Peptide inhibitors of protein kinases - Discovery, characterisation and use

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1754, Issue 1-2, 2005, Pages 79-99

  Bogoyevitch, Marie A ^a   Barr, Renae K ^a   Ketterman, Albert J ^b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Endogenous inhibitor; Library screening; Peptide design; Peptide inhibitor; Pseudosubstrate; Small molecule ATP non competitive inhibitor

Indexed keywords

[ALANINE 5]KEMPTIDE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CALMODULIN BINDING PROTEIN; CALMODULIN BINDING PROTEIN 1; CALMODULIN DEPENDENT PROTEIN KINASE[290-302]; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; HT 31 PEPTIDE; MYOSIN LIGHT CHAIN[11-19]; MYOSIN LIGHT CHAIN[480-501]; PEPTIDE 29; PEPTIDE 3; PEPTIDE 30; PEPTIDE 4; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN AKAP IS; PROTEIN C 4; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE C BETA[218-226]; PROTEIN KINASE C DELTA[8-17]; PROTEIN KINASE C ZETA[116-124]; PROTEIN KINASE C[20-28]; PROTEIN KINASE INHIBITOR[1-24]; PROTEIN KINASE INHIBITOR[11-30]; PROTEIN KINASE INHIBITOR[14-22]; PROTEIN KINASE INHIBITOR[5-24]; PROTEIN KRX 014.H151; PROTEIN KRX 147.D103; PROTEIN KRX 702.H105; UNCLASSIFIED DRUG; UNINDEXED DRUG; Y 1007;

AMINO ACID SEQUENCE; ANALYTIC METHOD; CONFERENCE PAPER; CONJUGATION; ENZYME INHIBITION; ENZYME SUBSTRATE; GENE LIBRARY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; BIOLOGICAL AVAILABILITY; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; PEPTIDE LIBRARY; PEPTIDES; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 29144523190     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2005.07.025     Document Type: Conference Paper

References (180)

1. S.K. Hanks, A.M. Quinn, and T. Hunter The protein kinase family: conserved features and deduced phylogeny of the catalytic domains Science 241 1988 42 52
2. G. Manning, D.B. Whyte, R. Martinez, T. Hunter, and S. Sudarsanam The protein kinase complement of the human genome Science 298 2002 912 934
3. S. Caenepeel, G. Charydczak, S. Sudarsanam, T. Hunter, and G. Manning The mouse kinome: discovery and comparative genomics of all mouse protein kinases Proc. Natl. Acad. Sci. U. S. A. 101 2004 11707 11712
4. P. Cohen Protein kinases-The major drug targets of the twenty-first century? Nat. Rev., Drug Discov. 1 2002 309 315
5. P.M. Fischer The design of drug candidate molecules as selective inhibitors of therapeutically relevant protein kinases Curr. Med. Chem. 11 2004 1563 1583
6. P.M. Fischer, and D.P. Lane Small-molecule inhibitors of the p53 suppressor HDM2: have protein-protein interactions come of age as drug targets? Trends Pharmacol. Sci. 25 2004 343 346
7. D.R. Knighton, J.H. Zheng, L.F. Ten Eyck, V.A. Ashford, N.H. Xuong, S.S. Taylor, and J.M. Sowadski Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase Science 253 1991 407 414
8. B. Nolen, S. Taylor, and G. Ghosh Regulation of protein kinases; controlling activity through activation segment conformation Mol. Cell 15 2004 661 675
9. Y.S. Heo, S.K. Kim, C.I. Seo, Y.K. Kim, B.J. Sung, H.S. Lee, J.I. Lee, S.Y. Park, J.H. Kim, K.Y. Hwang, Y.L. Hyun, Y.H. Jeon, S. Ro, J.M. Cho, T.G. Lee, and C.H. Yang Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 EMBO J. 23 2004 2185 2195
10. D.A. Walsh, C.D. Ashby, C. Gonzalez, D. Calkins, E.H. Fischer, and E.G. Krebs Purification and characterization of a protein inhibitor of adenosine 3′,5′-monophosphate-dependent protein kinases J. Biol. Chem. 246 1971 1977 1985
11. C.D. Ashby, and D.A. Walsh Characterization of the interaction of a protein inhibitor with adenosine 3′,5′-monophosphate-dependent protein kinases. II. Mechanism of action with the holoenzyme J. Biol. Chem. 248 1973 1255 1261
12. A. Szmigielski, A. Guidotti, and E. Costa Endogenous protein kinase inhibitors. Purification, characterization, and distribution in different tissues J. Biol. Chem. 252 1977 3848 3853
13. J.G. Demaille, K.A. Peters, and E.H. Fischer Isolation and properties of the rabbit skeletal muscle protein inhibitor of adenosine 3′,5′- monophosphate dependent protein kinases Biochemistry 16 1977 3080 3086
14. J.D. Scott, E.H. Fischer, J.G. Demaille, and E.G. Krebs Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase Proc. Natl. Acad. Sci. U. S. A. 82 1985 4379 4383
15. J.D. Scott, E.H. Fischer, K. Takio, J.G. Demaille, and E.G. Krebs Amino acid sequence of the heat-stable inhibitor of the cAMP-dependent protein kinase from rabbit skeletal muscle Proc. Natl. Acad. Sci. U. S. A. 82 1985 5732 5736
16. J.D. Scott, M.B. Glaccum, E.H. Fischer, and E.G. Krebs Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase Proc. Natl. Acad. Sci. U. S. A. 83 1986 1613 1616
