CXCR4 antagonist AMD3100 accelerates impaired wound healing in diabetic mice

Journal of Investigative Dermatology

Volumn 132, Issue 3 PART 1, 2012, Pages 711-720

  Nishimura, Yukihide ^a,b,c   Ii, Masaaki ^a,d   Qin, Gangjian ^a   Hamada, Hiromichi ^e   Asai, Jun ^b   Takenaka, Hideya ^b   Sekiguchi, Haruki ^a   Renault, Marie Ange ^a   Jujo, Kentaro ^a   Katoh, Norito ^b   Kishimoto, Saburo ^b   Ito, Aiko ^a   Kamide, Christine ^a   Kenny, John ^a   Millay, Meredith ^a   Misener, Sol ^a   Thorne, Tina ^a   Losordo, Douglas W ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c Nishiyama Hospital   (Japan)

^d OSAKA MEDICAL COLLEGE   (Japan)

^e Tokyo Women s Medical University   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; LEPTIN RECEPTOR; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR B; PLERIXAFOR; SODIUM CHLORIDE; STROMAL CELL DERIVED FACTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY DENSITY; CELL COUNT; CELL MIGRATION; CELL PROLIFERATION; CELL STRAIN 3T3; COLLAGEN SYNTHESIS; DIABETES MELLITUS; FEMALE; MACROPHAGE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN FIBROBLAST; SKIN INJURY; WOUND CLOSURE; WOUND HEALING; WOUND HEALING IMPAIRMENT;

EID: 84857054917     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2011.356     Document Type: Article

References (49)

