Intravenous N-acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: A placebo-controlled clinical trial

Hepatology

Volumn 57, Issue 4, 2013, Pages 1542-1549

  Squires, Robert H ^a   Dhawan, Anil ^b   Alonso, Estella ^c   Narkewicz, Michael R ^d   Shneider, Benjamin L ^a   Rodriguez Baez, Norberto ^e   Olio, Dominic Dell ^f   Karpen, Saul ^g,w   Bucuvalas, John ^h   Lobritto, Steven ⁱ   Rand, Elizabeth ^j   Rosenthal, Philip ^k   Horslen, Simon ^l   Ng, Vicky ^m   Subbarao, Girish ⁿ   Kerkar, Nanda ^o   Rudnick, David ^p   Lopez, M James ^q   Schwarz, Kathleen ^r   Romero, Rene ^s   Elisofon, Scott ^t   Doo, Edward ^u   Robuck, Patricia R ^u   Lawlor, Sharon ^v   Belle, Steven H ^v   more..

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c NORTHWESTERN UNIVERSITY   (United States)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^f BIRMINGHAM CHILDREN S HOSPITAL   (United Kingdom)

^g BAYLOR COLLEGE OF MEDICINE   (United States)

^h CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

ⁱ Och Spine at New York Presbyterian Hospitals   (United States)

^j CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^k UNIVERSITY OF CALIFORNIA   (United States)

^l UNIVERSITY OF WASHINGTON   (United States)

^m HOSPITAL FOR SICK CHILDREN   (Canada)

ⁿ INDIANA UNIVERSITY   (United States)

^o MOUNT SINAI MEDICAL CENTER   (United States)

^p WASHINGTON UNIVERSITY   (United States)

^q UNIVERSITY OF MICHIGAN   (United States)

^r JOHNS HOPKINS UNIVERSITY   (United States)

^s EMORY UNIVERSITY   (United States)

^t BOSTON CHILDREN S HOSPITAL   (United States)

^u NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^v UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^w Emory Children's Center   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; GLUCOSE; PLACEBO;

ACUTE LIVER FAILURE; APLASTIC ANEMIA; ARTICLE; BACTEREMIA; BRADYCARDIA; BRONCHOSPASM; CHILD; CHILDHOOD DISEASE; CHILL; CONTINUOUS INFUSION; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG FEVER; EPSTEIN BARR VIRUS INFECTION; EVENT FREE SURVIVAL; FEMALE; HEART ARRHYTHMIA; HEPATIC ENCEPHALOPATHY; HUMAN; HYPERTENSION; HYPOGLYCEMIA; INFECTION; INTENSIVE CARE UNIT; LENGTH OF STAY; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MULTIPLE ORGAN FAILURE; OUTCOME ASSESSMENT; PLEURA EFFUSION; POSTTRANSPLANT LYMPHOPROLIFERATIVE DISEASE; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY DISTRESS; SCHOOL CHILD; SCORING SYSTEM; SINUSITIS; STAPHYLOCOCCUS INFECTION; SURVIVAL RATE; SURVIVAL TIME; TREATMENT DURATION;

ACETYLCYSTEINE; ADOLESCENT; CHILD; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; FEMALE; FREE RADICAL SCAVENGERS; HEPATIC ENCEPHALOPATHY; HUMANS; INFANT; INFANT, NEWBORN; INFUSIONS, INTRAVENOUS; LIVER FAILURE, ACUTE; LIVER TRANSPLANTATION; MALE; SEVERITY OF ILLNESS INDEX; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 84876101011     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.26001     Document Type: Article

References (37)