17. H.C. Cheng, B.E. Kemp, R.B. Pearson, A.J. Smith, L. Misconi, S.M. Van Patten, and D.A. Walsh A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase J. Biol. Chem. 261 1986 989 992
18. J. Reed, V. Kinzel, H.C. Cheng, and D.A. Walsh Circular dichroic investigations of secondary structure in synthetic peptide inhibitors of cAMP-dependent protein kinase: a model for inhibitory potential Biochemistry 26 1987 7641 7647
19. D.B. Glass, H.C. Cheng, L. Mende-Mueller, J. Reed, and D.A. Walsh Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein J. Biol. Chem. 264 1989 8802 8810
20. J. Zheng, D.R. Knighton, L.F. ten Eyck, R. Karlsson, N. Xuong, S.S. Taylor, and J.M. Sowadski Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor Biochemistry 32 1993 2154 2161
21. D.A. Walsh, and D.B. Glass Utilization of the inhibitor protein of adenosine cyclic monophosphate-dependent protein kinase, and peptides derived from it, as tools to study adenosine cyclic monophosphate-mediated cellular processes Methods Enzymol. 201 1991 304 316
22. J.R. Grove, P.J. Deutsch, D.J. Price, J.F. Habener, and J. Avruch Plasmids encoding PKI(1-31), a specific inhibitor of cAMP-stimulated gene expression, inhibit the basal transcriptional activity of some but not all cAMP-regulated DNA response elements in JEG-3 cells J. Biol. Chem. 264 1989 19506 19513
23. A. Fernandez, J. Mery, M. Vandromme, M. Basset, J.C. Cavadore, and N.J. Lamb Effective intracellular inhibition of the cAMP-dependent protein kinase by microinjection of a modified form of the specific inhibitor peptide PKi in living fibroblasts Exp. Cell Res. 195 1991 468 477
24. N.J. Lamb, J.C. Cavadore, J.C. Labbe, R.A. Maurer, and A. Fernandez Inhibition of cAMP-dependent protein kinase plays a key role in the induction of mitosis and nuclear envelope breakdown in mammalian cells EMBO J. 10 1991 1523 1533
25. B. Yu, Y. Wang, Y. Liu, Y. Liu, X. Li, D. Wu, Z. Zong, J. Zhang, and D. Yu Protein kinase A regulates cell cycle progression of mouse fertilized eggs by means of MPF Dev. Dyn. 232 2005 98 105
26. B. Meister, J. Fryckstedt, M. Schalling, R. Cortes, T. Hokfelt, A. Aperia, H.C. Hemmings, A.C. Nairn, M. Ehrlich, and P. Greengard Dopamine- and cAMP-regulated phosphoprotein (DARPP-32) and dopamine DA1 agonist-sensitive Na+,K+-ATPase in renal tubule cells Proc. Natl. Acad. Sci. U. S. A. 86 1989 8068 8072
27. M.J. Lohse, J.L. Benovic, M.G. Caron, and R.J. Lefkowitz Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors J. Biol. Chem. 265 1990 3202 3211
28. K.S. Murthy, and G.M. Makhlouf Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells Am. J. Physiol. 268 1995 C171 C180
29. G.D. Dalton, F.L. Smith, P.A. Smith, and W.L. Dewey Alterations in brain protein kinase A activity and reversal of morphine tolerance by two fragments of native protein kinase A inhibitor peptide (PKI) Neuropharmacology 48 2005 648 657
30. T.E. Harris, S.J. Persaud, and P.M. Jones Pseudosubstrate inhibition of cyclic AMP-dependent protein kinase in intact pancreatic islets: effects on cyclic AMP-dependent and glucose-dependent insulin secretion Biochem. Biophys. Res. Commun. 232 1997 648 651
31. H. Tong, D. Bernstein, E. Murphy, and C. Steenbergen The role of beta-adrenergic receptor signaling in cardioprotection FASEB J. 19 2005 983 985
32. K.S. Murthy, H. Zhou, and G.M. Makhlouf PKA-dependent activation of PDE3A and PDE4 and inhibition of adenylyl cyclase V/VI in smooth muscle Am. J. Physiol. 282 2002 C508 C517
33. L.O. Flowers, H.M. Johnson, M.G. Mujtaba, M.R. Ellis, S.M. Haider, and P.S. Subramaniam Characterization of a peptide inhibitor of Janus kinase 2 that mimics suppressor of cytokine signaling 1 function J. Immunol. 172 2004 7510 7518
34. B.E. Kemp, E. Benjamini, and E.G. Krebs Synthetic hexapeptide substrates and inhibitors of 3′:5′-cyclic AMP-dependent protein kinase Proc. Natl. Acad. Sci. U. S. A. 73 1976 1038 1042
35. J.R. Feramisco, and E.G. Krebs Inhibition of cyclic AMP-dependent protein kinase by analogues of a synthetic peptide substrate J. Biol. Chem. 253 1978 8968 8971
36. H.N. Bramson, N. Thomas, R. Matsueda, N.C. Nelson, S.S. Taylor, and E.T. Kaiser Modification of the catalytic subunit of bovine heart cAMP-dependent protein kinase with affinity labels related to peptide substrates J. Biol. Chem. 257 1982 10575 10581
37. A. Salerno, and D.S. Lawrence Covalent modification with concomitant inactivation of the cAMP-dependent protein kinase by affinity labels containing only l-amino acids J. Biol. Chem. 268 1993 13043 13049
38. W.T. Miller, and E.T. Kaiser Probing the peptide binding site of the cAMP-dependent protein kinase by using a peptide-based photoaffinity label Proc. Natl. Acad. Sci. U. S. A. 85 1988 5429 5433
