The inflammatory response to injury in children

Current Opinion in Pediatrics

Volumn 22, Issue 3, 2010, Pages 315-320

  Wood, James H ^a   Partrick, David A ^a   Johnston Jr , Richard B ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Inflammation; Innate immunity; Multiple organ failure; Pediatric trauma

Indexed keywords

CD24 ANTIGEN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 6; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LUNG INJURY; AGE; BACTERIAL IMMUNITY; BURN; CHILDHOOD INJURY; CRITICALLY ILL PATIENT; CYTOKINE PRODUCTION; FEMUR FRACTURE; HEMORRHAGIC SHOCK; HUMAN; INCIDENCE; INFLAMMATION; INNATE IMMUNITY; MULTIPLE ORGAN FAILURE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TH1 CELL; TH2 CELL;

ACUTE LUNG INJURY; DISEASE PROGRESSION; HUMANS; IMMUNITY, INNATE; MULTIPLE ORGAN FAILURE; RISK FACTORS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; WOUNDS AND INJURIES;

EID: 77952426136     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOP.0b013e328338da48     Document Type: Review

References (93)

1. Aller MA, Arias JL, Nava MP, Arias J. Posttraumatic inflammation is a complex response based on the pathological expression of the nervous, immune, and endocrine functional systems. Exp Biol Med 2004; 229:170-181.
2. Moore FA, Moore EE. Evolving concepts in the pathogenesis of postinjury multiple organ failure. Surg Clin North Am 1995; 75:257-277.
3. Stahel PF, Smith WR, Moore EE. Role of biological modifiers regulating the immune response after trauma. Injury 2007; 38:1409-1422.
4. Tschoeke SK, Ertel W. Immunoparalysis after multiple trauma. Injury 2007; 38:1346-1357.
5. Baue AE, Durham R, Faist E. Systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), multiple organ failure (MOF): are we winning the battle? Shock 1998; 10:79-89.
6. Keel M, Trentz O. Pathophysiology of polytrauma. Injury 2005; 36:691-709.
7. Osuchowski MF, Welch K, Siddiqui J, Remick DG. Circulating cytokine/ inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J Immunol 2006; 177:1967-1974.
8. Proulx F, Joyal JS, Mariscalco M, et al. The pediatric multiple organ dysfunction syndrome. Pediatr Crit Care Med 2009; 10:12-22.
9. Calkins CM, Bensard DD, Moore EE, et al. The injured child is resistant to multiple organ failure: a different inflammatory response? J Trauma 2002; 53:1058-1063.
10. Proulx F, Gauthier M, Nadeau D, et al. Timing and predictors of death in pediatric patients with multiple organ system failure. Crit Care Med 1994; 22:1025-1031.
11. Wilkinson J, Pollack M, Glass N, et al. Outcome of pediatric patients with multiple organ failure. Crit Care Med 1986; 14:271-274.
12. Tantalean J, Leon R, Santos A, et al. Multiple organ dysfunction syndrome in children. Pediatr Crit Care Med 2003; 4:181-185.
13. Leteurtre S, Martinot A, Duhamel A, et al. Validation of the paediatric logistic organ dysfunction score: prospective, observational, multicentre study. Lancet 2003; 362:192-197.
14. Tan G, Tan T, Goh D, et al. Risk factors for predicting mortality in a paediatric intensive care unit. Ann Acad Med Singapore 1998;27:813-818.
15. Leteurtre S, Martinot A, Duhamel A, et al. Development of a pediatric multiple organ dysfunction score: use of two strategies. Med Decis Making 1999; 19:399-410.
16. Khilnani P, Sarma D, Zimmerman J. Epidemiology and peculiarities of pediatric multiple organ dysfunction syndrome in New Delhi, India. Intensive Care Med 2006; 32:1856-1862.
17. Typpo KV, Petersen NJ, Petersen LA, Mariscalco MM. Children with chronic illness return to their baseline functional status after organ dysfunction on the first day of admission in the pediatric intensive care unit. J Pediatr (in press).
