SDF-1α Mediates Wound-Promoted Tumor Growth in a Syngeneic Orthotopic Mouse Model of Breast Cancer

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Stuelten, Christina H ^a   Cervoni Curet, Frances N ^a   Busch, Johanna I ^a   Sutton, Emily ^a   Webster, Joshua D ^a   Kavalukas, Sandra L ^b   Wakefield, Lalage M ^a   Barbul, Adrian ^b,c   Niederhuber, John E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SINAI HOSPITAL OF BALTIMORE   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; STROMAL CELL DERIVED FACTOR 1ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; BREAST METASTASIS; CANCER CELL; CANCER GROWTH; CANCER SIZE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; MOUSE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT;

ANALYSIS OF VARIANCE; ANIMALS; AZO COMPOUNDS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMOKINE CXCL12; COLLAGEN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HETEROCYCLIC COMPOUNDS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED BALB C; MICROARRAY ANALYSIS; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC; WOUNDS AND INJURIES;

ANIMALIA;

EID: 84876148026     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060919     Document Type: Article

References (22)

1. Kurian AW, Fish K, Shema SJ, Clarke CA, (2010) Lifetime risks of specific breast cancer subtypes among women in four racial/ethnic groups. Breast Cancer Res 12: R99.
2. Proia DA, Kuperwasser C, (2005) Stroma: tumor agonist or antagonist. Cell Cycle 4: 1022-1025.
3. Dolberg DS, Hollingsworth R, Hertle M, Bissell MJ, (1985) Wounding and its role in RSV-mediated tumor formation. Science 230: 676-678.
4. Stuelten CH, Barbul A, Busch JI, Sutton E, Katz R, et al. (2008) Acute wounds accelerate tumorigenesis by a T cell-dependent mechanism. Cancer Res 68: 7278-7282.
5. Yates CC, Bodnar R, Wells A, (2011) Matrix control of scarring. Cell Mol Life Sci 68: 1871-1881.
6. Kondo T, Ishida Y, (2010) Molecular pathology of wound healing. Forensic Sci Int 203: 93-98.
7. Nagasawa T (2001) Role of chemokine SDF-1/PBSF and its receptor CXCR4 in blood vessel development. Ann N Y Acad Sci 947: 112-115; discussion 115-116.
8. Juarez J, Bendall L, (2004) SDF-1 and CXCR4 in normal and malignant hematopoiesis. Histol Histopathol 19: 299-309.
9. Kucia M, Jankowski K, Reca R, Wysoczynski M, Bandura L, et al. (2004) CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion. J Mol Histol 35: 233-245.
10. Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, et al. (2005) Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121: 335-348.
11. Ao M, Franco OE, Park D, Raman D, Williams K, et al. (2007) Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium. Cancer Res 67: 4244-4253.
12. Baker DG, Masterson TM, Pace R, Constable WC, Wanebo H, (1989) The influence of the surgical wound on local tumor recurrence. Surgery 106: 525-532.
13. Hofer SO, Molema G, Hermens RA, Wanebo HJ, Reichner JS, et al. (1999) The effect of surgical wounding on tumour development. EurJSurgOncol 25: 231-243.
14. Burger JA, Peled A, (2009) CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers. Leukemia 23: 43-52.
15. Burger JA, Kipps TJ, (2006) CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood 107: 1761-1767.
16. Balkwill F, (2004) The significance of cancer cell expression of the chemokine receptor CXCR4. Semin Cancer Biol 14: 171-179.
17. Muller A, Homey B, Soto H, Ge N, Catron D, et al. (2001) Involvement of chemokine receptors in breast cancer metastasis. Nature 410: 50-56.
18. Takemoto Y, Li TS, Kubo M, Ohshima M, Ueda K, et al. (2011) Operative injury accelerates tumor growth by inducing mobilization and recruitment of bone marrow-derived stem cells. Surgery 149: 792-800.
19. Tepper OM, Carr J, Allen RJ Jr, Chang CC, Lin CD, et al. (2010) Decreased circulating progenitor cell number and failed mechanisms of stromal cell-derived factor-1alpha mediated bone marrow mobilization impair diabetic tissue repair. Diabetes 59: 1974-1983.
20. Nishimura Y, Ii M, Qin G, Hamada H, Asai J, et al. (2012) CXCR4 antagonist AMD3100 accelerates impaired wound healing in diabetic mice. J Invest Dermatol 132: 711-720.
21. Toupadakis CA, Wong A, Genetos DC, Chung DJ, Murugesh D, et al. (2012) Long-term administration of AMD3100, an antagonist of SDF-1/CXCR4 signaling, alters fracture repair. J Orthop Res 30: 1853-1859.
22. Pazdur R (2010) FDA Approval for Plerixafor. Cancer Drug Information: National Cancer Institute.