39. C.A. O'Brian, N.E. Ward, R.M. Liskamp, D.B. de Bont, and J.H. van Boom N-myristyl-Lys-Arg-Thr-Leu-Arg: a novel protein kinase C inhibitor Biochem. Pharmacol. 39 1990 49 57
40. N.E. Ward, and C.A. O'Brian Inhibition of protein kinase C by N-myristoylated peptide substrate analogs Biochemistry 32 1993 11903 11909
41. C.G. Ioannides, R.S. Freedman, R.M. Liskamp, N.E. Ward, and C.A. O'Brian Inhibition of IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat by a novel peptide inhibitor of protein kinase C Cell. Immunol. 131 1990 242 252
42. N.E. Ward, K.R. Gravitt, and C.A. O'Brian Irreversible inactivation of protein kinase C by a peptide-substrate analog J. Biol. Chem. 270 1995 8056 8060
43. J.H. Lee, S.K. Nandy, and D.S. Lawrence A highly potent and selective PKCalpha inhibitor generated via combinatorial modification of a peptide scaffold J. Am. Chem. Soc. 126 2004 3394 3395
44. T. Obata, M.B. Yaffe, G.G. Leparc, E.T. Piro, H. Maegawa, A. Kashiwagi, R. Kikkawa, and L.C. Cantley Peptide and protein library screening defines optimal substrate motifs for AKT/PKB J. Biol. Chem. 275 2000 36108 36115
45. Y. Luo, R.A. Smith, R. Guan, X. Liu, V. Klinghofer, J. Shen, C. Hutchins, P. Richardson, T. Holzman, S.H. Rosenberg, and V.L. Giranda Pseudosubstrate peptides inhibit Akt and induce cell growth inhibition Biochemistry 43 2004 1254 1263
46. D. Graves, C. Bartleson, A. Biorn, and M. Pete Substrate and inhibitor recognition of protein kinases: what is known about the catalytic subunit of phosphorylase kinase? Pharmacol. Ther. 82 1999 143 155
47. L.B. Tabatabai, and D.J. Graves Kinetic mechanism and specificity of the phosphorylase kinase reaction J. Biol. Chem. 253 1978 2196 2202
48. G. Pfitzer Invited review: regulation of myosin phosphorylation in smooth muscle J. Appl. Physiol. 91 2001 497 503
49. R.B. Pearson, L.Y. Misconi, and B.E. Kemp Smooth muscle myosin kinase requires residues on the COOH-terminal side of the phosphorylation site. Peptide inhibitors J. Biol. Chem. 261 1986 25 27
50. K.S. Lam, J. Wu, and Q. Lou Identification and characterization of a novel synthetic peptide substrate specific for Src-family protein tyrosine kinases Int. J. Pept. Protein Res. 45 1995 587 592
51. J. Alfaro-Lopez, W. Yuan, B.C. Phan, J. Kamath, Q. Lou, K.S. Lam, and V.J. Hruby Discovery of a novel series of potent and selective substrate-based inhibitors of p60c-src protein tyrosine kinase: conformational and topographical constraints in peptide design J. Med. Chem. 41 1998 2252 2260
52. J.R. Kamath, R. Liu, A.M. Enstrom, Q. Lou, and K.S. Lam Development and characterization of potent and specific peptide inhibitors of p60c-src protein tyrosine kinase using pseudosubstrate-based inhibitor design approach J. Pept. Res. 62 2003 260 268
53. L. Ramdas, N.U. Obeyesekere, G. Sun, J.S. McMurray, and R.J. Budde N-myristoylation of a peptide substrate for Src converts it into an apparent slow-binding bisubstrate-type inhibitor J. Pept. Res. 53 1999 569 577
54. K. Parang, and P.A. Cole Designing bisubstrate analog inhibitors for protein kinases Pharmacol. Ther. 93 2002 145 157
55. A. Ricouart, J.C. Gesquiere, A. Tartar, and C. Sergheraert Design of potent protein kinase inhibitors using the bisubstrate approach J. Med. Chem. 34 1991 73 78
56. D. Medzihradszky, S.L. Chen, L.C. Kenyon, and B.W. Gibson Solid-phase synthesis of adenosine phosphopeptides as potential bisubstrate inhibitors of protein kinases J. Am. Chem. Soc. 116 1994 9413 9419
57. A.C. Hines, and P.A. Cole Design, synthesis, and characterization of an ATP-peptide conjugate inhibitor of protein kinase A Bioorg. Med. Chem. Lett. 14 2004 2951 2954
58. A. Kuznetsov, A. Uri, G. Raidaru, and J. Jarv Kinetic analysis of inhibition of cAMP-dependent protein kinase catalytic subunit by the peptide-nucleoside conjugate AdcAhxArg6 Bioorg. Chem. 32 2004 527 535
59. K. Parang, J.H. Till, A.J. Ablooglu, R.A. Kohanski, S.R. Hubbard, and P.A. Cole Mechanism-based design of a protein kinase inhibitor Nat. Struct. Biol. 8 2001 37 41
60. S.E. Shoelson, S. Chatterjee, M. Chaudhuri, and M.F. White YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase Proc. Natl. Acad. Sci. U. S. A. 89 1992 2027 2031
61. A.J. Ablooglu, J.H. Till, K. Kim, K. Parang, P.A. Cole, S.R. Hubbard, and R.A. Kohanski Probing the catalytic mechanism of the insulin receptor kinase with a tetrafluorotyrosine-containing peptide substrate J. Biol. Chem. 275 2000 30394 30398
62. B.E. Kemp, R.B. Pearson, and C.M. House Pseudosubstrate-based peptide inhibitors Methods Enzymol. 201 1991 287 304