18. Typpo K, Petersen N, Hallman D, et al. Day 1 multiple organ dysfunction syndrome is associated with poor functional outcome and mortality in the pediatric intensive care unit. Pediatr Crit Care Med 2009; 10:562-570.
19. Wilkinson JD, Pollack MM, Glass NL, et al. Mortality associated with multiple organ system failure and sepsis in pediatric intensive care unit. J Pediatr 1987; 111:324-328.
20. Proulx F, Fayon M, Farrell C, et al. Epidemiology of sepsis and multiple organ dysfunction syndrome in children. Chest 1996; 109:1033-1037.
21. Goh A, Lum L. Sepsis, severe sepsis and septic shock in paediatric multiple organ dysfunction syndrome. J Paediatr Child Health 1999; 35:488-492.
22. Kutko M, Calarco M, Flaherty M, et al. Mortality rates in pediatric septic shock with and without multiple organ system failure. Pediatr Crit Care Med 2003; 4:333-337.
23. Leclerc F, Leteurtre S, Duhamel A, et al. Cumulative influence of organ dysfunctions and septic state on mortality of critically ill children. Am J Respir Crit Care Med 2005; 171:348-353.
24. Seghaye MC, Engelhardt W, Grabitz RG, et al. Multiple organ failure after open heart surgery in infants and children. Thorac Cardiovasc Surg 1993; 41:49-53.
25. Feickert H, Schepers A, Rodeck B, et al. Incidence, impact on survival, and risk factors for multiorgan system failure in children following liver transplantation. Pediatr Transplant 2001; 5:266-273.
26. Keenan HT, Bratton SL, Martin LD, et al. Outcome of children who require mechanical ventilator support after bone marrow transplantation. Crit Care Med 2000; 28:830-835.
27. Lamas A, Otheo E, Ros P, et al. Prognosis of child recipients of hematopoietic stem cell transplantation requiring intensive care. Intensive Care Med 2003; 29:91-96.
28. Ciesla DJ, Moore EE, Johnson JL, et al. A 12-year prospective study of postinjury multiple organ failure: has anything changed? Arch Surg 2005; 140:432-440.
29. Sauaia A, Moore FA, Moore EE, et al. Multiple organ failure can be predicted as early as 12 h after injury. J Trauma 1998; 45:291-301.
30. Sauaia A, Moore FA, Moore EE, et al. Early predictors of postinjury multiple organ failure. Arch Surg 1994; 129:39-45.
31. Crump JM, Duncan DA, Wears R. Analysis of multiple organ system failure in trauma and nontrauma patients. Am Surg 1988; 54:702-708.
32. Souminen P, Kivioja A, Ohman J, et al. Severe and fatal childhood trauma. Injury 1998; 129:39-45.
33. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 1992; 101:1644-1655.
34. Ciesla D, Moore E, Johnson J, et al. Multiple organ dysfunction during resuscitation is not postinjury multiple organ failure. Arch Surg 2004; 139:590-595.
35. Chaudry IH, Bland KI. Cellular mechanisms of injury after major trauma. Br J Surg 2009; 96:1097-1098.
36. Hsieh CH, Nickel EA, Hsu J, et al. Trauma-hemorrhage and hypoxia differently influence kupffer cell phagocytic capacity. Ann Surg 2009; 250:995-1001.
37. Kaczorowski DJ, Mollen KP, Edmonds R, Billar TR. Early events in the recognition of danger signals after tissue injury. J Leukoc Biol 2008; 83:546-552.
38. Flohe SB, Flohe S, Schade FU. Deterioration of the immune system after trauma: signals and cellular mechanisms. Innate Immun 2008; 14:333-344.
39. Lenz A, Franklin GA, Cheadle WG. Systemic inflammation after trauma. Injury 2007; 38:1336-1345.
40. Heideman M. The role of complement in trauma. Acta Chir Scand Suppl 1985; 522:233-244.
41. Heitbrink F, Koenderman L, Rijkers G, Leenen L. Trauma: the role of the innate immune system. World J Emerg Surg 2006; 1:15.
42. Risberg B, Medegard A, Heideman M, et al. Early activation of humoral proteolytic systems in patients with multiple trauma. Crit Care Med 1986; 14:917-925.
43. Schlag G, Redl H. Mediators of injury and inflammation. World J Surg 1996; 20:406-410.
