Effects of aspartame metabolites on astrocytes and neurons

Folia Neuropathologica

Volumn 51, Issue 1, 2013, Pages 10-17

  Rycerz, Karol ^a   Jaworska Adamu, Jadwiga Elzbieta ^a  

^a UNIVERSITY OF LIFE SCIENCES IN LUBLIN   (Poland)

Author keywords

Aspartame; Aspartate; Diketopiperazine; Neurodegeneration; Phenyloalanine; Receptors; Transporters

Indexed keywords

ASPARTAME; ASPARTIC ACID; DOPAMINE; EXCITATORY AMINO ACID; GLUTAMIC ACID DERIVATIVE; METHANOL; PHENYLALANINE; PIPERAZINEDIONE; SEROTONIN;

AMINO ACID TRANSPORT; ASTROCYTE; BLOOD BRAIN BARRIER; CARCINOGENESIS; CENTRAL NERVOUS SYSTEM DEPRESSION; COMA; DOPAMINERGIC SYSTEM; DRUG CARCINOGENICITY; EXCITOTOXICITY; GLIOMA; HUMAN; MENINGIOMA; METABOLIC ACIDOSIS; OXIDATIVE STRESS; REVIEW; SYNAPTOGENESIS; VISUAL DISORDER;

EID: 84876231129     PISSN: 16414640     EISSN: 1509572X     Source Type: Journal    
DOI: 10.5114/fn.2013.34191     Document Type: Review

References (32)

