Acute liver failure in children

Seminars in Liver Disease

Volumn 28, Issue 2, 2008, Pages 153-166

  Squires Jr , Robert H ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Acetaminophen; Acute liver failure; APAP; Hepatitis

Indexed keywords

ACETYLCYSTEINE; ACICLOVIR; AMANITIN; ANTIOXIDANT; CARBAMAZEPINE; CORTICOSTEROID; ETOPOSIDE; GLUCOSE; HYDROCORTISONE; IMMUNOGLOBULIN; PARACETAMOL; PENICILLIN G; PHENOBARBITAL; PHENYTOIN; PLACEBO; PLECONARIL; PYRROLIZIDINE ALKALOID; SILIBININ; VALPROIC ACID;

ALBUMIN DIALYSIS; ASCITES; AUTOIMMUNE HEPATITIS; BLOOD CLOTTING DISORDER; BONE MARROW DEPRESSION; CLINICAL TRIAL; DRUG INTOXICATION; DRUG OVERDOSE; ENTEROVIRUS INFECTION; FEVER; GASTROINTESTINAL HEMORRHAGE; HEMOCHROMATOSIS; HEMOPHAGOCYTIC SYNDROME; HEPATIC ENCEPHALOPATHY; HERPES VIRUS INFECTION; HUMAN; HYPOGLYCEMIA; HYPOKALEMIA; HYPOPHOSPHATEMIA; INFECTION; INTOXICATION; KIDNEY FAILURE; LIVER FAILURE; LIVER INJURY; LIVER SUPPORT; LIVER TRANSPLANTATION; MENTAL HEALTH; METABOLIC DISORDER; NEUROLOGICAL COMPLICATION; PARVOVIRUS INFECTION; PLASMAPHERESIS; PRIORITY JOURNAL; RASH; RESPIRATORY ACIDOSIS; RESPIRATORY ALKALOSIS; REVIEW; TREATMENT FAILURE; TREATMENT OUTCOME; WILSON DISEASE;

ACETAMINOPHEN; ADRENAL CORTEX HORMONES; ANALGESICS, NON-NARCOTIC; CHILD; DRUG THERAPY; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; INFECTION; LIVER FAILURE, ACUTE; LIVER TRANSPLANTATION; METABOLISM, INBORN ERRORS; PHYTOTHERAPY; PLASMA EXCHANGE; PLASMAPHERESIS; POISONS; RENAL DIALYSIS;

EID: 43049121405     PISSN: 02728087     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1073115     Document Type: Review

References (176)

1. Lee WM. Acute liver failure. N Engl J Med 1993;329: 1862-1872
2. Nevens F. Acute liver failure. Acta Gastroenterol Belg 1997;60:298-301
3. Colquhoun SD, Lipkin C, Connelly CA. The pathophysiology, diagnosis, and management of acute hepatic encephalopathy. Adv Intern Med 2001;46(suppl 4):155-176
4. Devictor D, Desplanques L, Debray D, et al. Emergency liver transplantation for fulminant liver failure in infants and children. Hepatology 1992;16:1156-1162
5. Psacharopoulos HT, Mowat AP, Davies M, et al. Fulminant hepatic failure in childhood: an analysis of 31 cases. Arch Dis Child 1980;55:252-258
6. Rivera-Penera T, Moreno J, Skaff C, et al. Delayed encephalopathy in fulminant hepatic failure in the pediatric population and the role of liver transplantation. J Pediatr Gastroenterol Nutr 1997;24:128-134
7. Ee LC, Shepherd RW, Cleghorn GJ, et al. Acute liver failure in children: a regional experience. J Paediatr Child Health 2003;39:107-110
8. Lee WS, McKiernan P, Kelly DA. Etiology, outcome and prognostic indicators of childhood fulminant hepatic failure in the United Kingdom. J Pediatr Gastroenterol Nutr 2005;40:575-581
9. Squires RH Jr, Shneider BL, Bucuvalas J, et al. Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. J Pediatr 2006;148:652-658
10. Huo TI, Wu JC, Sheng WY, et al. Prognostic factor analysis of fulminant and subfulminant hepatic failure in an area endemic for hepatitis B. J Gastroenterol Hepatol 1996; 11:560-565
11. Williams R. Classification, etiology, and considerations of outcome in acute liver failure. Semin Liver Dis 1996;16: 343-348
12. Bates MD, Bucuvalas JC, Alonso MH, Ryckman FC. Biliary atresia: pathogenesis and treatment. Semin Liver Dis 1998;18:281-293
13. Riely CA. Acute hepatic failure in children. Yale J Biol Med 1984;57:161-184
14. Uribe M, Buckel E, Ferrario M, et al. Pediatric liver retransplantation: indications and outcome. Transplant Proc 2007;39:609-611
15. Schiødt FV, Atillasoy E, Shakil AO, et al. Etiology and outcome for 295 patients with acute liver failure in the United States. Liver Transpl Surg 1999;5:29-34
