메뉴 건너뛰기




Volumn 13, Issue , 2013, Pages

Dimethylaminoparthenolide and gemcitabine: A survival study using a genetically engineered mouse model of pancreatic cancer

Author keywords

Chemoprevention; Gemcitabine; NF B; Pancreatic cancer; Parthenolide; Therapy

Indexed keywords

DIMETHYLAMINOPARTHENOLIDE; EOTAXIN; GEMCITABINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; K RAS PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PARTHENOLIDE; PLACEBO; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CYTOKINE; DEOXYCYTIDINE; LC-1 COMPOUND; SESQUITERPENE;

EID: 84876082602     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-194     Document Type: Article
Times cited : (39)

References (38)
  • 1
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • 10.3322/caac.20121, 21685461
    • Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011, 61:212-236. 10.3322/caac.20121, 21685461.
    • (2011) CA Cancer J Clin , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3    Jemal, A.4
  • 2
    • 0030964122 scopus 로고    scopus 로고
    • Assessing clinical benefit in the treatment of pancreas cancer: gemcitabine compared to 5-fluorouracil
    • Burris H, Storniolo AM. Assessing clinical benefit in the treatment of pancreas cancer: gemcitabine compared to 5-fluorouracil. Eur J Cancer 1997, 33(Suppl 1):S18-S22.
    • (1997) Eur J Cancer , vol.33 , Issue.SUPPL. 1
    • Burris, H.1    Storniolo, A.M.2
  • 4
    • 0037280222 scopus 로고    scopus 로고
    • Metastatic pancreatic cancer: emerging strategies in chemotherapy and palliative care
    • el-Kamar FG, Grossbard ML, Kozuch PS. Metastatic pancreatic cancer: emerging strategies in chemotherapy and palliative care. Oncologist 2003, 8:18-34.
    • (2003) Oncologist , vol.8 , pp. 18-34
    • el-Kamar, F.G.1    Grossbard, M.L.2    Kozuch, P.S.3
  • 5
    • 78650504316 scopus 로고    scopus 로고
    • Endoscopic ultrasonography-guided ethanol lavage with paclitaxel injection treats patients with pancreatic cysts
    • 10.1053/j.gastro.2010.10.001, 20950614
    • Oh HC, Seo DW, Song TJ, Moon SH, Park do H, Soo Lee S, Lee SK, Kim MH, Kim J. Endoscopic ultrasonography-guided ethanol lavage with paclitaxel injection treats patients with pancreatic cysts. Gastroenterology 2011, 140:172-179. 10.1053/j.gastro.2010.10.001, 20950614.
    • (2011) Gastroenterology , vol.140 , pp. 172-179
    • Oh, H.C.1    Seo, D.W.2    Song, T.J.3    Moon, S.H.4    Park do, H.5    Soo Lee, S.6    Lee, S.K.7    Kim, M.H.8    Kim, J.9
  • 6
    • 84861879404 scopus 로고    scopus 로고
    • Genetically engineered mouse models: closing the gap between preclinical data and trial outcomes
    • 10.1158/0008-5472.CAN-11-2786, 22593194
    • Singh M, Murriel CL, Johnson L. Genetically engineered mouse models: closing the gap between preclinical data and trial outcomes. Cancer Res 2012, 72:2695-2700. 10.1158/0008-5472.CAN-11-2786, 22593194.
    • (2012) Cancer Res , vol.72 , pp. 2695-2700
    • Singh, M.1    Murriel, C.L.2    Johnson, L.3
  • 7
    • 19344362405 scopus 로고    scopus 로고
    • Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    • 10.1016/j.ccr.2005.04.023, 15894267
    • Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, Hruban RH, Rustgi AK, Chang S, Tuveson DA. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 2005, 7:469-483. 10.1016/j.ccr.2005.04.023, 15894267.
    • (2005) Cancer Cell , vol.7 , pp. 469-483
    • Hingorani, S.R.1    Wang, L.2    Multani, A.S.3    Combs, C.4    Deramaudt, T.B.5    Hruban, R.H.6    Rustgi, A.K.7    Chang, S.8    Tuveson, D.A.9
  • 8
    • 84872065981 scopus 로고    scopus 로고
    • Oncogenic transcription factors: cornerstones of inflammation-linked pancreatic carcinogenesis
    • 10.1136/gutjnl-2011-301008, 3539739, 21997559
    • Baumgart S, Ellenrieder V, Fernandez-Zapico ME. Oncogenic transcription factors: cornerstones of inflammation-linked pancreatic carcinogenesis. Gut 2013, 62(2):310-316. 10.1136/gutjnl-2011-301008, 3539739, 21997559.
