of heterogeneous DNA methylation for the accurate quantification of methylation. Epigenomics. 2010; 2: 561-573.
34. Voisin T, Firar AE, Avondo V, Laburthe M. Orexin-induced apoptosis: the key role of the seven-transmembrane domain orexin type 2 receptor. Endocrinology. 2006; 147: 4977-4984.
35. Spinazzi R, Rucinski M, Neri G, Malendowicz LK, Nussdorfer GG. Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells. J Clin Endocrinol Metab. 2005; 90: 3544-3549.
36. DeCarvalho DD, Sharma S, You JS, et al. DNA methylation screening identifies driver epigenetic events of cancer cell survival. Cancer Cell. 2012; 21: 655-667.
37. Nitkiewicz A, Smolinska N, Maleszka A, Kiezun M, Kaminski T. Localization of orexin A and orexin B in the porcine uterus. Reprod Biol. 2012; 12: 135-155.