16. Cranswick N, Coghlan D. Paracetamol efficacy and safety in children: the first 40 years. Am J Ther 2000;7:135-141
17. James LP, Mayeux PR, Hinson JA. Acetaminophen-induced hepatotoxicity. Drug Metab Dispos 2003;31: 1499-1506
18. James LP, Wilson JT, Simar R, Farrar HC, et al. Evaluation of occult acetaminophen hepatotoxicity in hospitalized children receiving acetaminophen. Pediatric Pharmacology Research Unit Network. Clin Pediatr (Phila) 2001;40:243-248
19. Anderson BJ, Holford NH, Armishaw JC, et al. Predicting concentrations in children presenting with acetaminophen overdose. J Pediatr 1999;135:290-295
20. Gee P, Ardagh M. Paediatric exploratory ingestions of paracetamol. N Z Med J 1998;111:186-188
21. Shneider BL, Rinaldo P, Emre S, et al. Abnormal concentrations of esterified carnitine in bile: a feature of pediatric acute liver failure with poor prognosis. Hepatology 2005;41:717-721
22. Rumack BH. Acetaminophen overdose in children and adolescents. Pediatr Clin North Am 1986;33:691-701
23. Smith DW, Isakson G, Frankel LR, Kerner JA Jr. Hepatic failure following ingestion of multiple doses of acetaminophen in a young child. J Pediatr Gastroenterol Nutr 1986;5:822-825
24. Alander SW, Dowd MD, Bratton SL, Kearns GL. Pediatric acetaminophen overdose: risk factors associated with hepatocellular injury. Arch Pediatr Adolesc Med 2000;154: 346-350
25. Heubi JE, Barbacci MB, Zimmerman HJ. Therapeutic misadventures with acetaminophen: hepatoxicity after multiple doses in children. J Pediatr 1998;132:22-27
26. Price VF, Miller MG, Jollow DJ. Mechanisms of fasting-induced potentiation of acetaminophen hepatotoxicity in the rat. Biochem Pharmacol 1987;36:427-433
27. Krahenbuhl S, Brauchli Y, Kummer O, et al. Acute liver failure in two patients with regular alcohol consumption ingesting paracetamol at therapeutic dosage. Digestion 2007;75:232-237
28. James LP, Alonso EM, Hynan LS, et al. Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause. Pediatrics 2006;118:e676-e681
29. Mitchell AA, Lacouture PG, Sheehan JE, Kauffman RE, Shapiro S. Adverse drug reactions in children leading to hospital admission. Pediatrics 1988;82:24-29
30. Kaplowitz N. Causality assessment versus guilt-by-association in drug hepatotoxicity. Hepatology 2001;33:308-310
31. Lucena MI, Camargo R, Andrade RJ, et al. Comparison of two clinical scales for causality assessment in hepatotoxicity. Hepatology 2001;33:123-130
32. Anderson GD. Children versus adults: pharmacokinetic and adverse-effect differences. Epilepsia 2002;43(suppl 3):53-59
33. Blake MJ, Abdul-Rahman SM, Pearce RE, Leeder JS, Kearns GL. Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants. Pediatr Res 2006;60:717-723
34. Strassburg CP, Strassburg A, Kneip S, et al. Developmental aspects of human hepatic drug glucuronidation in young children and adults. Gut 2002;50:259-265
35. Mas A. Mushrooms, amatoxins and the liver. J Hepatol 2005;42:166-169
36. Centers for Disease Control and Prevention (CDC). Amanita phalloides mushroom poisoning - Northern California, January 1997. MMWR Morb Mortal Wkly Rep 1997;46:489-492
37. Yagupsky P, Gazala E, Sofer S, Maor E, Abarbanel J. Fatal hepatic failure and encephalopathy associated with amiodarone therapy. J Pediatr 1985;107:967-970
38. Vanderhoof JA, Ament ME. Fatal hepatic necrosis due to isoniazid chemoprophylaxis in a 15-year-old girl. J Pediatr 1976;88:867-868
39. Kiessling S, Forrest K, Moscow J, et al. Interstitial nephritis, hepatic failure, and systemic eosinophilia after minocycline treatment. Am J Kidney Dis 2001;38:E36
40. Marotta PJ, Roberts EA. Pemoline hepatotoxicity in children. J Pediatr 1998;132:894-897