1. Barua J, Bal A. Emerging facts about aspartame. Journal of the Diabetic Association of India 1995; http://dorway.com/doctorsspeak-out/emerging-facts- about-aspartame/.
2. Blaylock RL. Excitotoxins, Neurodegeneration & Neurodevelopment. Dorway 2000; http://dorway.com/doctors-speak-out/dr-blaylock/excitotoxins- neurodegeneration-neurodevelopment/.
3. Bowen J, Evangelista AM. Brain cell damage from amino acid isolates: a primary concern from aspartame-based products and artificial sweetening agents. World Natural Health Organisation 2002; http://www.wnho.net/aspartame-brain- damage.htm.
4. Brookes N. Neutral amino acid transport in astrocytes: characterisation of Na+-dependent and Na+-independent components of a-aminoisobutyric acid uptake. J Neurochem 1988; 51: 1913-1918.
5. Butchko HH, Stargel WW, Comer CP, Mayhew DA, Benninger C, Blackburn GL, de Sonneville LMJ, Geha RS, Hertelendy Z, Koestner A, Leon AS, Liepa GU, McMartin KE, Mendenhall CL, Munro IC, Novotny EJ, Renwick AG, Schiffman SS, Schomer DL, Shaywitz BA, Spiers PA, Tephly TR, Thomas JA, Trefz FK. Aspartame: review of safety. Reg Toxicol Pharmacol 2002; 35: S1-S93.
6. Daubert EA, Condron BG. Serotonin: a regulator of neuronal morphology and circuitry. Trends Neurosci 2010; 33: 424-434.
7. Ekong MB. Aspartame: Sweet or Bitter. The Internet Journal of Health 2009; 9: 2.
8. European Commision, Health and Consumer Protection Directorate-General. Opinion of the Scientific Commitee on Food: Update on the Safety of Aspartame. European Commition on Food 2002; ec.europa.eu/food/fs/sc/scf/out155-en.pdf.
9. Evangelista AM. History of aspartame. World Natural Health Organisation 2004; http://www.wnho.net/history-of-aspartame.htm.
10. Ferrazzoli AE. Vesicular packaging of serotonin by astrocytes. Central Connecticut State University Theses, Dissertations & Select Projects 2007; http://content.library.ccsu.edu/cdm4/item-viewer.php?CISOROOT=/ ccsutheses&CISOPTR=1172&CISOBOX=1&REC=3.
11. Gaspar P, Cases O, Maroteaux L. The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci 2003; 4: 1002-1012.
12. Gurney JG, Pogoda JM, Holly EA, Hecht SS, Preston-Martin S. Asparteme consumption in relation to childhood brain tumor risk: results from a case-control study. JNCI 1997; 89: 1072-1074.
13. Hamilton MB, Attwel D. Do astrocytes really exocytose neurotransmitters? Nat Rev Neurosci 2010; 11: 227-238.
14. Hawkins RA, O'Kane RL, Simpson IA, Vina JR. Structure of the bloodbrain barrier and its role in the transport of amino acids. J Nutr 2006; 136: 218S-226S.
15. Humphries P, Pretorius E, Naude H. Direct and indirect cellular effects of aspartame on the brain. Eur J Clin Nutr 2008; 62: 451-462.
16. Lim U, Subar AF, Mouw T, Hartge P, Morton LM, Stolzenberg-Solomon R, Campbell D, Hollenbeck AR, Schatzkin A. Consumption of Aspartam-Containing Beverages and Incidence of Hematopoietic and Brain Malignancies. Cancer Epidemiol Biomarkers Prev 2006; 15: 1654-1659.
17. Magnuson BA, Burdock GA, Doull J, Kroes RM, Marsh GM, Pa riza MW, Spencer PS, Waddell WJ, Walker R, Williams GM. Aspartame: a safety evaluation based on current use levels, regulations and toxicological and epidemiological studies. Crit Rev Toxicol 2007; 37: 629-727.
18. Monte WC. Aspartame, Methanol & the Public Health. J Appl Nutr 1984; 36: 42-54.
19. Mourad IM, Noor NA. Aspartame (a widely used artificial sweetener) and oxidative stress in the rat cerebral cortex. Int J Pharm Biomed Sci 2011; 2: 4-10.
20. Nedergaard M, Ransom B, Goldman AS. New roles for astrocytes: redefining the functional architecture of the brain. Trends Neurosci 2003; 26: 523-530.
21. Nelson DL, Cox MM. Lehninger Principles of Biochemistry. 5th ed. W. H. Freeman and Company, New York 2008.
22. Olney JW, Farber NB, Spitznagel E, Robins LN. Increasing brain tumor rates: is there a link to aspartame? J Neuropathol Exp Neurol 1996; 55: 1115-1123.
23. Omidi Y, Barar J, Ahmadian S, Heidari HR, Gumbleton M. Characterisation and astrocitic modulation of system L transporters in brain microvasculature endothelial cells. Cell Biochem Funct 2008; 26: 381-391.
24. Pinheiro PS, Mulle C. Presynaptic glutamate receptors: physiological functions and mechanisms of action. Nat Rev Neurosci 2008; 9: 423-436.
25. Roberts HJ. Does Aspartame Cause Human Brain Cancer? J Adv Med 1991; 4: 231-241.
26. Rowe RC, Sheskey PJ, Quinn ME. Handbook of Pharmaceutical Excipients. 6th ed. Pharmaceutical Press and American Pharmacists Association, London 2009.
27. Rój A, Stasiuk E. Oznaczenia jakosciowe w zakresie zawartosci aspartamu i jego metabolitów w napojach gazowanych bezalkoholowych z zastosowaniem techniki HPLC. Bromat Chem Toksykol 2009; 3: 543-547.
28. Sekalska B. Zawartosc sztucznych substancji slodzacychaspartamu, acesulfamu K i sacharynianu sodu wnapojach dietetycznych. Zywn Nauka Technol Jakosc 2007; 3: 127-138.
29. Soffritti M, Belpoggi F, Esposti DD, Lambertini L, Tibaldi E, Rigano A. First Experimental Demonstration of the Multipotential Cancerogenic Effects of Aspartame Administrated in the Feed to Sprague-Dawley Rats. Environ Health Perspect 2006; 114: 379-385.
30. Stegink LD, Wolf-Novak LC, Filer LJ Jr, Bell EF, Ziegler EE, Krause WL, Brummel MC. Aspartame-sweetened beverage: effect on plasma amino acid concentrations in normal adults and adults heterozygous for phenylketonuria. J Nutr 1987; 117: 1989-1995.
31. Szydlowska K, Kaminska B. Farmakologiczna modulacja funkcji i zywotnosci astrocytówjako nowa strategia neuroprotekcji po niedokrwieniu. Kosmos 2008; 57: 315-329.
32. Zhou Q, Palmiter RD. Dopamine-deficient mice are severely hypoactive, adipsic and aphagic. Cell 1995; 83: 1197-1209.