메뉴 건너뛰기




Volumn 38, Issue 4, 2013, Pages 742-752

Improvement of hypoxia-ischemia-induced white matter injury in immature rat brain by ethyl pyruvate

Author keywords

Apoptosis; Ethyl pyruvate; Hypomyelination; Hypoxia ischemia; Inflammation; Oligodendrocyte

Indexed keywords

CASPASE 3; INTERLEUKIN 1BETA; NEUROPROTECTIVE AGENT; PROTEIN BAX; PROTEIN BCL 2; PYRUVIC ACID DERIVATIVE; PYRUVIC ACID ETHYL ESTER; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84876173273     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-013-0972-9     Document Type: Article
Times cited : (20)

References (44)
  • 1
    • 0038080904 scopus 로고    scopus 로고
    • Cerebral white matter injury of the premature infant - More common than you think
    • DOI 10.1542/peds.112.1.176
    • Volpe JJ (2003) Cerebral white matter injury of the premature infant - more common than you think. Pediatrics 112:176-180 (Pubitemid 36792944)
    • (2003) Pediatrics , vol.112 , Issue.1 , pp. 176-180
    • Volpe, J.J.1
  • 2
    • 62949112658 scopus 로고    scopus 로고
    • Periventricular white matter damage in the hypoxic neonatal brain: Role of microglial cells
    • 19428957 10.1016/j.pneurobio.2009.01.003 1:CAS:528:DC%2BD1MXjslOnt7s%3D
    • Kaur C, Ling EA (2009) Periventricular white matter damage in the hypoxic neonatal brain: role of microglial cells. Prog Neurobiol 87:264-280
    • (2009) Prog Neurobiol , vol.87 , pp. 264-280
    • Kaur, C.1    Ling, E.A.2
  • 3
    • 33644613392 scopus 로고    scopus 로고
    • Encephalopathy of prematurity includes neuronal abnormalities
    • 15995055 10.1542/peds.2005-0191
    • Volpe JJ (2005) Encephalopathy of prematurity includes neuronal abnormalities. Pediatrics 116:221-225
    • (2005) Pediatrics , vol.116 , pp. 221-225
    • Volpe, J.J.1
  • 5
    • 33745865559 scopus 로고    scopus 로고
    • Inflammation, brain damage and visual dysfunction in preterm infants
    • DOI 10.1016/j.siny.2006.02.003, PII S1744165X06000205, Inflamation and Perinatal Disease
    • Dammann O, Leviton A (2006) Inflammation, brain damage and visual dysfunction in preterm infants. Semin Fetal Neonatal Med 11:363-368 (Pubitemid 44038696)
    • (2006) Seminars in Fetal and Neonatal Medicine , vol.11 , Issue.5 , pp. 363-368
    • Dammann, O.1    Leviton, A.2
  • 6
    • 33846569483 scopus 로고    scopus 로고
    • Maturation-dependent vulnerability of perinatal white matter in premature birth
    • DOI 10.1161/01.STR.0000254729.27386.05, PII 0000767020070200100028
    • Back SA, Riddle A, McClure MM (2007) Maturation-dependent vulnerability of perinatal white matter in premature birth. Stroke 38:724-730 (Pubitemid 46184249)
    • (2007) Stroke , vol.38 , Issue.2 PART 2 , pp. 724-730
    • Back, S.A.1    Riddle, A.2    McClure, M.M.3
  • 8
    • 64149090699 scopus 로고    scopus 로고
    • Ethyl pyruvate improves survival in awake hemorrhage
    • 10.1007/s00109-009-0441-8 1:CAS:528:DC%2BD1MXktFCiurw%3D
    • Cai B, Brunner M, Wang H, Wang P, Deitch EA, Ulloa L (2009) Ethyl pyruvate improves survival in awake hemorrhage. J Mol Med (Berl) 87:423-433
    • (2009) J Mol Med (Berl) , vol.87 , pp. 423-433
    • Cai, B.1    Brunner, M.2    Wang, H.3    Wang, P.4    Deitch, E.A.5    Ulloa, L.6
  • 9
    • 34247584500 scopus 로고    scopus 로고
    • Ethyl pyruvate: A novel treatment for sepsis
