Preventive and curative effects of ginger extract against histopathologic changes of gentamicin-induced tubular toxicity in rats

International Journal of Preventive Medicine

Volumn 4, Issue 3, 2013, Pages 316-321

  Nasri, Hamid ^a   Nematbakhsh, Mehdi ^a   Ghobadi, Shamin ^b   Ansari, Roya ^b   Shahinfard, Najmeh ^b   Rafieian Kopaei, Mahmoud ^b  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Gentamicin; Ginger; Nephrotoxicity; Tubular damage; Zingiber officinale

Indexed keywords

FLAVONOID; GENTAMICIN; GINGER EXTRACT; PHENOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DEGENERATION; DISEASE SEVERITY; DRUG EFFICACY; HISTOPATHOLOGY; KIDNEY PARENCHYMA; KIDNEY TUBULE DISORDER; MALE; NEPHROTOXICITY; NONHUMAN; PHYTOCHEMISTRY; PLANT ROOT; RAT; RENAL PROTECTION; TREATMENT DURATION;

EID: 84876182544     PISSN: 20087802     EISSN: 20088213     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Kopple JD, Ding H, Letoha A, Ivanyi B, Qing DP, Dux L, et al. L-carnitine ameliorates gentamicin-induced renal injury in rats. Nephrol Dial Transplant 2002;17:2122-31.
2. Zorov DB, Filburn CR, Klotz LO, Zweier JL, Sollott SJ. Reactive oxygen species (ROS)-induced ROS release: A new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J Exp Med 2000;192:1001-4.
3. Ali BH, Al Za'abi M, Blunden G, Nemmar A. Experimental gentamicin nephrotoxicity and agents that modify it: A mini-review of recent research. Basic Clin Pharmacol Toxicol 2011;109:225-32.
4. Rafieian-Kopaei M, Nasri H, Nematbakhsh M, Baradaran A, Gheissari A, Rouhi H, et al. Erythropoietin ameliorates genetamycin-induced renal toxicity: A biochemical and histopathological study. J Nephropathology 2012;1:109-16.
5. Kadkhodaee M. Erythropoietin; bright future and new hopes for an old drug. J Nephropathology 2012;1:81-2.
6. Khajehdehi P. Turmeric: Reemerging of a neglected Asian traditional remedy. J Nephropathology 2012;1:17-22.
7. Lopez-Novoa JM, Quiros Y, Vicente L, Morales AI, Lopez-Hernandez FJ. New insights in to the mechanism of aminoglycoside nephrotoxicity: An integrative point of view. Kidney Int 2011;79:33-45.
8. Quiros Y, Vicente-Vicente L, Morales AI, López-Novoa JM, López-Hernández FJ. An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin. Toxicol Sci 2011;119:245-56.
9. Simmons CF, Bogusky RT, Humes HD. Inhibitory effects of gentamicin on renal mitochondrial oxidative phosphorylation. J Pharmacol Exp Ther 1980;214:709-15.
10. Tavafi M. Inhibition of gentamicin-induced renal tubular cell necrosis. J Nephropathology 2012;1:83-6.
11. Kiritoshi S, Nishikawa T, Sonoda K, Kukidome D, Senokuchi T, Maztsuo T, et al. Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells: Potential role in diabetic nephropathy. Diabetes 2003;52:2570-7.
12. Heeba GH, Abd-Elghany MI. Effect of combined administration of ginger (Zingiber officinale Roscoe) and atorvastatin on the liver of rats. Phytomedicine 2010;17:1076-81.
13. Maghsoudi S, Gol A, Dabiri S, Javadi A. Preventive effect of ginger (Zingiber officinale) pretreatment on renal ischemia-reperfusion in rats. Eur Surg Res 2011;46:45-51.
14. Lakshmi BV, Sudhakar M. Protective effect of Zingiber officinale on gentamicin-induced nephrotoxicity in rats. Int J Pharmacol 2010;6:58-62.
15. Shirzad H, Taji F, Rafieian-Kopaei M. Correlation between antioxidant activity of garlic extracts and WEHI-164 fibrosarcoma tumor growth in BALB/c mice. J Med Food 2011;14:969-74.
16. Bahmani M, Rafieian-kopaei M, Parsaei P, Mohsenzadegan A. The anti-leech effect of Peganum harmala L. extract and some anti-parasite drugs on Limnatis nilotica. Afr J Microbiol Res 2012;6:2586-90.
17. Mirzaei MG, Sewell RD, Kheiri S, Rafieian-Kopaei M. A clinical trial of the effect of St. John's Wort on migraine headaches in patients receiving sodium valproate. J Med Plants Res 2012;6:1519-23.