63. D. Mochly-Rosen Localization of protein kinases by anchoring proteins: a theme in signal transduction Science 268 1995 247 251
64. D. Mochly-Rosen, and A.S. Gordon Anchoring proteins for protein kinase C: a means for isozyme selectivity FASEB J. 12 1998 35 42
65. C. House, and B.E. Kemp Protein kinase C contains a pseudosubstrate prototope in its regulatory domain Science 238 1987 1726 1728
66. C. House, and B.E. Kemp Protein kinase C pseudosubstrate prototope: structure-function relationships Cell. Signal. 2 1990 187 190
67. A. Ricouart, A. Tartar, and C. Sergheraert Inhibition of protein kinase C by retro-inverso pseudosubstrate analogues Biochem. Biophys. Res. Commun. 165 1989 1382 1390
68. D.R. Alexander, J.D. Graves, S.C. Lucas, D.A. Cantrell, and M.J. Crumpton A method for measuring protein kinase C activity in permeabilized T lymphocytes by using peptide substrates. Evidence for multiple pathways of kinase activation Biochem. J. 268 2 1990 303 308
69. D.R. Alexander, J.M. Hexham, S.C. Lucas, J.D. Graves, D.A. Cantrell, and M.J. Crumpton A protein kinase C pseudosubstrate peptide inhibits phosphorylation of the CD3 antigen in streptolysin-O-permeabilized human T lymphocytes Biochem. J. 260 1989 893 901
70. T. Eichholtz, J. Alblas, M. van Overveld, W. Moolenaar, and H. Ploegh A pseudosubstrate peptide inhibits protein kinase C-mediated phosphorylation in permeabilized Rat-1 cells FEBS Lett. 261 1990 147 150
71. S.S. Shen, and W.R. Buck A synthetic peptide of the pseudosubstrate domain of protein kinase C blocks cytoplasmic alkalinization during activation of the sea urchin egg Dev. Biol. 140 1990 272 280
72. S.C. Ahlgren, and J.D. Levine Protein kinase C inhibitors decrease hyperalgesia and C-fiber hyperexcitability in the streptozotocin-diabetic rat J. Neurophysiol. 72 1994 684 692
73. S.G. Rane, M.P. Walsh, J.R. McDonald, and K. Dunlap Specific inhibitors of protein kinase C block transmitter-induced modulation of sensory neuron calcium current Neuron 3 1989 239 245
74. R. Malinow, H. Schulman, and R.W. Tsien Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP Science 245 1989 862 866
75. O. Hvalby, H.C. Hemmings, O. Paulsen, A.J. Czernik, A.C. Nairn, J.M. Godfraind, V. Jensen, M. Raastad, J.F. Storm, P. Andersen, and P. Greengard Specificity of protein kinase inhibitor peptides and induction of long-term potentiation Proc. Natl. Acad. Sci. U. S. A. 91 1994 4761 4765
76. T. Eichholtz, D.B. de Bont, J. de Widt, R.M. Liskamp, and H.L. Ploegh A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor J. Biol. Chem. 268 1993 1982 1986
77. A.J. Verhoeven, J.H. Leusen, G.C. Kessels, P.M. Hilarius, D.B. de Bont, and R.M. Liskamp Inhibition of neutrophil NADPH oxidase assembly by a myristoylated pseudosubstrate of protein kinase C J. Biol. Chem. 268 1993 18593 18598
78. T.E. Harris, S.J. Persaud, T. Saermark, and P.M. Jones A myristoylated pseudosubstrate peptide inhibitor of protein kinase C: effects on glucose- and carbachol-induced insulin secretion Mol. Cell. Endocrinol. 121 1996 133 141
79. P.J. Bergman, K.R. Gravitt, and C.A. O'Brian An N-myristoylated protein kinase C-alpha pseudosubstrate peptide that functions as a multidrug resistance reversal agent in human breast cancer cells is not a P-glycoprotein substrate Cancer Chemother. Pharmacol. 40 1997 453 456
80. L. Theodore, D. Derossi, G. Chassaing, B. Llirbat, M. Kubes, P. Jordan, H. Chneiweiss, P. Godement, and A. Prochiantz Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse J. Neurosci. 15 1995 7158 7167
81. M.A. Bogoyevitch, T.S. Kendrick, D.C.H. Ng, and R.K. Barr Taking the cell by stealth or storm? Protein transduction domains (PTDs) as versatile vectors for delivery DNA Cell Biol. 21 2002 879 894
82. I. Dominguez, M.T. Diaz-Meco, M.M. Municio, E. Berra, A. Garcia de Herreros, M.E. Cornet, L. Sanz, and J. Moscat Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes Mol. Cell. Biol. 12 1992 3776 3783
83. I. Dominguez, L. Sanz, F. Arenzana-Seisdedos, M.T. Diaz-Meco, J.L. Virelizier, and J. Moscat Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes Mol. Cell. Biol. 13 1993 1290 1295
84. B.P. De, S. Gupta, S. Gupta, and A.K. Banerjee Cellular protein kinase C isoform zeta regulates human parainfluenza virus type 3 replication Proc. Natl. Acad. Sci. U. S. A. 92 1995 5204 5208
85. G. Bandyopadhyay, M.L. Standaert, L. Galloway, J. Moscat, and R.V. Farese Evidence for involvement of protein kinase C (PKC)-zeta and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes Endocrinology 138 1997 4721 4731
86. S.H. Tang, and G.W. Sharp Atypical protein kinase C isozyme zeta mediates carbachol-stimulated insulin secretion in RINm5F cells Diabetes 47 1998 905 912