41. Stickel F, Patsenker E, Schuppan D. Herbal hepatotoxicity. J Hepatol 2005;43:901-910
42. Stillman AE, Huxtable RJ, Fox D, Hart M, Bergeson P. Pyrrolizidine (Senecio) poisoning in Arizona: severe liver damage due to herbal teas. Ariz Med 1977;34:545-546
43. Roulet M, Laurini R, Rivier L, Calame A. Hepatic venoocclusive disease in newborn infant of a woman drinking herbal tea. J Pediatr 1988;112:433-436
44. Eadie MJ, Hooper WD, Dickinson RG. Valproate-associated hepatotoxicity and its biochemical mechanisms. Med Toxicol Adverse Drug Exp 1988;3:85-106
45. Schwabe MJ, Dobyns WB, Burke B, Armstrong DL. Valproate-induced liver failure in one of two siblings with Alpers disease. Pediatr Neurol 1997;16:337-343
46. Bicknese AR, May W, Hickey WF, Dodson WE. Early childhood hepatocerebral degeneration misdiagnosed as valproate hepatotoxicity. Ann Neurol 1992;32:767-775
47. Dickinson RG, Bassett ML, Searle J, Tyrer JH, Eadie MJ. Valproate hepatotoxicity: a review and report of two instances in adults. Clin Exp Neurol 1985;21:79-91
48. Li AM, Nelson EA, Hon EK, Cheng FW. Hepatic failure in a child with anti-epileptic hypersensitivity syndrome. J Paediatr Child Health 2005;41:218-220
49. Koff RS. Hepatitis B school-based vaccination programmes in the USA: a model for hepatitis A and B. Vaccine 2000; 18(suppl 1):S77-S79
50. Koff RS. Fulminant hepatitis A: disappearing, but not soon enough. Hepatology 2006;44:1397-1399
51. Kyrlagkitsis I, Cramp ME, Smith H, Portmann B, O'Grady J. Acute hepatitis A virus infection: a review of prognostic factors from 25 years experience in a tertiary referral center. Hepatogastroenterology 2002;49:524-528
52. Chancellor DD, Tyagi S, Bazaco MC, et al. Green onions: potential mechanism for hepatitis A contamination. J Food Prot 2006;69:1468-1472
53. Durand P, Debray D, Mandel R, et al. Acute liver failure in infancy: a 14-year experience of a pediatric liver transplantation center. J Pediatr 2001;139:871-876
54. Wai CT, Fontana RJ, Poison J, et al. Clinical outcome and virological characteristics of hepatitis B-related acute liver failure in the United States. J Viral Hepat 2005;12:192-198
55. Shaikh A, Nelson-Piercy C. Fulminant liver failure following hepatitis E in pregnancy. J Obstet Gynaecol 2006;26:159-160
56. Banait VS, Sandur V, Parikh F, et al. Outcome of acute liver failure due to acute hepatitis E in pregnant women. Indian J Gastroenterol 2007;26:6-10
57. Kaur B, Gottardo NG, Keil AD, Hallam LA, Baker DL. A rare case of adenoviral fulminant hepatic necrosis after chemotherapy. Pediatr Hematol Oncol 2002;19:361-371
58. Steiner I, Aebi C, Ridolfi Lüthy A, Wagner B, Leibundgut K. Fatal adenovirus hepatitis during maintenance therapy for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 2008;50:647-649
59. Rocholl C, Gerber K, Daly J, Pavia AT, Byington CL. Adenoviral infections in children: the impact of rapid diagnosis. Pediatrics 2004;113:e51-e56
60. Harma M, Hockerstedt K, Lautenschlager I. Human herpesvirus-6 and acute liver failure. Transplantation 2003; 76:536-539
61. Verboon-Maciolek MA, Swanink CM, Krediet TG, et al. Severe neonatal echovirus 20 infection characterized by hepatic failure. Pediatr Infect Dis J 1997;16:524-527
62. Yen HR, Lien R, Fu RH, Chang LY. Hepatic failure in a newborn with maternal peripartum exposure to echovirus 6 and enterovirus 71. Eur J Pediatr 2003;162:648-649
63. Karetnyi YV, Beck PR, Markin RS, Langnas AN, Naides SJ. Human parvovirus B19 infection in acute fulminant liver failure. Arch Virol 1999;144:1713-1724
64. Ozcay F, Bikmaz YE, Canan O, Ozbek N. Hepatitis A and parvovirus B19 infections in an infant with fulminant hepatic failure. Turk J Gastroenterol 2006;17:148-150