    • DOI 10.2174/138945007780362791
    • Fink MP (2007) Ethyl pyruvate: a novel treatment for sepsis. Curr Drug Targets 8:515-518 (Pubitemid 46672619)
    • (2007) Current Drug Targets , vol.8 , Issue.4 , pp. 515-518
    • Fink, M.P.1
  • 10
    • 34748905416 scopus 로고    scopus 로고
    • Ethyl pyruvate improves survival and ameliorates distant organ injury in rats with severe acute pancreatitis
    • DOI 10.1097/MPA.0b013e318064678a, PII 0000667620071000000010
    • Cheng BQ, Liu CT, Li WJ, Fan W, Zhong N, Zhang Y, Jia XQ, Zhang SZ (2007) Ethyl pyruvate improves survival and ameliorates distant organ injury in rats with severe acute pancreatitis. Pancreas 35:256-261 (Pubitemid 47482519)
    • (2007) Pancreas , vol.35 , Issue.3 , pp. 256-261
    • Cheng, B.-Q.1    Liu, C.-T.2    Li, W.-J.3    Fan, W.4    Zhong, N.5    Zhang, Y.6    Jia, X.-Q.7    Zhang, S.-Z.8
  • 12
    • 67049132380 scopus 로고    scopus 로고
    • Ethyl pyruvate attenuates spinal cord ischemic injury with a wide therapeutic window through inhibiting high-mobility group box 1 release in rabbits
    • 19417608 10.1097/ALN.0b013e3181a160d6 1:CAS:528:DC%2BD1MXmtFKntLg%3D
    • Wang Q, Ding Q, Zhou Y, Gou X, Hou L, Chen S, Zhu Z, Xiong L (2009) Ethyl pyruvate attenuates spinal cord ischemic injury with a wide therapeutic window through inhibiting high-mobility group box 1 release in rabbits. Anesthesiology 110:1279-1286
    • (2009) Anesthesiology , vol.110 , pp. 1279-1286
    • Wang, Q.1    Ding, Q.2    Zhou, Y.3    Gou, X.4    Hou, L.5    Chen, S.6    Zhu, Z.7    Xiong, L.8
  • 13
    • 77950515496 scopus 로고    scopus 로고
    • Ethyl pyruvate has a neuroprotective effect through activation of extracellular signal-regulated kinase in Parkinson's disease model
    • 20307492 10.1016/j.bbrc.2010.03.105 1:CAS:528:DC%2BC3cXks1Kit7s%3D
    • Choi JS, Lee MS, Jeong JW (2010) Ethyl pyruvate has a neuroprotective effect through activation of extracellular signal-regulated kinase in Parkinson's disease model. Biochem Biophys Res Commun 394:854-858
    • (2010) Biochem Biophys Res Commun , vol.394 , pp. 854-858
    • Choi, J.S.1    Lee, M.S.2    Jeong, J.W.3
  • 14
    • 26944449700 scopus 로고    scopus 로고
    • Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain
    • DOI 10.1016/j.brainres.2005.08.029, PII S0006899305012047
    • Kim JB, Yu YM, Kim SW, Lee JK (2005) Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain. Brain Res 1060:188-192 (Pubitemid 41483605)
    • (2005) Brain Research , vol.1060 , Issue.1-2 , pp. 188-192
    • Kim, J.-B.1    Yu, Y.-M.2    Kim, S.-W.3    Lee, J.-K.4
  • 15
    • 26444558061 scopus 로고    scopus 로고
    • Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window
    • DOI 10.1161/01.STR.0000181779.83472.35
    • Yu YM, Kim JB, Lee KW, Kim SY, Han PL, Lee JK (2005) Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window. Stroke 36:2238-2243 (Pubitemid 41429253)
    • (2005) Stroke , vol.36 , Issue.10 , pp. 2238-2243
    • Yu, Y.-M.1    Kim, J.-B.2    Lee, K.-W.3    Kim, S.Y.4    Han, P.-L.5    Lee, J.-K.6
  • 16
    • 79953853318 scopus 로고    scopus 로고
    • Hypoxia-ischemia induces hypo-phosphorylation of collapsin response mediator protein 2 in a neonatal rat model of periventricular leukomalacia
    • 21333637 10.1016/j.brainres.2011.02.027 1:CAS:528:DC%2BC3MXksFejt7k%3D
