TRAF2 is upregulated in relapsing-remitting multiple sclerosis

NeuroImmunoModulation

Volumn 20, Issue 3, 2013, Pages 177-183

  Reuß, Reinhard ^a,c   Mirau, Andreas ^c   Mistarz, Marta ^c   Kraus, Jörg ^e   Bödeker, Rolf Hasso ^d   Oschmann, Patrick ^b  

^a BKH Bayreuth ^*  (Germany)

^b Hospital Hohe Warte   (Germany)

^c JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^d JUSTUS LIEBIG UNIVERSITY   (Germany)

^e PARACELSUS MEDICAL UNIVERSITY   (Austria)

Author keywords

Multiple sclerosis; RIP; TRAF2; Tumor necrosis factor; Tumor necrosis factor receptor

Indexed keywords

RECEPTOR INTERACTING PROTEIN 140; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; CARRIER PROTEINS AND BINDING PROTEINS; MESSENGER RNA; RECEPTOR INTERACTING PROTEIN 1; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE COURSE; EXPANDED DISABILITY STATUS SCALE; FEMALE; GENE EXPRESSION; HUMAN; LEUKOCYTE; MALE; MULTIPLE SCLEROSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; DISEASE DURATION; MAJOR CLINICAL STUDY; MIDDLE AGED; PROTEIN EXPRESSION; RELAPSE; SIGNAL TRANSDUCTION;

CROSS-SECTIONAL STUDIES; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; NUCLEAR PORE COMPLEX PROTEINS; RNA, MESSENGER; RNA-BINDING PROTEINS; SEVERITY OF ILLNESS INDEX; TNF RECEPTOR-ASSOCIATED FACTOR 2; UP-REGULATION;

EID: 84876095016     PISSN: 10217401     EISSN: 14230216     Source Type: Journal    
DOI: 10.1159/000346794     Document Type: Article

References (29)