65. So K, Macquillan G, Garas G, et al. Urgent liver transplantation for acute liver failure due to parvovirus B19 infection complicated by primary Epstein-Barr virus and cytomegalovirus infections and aplastic anaemia. Intern Med J 2007;37:192-195
66. Tung J, Hadzic N, Layton M, et al. Bone marrow failure in children with acute liver failure. J Pediatr Gastroenterol Nutr 2000;31:557-561
67. Williams R, Riordan SM. Acute liver failure: established and putative hepatitis viruses and therapeutic implications. J Gastroenterol Hepatol 2000;15(suppl):G17-G25
68. Ghosh A, Ghoshal UC, Kochhar R, Ghoshal P, Banerjee PK. Infectious mononucleosis hepatitis: report of two patients. Indian J Gastroenterol 1997;16:113-114
69. Palanduz A, Yildirmak Y, Telhan L, et al. Fulminant hepatic failure and autoimmune hemolytic anemia associated with Epstein-Barr virus infection. J Infect 2002;45:96-98
70. Stephan JL, Kone-Paut I, Galambrun C, et al. Reactive haemophagocytic syndrome in children with inflammatory disorders: a retrospective study of 24 patients. Rheumatology (Oxford) 2001;40:1285-1292
71. Bernal W, Ma Y, Smith HM, Portmann B, Wendon J, Vergani D. The significance of autoantibodies and immunoglobulins in acute liver failure: a cohort study. J Hepatol 2007;47:664-670
72. Mieli-Vergani G, Vergani D. Autoimmune hepatitis in children. Clin Liver Dis 2002;6:623-634
73. Nunez-Martinez O, De la Cruz G, Salcedo M, et al. Liver transplantation for autoimmune hepatitis: fulminant versus chronic hepatitis presentation. Transplant Proc 2003;35: 1857-1858
74. Tokumoto Y, Onji M. Acute-onset autoimmune hepatitis. Intern Med 2007;46:1-2
75. Henter JI, Home A, Aricó M, et al. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 2007;48:124-131
76. Janka GE. Hemophagocytic syndromes. Blood Rev 2007;21: 245-253
77. Katsibardi K, Moschovi MA, Theodoridou M, et al. Enterovirus-associated hemophagocytic syndrome in children with malignancy: report of three cases and review of the literature. Eur J Pediatr 2008;167:97-102
78. Schneider EM, Lorenz I, Müller-Rosenberger M, et al. Hemophagocytic lymphohistiocytosis is associated with deficiencies of cellular cytolysis but normal expression of transcripts relevant to killer-cell-induced apoptosis. Blood 2002;100:2891-2898
79. Ojetti V, Fini L, Zileri Dal Verme L, Migneco A, Pola P, Gasbarrini A. Acute cryptogenic liver failure in an untreated coeliac patient: a case report. Eur J Gastroenterol Hepatol 2005;17:1119-1121
80. Kaukinen K, Halme L, Collin P, et al. Celiac disease in patients with severe liver disease: gluten-free diet may reverse hepatic failure. Gastroenterology 2002;122:881-888
81. Bergquist A, Glaumann H, Lindberg B, Broomé U. Primary sclerosing cholangitis can present with acute liver failure: report of two cases. J Hepatol 2006;44:1005-1008
82. Clayton PT. Inborn errors presenting with liver dysfunction. Semin Neonatol 2002;7:49-63
83. Dubern B, Broue P, Dubuisson C, et al. Orthotopic liver transplantation for mitochondrial respiratory chain disorders: a study of 5 children. Transplantation 2001;71:633-637
84. Bakker HD, Scholte HR, Dingemans KP, et al. Depletion of mitochondrial deoxyribonucleic acid in a family with fatal neonatal liver disease. J Pediatr 1996;128:683-687
85. Loeffen JL, Smeitink JA, Trijbels JM, et al. Isolated complex I deficiency in children: clinical, biochemical and genetic aspects. Hum Mutat 2000;15:123-134
86. Bennett MJ, Rinaldo P, Strauss AW. Inborn errors of mitochondrial fatty acid oxidation. Crit Rev Clin Lab Sci 2000;37:1-44