    • Sato Y, Ishida-Nakajima W, Kawamura M, Miura S, Oguma R, Arai H, Takahashi T (2011) Hypoxia-ischemia induces hypo-phosphorylation of collapsin response mediator protein 2 in a neonatal rat model of periventricular leukomalacia. Brain Res 1386:165-174
    • (2011) Brain Res , vol.1386 , pp. 165-174
    • Sato, Y.1    Ishida-Nakajima, W.2    Kawamura, M.3    Miura, S.4    Oguma, R.5    Arai, H.6    Takahashi, T.7
  • 17
    • 27744545706 scopus 로고    scopus 로고
    • IGF-1 protects oligodendrocyte progenitor cells and improves neurological functions following cerebral hypoxia-ischemia in the neonatal rat
    • DOI 10.1016/j.brainres.2005.09.042, PII S0006899305013594
    • Lin S, Fan LW, Pang Y, Rhodes PG, Mitchell HJ, Cai Z (2005) IGF-1 protects oligodendrocyte progenitor cells and improves neurological functions following cerebral hypoxia-ischemia in the neonatal rat. Brain Res 1063:15-26 (Pubitemid 41628203)
    • (2005) Brain Research , vol.1063 , Issue.1 , pp. 15-26
    • Lin, S.1    Fan, L.-W.2    Pang, Y.3    Rhodes, P.G.4    Mitchell, H.J.5    Cai, Z.6
  • 18
    • 0035866062 scopus 로고    scopus 로고
    • Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injury
    • Back SA, Luo NL, Borenstein NS, Levine JM, Volpe JJ, Kinney HC (2001) Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injury. J Neurosci 21:1302-1312 (Pubitemid 32128775)
    • (2001) Journal of Neuroscience , vol.21 , Issue.4 , pp. 1302-1312
    • Back, S.A.1    Luo, N.L.2    Borenstein, N.S.3    Levine, J.M.4    Volpe, J.J.5    Kinney, H.C.6
  • 20
    • 43049181767 scopus 로고    scopus 로고
    • Post-insult minocycline treatment attenuates hypoxia-ischemia-induced neuroinflammation and white matter injury in the neonatal rat: A comparison of two different dose regimens
    • 18387771 10.1016/j.ijdevneu.2008.02.005 1:CAS:528:DC%2BD1cXlslOktbk%3D
    • Carty ML, Wixey JA, Colditz PB, Buller KM (2008) Post-insult minocycline treatment attenuates hypoxia-ischemia-induced neuroinflammation and white matter injury in the neonatal rat: a comparison of two different dose regimens. Int J Dev Neurosci 26:477-485
    • (2008) Int J Dev Neurosci , vol.26 , pp. 477-485
    • Carty, M.L.1    Wixey, J.A.2    Colditz, P.B.3    Buller, K.M.4
  • 21
    • 77957583421 scopus 로고    scopus 로고
    • Simvastatin attenuates hypomyelination induced by hypoxia-ischemia in neonatal rats
    • 20433776 10.1179/016164110X12670144737774 1:CAS:528:DC%2BC3cXhsVCru73I
    • Li A, Lv S, Yu Z, Zhang Y, Ma H, Zhao H, Piao H, Li S, Zhang N, Sun C (2010) Simvastatin attenuates hypomyelination induced by hypoxia-ischemia in neonatal rats. Neurol Res 32:945-952
    • (2010) Neurol Res , vol.32 , pp. 945-952
    • Li, A.1    Lv, S.2    Yu, Z.3    Zhang, Y.4    Ma, H.5    Zhao, H.6    Piao, H.7    Li, S.8    Zhang, N.9    Sun, C.10
  • 22
    • 1842839965 scopus 로고    scopus 로고
    • Selective vulnerability in the developing central nervous system
    • DOI 10.1016/j.pediatrneurol.2003.10.001, PII S0887899403005319
    • McQuillen PS, Ferriero DM (2004) Selective vulnerability in the developing central nervous system. Pediatr Neurol 30:227-235 (Pubitemid 38490432)
    • (2004) Pediatric Neurology , vol.30 , Issue.4 , pp. 227-235
    • McQuillen, P.S.1    Ferriero, D.M.2
  • 23
    • 71849085729 scopus 로고    scopus 로고