    • (2013) Gut , vol.62 , Issue.2 , pp. 310-316
    • Baumgart, S.1    Ellenrieder, V.2    Fernandez-Zapico, M.E.3
  • 9
    • 41149089359 scopus 로고    scopus 로고
    • The role of nuclear factor kappaB in pancreatic cancer and the clinical applications of targeted therapy
    • 10.1097/MPA.0b013e31815b3207, 18362834
    • Holcomb B, Yip-Schneider M, Schmidt CM. The role of nuclear factor kappaB in pancreatic cancer and the clinical applications of targeted therapy. Pancreas 2008, 36:225-235. 10.1097/MPA.0b013e31815b3207, 18362834.
    • (2008) Pancreas , vol.36 , pp. 225-235
    • Holcomb, B.1    Yip-Schneider, M.2    Schmidt, C.M.3
  • 10
    • 0032943591 scopus 로고    scopus 로고
    • The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
    • Wang W, Abbruzzese JL, Evans DB, Larry L, Cleary KR, Chiao PJ. The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res 1999, 5:119-127.
    • (1999) Clin Cancer Res , vol.5 , pp. 119-127
    • Wang, W.1    Abbruzzese, J.L.2    Evans, D.B.3    Larry, L.4    Cleary, K.R.5    Chiao, P.J.6
  • 11
    • 84855946746 scopus 로고    scopus 로고
    • Kras(G12D)-Induced IKK2/beta/NF-kappaB Activation by IL-1alpha and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma
    • 10.1016/j.ccr.2011.12.006, 3360958, 22264792
    • Ling J, Kang Y, Zhao R, Xia Q, Lee DF, Chang Z, Li J, Peng B, Fleming JB, Wang H. Kras(G12D)-Induced IKK2/beta/NF-kappaB Activation by IL-1alpha and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma. Cancer Cell 2012, 21:105-120. 10.1016/j.ccr.2011.12.006, 3360958, 22264792.
    • (2012) Cancer Cell , vol.21 , pp. 105-120
    • Ling, J.1    Kang, Y.2    Zhao, R.3    Xia, Q.4    Lee, D.F.5    Chang, Z.6    Li, J.7    Peng, B.8    Fleming, J.B.9    Wang, H.10
  • 12
    • 77953593354 scopus 로고    scopus 로고
    • Chemoprevention strategies for pancreatic cancer
    • 2927967, 20440279
    • Stan SD, Singh SV, Brand RE. Chemoprevention strategies for pancreatic cancer. Nat Rev Gastroenterol Hepatol 2010, 7:347-356. 2927967, 20440279.
    • (2010) Nat Rev Gastroenterol Hepatol , vol.7 , pp. 347-356
    • Stan, S.D.1    Singh, S.V.2    Brand, R.E.3
  • 13
    • 34250698168 scopus 로고    scopus 로고
    • NF-kappaB, inflammation and pancreatic carcinogenesis: NF-kappaB as a chemoprevention target (review)
    • Zhang Z, Rigas B. NF-kappaB, inflammation and pancreatic carcinogenesis: NF-kappaB as a chemoprevention target (review). Int J Oncol 2006, 29:185-192.
    • (2006) Int J Oncol , vol.29 , pp. 185-192
    • Zhang, Z.1    Rigas, B.2
  • 14
    • 67650311657 scopus 로고    scopus 로고
    • Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1)
    • 10.1016/j.bmcl.2009.05.092, 19505822
    • Neelakantan S, Nasim S, Guzman ML, Jordan CT, Crooks PA. Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1). Bioorg Med Chem Lett 2009, 19:4346-4349. 10.1016/j.bmcl.2009.05.092, 19505822.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 4346-4349
    • Neelakantan, S.1    Nasim, S.2    Guzman, M.L.3    Jordan, C.T.4    Crooks, P.A.5
  • 15
    • 58149359316 scopus 로고    scopus 로고
    • Effect of celecoxib and the novel anti-cancer agent, dimethylamino-parthenolide, in a developmental model of pancreatic cancer
    • 10.1097/MPA.0b013e318172b4dd, 18815538
    • Yip-Schneider MT, Wu H, Njoku V, Ralstin M, Holcomb B, Crooks PA, Neelakantan S, Sweeney CJ, Schmidt CM. Effect of celecoxib and the novel anti-cancer agent, dimethylamino-parthenolide, in a developmental model of pancreatic cancer. Pancreas 2008, 37:e45-e53. 10.1097/MPA.0b013e318172b4dd, 18815538.