87. A. Muscella, S. Greco, M.G. Elia, C. Storelli, and S. Marsigliante PKC-zeta is required for angiotensin II-induced activation of ERK and synthesis of C-FOS in MCF-7 cells J. Cell. Physiol. 197 2003 61 68
88. M. McConkey, H. Gillin, C.R. Webster, and M.S. Anwer Cross-talk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes J. Biol. Chem. 279 2004 20882 20888
89. P. Serrano, Y. Yao, and T.C. Sacktor Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term potentiation J. Neurosci. 25 2005 1979 1984
90. D. Bonnet, K. Thiam, E. Loing, O. Melnyk, and H. Gras-Masse Synthesis by chemoselective ligation and biological evaluation of novel cell-permeable PKC-zeta pseudosubstrate lipopeptides J. Med. Chem. 44 2001 468 471
91. B.E. Kemp, R.B. Pearson, V. Guerriero, I.C. Bagchi, and A.R. Means The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence J. Biol. Chem. 262 1987 2542 2548
92. M. Ikebe, M. Stepinska, B.E. Kemp, A.R. Means, and D.J. Hartshorne Proteolysis of smooth muscle myosin light chain kinase. Formation of inactive and calmodulin-independent fragments J. Biol. Chem. 262 1987 13828 13834
93. T. Itoh, M. Ikebe, G.J. Kargacin, D.J. Hartshorne, B.E. Kemp, and F.S. Fay Effects of modulators of myosin light-chain kinase activity in single smooth muscle cells Nature 338 1989 164 167
94. T.J. Lukas, S. Mirzoeva, U. Slomczynska, and D.M. Watterson Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge J. Med. Chem. 42 1999 910 919
95. M.E. Payne, Y.L. Fong, T. Ono, R.J. Colbran, B.E. Kemp, T.R. Soderling, and A.R. Means Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains J. Biol. Chem. 263 1988 7190 7195
96. R.J. Colbran, M.K. Smith, C.M. Schworer, Y.L. Fong, and T.R. Soderling Regulatory domain of calcium/calmodulin-dependent protein kinase II. Mechanism of inhibition and regulation by phosphorylation J. Biol. Chem. 264 1989 4800 4804
97. 2+-induced and phorbol ester-stabilized membrane bindings of protein kinase C J. Biol. Chem. 261 1986 16438 16445
98. D. Mochly-Rosen, C.J. Henrich, L. Cheever, H. Khaner, and P.C. Simpson A protein kinase C isozyme is translocated to cytoskeletal elements on activation Cell. Regul. 1 1990 693 706
99. D. Ron, J.H. Luo, and D. Mochly-Rosen C2 region-derived peptides inhibit translocation and function of beta protein kinase C in vivo J. Biol. Chem. 270 1995 24180 24187
100. 2+ channels Circ. Res. 80 1997 720 729
101. J.A. Johnson, M.O. Gray, C.-H. Chen, and D. Mochly-Rosen A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function J. Biol. Chem. 271 1996 24962 24966
102. M.O. Gray, J.S. Karliner, and D. Mochly-Rosen A selective epsilon-peptide protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death J. Biol. Chem. 272 1997 30945 30951
103. M. Yedovitzky, D. Mochly-Rosen, J.A. Johnson, M.O. Fray, D. Ron, E. Abramovitch, E. Cerasi, and R. Nesher Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells J. Biol. Chem. 272 1997 1417 1420
104. G.C. Mayne, and A.W. Murray Evidence that protein kinase Cepsilon mediates phorbol ester inhibition of calphostin C- and tumor necrosis factor-alpha-induced apoptosis in U937 histiocytic lymphoma cells J. Biol. Chem. 273 1998 24115 24121
105. Y. Chen, A.R. Cantrell, R.O. Messing, T. Scheuer, and W.A. Catterall Specific modulation of Na+ channels in hippocampal neurons by protein kinase Cepsilon J. Neurosci. 25 2005 507 513
106. L. Chen, H. Hahn, G. Wu, C.H. Chen, T. Liron, D. Schechtman, G. Cavallaro, L. Banci, Y. Guo, R. Bolli, G.W. Dorn, and D. Mochly-Rosen Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC Proc. Natl. Acad. Sci. U. S. A. 98 2001 11114 11119
107. K. Inagaki, L. Chen, F. Ikeno, F.H. Lee, K. Imahashi, D.M. Bouley, M. Rezaee, P.G. Yock, E. Murphy, and D. Mochly-Rosen Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo Circulation 108 2003 2304 2307
108. K. Inagaki, H.S. Hahn, G.W. Dorn, and D. Mochly-Rosen Additive protection of the ischemic heart ex vivo by combined treatment with delta-protein kinase C inhibitor and epsilon-protein kinase C activator Circulation 108 2003 869 875
109. C.L. Murriel, E. Churchill, K. Inagaki, L.I. Szweda, and D. Mochly-Rosen Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria J. Biol. Chem. 279 2004 47985 47991
110. R. Bright, A.P. Raval, J.M. Dembner, M.A. Perez-Pinzon, G.K. Steinberg, M.A. Yenari, and D. Mochly-Rosen Protein kinase C delta mediates cerebral reperfusion injury in vivo J. Neurosci. 24 2004 6880 6888
111. M. Tanaka, R.D. Terry, G.K. Mokhtari, K. Inagaki, T. Koyanagi, T. Kofidis, D. Mochly-Rosen, and R.C. Robbins Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts Circulation 110 11 Suppl. 1 2004 II194 II199