    • Long-term cognitive impairment and myelination deficiency in a rat model of perinatal hypoxic-ischemic brain injury
    • 19747899 10.1016/j.brainres.2009.09.006 1:CAS:528:DC%2BD1MXhtlygtrbE
    • Huang Z, Liu J, Cheung PY, Chen C (2009) Long-term cognitive impairment and myelination deficiency in a rat model of perinatal hypoxic-ischemic brain injury. Brain Res 1301:100-109
    • (2009) Brain Res , vol.1301 , pp. 100-109
    • Huang, Z.1    Liu, J.2    Cheung, P.Y.3    Chen, C.4
  • 24
    • 75949122041 scopus 로고    scopus 로고
    • Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms
    • 20026271 10.1016/j.nbd.2009.12.010 1:CAS:528:DC%2BC3cXitV2ku74%3D
    • Shen H, Hu X, Liu C, Wang S, Zhang W, Gao H, Stetler RA, Gao Y, Chen J (2010) Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms. Neurobiol Dis 37:711-722
    • (2010) Neurobiol Dis , vol.37 , pp. 711-722
    • Shen, H.1    Hu, X.2    Liu, C.3    Wang, S.4    Zhang, W.5    Gao, H.6    Stetler, R.A.7    Gao, Y.8    Chen, J.9
  • 25
    • 0036709907 scopus 로고    scopus 로고
    • Periventricular leukomalacia, inflammation and white matter lesions within the developing nervous system
    • DOI 10.1046/j.1440-1789.2002.00438.x
    • Rezaie P, Dean A (2002) Periventricular leukomalacia, inflammation and white matter lesions within the developing nervous system. Neuropathology 22:106-132 (Pubitemid 35252702)
    • (2002) Neuropathology , vol.22 , Issue.3 , pp. 106-132
    • Rezaie, P.1    Dean, A.2
  • 26
    • 77955170116 scopus 로고    scopus 로고
    • Microglia-derived macrophage colony stimulating factor promotes generation of proinflammatory cytokines by astrocytes in the periventricular white matter in the hypoxic neonatal brain
    • 20406232 1:CAS:528:DC%2BC3cXhtFKht7bP
    • Deng YY, Lu J, Ling EA, Kaur C (2010) Microglia-derived macrophage colony stimulating factor promotes generation of proinflammatory cytokines by astrocytes in the periventricular white matter in the hypoxic neonatal brain. Brain Pathol 20:909-925
    • (2010) Brain Pathol , vol.20 , pp. 909-925
    • Deng, Y.Y.1    Lu, J.2    Ling, E.A.3    Kaur, C.4
  • 27
    • 44649109539 scopus 로고    scopus 로고
    • Amoeboid microglia in the periventricular white matter induce oligodendrocyte damage through expression of proinflammatory cytokines via MAP kinase signaling pathway in hypoxic neonatal rats
    • DOI 10.1111/j.1750-3639.2008.00138.x
    • Deng Y, Lu J, Sivakumar V, Ling EA, Kaur C (2008) Amoeboid microglia in the periventricular white matter induce oligodendrocyte damage through expression of proinflammatory cytokines via MAP kinase signaling pathway in hypoxic neonatal rats. Brain Pathol 18:387-400 (Pubitemid 351782848)
    • (2008) Brain Pathology , vol.18 , Issue.3 , pp. 387-400
    • Deng, Y.1    Lu, J.2    Sivakumar, V.3    Ling, E.A.4    Kaur, C.5
  • 28
    • 83055185642 scopus 로고    scopus 로고
    • Iron and iron regulatory proteins in amoeboid microglial cells are linked to oligodendrocyte death in hypoxic neonatal rat periventricular white matter through production of proinflammatory cytokines and reactive oxygen/nitrogen species
    • 22159112 10.1523/JNEUROSCI.2250-11.2011 1:CAS:528:DC%2BC3MXhs1antrzE