44. Stahel PF, Morganti-Kossmann MC, Kossmann T. The role of the complement system in traumatic brain injury. Brain Res Rev 1998; 27:243-256.
45. Liu AH, Zasloff MA, Johnston RB Jr. Innate Immunity. In: Adkinson FN, editor. Middleton's allergy: principles and practice. 7th ed. Philadelphia: Elsevier Mosby; 2008.
46. Kumar H, Kawai K, Akira S. Toll-like receptors and innate immunity. Biochem Biophys Res Commun 2009; 388:621-625.
47. Medzhitov R. Recognition of microorganisms and activation of the immune response. Nature 2007; 449:819-826.
48. Bianchi ME. DAMPs, PAMPs and alarmins: all we need to know about danger. J Leuk Biol 2007; 81:1-5.
49. Miyake K. Innate immune sensing of pathogens and danger signals by cell surface toll-like receptors. Semin Immunol 2007; 19:3-10.
50. Jiang D, Liang J, Fan J, et al. Regulation of lung injury and repair by toll-like receptors and hyaluronan. Nat Med 2005; 11:1173-1179.
51. Mollen KP, Anand RJ, Tsung A, et al. Emerging paradigm: toll-like receptor 4: sentinel for the detection of tissue damage. Shock 2006; 26:430-437.
52. Wu H, Chen G, Wyburn KR, et al. TLR4 activation mediates ischemia/ reperfusion injury. J Clin Invest 2007; 117:2847-2859.
53. Matzinger P. The danger model: a renewed sense of self. Science 2002; 296:301-305.
54. Oppenheim JJ, Yang D. Alarmins: chemotactic activators of immune response. Curr Opin Immunol 2005; 17:359-365.
55. Prince JM, Levy RM, Mollen KP, Fink MP. Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock. J Am Coll Surg 2006; 202:407-411.
56. Barsness KA, Arcaroli J, Harken AH, et al. Hemorrhage-induced acute lung injury is TLR-4 dependent. Am J Physiol Regul Integr Comp Physiol 2004; 287:R592-R599.
57. Lv T, Shen X, Shi Y, Song Y. TLR4 is essential in acute lung injury induced by unresuscitated hemorrhagic shock. J Trauma 2009; 66:124-131.
58. Levy RM, Prince JM, Yang R, et al. Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4. Am J Physiol Regul Integr Comp Physiol 2006; 291:R970-R976.
59. Seely AJ, Pascual JL, Christou NV. Science review: cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance. Crit Care 2003; 7:291-307.
60. Majetschak M, Borgermann J, Waydhas C, et al. Whole blood tumor necrosis factor-alpha production and its relation to systemic concentrations of interleukin 4, interleukin 10, and transforming growth factor-beta 1 in multiply injured blunt trauma victims. Crit Care Med 2000; 28:1847-1853.
61. Pasquale MD, Cipolle MD, Monaco J, Simon N. Early inflammatory response correlates with the severity of injury. Crit Care Med 1996; 24:1238-1242.
62. Nuytinck JK, Goris JA, Redl H, et al. Posttraumatic complications and inflammatory mediators. Arch Surg 1986; 121:886-890.
63. Carroll MC, Holers VM. Innate autoimmunity. Adv Immunol 2005; 86:137-157.
64. Fleming SD, Tsokos GC. Complement, natural antibodies, autoantibodies and tissue injury. Autoimmun Rev 2006; 5:82-92.
65. Mastellos D, Lambris JD. Complement: more than a 'guard' against invading pathogens? Trends Immunol 2002; 23:485-491.
66. Morgan BP, Marchblank KJ, Longhi MP, et al. Complement: central to innate immunity and bridging to adaptive responses. Immunol Lett 2005; 2005:171-179.
67. Partrick DA, Moore FA, Moore EE, et al. Neutrophil priming and activation in the pathogenesis of postinjury multiple organ failure. New Horiz 1996; 4: 194-210.
68. Biffl WL, Moore EE, Moore FA, et al. Interleukin-6 potentiates neutrophil priming with platelet activating factor. Arch Surg 1994; 129:1131-1136.
69. Botha AJ, Moore FA, Moore EE, et al. Postinjury neutrophil priming and activation: an early vulnerable window. Surgery 1995; 118:358-364.