    • (2008) Pancreas , vol.37
    • Yip-Schneider, M.T.1    Wu, H.2    Njoku, V.3    Ralstin, M.4    Holcomb, B.5    Crooks, P.A.6    Neelakantan, S.7    Sweeney, C.J.8    Schmidt, C.M.9
  • 16
    • 34250703218 scopus 로고    scopus 로고
    • Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo
    • 10.1158/1535-7163.MCT-06-0794, 17541034
    • Yip-Schneider MT, Wu H, Ralstin M, Yiannoutsos C, Crooks PA, Neelakantan S, Noble S, Nakshatri H, Sweeney CJ, Schmidt CM. Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo. Mol Cancer Ther 2007, 6:1736-1744. 10.1158/1535-7163.MCT-06-0794, 17541034.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1736-1744
    • Yip-Schneider, M.T.1    Wu, H.2    Ralstin, M.3    Yiannoutsos, C.4    Crooks, P.A.5    Neelakantan, S.6    Noble, S.7    Nakshatri, H.8    Sweeney, C.J.9    Schmidt, C.M.10
  • 17
    • 0038621384 scopus 로고    scopus 로고
    • Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death
    • 10.1038/sj.onc.1206390, 12761494
    • Arlt A, Gehrz A, Muerkoster S, Vorndamm J, Kruse ML, Folsch UR, Schafer H. Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene 2003, 22:3243-3251. 10.1038/sj.onc.1206390, 12761494.
    • (2003) Oncogene , vol.22 , pp. 3243-3251
    • Arlt, A.1    Gehrz, A.2    Muerkoster, S.3    Vorndamm, J.4    Kruse, M.L.5    Folsch, U.R.6    Schafer, H.7
  • 18
    • 47749086343 scopus 로고    scopus 로고
    • Pancreatic cancer cell genetics and signaling response to treatment correlate with efficacy of gemcitabine-based molecular targeting strategies
    • 10.1007/s11605-007-0406-6, 18049840
    • Holcomb B, Yip-Schneider MT, Matos JM, Dixon J, Kennard J, Mahomed J, Shanmugam R, Sebolt-Leopold J, Schmidt CM. Pancreatic cancer cell genetics and signaling response to treatment correlate with efficacy of gemcitabine-based molecular targeting strategies. J Gastrointest Surg 2008, 12:288-296. 10.1007/s11605-007-0406-6, 18049840.
    • (2008) J Gastrointest Surg , vol.12 , pp. 288-296
    • Holcomb, B.1    Yip-Schneider, M.T.2    Matos, J.M.3    Dixon, J.4    Kennard, J.5    Mahomed, J.6    Shanmugam, R.7    Sebolt-Leopold, J.8    Schmidt, C.M.9
  • 19
    • 77952420656 scopus 로고    scopus 로고
    • Dihydroartemisinin inactivates NF-kappaB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo
    • 10.1016/j.canlet.2010.01.001, 20137856
    • Wang SJ, Gao Y, Chen H, Kong R, Jiang HC, Pan SH, Xue DB, Bai XW, Sun B. Dihydroartemisinin inactivates NF-kappaB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo. Cancer Lett 2010, 293:99-108. 10.1016/j.canlet.2010.01.001, 20137856.