18. Said MM. The protective effect of eugenol against gentamicin-induced nephrotoxicity and oxidative damage in rat kidney. Fundam Clin Pharmacol 2011;25:708-16.
19. Nasri H, Mortazavi M, Ghorbani A, Shahbazian H, Kheiri S, Baradaran A, et al. Oxford-MEST classification in IgA nephropathy patients: A report from Iran. J Nephropathology 2012;1:31-42.
20. Nematbakhsh M, Ashrafi F, Safari T, Talebi A, Nasri H, Mortazavi M, et al. Administration of vitamin E and losartan as prophylaxes in cisplatin-induced nephrotoxicity model in rats. J Nephrol 2012;25:410-7.
21. Eshraghi-Jazi F, Nematbakhsh M, Nasri H, Talebi T, Haghighi M, Pezeshki Z et al. The protective role of endogenous nitric oxide donor (L-arginine) in cisplatin-induced nephrotoxicity: Gender related differences in rat model. J Res Med Sci 2011;16:1389-96.
22. Nakatani N. Phenolic antioxidants from herbs and spices. Biofactors 2000;13:141-6.
23. Ho CT, Wang M, Wei GJ, Huang TC, Huang MT. Chemistry and antioxidative factors in rosemary and sage. Biofactors 2000;13:161-6.
24. Shan B, Cai YZ, Sun M, Corke H. Antioxidant capacity of 26 spice extracts and characterization of their phenolic constituents. J Agric Food Chem 2005;53:7749-59.
25. Policegoudra RS, Aradhya SM, Singh L. Mango ginger (Curcuma amada Roxb.), a promising spice for phytochemicals and biological activities. J Biosci 2011;36:739-48.
26. Masuda Y, Kikuzaki H, Hisamoto M, Nakatani N. Antioxidant properties of gingerol related compounds from ginger. Biofactors 2004;21:293-6.
27. Ma J, Jin X, Yang L, Liu ZL. Diarylheptanoids from the rhizomes of Zingiber officinale. Phytochemistry 2004;65:1137-43.
28. Rouhi H, Ganji F, Nasri H. Effects of Ginger on the improvement of asthma [the evaluation of Its treatmental effects]. Pakistan J Nutr 2006;5:373-6.
29. Mehrdad M, Messripour M, Ghobadipour M. The effect of ginger extract on blood urea nitrogen and creatinine in mice. Pak J Biol Sci 2007;10:2968-71.
30. Ramudu SK, Korivi M, Kesireddy N, Lee LC, Cheng IS, Kuo CH, et al. Nephro-protective effects of a ginger extract on cytosolic and mitochondrial enzymes against streptozotocin (STZ)-induced diabetic complications in rats. Chin J Physiol 2011;54:79-86.
31. Mahmoud MF, Diaai AA, Ahmed F. Evaluation of the efficacy of ginger, Arabic gum, and Boswellia in acute and chronic renal failure. Ren Fail 2012;34:73-82.
32. Hamed MA, Ali SA, El-Rigal NS. Therapeutic potential of Ginger against renal injury induced by carbon tetrachloride in rats. ScientificWorldJournal 2012;2012:840421.
33. Ramudu SK, Korivi M, Kesireddy N, Chen CY, Kuo CH, Kesireddy SR. Ginger feeding protects against renal oxidative damage caused by alcohol consumption in rats. J Ren Nutr 2011;21:263-70.
34. Sharkovska Y, Kalk P, von Websky K, Relle K, Pfab T, Alter M, et al. Renoprotective effects of combined endothelin-converting enzyme/neutral endopeptidase inhibitor SLV338 in acute and chronic experimental renal damage. Clin Lab 2011;57:507-15.
35. Uz E, Karatas OF, Mete E, Bayrak R, Bayrak O, Atmaca AF et al. The effect of dietary ginger (Zingiber officinale Rosc) on renal ischemia/reperfusion injury in rat kidneys. Ren Fail 2009;31:251-60.
36. Tayebi Khosroshahi H. Short history about renal transplantation program in Iran and the world: Special focus on world kidney day 2012. J Nephropathology 2012;1:5-10.
37. Tolou-Ghamari Z. Nephro and neurotoxicity, mechanisms of rejection: A review on Tacrolimus and Cyclosporin in organ transplantation. J Nephropathology 2012;1:23-30.
38. Assadi F. The epidemic of pediatric chronic kidney disease: the danger of skepticism. J Nephropathology 2012;1:61-4.
39. Ardalan MR, Samadifar Z, Vahedi A. Creatine monohydrate supplement induced interstitial nephritis. J Nephropathology 2012;1:117-20.