1. Farias AS, de la Hoz C, Castro FR, Oliveira EC, Ribeiro dos Reis JR, Silva JS, Langone F, Santos LMB: Nitric oxide and TNF-α effects in experimental autoimmune encephalomyelitis demyelination. Neuroimmunomodulation 2007; 14: 32-38 (Pubitemid 47340633)
2. Hsu H, Shu HB, Pan MG, Goeddel DV: TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 1996; 84: 299-308 (Pubitemid 26042835)
3. Hsu H, Xiong J, Goeddel DV: The TNF receptor 1-Associated protein TRADD signals cell death and NF-kappa B activation. Cell 1995; 81: 495-504
4. Jiang Y, Woronicz JD, Liu W, Goeddel DV: Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. Science 1999; 288: 543-546
5. Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV: TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 1996; 4: 387-396 (Pubitemid 26174054)
6. Micheau O, Tschopp J: Induction of TNF receptor I-mediated apoptois via two sequential signalling complexes. Cell 2003; 114: 181-190 (Pubitemid 36936912)
7. Schneider-Brachert W, Tchikov V, Neumeyer I, Jakob M, Winoto-Morbach S, Held-Feindt J, Heinrich M, Merkel O, Ehrenschwender M, Adam D, Mentlein R, Kabelitz D, Schutze S: Compartmentalization of TNF receptor 1 signaling: Internalized TNF receptosomes as death signaling vesicles. Immunity 2004; 21: 415-428 (Pubitemid 39208342)
8. Tartaglia LA, Ayres TM, Wong GH, Goeddel DV: A novel domain within the 55 kd TNF receptor signals cell death. Cell 1993; 74: 845-853 (Pubitemid 23270604)
9. Fotin-Mleczek M, Henkler F, Samel D, Reichwein M, Hausser A, Pamryd I, Scheurich P, Schmid JA, Wajant H: Apoptotic crosstalk of TNF receptors: TNF-R2 induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8. J Cell Sci 2002; 115: 2757-2770 (Pubitemid 34846516)
10. Bachmann R, Eugster HP, Frei K, Fontana A, Lassmann H: Impairment of TNF-receptor-1 signaling but not fas signaling diminishes Tcell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis in mice. Am J Pathol 1999; 154: 1417-1422 (Pubitemid 29226436)
11. Akassoglou K, Douni E, Bauer J, Lassmann H, Kollias G, Probert L: Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice. Proc Natl Acad Sci USA 2003; 100: 709-714 (Pubitemid 36126117)
12. Gomes AC, Jonsson G, Mjornheim S, Olsson T, Hillert J, Grandien A: Upregulation of the apoptosis regulators cFLIP, CD95 and CD95 ligand in peripheral blood mononuclear cells in relapsing-remitting multiple sclerosis. J Neuroimmunol 2003; 135: 126-134 (Pubitemid 36170159)
13. Sharief MK, Noori MA, Zoukos Y: Reduced expression of the inhibitor of apoptosis proteins in T cells from patients with multiple sclerosis following interferon-beta therapy. J Neuroimmunol 2002; 129: 224-231 (Pubitemid 34874927)
14. Gniadek P, Aktas O, Wandinger KP, Bellmann-Strobl J, Wengert O, Weber A, von Wussow P, Obert HJ, Zipp F: Systemic IFNbeta treatment induces apoptosis of peripheral immune cells in MS patients. J Neuroimmunol 2003; 137: 187-196 (Pubitemid 36351581)
15. Reuss R, Pohle S, Retzlaff K, Hemberger J, Oschmann P: Interferon beta-1a induces tumor necrosis factor receptor 1 but decreases tumor necrosis factor receptor 2 leukocyte mRNA levels in relapsing-remitting multiple sclerosis. Neuroimmunomodulation 2009; 16: 171-176
16. Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtellotte WW: New diagnostic criteria for multiple sclerosis: Guidelines for research protocols. Ann Neurol 1983; 13: 227-231 (Pubitemid 13158528)
17. Kurtzke JF: Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology 1983; 33: 1444-1452 (Pubitemid 14237132)
18. Kuhne BS, Oschmann P: Quantitative realtime RT-PCR using hybridization probes and imported standard curves for cytokine gene expression analysis. Biotechniques 2000; 33: 1078, 1080-1082, 1084
19. Lenercept Multiple Sclerosis Study Group, University of British Columbia MS/MRI Analysis Group: TNF neutralization in MS: Results of a randomized, placebo-controlled multicenter study. Neurology 1999; 53: 457-465
20. Frischer JM, Bramow S, Dal-Bianco A, Lucchinetti C, Rauschka H, Schmidbauer M, Laursen H, Sorensen PS, Lassmann H: The relation between inflammation and neurodegeneration in multiple sclerosis brains. Brain 2009; 132: 1175-1189
21. Pimentel-Muinos FX, Seed B: Regulated commitment of TNF receptor signaling: A molecular switch for death or activation. Immunity 1999; 11: 783-793 (Pubitemid 30030717)
22. Sawanobori M, Yamaguchi S, Hasegawa M, Inoue M, Suzuki K, Kamiyama R, Hirokawa K, Kitagawa M: Expression of TNF receptors and related signaling molecules in the bone marrow from patients with myelodysplastic syndromes. Leuk Res 2003; 27: 583-591 (Pubitemid 36398093)
23. Zhu L, Yang X, Ji Y, Chen W, Guan W, Zhou SF, Yu X: Up-regulated renal expression of TNF-α signalling adapter proteins in lupus glomerulonephritis. Lupus 2009; 18: 116-127
24. Zhu L, Yang X, Chen W, Li X, Ji Y, Mao H, Nie J, Yu X: Decreased expressions of the TNF-α signaling adapters in peripheral blood mononuclear cells (PBMCs) are correlated with disease activity in patients with systemic lupus erythematosus. Clin Rheumatol 2007; 26: 1481-1489 (Pubitemid 47193565)
25. Hill NJ, Stotland A, Solomon M, Secrest P, Getzoff E, Sarvetnick N: Resistance of the target islet tissue to autoimmune destruction contributes to genetic susceptibility in type 1 diabetes. Biol Direct 2007; 2: 5
26. Arnett HA, Mason J, Marino M, Suzuki K, Matsushima GK, Ting JP: TNF-Alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat Neurosci 2001; 4: 1116-1122 (Pubitemid 34116557)
27. Suvannavejh GC, Lee HO, Padilla J, Dal Canto MC, Barrett TA, Miller SD: Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis. Cell Immunol 2000; 205: 24-33
28. Lees SJ, Zwetsloot KA, Booth FW: Muscle precursor cells isolated from aged rats exhibit an increased tumor necrosis factor-Alpha response. Aging Cell 2009; 8: 26-35
29. Aggarwal S, Gollapudi S, Gupta S: Increased TNF-Alpha-induced apoptosis in lymphocytes from aged humans: Changes in TNF-Alpha receptor expression and activation of caspases. J Immunol 1999; 162: 2154-2161 (Pubitemid 29288837).