87. Lee WS, Sokol RJ. Mitochondrial hepatopathies: advances in genetics and pathogenesis. Hepatology 2007;45:1555-1565
88. Odaib AA, Shneider BL, Bennett MJ, et al. A defect in the transport of long-chain fatty acids associated with acute liver failure. N Engl J Med 1998;339:1752-1757
89. Bennett MJ, Spotswood SD, Ross KF, et al. Fatal hepatic short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase deficiency: clinical, biochemical, and pathological studies on three subjects with this recently identified disorder of mitochondrial beta-oxidation. Pediatr Dev Pathol 1999;2: 337-345
90. Tyni T, Palotie A, Viinikka L, et al. Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency with the G1528C mutation: clinical presentation of thirteen patients. J Pediatr 1997;130:67-76
91. Enns GM, Bennett MJ, Hoppel CL, et al. Mitochondrial respiratory chain complex I deficiency with clinical and biochemical features of long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency. J Pediatr 2000;136:251-254
92. Gordon N. Alpers syndrome: progressive neuronal degeneration of children with liver disease. Dev Med Child Neurol 2006;48:1001-1003
93. Kitazawa J, Kaizuka M, Kasai M, et al. Hemolytic crisis with fulminant hepatic failure in Wilson disease without consanguinity. Pediatr Int 2004;46:726-729
94. Kenngott S, Bilzer M. Inverse correlation of serum bilirubin and alkaline phosphatase in fulminant Wilson's disease. J Hepatol 1998;29:683
95. Shaver WA, Bhatt H, Combes B. Low serum alkaline phosphatase activity in Wilson's disease. Hepatology 1986; 6:859-863
96. Whitington PF, Kelly S, Ekong UD. Neonatal hemochromatosis: fetal liver disease leading to liver failure in the fetus and newborn. Pediatr Transplant 2005;9:640-645
97. Whitington PF, Malladi P. Neonatal hemochromatosis: is it an alloimmune disease? J Pediatr Gastroenterol Nutr 2005; 40:544-549
98. Aydoǧdu S, Ozgenç F, Yurtsever S, et al. Our experience with fulminant hepatic failure in Turkish children: etiology and outcome. J Trop Pediatr 2003;49:367-370
99. Kori I, Bar-Zohar D, Carmiel-Haggai M, et al. Budd-Chiari syndrome and acute portal vein thrombosis: management by a transjugular intrahepatic portosystemic shunt (TIPS) and portal vein interventions via a TIPS. J Gastrointest Surg 2006;10:417-421
100. Chitturi S, Farrell GC. Herbal hepatotoxicity: an expanding but poorly defined problem. J Gastroenterol Hepatol 2000; 15:1093-1099
101. Lettieri CJ, Berg BW. Clinical features of non-Hodgkins lymphoma presenting with acute liver failure: a report of five cases and review of published experience. Am J Gastroenterol 2003;98:1641-1646
102. Bhat YM, Krasinskas A, Craig FE, Shaw-Stiffel TA. Acute liver failure as an initial manifestation of an infiltrative hematolymphoid malignancy. Dig Dis Sci 2006;51:63-67
103. Biesel-Desthieux MN, Tissières P, Belli DC, et al. Fulminant liver failure in a child with invasive group A streptococcal infection. Eur J Pediatr 2003;162:245-247
104. Raman JS, Kochi K, Morimatsu H, Buxton B, Bellomo R. Severe ischemic early liver injury after cardiac surgery. Ann Thorac Surg 2002;74:1601-1606
105. Giallourakis CC, Rosenberg PM, Friedman LS. The liver in heart failure. Clin Liver Dis 2002;6:947-967, viii-ix
106. Wagner M, Kaufmann P, Fickert P, Trauner M, Lackner C, Stauber RE. Successful conservative management of acute hepatic failure following exertional heatstroke. Eur J Gastroenterol Hepatol 2003;15:1135-1139
107. Teo EK, Ostapowicz G, Hussain M, et al. Hepatitis B infection in patients with acute liver failure in the United States. Hepatology 2001;33:972-976
108. Umemura T, Tanaka E, Ostapowicz G, et al. Investigation of SEN virus infection in patients with cryptogenic acute liver failure, hepatitis-associated aplastic anemia, or acute and chronic non-A-E hepatitis. J Infect Dis 2003;188:1545-1552
