Patophysiology of diabetic retinopathy;Patofyziologie diabetické retinopatie

Vnitrni Lekarstvi

Volumn 59, Issue 3, 2013, Pages 173-176

  Kolar P ^a  

^a UNIVERSITY HOSPITAL BRNO   (Czech Republic)

Author keywords

Diabetes mellitus; Diabetic retinopathy; Hematoretinal Barrier; Pathophysiology; VEGF; Vitreo retinal interface

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; ANGIOTENSIN II; HISTAMINE; MATRIX METALLOPROTEINASE; PROTEIN KINASE C; VASCULOTROPIN;

ARTICLE; BLOOD RETINA BARRIER; CELL LOSS; DIABETIC MICROANGIOPATHY; DIABETIC RETINOPATHY; ENDOTHELIUM CELL; HUMAN; HYPERGLYCEMIA; LEUKOCYTE; PERICYTE; VITREOUS BODY;

DIABETIC RETINOPATHY; HUMANS;

EID: 84876099557     PISSN: 0042773X     EISSN: 18017592     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Pinach S, Burt D, Berrone E et al. Retinal heat shock protein 25 in early experimental diabetes. Acta Diabetol 2011; published online http://link.springer.com/article/10.1007/s00592-011-0346-1.
2. Coral K, Angayarkanni N, Gomathy N et al. Homocysteine levels in the vitreous of proliferative diabetic retinopathy and rhegmatogenous retinal detachment: its modulating role on lysyl oxidase. Invest Ophthalmol Vis Sci 2009; 50: 3607-3612.
3. Chung SS, Chung SK. Aldose reductase in diabetic microvascular complications. Curr Drug Targets 2005; 6: 475-486.
4. Bandello F, Lattanzio R, Zucchiatti I et al. Pathophysiology and treatment of diabetic retinopathy. Acta Diabetol 2012; 50: 1-20.
5. Wong HC, Boulton M, McLeod D et al. Retinal pigment epithelial cells in culture produce retinal vascular mitogens. Arch Ophthalmol. 1988; 106: 1439-1443.
6. Gillies MC, Su T, Stayt J et al. Effect of high glucose on permeability of retinal capillary endothelium in vitro. Invest Ophthalmol Vis Sci 1997; 38: 635-642.
7. Grimes PA, Laties AM. Early morphological alteration of the pigment epithelium in streptozotocin-induced diabetes: increased surface area of the basal cell membrane. Exp Eye Res 1980; 30:631-639.
8. Kristinsson JK, Gottfredsdottir MS, Stefansson E. Retinal vessel dilatation and elongation precedes diabetic macular oedema. Br J Ophthalmol 1997; 81: 274-278.
9. Dosso AA, Leuenberger PM, Rungger-Brandle E. Remodeling of retinal capillaries in the diabetic hypertensive rat. Invest Ophthalmol Vis Sci 1999;40:2405-2410.
10. Joussen AM, Murata T, Tsujikawa A et al. Leukocytemediated endothelial cell injury and death in the diabetic retina. Am J Pathol. 2001;158:147-52
11. Joussen AM, Poulaki V, Le ML, et al. A central role for inflammation in the pathogenesis of diabetic retinopathy. Faseb J 2004; 18: 1450-1452.
12. Kaji Y, Usui T, Ishida S et al. Inhibition of diabetic leukostasis and blood - retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products. Invest Ophthalmol Vis Sci 2007; 48: 858-865.
13. Barile GR, Pachydaki SI, Tari SR et al. The RAGE axis in early diabetic retinopathy. Invest Ophthalmol Vis Sci 2005; 46: 2916-2924.
14. Lu M, Kuroki M, Amano S et al. Advanced glycation end products increase retinal vascular endothelial growth factor expression. J Clin Invest 1998; 101: 1219-1224.
15. Antonetti D, Lieth E, Barber A et al. Molecular mechanisms of vascular permeability in diabetic retinopathy. Sem Ophthalmol 1999; 14: 240-248.
16. Bhagat N, Grigorian RA, Tutela A et al. Diabetic macular edema: Pathogenesis and treatment. Surv Ophthalmol 2009; 54: 1-32.
17. Aiello LP, Bursell SE, Clermont A et al. Vascular endothelial growth factor - induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta isoform selective inhibitor. Diabetes 1997; 46: 1473-1480.
18. Sone H, Kawakami Y, Okuda Y et al. Ocular vascular endothelial growth factor levels in diabetic rats are elevated before observable retinal proliferative changes. Diabetologia 1997; 40: 726-730.