    • Rathnasamy G, Ling EA, Kaur C (2011) Iron and iron regulatory proteins in amoeboid microglial cells are linked to oligodendrocyte death in hypoxic neonatal rat periventricular white matter through production of proinflammatory cytokines and reactive oxygen/nitrogen species. J Neurosci 31:17982-17995
    • (2011) J Neurosci , vol.31 , pp. 17982-17995
    • Rathnasamy, G.1    Ling, E.A.2    Kaur, C.3
  • 29
    • 29744434032 scopus 로고    scopus 로고
    • Minocycline alleviates hypoxic-ischemic injury to developing oligodendrocytes in the neonatal rat brain
    • DOI 10.1016/j.neuroscience.2005.09.023, PII S0306452205010754
    • Cai Z, Lin S, Fan LW, Pang Y, Rhodes PG (2006) Minocycline alleviates hypoxic-ischemic injury to developing oligodendrocytes in the neonatal rat brain. Neuroscience 137:425-435 (Pubitemid 43031509)
    • (2006) Neuroscience , vol.137 , Issue.2 , pp. 425-435
    • Cai, Z.1    Lin, S.2    Fan, L.-W.3    Pang, Y.4    Rhodes, P.G.5
  • 30
    • 33746570748 scopus 로고    scopus 로고
    • Neuroprotection of α-phenyl-n-tert-butyl-nitrone on the neonatal white matter is associated with anti-inflammation
    • DOI 10.1016/j.neulet.2006.06.063, PII S0304394006006227
    • Lin S, Cox HJ, Rhodes PG, Cai Z (2006) Neuroprotection of alpha-phenyl-n-tert-butyl-nitrone on the neonatal white matter is associated with anti-inflammation. Neurosci Lett 405:52-56 (Pubitemid 44142826)
    • (2006) Neuroscience Letters , vol.405 , Issue.1-2 , pp. 52-56
    • Lin, S.1    Cox, H.J.2    Rhodes, P.G.3    Cai, Z.4
  • 31
  • 32
    • 80052669019 scopus 로고    scopus 로고
    • Beneficial effects of ethyl pyruvate through inhibiting high-mobility group box 1 expression and TLR4/NF-kappaB pathway after traumatic brain injury in the rat
    • 21772666 10.1155/2011/807142
    • Su X, Wang H, Zhao J, Pan H, Mao L (2011) Beneficial effects of ethyl pyruvate through inhibiting high-mobility group box 1 expression and TLR4/NF-kappaB pathway after traumatic brain injury in the rat. Mediators Inflamm 2011:807142
    • (2011) Mediators Inflamm , vol.2011 , pp. 807142
    • Su, X.1    Wang, H.2    Zhao, J.3    Pan, H.4    Mao, L.5
  • 34
    • 79851477244 scopus 로고    scopus 로고
    • Expression of N-methyl D-aspartate receptor subunits in amoeboid microglia mediates production of nitric oxide via NF-kappaB signaling pathway and oligodendrocyte cell death in hypoxic postnatal rats
    • 21319220 10.1002/glia.21121
    • Murugan M, Sivakumar V, Lu J, Ling EA, Kaur C (2011) Expression of N-methyl D-aspartate receptor subunits in amoeboid microglia mediates production of nitric oxide via NF-kappaB signaling pathway and oligodendrocyte cell death in hypoxic postnatal rats. Glia 59:521-539
    • (2011) Glia , vol.59 , pp. 521-539
    • Murugan, M.1    Sivakumar, V.2    Lu, J.3    Ling, E.A.4    Kaur, C.5
  • 37
    • 0033817982 scopus 로고    scopus 로고
    • Caspases determine the vulnerability of oligodendrocytes in the ischemic brain
    • 10974017 10.1172/JCI10203 1:CAS:528:DC%2BD3cXmsVajtL0%3D
    • Shibata M, Hisahara S, Hara H, Yamawaki T, Fukuuchi Y, Yuan J, Okano H, Miura M (2000) Caspases determine the vulnerability of oligodendrocytes in the ischemic brain. J Clin Invest 106:643-653
    • (2000) J Clin Invest , vol.106 , pp. 643-653
    • Shibata, M.1    Hisahara, S.2    Hara, H.3    Yamawaki, T.4    Fukuuchi, Y.5    Yuan, J.6    Okano, H.7    Miura, M.8
  • 38