1. Adis Data Information BV (2007) Plerixafor: AMD 3100, AMD3100, JM 3100, SDZ SID 791. Drugs R D 8:113-9
2. Asahara T, Murohara T, Sullivan A et al. (1997) Isolation of putative progenitor endothelial cells for angiogenesis. Science 275:964-7 (Pubitemid 27087709)
3. Asai J, Takenaka H, Katoh N et al. (2006a) Dibutyryl cAMP influences endothelial progenitor cell recruitment during wound neovascularization. J Invest Dermatol 126:1159-67
4. Asai J, Takenaka H, Kusano KF et al. (2006b) Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling. Circulation 113:2413-24 (Pubitemid 43948049)
5. Avniel S, Arik Z, Maly A et al. (2006) Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burns. J Invest Dermatol 126:468-76 (Pubitemid 43323185)
6. Bergers G, Song S, Meyer-Morse N et al. (2003) Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 111:1287-95 (Pubitemid 36554699)
7. Bleul CC, Farzan M, Choe H et al. (1996) The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382:829-33 (Pubitemid 26299570)
8. Boulton AJ, Vileikyte L, Ragnarson-Tennvall G et al. (2005) The global burden of diabetic foot disease. Lancet 366:1719-24 (Pubitemid 41587452)
9. Brem H, Balledux J, Bloom T et al. (2000) Healing of diabetic foot ulcers and pressure ulcers with human skin equivalent: A new paradigm in wound healing. Arch Surg 135:627-34 (Pubitemid 30350278)
10. Brem H, Tomic-Canic M (2007) Cellular and molecular basis of wound healing in diabetes. J Clin Invest 117:1219-22 (Pubitemid 46718408)
11. Broxmeyer HE, Orschell CM, Clapp DW et al. (2005) Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. J Exp Med 201:1307-18 (Pubitemid 40629073)
12. Capla JM, Grogan RH, Callaghan MJ et al. (2007) Diabetes impairs endothelial progenitor cell-mediated blood vessel formation in response to hypoxia. Plast Reconstr Surg 119:59-70 (Pubitemid 46360247)
13. Chen YH, Lin SJ, Lin FY et al. (2007) High glucose impairs early and late endothelial progenitor cells by modifying nitric oxiderelated but not oxidative stress-mediated mechanisms. Diabetes 56: 1559-68
14. Falanga V (2005) Wound healing and its impairment in the diabetic foot. Lancet 366:1736-43 (Pubitemid 41587454)
15. Folkman J, Shing Y (1992) Angiogenesis. J Biol Chem 267:10931-4
16. Galiano RD, Tepper OM, Pelo CR et al. (2004) Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. Am J Pathol 164:1935-47 (Pubitemid 38669343)
17. Gallagher KA, Liu ZJ, Xiao M et al. (2007) Diabetic impairments in NOmediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha. J Clin Invest 117:1249-59 (Pubitemid 46718413)
18. Gao Z, Sasaoka T, Fujimori T et al. (2005) Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing. J Biol Chem 280:9375-89 (Pubitemid 40409631)
19. Greenhalgh DG, Sprugel KH, Murray MJ et al. (1990) PDGF and FGF stimulate wound healing in the genetically diabetic mouse. Am J Pathol 136:1235-46 (Pubitemid 20210322)
20. Guillemin GJ, Brew BJ (2004) Microglia, macrophages, perivascular macrophages, and pericytes: A review of function and identification. J Leukoc Biol 75:388-97 (Pubitemid 38316367)
21. Isner JM, Asahara T (1999) Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization. J Clin Invest 103: 1231-6 (Pubitemid 29218292)
22. Iwakura A, Luedemann C, Shastry S et al. (2003) Estrogen-mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells contributes to reendothelialization after arterial injury. Circulation 108:3115-21 (Pubitemid 38031801)
23. Jeffcoate WJ, Harding KG (2003) Diabetic foot ulcers. Lancet 361:1545-51 (Pubitemid 36566350)
24. Jujo K, Hamada H, Iwakura A et al. (2010) CXCR4 blockade augments bone marrow progenitor cell recruitment to the neovasculature and reduces mortality after myocardial infarction. Proc Natl Acad Sci USA 107:11008-13
25. Junqueira LC, Bignolas G, Brentani RR (1979) Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem J 11:447-55 (Pubitemid 9238595)
26. Maddox DE, Shibata S, Goldstein IJ (1982) Stimulated macrophages express a new glycoprotein receptor reactive with Griffonia simplicifolia I-B4 isolectin. Proc Natl Acad Sci USA 79:166-70 (Pubitemid 12181507)
27. Marston WA, Hanft J, Norwood P et al. (2003) The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers: Results of a prospective randomized trial. Diabetes Care 26:1701-5 (Pubitemid 36929107)
28. Maruyama K, Asai J, Ii M et al. (2007) Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. Am J Pathol 170:1178-91 (Pubitemid 47339326)
29. Ochoa O, Torres FM, Shireman PK (2007) Chemokines and diabetic wound healing. Vascular 15:350-5 (Pubitemid 350305401)
30. Orimo A, Gupta PB, Sgroi DC et al. (2005) Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121:335-48 (Pubitemid 40692295)
31. Palumbo PJ, Melton JL III (1995) Peripheral vascular disease and diabetes. In: Diabetes in America (Harris MI, Cowie CC, Stern MP, Boyko EJ, Reiber GE, Bennett PH, eds). Washington: National Institute of Diabetes and Digestive and Kidney Diseases, 401-8
32. Petit I, Szyper-Kravitz M, Nagler A et al. (2002) G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol 3:687-94 (Pubitemid 34752479)
33. Rajkumar VS, Shiwen X, Bostrom M et al. (2006) Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing. Am J Pathol 169:2254-65 (Pubitemid 351181983)
34. Rey M, Valenzuela-Fernandez A, Urzainqui A et al. (2007) Myosin IIA is involved in the endocytosis of CXCR4 induced by SDF-1alpha. J Cell Sci 120:1126-33 (Pubitemid 46638524)
35. Schatteman GC, Ma N (2006) Old bone marrow cells inhibit skin wound vascularization. Stem Cells 24:717-21 (Pubitemid 44464776)
36. Shepherd RM, Capoccia BJ, Devine SM et al. (2006) Angiogenic cells can be rapidly mobilized and efficiently harvested from the blood following treatment with AMD3100. Blood 108:3662-7 (Pubitemid 44864542)
37. Singer AJ, Clark RA (1999) Cutaneous wound healing. N Engl J Med 341:738-46 (Pubitemid 29407375)
38. Sivan-Loukianova E, Awad OA, Stepanovic V et al. (2003) CD34+ blood cells accelerate vascularization and healing of diabetic mouse skin wounds. J Vasc Res 40:368-77 (Pubitemid 37188106)
39. Smiell JM (1998) Clinical safety of becaplermin (rhPDGF-BB) gel. Becaplermin Studies Group. Am J Surg 176:68S-73S (Pubitemid 28460660)
40. Sorokin SP, Hoyt RF Jr (1992) Macrophage development: I. Rationale for using Griffonia simplicifolia isolectin B4 as a marker for the line. Anat Rec 232:520-6
41. Staller P, Sulitkova J, Lisztwan J et al. (2003) Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 425:307-11 (Pubitemid 37158407)
42. Suh W, Kim KL, Kim JM et al. (2005) Transplantation of endothelial progenitor cells accelerates dermal wound healing with increased recruitment of monocytes/macrophages and neovascularization. Stem Cells 23:1571-8 (Pubitemid 41741006)
43. Tepper OM, Galiano RD, Capla JM et al. (2002) Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation 106:2781-6 (Pubitemid 35396976)
44. Urbich C, Dimmeler S (2004) Endothelial progenitor cells: Characterization and role in vascular biology. Circ Res 95:343-53 (Pubitemid 39100452)
45. Vasa M, Fichtlscherer S, Aicher A et al. (2001) Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 89:E1-7
46. Velazquez OC (2007) Angiogenesis and vasculogenesis: Inducing the growth of new blood vessels and wound healing by stimulation of bone marrowderived progenitor cell mobilization and homing. J Vasc Surg 45(Suppl A):A39-47
47. Warfel AH, Zucker-Franklin D, Zheng ZY (1991) Macrophage membrane glycoproteins that bind Griffonia simplicifolia I-B4: Effect on cytotoxicity and protein secretion. J Cell Physiol 147:265-73 (Pubitemid 21910107)
48. Werner C, Kamani CH, Gensch C et al. (2007) The peroxisome proliferatoractivated receptor-gamma agonist pioglitazone increases number and function of endothelial progenitor cells in patients with coronary artery disease and normal glucose tolerance. Diabetes 56:2609-15 (Pubitemid 47523269)
49. Yamaguchi J, Kusano KF, Masuo O et al. (2003) Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation 107:1322-8 (Pubitemid 36314418)