109. James LP, Farrar HC, Sullivan JE, et al. Measurement of acetaminophen-protein adducts in children and adolescents with acetaminophen overdoses. J Clin Pharmacol 2001;41: 846-851
110. Squires RH Jr. From whence does biliary atresia arise? Pediatr Transplant 2005;9:145-147
111. Whitington PF, Alonso EM. Fulminant hepatitis in children: evidence for an unidentified hepatitis virus. J Pediatr Gastroenterol Nutr 2001;33:529-536
112. Bucuvalas J, Yazigi N, Squires RH Jr. Acute liver failure in children. Clin Liver Dis 2006;10:149-168
113. Dhawan A, Cheeseman P, Mieli-Vergani G. Approaches to acute liver failure in children. Pediatr Transplant 2004;8: 584-588
114. Han MK, Hyzy R. Advances in critical care management of hepatic failure and insufficiency. Crit Care Med 2006; 34(suppl):S225-S231
115. Kelly DA. Managing liver failure. Postgrad Med J 2002; 78:660-667
116. Haussinger D, Schliess F, Kircheis G. Pathogenesis of hepatic encephalopathy. J Gastroenterol Hepatol 2002; 17(suppl 3):S256-S259
117. Saxena N, Bhatia M, Joshi YK, et al. Electrophysiological and neuropsychological tests for the diagnosis of subclinical hepatic encephalopathy and prediction of overt encephalopathy. Liver 2002;22:190-197
118. Bal C, Longkumer T, Patel C, Gupta SD, Acharya SK. Renal function and structure in subacute hepatic failure. J Gastroenterol Hepatol 2000;15:1318-1324
119. Bihari D, Gimson AE, Lindridge J, Williams R. Lactic acidosis in fulminant hepatic failure: some aspects of pathogenesis and prognosis. J Hepatol 1985;1:405-416
120. Butterworth RF. Hepatic encephalopathy and brain edema in acute hepatic failure: does glutamate play a role? Hepatology 1997;25:1032-1034
121. Conn HO. Hyperammonemia and intracranial hypertension: lying in wait for patients with hepatic disorders? Am J Gastroenterol 2000;95:814-816
122. Galus M, Schiffman R, Olkowska D. Massive liver necrosis associated with hyperamylasemia. Liver 1998;18:205-207
123. Holt S, Marley R, Fernando B, et al. Acute cholestasis-induced renal failure: effects of antioxidants and ligands for the thromboxane A2 receptor. Kidney Int 1999;55:271-277
124. Khanlou H, Souto H, Lippmann M, et al. Resolution of adult respiratory distress syndrome after recovery from fulminant hepatic failure. Am J Med Sci 1999;317:134-136
125. Moore K. Renal failure in acute liver failure. Eur J Gastroenterol Hepatol 1999;11:967-975
126. Rolando N, Philpott-Howard J, Williams R. Bacterial and fungal infection in acute liver failure. Semin Liver Dis 1996;16:389-402
127. Rolando N, Wade J, Davalos M, et al. The systemic inflammatory response syndrome in acute liver failure. Hepatology 2000;32:734-739
128. Brusilow SW. Hyperammonemic encephalopathy. Medicine (Baltimore) 2002;81:240-249
129. Zamir D, Storch S, Kovach I, Storch R, Zamir C. Early detection of hepatic encephalopathy by recording visual evoked potential (VEP). Rocz Akad Med Bialymst 2002; 47:186-193
130. Strauss GI, Christiansen M, Møller K, et al. S-100b and neuron-specific enolase in patients with fulminant hepatic failure. Liver Transpl 2001;7:964-970
131. Sushma S, Dasarathy S, Tandon RK, Jain S, Gupta S, Bhist MS. Sodium benzoate in the treatment of acute hepatic encephalopathy: a double-blind randomized trial. Hepatology 1992;16:138-144
132. Efrati C, Masini A, Merli M, Valeriano V, Riggio O. Effect of sodium benzoate on blood ammonia response to oral glutamine challenge in cirrhotic patients: a note of caution. Am J Gastroenterol 2000;95:3574-3578