1. Dhawan A. Etiology and prognosis of acute liver failure in children. Liver Transpl 2008; 14( Suppl 2): S80-S84.
2. Squires RH Jr, Shneider BL, Bucuvalas J, Alonso E, Sokol RJ, Narkewicz MR, et al. Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. J Pediatr 2006; 148: 652-658.
3. Polson J, Lee WM. AASLD position paper: the management of acute liver failure. HEPATOLOGY 2005; 41: 1179-1197.
4. Squires RH Jr. Acute liver failure in children. Semin Liver Dis 2008; 28: 153-166.
5. Rivera-Penera T, Moreno J, Skaff C, McDiarmid S, Vargas J, Ament ME. Delayed encephalopathy in fulminant hepatic failure in the pediatric population and the role of liver transplantation. J Pediatr Gastroenterol Nutr 1997; 24: 128-134.
6. Baliga P, Alvarez S, Lindblad A, Zeng L. Posttransplant survival in pediatric fulminant hepatic failure: the SPLIT experience. Liver Transpl 2004; 10: 1364-1371.
7. Soltys KA, Mazariegos GV, Squires RH, Sindhi RK, Anand R. Late graft loss or death in pediatric liver transplantation: an analysis of the SPLIT database. Am J Transplant 2007; 7: 2165-2171.
8. Kortsalioudaki C, Taylor RM, Cheeseman P, Bansal S, Mieli-Vergani G, Dhawan A. Safety and efficacy of N-acetylcysteine in children with non-acetaminophen-induced acute liver failure. Liver Transpl 2008; 14: 25-30.
9. Sklar GE, Subramaniam M. Acetylcysteine treatment for non-acetaminophen-induced acute liver failure. Ann Pharmacother 2004; 38: 498-500.
10. Marzullo L. An update of N-acetylcysteine treatment for acute acetaminophen toxicity in children. Curr Opin Pediatr 2005; 17: 239-245.
11. Prescott LF, Illingworth RN, Critchley JA, Stewart MJ, Adam RD, Proudfoot AT. Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning. Br Med J 1979; 2: 1097-1100.
12. Harrison PM, Wendon JA, Gimson AE, Alexander GJ, Williams R. Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure. N Engl J Med 1991; 324: 1852-1857.
13. Lee WM, Hynan LS, Rossaro L, Fontana RJ, Stravitz RT, Larson AM, et al. Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure. Gastroenterology 2009; 137: 856-864, 64 e1.
14. Baker A, Alonso ME, Aw MM, Ciocca M, Porta G, Rosenthal P. Hepatic failure and liver transplant: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr 2004; 39( Suppl 2): S632-S639.
15. Durand P, Debray D, Mandel R, Baujard C, Branchereau S, Gauthier F, et al. Acute liver failure in infancy: a 14-year experience of a pediatric liver transplantation center. J Pediatr 2001; 139: 871-876.
16. Molnar Z, Shearer E, Lowe D. N-Acetylcysteine treatment to prevent the progression of multisystem organ failure: a prospective, randomized, placebo-controlled study. Crit Care Med 1999; 27: 1100-1104.
17. Walsh TS, Lee A. N-acetylcysteine administration in the critically ill. Intensive Care Med 1999; 25: 432-434.
18. Cox DR. Regression models and life tables. J R Stat Soc Ser B 1972; 34: 187-220.
19. O'Brien PC, Fleming TR. A multiple testing procedure for clinical trials. Biometrics 1979; 35: 549-556.
20. Davern TJ, 2nd, James LP, Hinson JA, Polson J, Larson AM, Fontana RJ, et al. Measurement of serum acetaminophen-protein adducts in patients with acute liver failure. Gastroenterology 2006; 130: 687-694.
21. James LP, Alonso EM, Hynan LS, Hinson JA, Davern TJ, Lee WM, et al. Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause. Pediatrics 2006; 118: e676-81.
22. Lee WM. Etiologies of acute liver failure. Semin Liver Dis 2008; 28: 142-152.
23. Ostapowicz G, Fontana RJ, Schiodt FV, Larson A, Davern TJ, Han SH, et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med 2002; 137: 947-954.
24. Yazigi N, Tial G, Filipovich A, Bucuvalas JC. Natural killer dysfunction in pediatric acute liver failure. Am J Transplant 2008; 8( Supp s2): 327A.
25. Khandelwal N, James LP, Sanders C, Larson AM, Lee WM. Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure. HEPATOLOGY 2011; 53: 567-576.
26. Rank N, Michel C, Haertel C, Lenhart A, Welte M, Meier-Hellmann A, et al. N-acetylcysteine increases liver blood flow and improves liver function in septic shock patients: results of a prospective, randomized, double-blind study. Crit Care Med 2000; 28: 3799-3807.
27. Peristeris P, Clark BD, Gatti S, Faggioni R, Mantovani A, Mengozzi M, et al. N-acetylcysteine and glutathione as inhibitors of tumor necrosis factor production. Cell Immunol 1992; 140: 390-399.
28. Modig J, Sandin R. Haematological, physiological and survival data in a porcine model of adult respiratory distress syndrome induced by endotoxaemia. Effects of treatment with N-acetylcysteine. Acta Chir Scand 1988; 154: 169-177.
29. Antoniades CG, Berry PA, Wendon JA, Vergani D. The importance of immune dysfunction in determining outcome in acute liver failure. J Hepatol 2008; 49: 845-861.
30. Mi Q, Li NY, Ziraldo C, Ghuma A, Mikheev M, Squires R, et al. Translational systems biology of inflammation: potential applications to personalized medicine. Per Med 2010; 7: 549-559.
31. Wood JH, Partrick DA, Johnston RB Jr. The inflammatory response to injury in children. Curr Opin Pediatr 2010; 22: 315-320.
32. Vodovotz Y. Translational systems biology of inflammation and healing. Wound Repair Regen 2010; 18: 3-7.
33. Flanagan RJ. The role of acetylcysteine in clinical toxicology. Med Toxicol 1987; 2: 93-104.
34. Wuyts WA, Vanaudenaerde BM, Dupont LJ, Demedts MG, Verleden GM. N-acetylcysteine reduces chemokine release via inhibition of p38 MAPK in human airway smooth muscle cells. Eur Respir J 2003; 22: 43-49.
35. Yang R, Miki K, He X, Killeen ME, Fink MP. Prolonged treatment with N-acetylcystine delays liver recovery from acetaminophen hepatotoxicity. Crit Care 2009; 13: R55.
36. Zhang H, Limphong P, Pieper J, Liu Q, Rodesch CK, Christians E, et al. Glutathione-dependent reductive stress triggers mitochondrial oxidation and cytotoxicity. FASEB J 2012; 26: 1442-1451.
37. Masubuchi Y, Nakayama J, Sadakata Y. Protective effects of exogenous glutathione and related thiol compounds against drug-induced liver injury. Biol Pharm Bull 2011; 34: 366-370.