Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type i serine proteases Fromtransmembrane anchors

Journal of Biological Chemistry

Volumn 288, Issue 15, 2013, Pages 10588-10598

  Raman, Kavita ^a   Trivedi, Neil N ^a   Raymond, Wilfred W ^a   Ganesan, Rajkumar ^b   Kirchhofer, Daniel ^b   Verghese, George M ^c   Craik, Charles S ^a   Schneider, Eric L ^a   Nimishakavi, Shilpa ^a   Caughey, George H ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GENENTECH INC   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EVOLUTIONARY MECHANISMS; HUMAN ENZYMES; MEMBRANE ANCHORS; NON-REDUNDANT; PHYLOGENETIC ANALYSIS; SERINE PROTEASE; TRANS-MEMBRANE PROTEINS; TRANSMEMBRANES;

AMINO ACIDS; PROTEINS;

MAMMALS;

ALPHA 2 MACROGLOBULIN; APROTININ; LEUPEPTIN; MARAPSIN; MEMBRANE PROTEIN; PROSTASIN; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; TRYPTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; EPITHELIUM CELL; HUMAN; HUMAN CELL; MOLECULAR EVOLUTION; MOUSE; NONHUMAN; NONSENSE MUTATION; PHYLOGENY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; CATTLE; CHO CELLS; CRICETINAE; CRICETULUS; EVOLUTION, MOLECULAR; GUINEA PIGS; HUMANS; MEMBRANE PROTEINS; MICE; MICE, MUTANT STRAINS; MOLE RATS; MUTATION; PAN PANISCUS; PAN TROGLODYTES; PROTEASE INHIBITORS; RATS; SERINE ENDOPEPTIDASES; SOLUBILITY; SPECIES SPECIFICITY;

MAMMALIA; MUS; RATTUS;

EID: 84876222161     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.449033     Document Type: Article

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