133. Hirsch W, Beck R, Behrmann C, Schobess A, Spielmann RP. Reliability of cranial CT versus intracerebral pressure measurement for the evaluation of generalised cerebral oedema in children. Pediatr Radiol 2000;30:439-443
134. Vaquero J, Fontana RJ, Larson AM, et al. Complications and use of intracranial pressure monitoring in patients with acute liver failure and severe encephalopathy. Liver Transpl 2005;11:1581-1589
135. Tripodi A, Caldwell SH, Hoffman M, Trotter JF, Sanyal AJ. Review article: the prothrombin time test as a measure of bleeding risk and prognosis in liver disease. Aliment Pharmacol Ther 2007;26:141-148
136. Hadzić N, Height S, Ball S, et al. Evolution in the management of acute liver failure-associated aplastic anaemia in children: a single centre experience. J Hepatol 2008; 48:68-73
137. Cattral MS, Langnas AN, Markin RS, et al. Aplastic anemia after liver transplantation for fulminant liver failure. Hepatology 1994;20:813-818
138. Ginès P, Guevara M, Arroyo V, Rodés J. Hepatorenal syndrome. Lancet 2003;362:1819-1827
139. Arroyo V, Terra C, Ginès P. Advances in the pathogenesis and treatment of type-1 and type-2 hepatorenal syndrome. J Hepatol 2007;46:935-946
140. Baquerizo A, Anselmo D, Shackleton C, et al. Phosphorus ans an early predictive factor in patients with acute liver failure. Transplantation 2003;75:2007-2014
141. Sarwar S, Khan AA, Alam A, et al. Predictors of fatal outcome in fulminant hepatic failure. J Coll Physicians Surg Pak 2006;16:112-116
142. Wasmuth HE, Kunz D, Yagmur E, et al. Patients with acute on chronic liver failure display "sepsis-like" immune paralysis. J Hepatol 2005;42:195-201
143. Singer AL, Olthoff KM, Kim H, Rand E, Zamir G, Shaked A. Role of plasmapheresis in the management of acute hepatic failure in children. Ann Surg 2001;234:418-424
144. Ho DW, Fan ST, To J, et al. Selective plasma filtration for treatment of fulminant hepatic failure induced by D-galactosamine in a pig model. Gut 2002;50:869-876
145. Rakela J, Mosley JW, Edwards VM, Govindarajan S, Alpert E. A double-blinded, randomized trial of hydrocortisone in acute hepatic failure. The Acute Hepatic Failure Study Group. Dig Dis Sci 1991;36:1223-1228
146. Harry R, Auzinger G, Wendon J. The effects of supraphysiological doses of corticosteroids in hypotensive liver failure. Liver Int 2003;23:71-77
147. Wigg AJ, Padbury RT. Liver support systems: promise and reality. J Gastroenterol Hepatol 2005;20:1807-1816
148. Covic A, Goldsmith DJ, Gusbeth-Tatomir P, et al. Successful use of Molecular Absorbent Regenerating System (MARS) dialysis for the treatment of fulminant hepatic failure in children accidentally poisoned by toxic mushroom ingestion. Liver Int 2003;23(suppl 3):21-27
149. Hommann M, Kasakow LB, Geoghegan J, et al. Application of MARS artificial liver support as bridging therapy before split liver retransplantation in a 15-month-old child. Pediatr Transplant 2002;6:340-343
150. Tissières P, Sasbón JS, Devictor D. Liver support for fulminant hepatic failure: is it time to use the molecular adsorbents recycling system in children? Pediatr Crit Care Med 2005;6:585-591
151. Habibullah CM, Syed IH, Qamar A, Taher-Uz Z. Human fetal hepatocyte transplantation in patients with fulminant hepatic failure. Transplantation 1994;58:951-952
152. Strom SC, Fisher RA, Rubinstein WS, et al. Transplantation of human hepatocytes. Transplant Proc 1997;29:2103-2106
153. Strom SC, Bruzzone P, Cai H, et al. Hepatocyte transplantation: clinical experience and potential for future use. Cell Transplant 2006;15(suppl 1):S105-S110
154. Baliga P, Alvarez S, Lindblad A, et al. Posttransplant survival in pediatric fulminant hepatic failure: the SPLIT experience. Liver Transpl 2004;10:1364-1371