112. M. Tanaka, F. Gunawan, R.D. Terry, K. Inagaki, A.D. Caffarelli, G. Hoyt, P.S. Tsao, D. Mochly-Rosen, and R.C. Robbins Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators J. Thorac. Cardiovasc. Surg. 129 2005 1160 1167
113. M.U. Braun, and D. Mochly-Rosen Opposing effects of delta- and zeta-protein kinase C isozymes on cardiac fibroblast proliferation: use of isozyme-selective inhibitors J. Mol. Cell. Cardiol. 35 2003 895 903
114. M. Goldenberg-Furmanov, I. Stein, E. Pikarsky, H. Rubin, S. Kasem, M. Wygoda, I. Weinstein, H. Reuveni, and S.A. Ben-Sasson Lyn is a target gene for prostate cancer: sequence-based inhibition induces regression of human tumor xenografts Cancer Res. 64 2004 1058 1066
115. M.Y. Niv, H. Rubin, J. Cohen, L. Tsirulnikov, T. Licht, A. Peretzman-Shemer, E. Can'an, A. Tartakovsky, I. Stein, S. Albeck, I. Weinstein, M. Goldenberg-Furmanov, D. Tobi, E. Cohen, M. Laster, S.A. Ben-Sasson, and H. Reuveni Sequence-based design of kinase inhibitors applicable for therapeutics and target identification J. Biol. Chem. 279 2004 1242 1255
116. J.J. Michel, and J.D. Scott AKAP mediated signal transduction Annu. Rev. Pharmacol. Toxicol. 42 2002 235 257
117. W. Wong, and J.D. Scott AKAP signalling complexes: focal points in space and time Nat. Rev., Mol. Cell Biol. 5 2004 959 970
118. M. Colledge, and J.D. Scott AKAPs: from structure to function Trends Cell Biol. 9 1999 216 221
119. D.W. Carr, D.A. DeManno, A. Atwood, M. Hunzicker-Dunn, and J.D. Scott Follicle-stimulating hormone regulation of A-kinase anchoring proteins in granulosa cells J. Biol. Chem. 268 1993 20729 20732
120. D.W. Carr, R.E. Stofko-Hahn, I.D. Fraser, S.M. Bishop, T.S. Acott, R.G. Brennan, and J.D. Scott Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif J. Biol. Chem. 266 1991 14188 14192
121. Z.E. Hausken, M.L. Dell'Acqua, V.M. Coghlan, and J.D. Scott Mutational analysis of the A-kinase anchoring protein (AKAP)-binding site on RII. Classification Of side chain determinants for anchoring and isoform selective association with AKAPs J. Biol. Chem. 271 1996 29016 29022
122. S.B. Glantz, Y. Li, and C.S. Rubin Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase II beta to the cytoskeleton J. Biol. Chem. 268 1993 12796 12804
123. S. Vijayaraghavan, S.A. Goueli, M.P. Davey, and D.W. Carr Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motility J. Biol. Chem. 272 1997 4747 4752
124. 2+ channel activity by cAMP-dependent protein kinase Proc. Natl. Acad. Sci. U. S. A. 94 1997 11067 11072
125. F.W. Herberg, A. Maleszka, T. Eide, L. Vossebein, and K. Tasken Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding J. Mol. Biol. 298 2000 329 339
126. C. Rosenmund, D.W. Carr, S.E. Bergeson, G. Nilaver, J.D. Scott, and G.L. Westbrook Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons Nature 368 1994 853 856
127. B.D. Johnson, T. Scheuer, and W.A. Catterall Voltage-dependent potentiation of L-type Ca2+ channels in skeletal muscle cells requires anchored cAMP-dependent protein kinase Proc. Natl. Acad. Sci. U. S. A. 91 1994 11492 11496
128. L.B. Lester, L.K. Langeberg, and J.D. Scott Anchoring of protein kinase A facilitates hormone-mediated insulin secretion Proc. Natl. Acad. Sci. U. S. A. 94 1997 14942 14947
129. R.S. Westphal, S.J. Tavalin, J.W. Lin, N.M. Alto, I.D. Fraser, L.K. Langeberg, M. Sheng, and J.D. Scott Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex Science 285 1999 93 96
130. E. Klussmann, K. Maric, B. Wiesner, M. Beyermann, and W. Rosenthal Protein kinase A anchoring proteins are required for vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells J. Biol. Chem. 274 1999 4934 4938
131. M.A. Fink, D.R. Zakhary, J.A. Mackey, R.W. Desnoyer, C. Apperson-Hansen, D.S. Damron, and M. Bond AKAP-mediated targeting of protein kinase a regulates contractility in cardiac myocytes Circ. Res. 88 2001 291 297
132. M.A. Moita, R. Lamprecht, K. Nader, and J.E. LeDoux A-kinase anchoring proteins in amygdala are involved in auditory fear memory Nat. Neurosci. 5 2002 837 838
133. M.G. Newlon, M. Roy, D. Morikis, Z.E. Hausken, V. Coghlan, J.D. Scott, and P.A. Jennings The molecular basis for protein kinase A anchoring revealed by solution NMR Nat. Struct. Biol. 6 1999 222 227
134. N.M. Alto, S.H. Soderling, N. Hoshi, L.K. Langeberg, R. Fayos, P.A. Jennings, and J.D. Scott Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring Proc. Natl. Acad. Sci. U. S. A. 100 2003 4445 4450
135. L.L. Burns-Hamuro, Y. Ma, S. Kammerer, U. Reineke, C. Self, C. Cook, G.L. Olson, C.R. Cantor, A. Braun, and S.S. Taylor Designing isoform-specific peptide disruptors of protein kinase A localization Proc. Natl. Acad. Sci. U. S. A. 100 2003 4072 4077