    • 34748845127 scopus 로고    scopus 로고
    • Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices
    • DOI 10.1097/01.anes.0000281898.01966.1e, PII 0000054220071000000019
    • Zeng J, Liu J, Yang GY, Kelly MJ, James TL, Litt L (2007) Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices. Anesthesiology 107:630-640 (Pubitemid 47480570)
    • (2007) Anesthesiology , vol.107 , Issue.4 , pp. 630-640
    • Zeng, J.1    Liu, J.2    Yang, G.-Y.3    Kelly, M.J.S.4    James, T.L.5    Litt, L.6
  • 39
    • 35449006772 scopus 로고    scopus 로고
    • Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells
    • 17611636 1:CAS:528:DC%2BD2sXpt1ehu7w%3D
    • Lim SC, Choi JE, Kim CH, Duong HQ, Jeong GA, Kang HS, Han SI (2007) Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells. Int J Mol Med 20:187-192
    • (2007) Int J Mol Med , vol.20 , pp. 187-192
    • Lim, S.C.1    Choi, J.E.2    Kim, C.H.3    Duong, H.Q.4    Jeong, G.A.5    Kang, H.S.6    Han, S.I.7
  • 40
    • 0031057656 scopus 로고    scopus 로고
    • Bcl-2 gene family in the nervous system
    • DOI 10.1146/annurev.neuro.20.1.245
    • Merry DE, Korsmeyer SJ (1997) Bcl-2 gene family in the nervous system. Annu Rev Neurosci 20:245-267 (Pubitemid 27106382)
    • (1997) Annual Review of Neuroscience , vol.20 , pp. 245-257
    • Merry, D.E.1    Korsmeyer, S.J.2
  • 41
    • 79951965680 scopus 로고    scopus 로고
    • Bax and calpain mediate excitotoxic oligodendrocyte death induced by activation of both AMPA and kainate receptors
    • 21414921 10.1523/JNEUROSCI.5578-10.2011 1:CAS:528:DC%2BC3MXislGit7o%3D
    • Sanchez-Gomez MV, Alberdi E, Perez-Navarro E, Alberch J, Matute C (2011) Bax and calpain mediate excitotoxic oligodendrocyte death induced by activation of both AMPA and kainate receptors. J Neurosci 31:2996-3006
    • (2011) J Neurosci , vol.31 , pp. 2996-3006
    • Sanchez-Gomez, M.V.1    Alberdi, E.2    Perez-Navarro, E.3    Alberch, J.4    Matute, C.5
  • 42
    • 0037989728 scopus 로고    scopus 로고
    • Differential lipid peroxidation, Mn superoxide, and bcl-2 expression contribute to the maturation-dependent vulnerability of oligodendrocytes to oxidative stress
    • Bernardo A, Greco A, Levi G, Minghetti L (2003) Differential lipid peroxidation, Mn superoxide, and bcl-2 expression contribute to the maturation-dependent vulnerability of oligodendrocytes to oxidative stress. J Neuropathol Exp Neurol 62:509-519 (Pubitemid 36560192)
    • (2003) Journal of Neuropathology and Experimental Neurology , vol.62 , Issue.5 , pp. 509-519
    • Bernardo, A.1    Greco, A.2    Levi, G.3    Minghetti, L.4
  • 43
    • 80053237664 scopus 로고    scopus 로고
    • Quercetin protects oligodendrocyte precursor cells from oxygen/glucose deprivation injury in vitro via the activation of the PI3K/Akt signaling pathway
    • 21803128 10.1016/j.brainresbull.2011.07.014 1:CAS:528:DC%2BC3MXht1WqurvE
    • Wang XQ, Yao RQ, Liu X, Huang JJ, Qi DS, Yang LH (2011) Quercetin protects oligodendrocyte precursor cells from oxygen/glucose deprivation injury in vitro via the activation of the PI3K/Akt signaling pathway. Brain Res Bull 86:277-284
    • (2011) Brain Res Bull , vol.86 , pp. 277-284
    • Wang, X.Q.1    Yao, R.Q.2    Liu, X.3    Huang, J.J.4    Qi, D.S.5    Yang, L.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.