155. Mack CL, Ferrario M, Abecassis M, Whitington PF, Superina RA, Alonso EM. Living donor liver transplantation for children with liver failure and concurrent multiple organ system failure. Liver Transpl 2001;7:890-895
156. Chenard-Neu MP, Boudjema K, Bernuau J, et al. Auxiliary liver transplantation: regeneration of the native liver and outcome in 30 patients with fulminant hepatic failure - a multicenter European study. Hepatology 1996;23:1119-1127
157. Girlanda R, Vilca-Melendez H, Srinivasan P, et al. Immunosuppression withdrawal after auxiliary liver transplantation for acute liver failure. Transplant Proc 2005; 37:1720-1721
158. O'Grady JG. Prognostication in acute liver failure: a tool or an anchor? Liver Transpl 2007;13:786-787
159. O'Grady JG, Alexander GJ, Hayllar KM, Williams R. Early indicators of prognosis in fulminant hepatic failure. Gastroenterology 1989;97:439-445
160. Bernal W, Donaldson N, Wyncoll D, Wendon J. Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study. Lancet 2002;359: 558-563
161. Dabos KJ, Newsome PN, Parkinson JA, et al. A biochemical prognostic model of outcome in paracetamol-induced acute liver injury. Transplantation 2005;80:1712-1717
162. Schmidt LE, Dalhoff K. Alpha-fetoprotein is a predictor of outcome in acetaminophen-induced liver injury. Hepatology 2005;41:26-31
163. Schmidt LE, Dalhoff K. Serum phosphate is an early predictor of outcome in severe acetaminophen-induced hepatotoxicity. Hepatology 2002;36:659-665
164. Bernal W, Wendon J, Rela M, et al. Use and outcome of liver transplantation in acetaminophen-induced acute liver failure. Hepatology 1998;27:1050-1055
165. Schiøt FV, Bangert K, Shakil AO, et al. Predictive value of actin-free Gc-globulin in acute liver failure. Liver Transpl 2007;13:1324-1329
166. Lu B, Gralla J, Liu E, et al. Evaluation of a scoring system for assessing prognosis in pediatric acute liver failure. Hepatology 2007;46(suppl):276A-277A
167. Delarue A, Paut O, Guys JM, et al. Inappropriate liver transplantation in a child with Alpers-Huttenlocher syndrome misdiagnosed as valproate-induced acute liver failure. Pediatr Transplant 2000;4:67-71
168. Verma A, Dhawan A, Zuckerman M, et al. Neonatal herpes simplex virus infection presenting as acute liver failure: prevalent role of herpes simplex virus type I. J Pediatr Gastroenterol Nutr 2006;42:282-286
169. Herzog-Tzarfati K, Shiloah E, Koren-Michowitz M, et al. Successful treatment of prolonged agranulocytosis caused by acute parvovirus B19 infection with intravenous immunoglobulins. Eur J Intern Med 2006;17:439-440
170. Marzullo L. An update of N-acetylcysteine treatment for acute acetaminophen toxicity in children. Curr Opin Pediatr 2005;17:239-245
171. Montanini S, Sinardi D, Pratico C, et al. Use of acetylcysteine as the life-saving antidote in Amanita phalloides (death cap) poisoning: case report on 11 patients. Arzneimittelforschung 1999;49:1044-1047
172. Grompe M. The pathophysiology and treatment of hereditary tyrosinemia type 1. Semin Liver Dis 2001;21:563-571
173. Medici V, Rossaro L, Sturniolo GC. Wilson disease: a practical approach to diagnosis, treatment and follow-up. Dig Liver Dis 2007;39:601-609
174. Treem WR. New developments in the pathophysiology, clinical spectrum, and diagnosis of disorders of fatty acid oxidation. Curr Opin Pediatr 2000;12:463-468
175. Flynn DM, Mohan N, McKiernan P, et al. Progress in treatment and outcome for children with neonatal haemochromatosis. Arch Dis Child Fetal Neonatal Ed 2003;88: F124-F127
176. Chavez-Tapia NC, Martinez-Salgado J, Granados J, et al. Clinical heterogeneity in autoimmune acute liver failure. World J Gastroenterol 2007;13:1824-1827