136. M. Dickens, J.S. Rogers, J. Cavanagh, A. Raitano, Z. Xia, J.R. Halpern, M.E. Greenberg, C.L. Sawyers, and R.J. Davis A cytoplasmic inhibitor of the JNK signal transduction pathway Science 277 1997 693 696
137. R.K. Barr, T.S. Kendrick, and M.A. Bogoyevitch Identification of the critical features of a small peptide inhibitor of JNK activity J. Biol. Chem. 277 2002 10987 10997
138. R.K. Barr, I. Boehm, P.V. Attwood, P.M. Watt, and M.A. Bogoyevitch The critical features and the mechanism of inhibition of a kinase interaction motif-based peptide inhibitor of JNK J. Biol. Chem. 279 2004 36327 36338
139. R.K. Barr, R.M. Hopkins, P.M. Watt, and M.A. Bogoyevitch Reverse two-hybrid screening identifies residues of JNK required for interaction with the kinase interaction motif of JNK-interacting protein-1 J. Biol. Chem. 279 2004 43178 43189
140. M.A. Bogoyevitch Therapeutic promise of JNK ATP-noncompetitive inhibitors Trends Mol. Med. 2005 232 239
141. C. Bonny, A. Oberson, S. Negri, C. Sauser, and D.F. Schorderet Cell-permeable inhibitors of JNK: novel blockers of cell death Diabetes 50 2001 77 82
142. J. Laine, G. Kunstle, T. Obata, M. Sha, and M. Noguchi The protooncogene TCL1 is an Akt kinase coactivator Mol. Cell 6 2000 395 407
143. M. Hiromura, F. Okada, T. Obata, D. Auguin, T. Shibata, C. Roumestand, and M. Noguchi Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1 J. Biol. Chem. 279 2004 53407 53418
144. M.J. Andrews, C. McInnes, G. Kontopidis, L. Innes, A. Cowan, A. Plater, and P.M. Fischer Design, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes Org. Biomol. Chem. 2 2004 2735 2741
145. C. Gondeau, S. Gerbal-Chaloin, P. Bello, G. Aldrian-Herrada, M.C. Morris, and G. Divita Design of a novel class of peptide inhibitors of cyclin-dependent kinase/cyclin activation J. Biol. Chem. 280 2005 13793 13800
146. J. Wu, Q.N. Ma, and K.S. Lam Identifying substrate motifs of protein kinases by a random library approach Biochemistry 33 1994 14825 14833
147. T. Nishi, R.J. Budde, J.S. McMurray, N.U. Obeyesekere, N. Safdar, V.A. Levin, and H. Saya Tight-binding inhibitory sequences against pp60(c-src) identified using a random 15-amino-acid peptide library FEBS Lett. 399 1996 237 240
148. W.R. Dostmann, M.S. Taylor, C.K. Nickl, J.E. Brayden, R. Frank, and W.J. Tegge Highly specific, membrane-permeant peptide blockers of cGMP-dependent protein kinase Ialpha inhibit NO-induced cerebral dilation Proc. Natl. Acad. Sci. U. S. A. 97 2000 14772 14777
149. T. Krieg, S. Philipp, L. Cui, W.R. Dostmann, J.M. Downey, and M.V. Cohen Peptide blockers of PKG inhibit ROS generation by acetylcholine and bradykinin in cardiomyocytes but fail to block protection in the whole heart Am. J. Physiol. 288 2005 H1976 H1981
150. M.S. Taylor, C. Okwuchukwuasanya, C.K. Nickl, W. Tegge, J.E. Brayden, and W.R. Dostmann Inhibition of cGMP-dependent protein kinase by the cell-permeable peptide DT-2 reveals a novel mechanism of vasoregulation Mol. Pharmacol. 65 2004 1111 1119
151. N.B. Dey, K.F. Foley, T.M. Lincoln, and W.R. Dostmann Inhibition of cGMP-dependent protein kinase reverses phenotypic modulation of vascular smooth muscle cells J. Cardiovasc. Pharmacol. 45 2005 404 413
152. W.J. Fantl, J.A. Escobedo, G.A. Martin, C.W. Turck, M. de Rosario, F. McCormick, and L.T. Williams Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathway Cell 69 1992 413 423
153. K. Nishikawa, S. Sawasdikosol, D.A. Fruman, J. Lai, Z. Songyang, S.J. Burakoff, M.B. Yaffe, and L.C. Cantley A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase Mol. Cell 6 2000 969 974
154. L.T. Nevalainen, T. Aoyama, M. Ikura, A. Crivici, H. Yan, N.H. Chua, and A.C. Nairn Characterization of novel calmodulin-binding peptides with distinct inhibitory effects on calmodulin-dependent enzymes Biochem. J. 321 1997 107 115
155. S.E. Perea, O. Reyes, Y. Puchades, O. Mendoza, N.S. Vispo, I. Torrens, A. Santos, R. Silva, B. Acevedo, E. Lopez, V. Falcon, and D.F. Alonso Antitumor effect of a novel proapoptotic peptide that impairs the phosphorylation by the protein kinase 2 (casein kinase 2) Cancer Res. 64 2004 7127 7129
156. W.S. Alexander, and D.J. Hilton The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response Annu. Rev. Immunol. 22 2004 503 529
157. H. Yasukawa, H. Misawa, H. Sakamoto, M. Masuhara, A. Sasaki, T. Wakioka, S. Ohtsuka, T. Imaizumi, T. Matsuda, J.N. Ihle, and A. Yoshimura The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop EMBO J. 18 1999 1309 1320
158. M. Villain, P.L. Jackson, M.K. Manion, W.J. Dong, Z. Su, G. Fassina, T.M. Johnson, T.T. Sakai, N.R. Krishna, and J.E. Blalock De novo design of peptides targeted to the EF hands of calmodulin J. Biol. Chem. 275 2000 2676 2685