    • (2010) Cancer Lett , vol.293 , pp. 99-108
    • Wang, S.J.1    Gao, Y.2    Chen, H.3    Kong, R.4    Jiang, H.C.5    Pan, S.H.6    Xue, D.B.7    Bai, X.W.8    Sun, B.9
  • 20
    • 1842609941 scopus 로고    scopus 로고
    • Inhibition of AKT abrogates chemotherapy-induced NF-kappaB survival mechanisms: implications for therapy in pancreatic cancer
    • 10.1016/j.jamcollsurg.2003.12.005, 15051014
    • Fahy BN, Schlieman MG, Virudachalam S, Bold RJ. Inhibition of AKT abrogates chemotherapy-induced NF-kappaB survival mechanisms: implications for therapy in pancreatic cancer. J Am Coll Surg 2004, 198:591-599. 10.1016/j.jamcollsurg.2003.12.005, 15051014.
    • (2004) J Am Coll Surg , vol.198 , pp. 591-599
    • Fahy, B.N.1    Schlieman, M.G.2    Virudachalam, S.3    Bold, R.J.4
  • 21
    • 84862496203 scopus 로고    scopus 로고
    • Dimethylamino parthenolide enhances the inhibitory effects of gemcitabine in human pancreatic cancer cells
    • 10.1007/s11605-012-1913-7, 22618517
    • Holcomb BK, Yip-Schneider MT, Waters JA, Beane JD, Crooks PA, Schmidt CM. Dimethylamino parthenolide enhances the inhibitory effects of gemcitabine in human pancreatic cancer cells. J Gastrointest Surg 2012, 16:1333-1340. 10.1007/s11605-012-1913-7, 22618517.
    • (2012) J Gastrointest Surg , vol.16 , pp. 1333-1340
    • Holcomb, B.K.1    Yip-Schneider, M.T.2    Waters, J.A.3    Beane, J.D.4    Crooks, P.A.5    Schmidt, C.M.6
  • 22
    • 84872091164 scopus 로고    scopus 로고
    • Efficacy of Dimethylaminoparthenolide and Sulindac in Combination With Gemcitabine in a Genetically Engineered Mouse Model of Pancreatic Cancer
    • 10.1097/MPA.0b013e318254f455, 22699205
    • Yip-Schneider MT, Wu H, Hruban RH, Lowy AM, Crooks PA, Schmidt CM. Efficacy of Dimethylaminoparthenolide and Sulindac in Combination With Gemcitabine in a Genetically Engineered Mouse Model of Pancreatic Cancer. Pancreas 2013, 42(1):160-167. 10.1097/MPA.0b013e318254f455, 22699205.
    • (2013) Pancreas , vol.42 , Issue.1 , pp. 160-167
    • Yip-Schneider, M.T.1    Wu, H.2    Hruban, R.H.3    Lowy, A.M.4    Crooks, P.A.5    Schmidt, C.M.6
  • 24
    • 34547613903 scopus 로고    scopus 로고
    • Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor
    • 10.1158/0008-5472.CAN-07-0970, 17652141
    • Funahashi H, Satake M, Dawson D, Huynh NA, Reber HA, Hines OJ, Eibl G. Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor. Cancer Res 2007, 67:7068-7071. 10.1158/0008-5472.CAN-07-0970, 17652141.
    • (2007) Cancer Res , vol.67 , pp. 7068-7071
    • Funahashi, H.1    Satake, M.2    Dawson, D.3    Huynh, N.A.4    Reber, H.A.5    Hines, O.J.6    Eibl, G.7
  • 25
    • 45849139787 scopus 로고    scopus 로고
    • Estrogen promotes tumor progression in a genetically defined mouse model of lung adenocarcinoma
    • 10.1677/ERC-08-0002, 18509000
    • Hammoud Z, Tan B, Badve S, Bigsby RM. Estrogen promotes tumor progression in a genetically defined mouse model of lung adenocarcinoma. Endocr Relat Cancer 2008, 15:475-483. 10.1677/ERC-08-0002, 18509000.
    • (2008) Endocr Relat Cancer , vol.15 , pp. 475-483
    • Hammoud, Z.1    Tan, B.2    Badve, S.3    Bigsby, R.M.4
  • 28
    • 39649125467 scopus 로고    scopus 로고
    • An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells
    • 10.1182/blood-2007-05-090621, 2234793, 17804695
    • Guzman ML, Rossi RM, Neelakantan S, Li X, Corbett CA, Hassane DC, Becker MW, Bennett JM, Sullivan E, Lachowicz JL. An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells. Blood 2007, 110:4427-4435. 10.1182/blood-2007-05-090621, 2234793, 17804695.
