Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 9, 2013, Pages 2579-2584

  Chandrasekharappa, Arun P ^a   Badiger, Sangamesh E ^a   Dubey, Pramod K ^b   Panigrahi, Sunil K ^a   Manukonda, Sekhar Reddy V V V ^a  

^a Aurigene Discovery Technologies Limited   (India)

^b JNTUH COLLEGE OF ENGINEERING   (India)

Author keywords

Benzimidazole; Benzoxazole; Diabetes; Oxamic acids; PTP1B; pTyr mimetics

Indexed keywords

BENZOXAZOLE DERIVATIVE; OXAMIC ACID; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZOXAZOLES; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; MICE; MOLECULAR DOCKING SIMULATION; OXAMIC ACID; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84876133082     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.02.109     Document Type: Article

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