159. G. Fassina, G. Cassani, and A. Corti Binding of human tumor necrosis factor alpha to multimeric complementary peptides Arch. Biochem. Biophys. 296 1992 137 143
160. J.E. Blalock, and K.L. Bost Binding of peptides that are specified by complementary RNAs Biochem. J. 234 1986 679 683
161. L.O. Flowers, P.S. Subramaniam, and H.M. Johnson A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells Oncogene 24 2005 2114 2120
162. J.F. Ohren, H. Chen, A. Pavlovsky, C. Whitehead, E. Zhang, P. Kuffa, C. Yan, P. McConnell, C. Spessard, C. Banotai, W.T. Mueller, A. Delaney, C. Omer, J. Sebolt-Leopold, D.T. Dudley, I.K. Leung, C. Flamme, J. Warmus, M. Kaufman, S. Barrett, H. Tecle, and C.A. Hasemann Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition Nat. Struct. Mol. Biol. 11 2004 1192 1197
163. K. Gumireddy, S.J. Baker, S.C. Cosenza, P. John, A.D. Kang, K.A. Robell, M.V. Reddy, and E.P. Reddy A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance Proc. Natl. Acad. Sci. U. S. A. 102 2005 1992 1997
164. A. Martinez, M. Alonso, A. Castro, C. Perez, and F.J. Moreno First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease J. Med. Chem. 45 2002 1292 1299
165. S. Conde, D.I. Perez, A. Martinez, C. Perez, and F.J. Moreno Thienyl and phenyl alpha-halomethyl ketones: new inhibitors of glycogen synthase kinase (GSK-3beta) from a library of compound searching J. Med. Chem. 46 2003 4631 4633
166. R. Saperstein, P.P. Vicario, H.V. Strout, E. Brady, E.E. Slater, W.J. Greenlee, D.L. Ondeyka, A.A. Patchett, and D.G. Hangauer Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells Biochemistry 28 1989 5694 5701
167. T.R. Burke, B. Lim, V.E. Marquez, Z.H. Li, J.B. Bolen, I. Stefanova, and I.D. Horak Bicyclic compounds as ring-constrained inhibitors of protein-tyrosine kinase p56lck J. Med. Chem. 36 1993 425 432
168. C.-K. Huang, F.-Y. Wu, and Y.-X. Ai Polyhydroxylated 3-(N-phenyl) carbamoyl-2-iminochromene derivatives as potent inhibitors of tyrosine kinase p60c-src Bioorg. Med. Chem. Lett. 5 1995 2423 2428
169. T.H. Marsilje, K.L. Milkiewicz, and D.G. Hangauer The design, synthesis and activity of non-ATP competitive inhibitors of pp60(c-src) tyrosine kinase: Part 1. Hydroxynaphthalene derivatives Bioorg. Med. Chem. Lett. 10 2000 477 481
170. K.L. Milkiewicz, T.H. Marsilje, R.P. Woodworth, N. Bifulco, M.J. Hangauer, and D.G. Hangauer The design, synthesis and activity of non-ATP competitive inhibitors of pp60(c-src) tyrosine kinase: Part 2. Hydroxyindole derivatives Bioorg. Med. Chem. Lett. 10 2000 483 486
171. D. Mochly-Rosen, H. Khaner, J. Lopez, and B.L. Smith Intracellular receptors for activated protein kinase C. Identification of a binding site for the enzyme J. Biol. Chem. 266 1991 14866 14868
172. H. Kaneto, Y. Nakatani, T. Miyatsuka, D. Kawamori, T.A. Matsuoka, M. Matsuhisa, Y. Kajimoto, H. Ichijo, Y. Yamasaki, and M. Hori Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide Nat. Med. 10 2004 1128 1132
173. T. Borsello, P.G. Clarke, L. Hirt, A. Vercelli, M. Repici, D.F. Schorderet, J. Bogousslavsky, and C. Bonny A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia Nat. Med. 9 2003 1180 1186
174. L. Hirt, J. Badaut, J. Thevenet, C. Granziera, L. Regli, F. Maurer, C. Bonny, and J. Bogousslavsky D-JNKI1, a cell-penetrating c-Jun-N-terminal kinase inhibitor, protects against cell death in severe cerebral ischemia Stroke 35 2004 1738 1743
175. G. Tezel, X. Yang, J. Yang, and M.B. Wax Role of tumor necrosis factor receptor-1 in the death of retinal ganglion cells following optic nerve crush injury in mice Brain Res. 996 2004 202 212
176. J. Wang, T.R. Van De Water, C. Bonny, F. de Ribaupierre, J.L. Puel, and A. Zine A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss J. Neurosci. 23 2003 8596 8607
177. J. Wang, S. Ladrech, R. Pujol, P. Brabet, T.R. Van De Water, and J.L. Puel Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment, prevent cisplatin-induced hearing loss Cancer Res. 64 2004 9217 9224
178. A.M. Minogue, A.W. Schmid, M.P. Fogarty, A.C. Moore, V.A. Campbell, C.E. Herron, and M.A. Lynch Activation of the c-Jun N-terminal kinase signaling cascade mediates the effect of amyloid-beta on long term potentiation and cell death in hippocampus: a role for interleukin-1beta? J. Biol. Chem. 278 2003 27971 27980
179. Q. Wang, D.M. Walsh, M.J. Rowan, D.J. Selkoe, and R. Anwyl Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5 J. Neurosci. 24 2004 3370 3378
180. X. Zhang, E. Moilanen, A. Lahti, M. Hamalainen, M.A. Giembycz, P.J. Barnes, M.A. Lindsay, and H. Kankaanranta Regulation of eosinophil apoptosis by nitric oxide: role of c-Jun-N-terminal kinase and signal transducer and activator of transcription 5 J. Allergy Clin. Immunol. 112 2003 93 101