    • (2007) Blood , vol.110 , pp. 4427-4435
    • Guzman, M.L.1    Rossi, R.M.2    Neelakantan, S.3    Li, X.4    Corbett, C.A.5    Hassane, D.C.6    Becker, M.W.7    Bennett, J.M.8    Sullivan, E.9    Lachowicz, J.L.10
  • 29
    • 40449086665 scopus 로고    scopus 로고
    • Dose translation from animal to human studies revisited
    • Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. FASEB J 2008, 22:659-661.
    • (2008) FASEB J , vol.22 , pp. 659-661
    • Reagan-Shaw, S.1    Nihal, M.2    Ahmad, N.3
  • 30
    • 33644514374 scopus 로고    scopus 로고
    • Comparison of standard-dose and low-dose gemcitabine regimens in pancreatic adenocarcinoma patients: a prospective randomized trial
    • 10.1007/s00535-005-1724-7, 16501860
    • Sakamoto H, Kitano M, Suetomi Y, Takeyama Y, Ohyanagi H, Nakai T, Yasuda C, Kudo M. Comparison of standard-dose and low-dose gemcitabine regimens in pancreatic adenocarcinoma patients: a prospective randomized trial. J Gastroenterol 2006, 41:70-76. 10.1007/s00535-005-1724-7, 16501860.
    • (2006) J Gastroenterol , vol.41 , pp. 70-76
    • Sakamoto, H.1    Kitano, M.2    Suetomi, Y.3    Takeyama, Y.4    Ohyanagi, H.5    Nakai, T.6    Yasuda, C.7    Kudo, M.8
  • 33
    • 18044376489 scopus 로고    scopus 로고
    • Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells
    • 10.1158/1535-7163.MCT-04-0215, 15827332
    • Yip-Schneider MT, Nakshatri H, Sweeney CJ, Marshall MS, Wiebke EA, Schmidt CM. Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells. Mol Cancer Ther 2005, 4:587-594. 10.1158/1535-7163.MCT-04-0215, 15827332.
    • (2005) Mol Cancer Ther , vol.4 , pp. 587-594
    • Yip-Schneider, M.T.1    Nakshatri, H.2    Sweeney, C.J.3    Marshall, M.S.4    Wiebke, E.A.5    Schmidt, C.M.6
  • 34
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kappaB transcription factors
    • 10.1038/sj.onc.1203239, 10602461
    • Pahl HL. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 1999, 18:6853-6866. 10.1038/sj.onc.1203239, 10602461.
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 35
    • 79952769599 scopus 로고    scopus 로고
    • RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in gammadelta T cells
    • 10.1016/j.immuni.2011.02.019, 21419662
    • Powolny-Budnicka I, Riemann M, Tanzer S, Schmid RM, Hehlgans T, Weih F. RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in gammadelta T cells. Immunity 2011, 34:364-374. 10.1016/j.immuni.2011.02.019, 21419662.
    • (2011) Immunity , vol.34 , pp. 364-374
    • Powolny-Budnicka, I.1    Riemann, M.2    Tanzer, S.3    Schmid, R.M.4    Hehlgans, T.5    Weih, F.6
  • 36
    • 77951744260 scopus 로고    scopus 로고
    • The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer
    • 10.1136/gut.2009.188961, 19880966
    • Fendrich V, Chen NM, Neef M, Waldmann J, Buchholz M, Feldmann G, Slater EP, Maitra A, Bartsch DK. The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer. Gut 2010, 59:630-637. 10.1136/gut.2009.188961, 19880966.
    • (2010) Gut , vol.59 , pp. 630-637
    • Fendrich, V.1    Chen, N.M.2    Neef, M.3    Waldmann, J.4    Buchholz, M.5    Feldmann, G.6    Slater, E.P.7    Maitra, A.8    Bartsch, D.K.9
  • 38
    • 78649233246 scopus 로고    scopus 로고
    • Chemoprevention of pancreatic cancer: ready for the clinic?
    • Logsdon CD, Abbruzzese JL. Chemoprevention of pancreatic cancer: ready for the clinic?. Cancer Prev Res (Phila) 2010, 3:1375-1378.
    • (2010) Cancer Prev Res (Phila) , vol.3 , pp. 1375-1378
    • Logsdon, C.D.1    Abbruzzese, J.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.