70. Barton G. A calculated response: control of inflammation by the innate immune system. J Clin Invest 2008; 118:413-420.
71. Nathan C. Points of control in inflammation. Nature 2002; 420:846-852.
72. Chen G, Tang J, Zheng P, Liu Y. CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Science 2009; 323:1722-1725.
73. Johnston RB Jr. Innate immunity in the newborn: overcoming fetal lethargy to defend the infant, but at the risk of uncontrolled inflammation. Neonatology 2008; 94:232-233.
74. Langrish CL, Buddie JC, Thrasher AJ, Goldblatt D. Neonatal dendritic cells are intrinsically biased against Th-1 immune responses. Clin Exp Immunol 2002; 128:118-123.
75. Levy O, Zarember KA, Roy RM, et al. Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848. J Immunol 2004; 173: 4627-4634.
76. Belderbos ME, van Bleek GM, Levy O, et al. Skewed pattern of toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life. Clin Immunol 2009; 133:228-237.
77. Halonen M, Lohman IC, Stern DA, et al. Th1/Th2 patterns and balance in cytokine production in the parents and infants of a large birth cohort. J Immunol 2009; 182:3285-3293.
78. Johnston RB Jr, Altenburger KM, Atkinson AWJ, Curry RH. Complement in the newborn infant. Pediatrics 1979; 64:781-786.
79. Johnston RB Jr. Function and cell biology of neutrophils and mononuclear phagocytes in the newborn infant. Vaccine 1998; 16:1363-1368.
80. Calkins CM, Bensard DD, Partrick DA, Karrer FM. Altered neutrophil function in the neonate protects against sepsis-induced lung injury. J Pediatr Surg 2002; 37:1042-1047.
81. Marodi L, Kapaszto R, Campbell DE, et al. Candidacidal mechanisms in the human neonate: impaired IFN-gamma activation of macrophages in newborn infants. J Immunol 1994; 153:5643-5649.
82. Chelvarajan RL, Collins SM, Doubinskaia IE, et al. Defective macrophage function in neonates and its impact on unresponsiveness of neonates to polysaccharide antigens. J Leukoc Biol 2004; 75:983-994.
83. Hartel C, Adam N, Strunk T, et al. Cytokine responses correlate differentially with age in infancy and early childhood. Clin Exp Immunol 2005; 142:446-453.
84. Upham JW, Lee PT, Holt BJ, et al. Development of interleukin-12-producing capacity throughout childhood. Infect Immun 2002; 70:6583-6588.
85. Smart JM, Kemp AS. Ontogeny of T-helper 1 and T-helper 2 cytokine production in childhood. Pediatr Allergy Immunol 2001; 12:181-187.
86. Hanna-Wakim R, Yasukawa LL, Sung P, et al. Age-related increases in the frequency of CD4+ T cells that produce interferon-γ in response to staphylococcal enterotoxin B during childhood. J Infect Dis 2009; 200:1921-1927.
87. Barsness KA, Bensard DD, Partrick DA, et al. Endotoxin induces an exaggerated interleukin-10 response in peritoneal macrophages of children compared with adults. J Pediatr Surg 2004; 39:912-915.
88. Barsness KA, Bensard DD, Partrick DA, et al. IL-1 β induces an exaggerated pro- and antiinflammatory response in peritoneal macrophages of children compared with adults. Pediatr Surg Int 2004; 20:238-242.
89. Finnerty CC, Jeschke MG, Herndon DN, et al. Temporal cytokine profiles in severely burned patients: a comparison of adults and children. Mol Med 2008; 14:553-560.
90. Ciesla D, Moore EE, Johnson JL, et al. The role of the lung in postinjury multiple organ failure. Surgery 2005; 138:749-757.
91. Rubenfeld GD, Caldwell E, Peabody E, et al. Incidence and outcomes of acute lung injury. N Engl J Med 2005; 353:1685-1693.
92. Zimmerman J, Akhtar S, Caldwell E, Rubenfeld G. Incidence and outcomes of pediatric acute lung injury. Pediatrics 2009; 124:87-95.
93. Zingarelli B, Hake PW, O'Connor M, et al. Lung injury after hemorrhage is age dependent: role of peroxisome proliferator-activated receptor-γ. Crit Care Med 2009;37:1978-1987.