19. Hammes HP, Lin J, Bretzel RG et al. Upregulation of the vascular endothelial growth factor receptor system in experimental background diabetic retinopathy of the rat. Diabetes 1998; 47:401-406.
20. Murata T, Nakagawa K, Khalil A et al. The relation between expression of vascular endothelial growth factor and breakdown of the blood-retinal barrier in diabetic rat retinas. Lab Invest 1996; 74: 819-825.
21. Chakrabarti S, Sima AAF. Endothelin 1 and endothelin 3 like immunoreactivity in the eyes of diabetic and non-diabetic BB/W rats. Diabetes Res Clin Pract 1997; 37: 109-120.
22. Chakravathy U, Gardiner TA, Archer DB et al. The effect of endothelin 1 on the retinal microvascular pericyte. Microvasc Res 1992; 43: 241-254.
23. Carroll WJ, Hollis TM. Aortic histamine synthesis and aortic albumin accumulation in diabetes: activity-uptake relationships. Exp Mol Pathol 1985; 42: 344-352.
24. Chua CC, Hamdy RC, Chua BH. Upregulation of vascular endothelial growth factor by angiotensin II in rat heart endothelial cells. Biochem Biophys Acta 1998; 1401: 187-194.
25. Jin M, Kashiwagi K, lizuka Y et al. Matrix metalloproteinases in human diabetic and nondiabetic vitreous. Retina 2001; 21: 28-31.
26. Das A, McGuire PG, Eriqat C et al. Human diabetic neovascular membranes contain high levels of urokinase and metalloproteinase enzymes. Invest Ophthalmol Vis Sci 1999; 40: 809-813.
27. Ogata N, Tombran-Tink J, Nishikawa M et al. Pigment epithelium-derived factor in the vitreous is low in diabetic retinopathy and high in rhegmatogenous retinal detachment. Am J Ophthalmol 2001; 132: 378-382.
28. Lindahl P, Johansson BR, Leveen P et al. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 1997; 277: 242-245.
29. McNeil PL, Muthukrishnan L, Warder E et al. Growth factors are released by mechanically wounded endothelial cells. J Cell Biol 1989; 109: 811-822.
30. Sakamoto T. Cell biology of hyalocytes. Nippon Ganka Gakkai Zasshi 2003; 107): 866-882, discussion 883.
31. Harbour JW, Smiddy WE, Flynn HWJ et al. Vitrectomy for diabetic macular edema associated with a thickened and taut posterior hyaloid membrane. Am J Ophthalmol 1996; 121: 405-413.
32. Sebag J. Anatomy and pathology of the vitreo-retinal interface. Eye 1992; 6: 541-552.
33. Lopes de Faria JM, Jalkh AE, Trempe CL et al. Diabetic macular edema: risk factors and concomitants. Acta Ophthalmol Scand 1999; 77: 170-175.
34. Huang D, Swanson EA, Lin CP et al. Optical coherence tomography. Science 1991; 254: 1178-1181.
35. Jalkh AE, Takahashi M, Topilow HW et al. Prognostic value of vitreous findings in diabetic retinopathy. Archives of Ophthalmology 1982; 100:432-434.
36. Sebag J. Aging of the vitreous. Eye 1987; 1: 254-262.
37. Jumper JM, Embabi SN, Toth CA et al. Electron immunocytochemical analysis of posterior hyaloid associated with diabetic macular edema. Retina 2000; 20: 63-68.
38. Kon CH, Occlestone NL, Charteris D. A prospective study of matrix metalloproteinases in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci 1998; 39: 1524-1529.
39. Massin P, Erginay A, Haouchine BJ et al. Retinal thickness in healthy and diabetic subjects measured using optical coherence tomography mapping software. Eur J Ophthalmol 2002; 12: 102-108.
40. Aiello LP, Northrup JM, Keyt BA et al. Hypoxic regulation of vascular endothelial growth factor in retinal cells. Arch Ophthalmol 1995; 113: 1538-1544.
41. Sebag J, Balazs EA. Pathogenesis of cystoid macular edema: an anatomic consideration of vitreoretinal adhesions. Surv Ophthalmol 1984; 28: (Suppl.): 493-498.
42. Amin RH, Frank RN, Kennedy A et al. Vascular endothelial growth factor is present in glial cells of the retina and optic nerve of human subjects with nonproliferative diabetic retinopathy. Invest Ophthalmol Vis Sci 1997; 38: 36-47.
43. Yamamoto T, Akabane N, Takeuchi S. Vitrectomy for diabetic macular edema: The role of posterior vitreous detachment and epimacular membrane. Am J Ophthalmol 2001; 132: 369-377.