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Volumn 110, Issue 15, 2013, Pages 6109-6114

Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers

(21)  Lin, De Chen a,b   Xu, Liang b   Ding, Ling Wen b   Sharma, Arjun b   Liu, Li Zhen b   Yang, Henry b   Tan, Patrick a   Vadgama, Jay c   Karlan, Beth Y d   Lester, Jenny d   Urban, Nicole e   Schummer, Michèl e   Doan, Ngan a   Said, Jonathan W a   Sun, Hongmao f   Walsh, Martin f   Thomas, Craig J f   Patel, Paresma g   Yin, Dong h   Chan, Daniel i   more..


Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; PHOSPHODIESTERASE 4D; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

EID: 84876062367     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1218206110     Document Type: Article
Times cited : (59)

References (30)
  • 1
    • 33748686575 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use
    • Bender AT, Beavo JA (2006) Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use. Pharmacol Rev 58(3):488-520.
    • (2006) Pharmacol Rev , vol.58 , Issue.3 , pp. 488-520
    • Bender, A.T.1    Beavo, J.A.2
  • 2
    • 34447265905 scopus 로고    scopus 로고
    • Biochemistry and physiology of cyclic nucleotide phosphodiesterases: Essential components in cyclic nucleotide signaling
    • Conti M, Beavo J (2007) Biochemistry and physiology of cyclic nucleotide phosphodiesterases: Essential components in cyclic nucleotide signaling. Annu Rev Biochem 76:481-511.
    • (2007) Annu Rev Biochem , vol.76 , pp. 481-511
    • Conti, M.1    Beavo, J.2
  • 3
    • 33847689816 scopus 로고    scopus 로고
    • Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity
    • Ke H, Wang H (2007) Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity. Curr Top Med Chem 7(4):391-403.
    • (2007) Curr Top Med Chem , vol.7 , Issue.4 , pp. 391-403
    • Ke, H.1    Wang, H.2
  • 4
    • 31144433061 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents
    • Lugnier C (2006) Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents. Pharmacol Ther 109(3):366-398.
    • (2006) Pharmacol Ther , vol.109 , Issue.3 , pp. 366-398
    • Lugnier, C.1
  • 5
    • 0033783798 scopus 로고    scopus 로고
    • Cyclic 3', 5'-nucleotide phosphodiesterases: Potential targets for anticancer therapy
    • Marko D, Pahlke G, Merz KH, Eisenbrand G (2000) Cyclic 3', 5'-nucleotide phosphodiesterases: Potential targets for anticancer therapy. Chem Res Toxicol 13(10):944-948.
    • (2000) Chem Res Toxicol , vol.13 , Issue.10 , pp. 944-948
    • Marko, D.1    Pahlke, G.2    Merz, K.H.3    Eisenbrand, G.4
  • 6
    • 59449107942 scopus 로고    scopus 로고
    • Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression
    • Goldhoff P, et al. (2008) Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression. Clin Cancer Res 14(23):7717-7725.
    • (2008) Clin Cancer Res , vol.14 , Issue.23 , pp. 7717-7725
    • Goldhoff, P.1
  • 7
    • 0034800269 scopus 로고    scopus 로고
    • Cyclic AMP specific phosphodiesterase activity and colon cancer cell motility
    • Murata K, et al. (2000) Cyclic AMP specific phosphodiesterase activity and colon cancer cell motility. Clin Exp Metastasis 18(7):599-604.
    • (2000) Clin Exp Metastasis , vol.18 , Issue.7 , pp. 599-604
    • Murata, K.1
  • 8
    • 0003226768 scopus 로고    scopus 로고
    • Type 4 cyclic adenosine monophosphate phosphodiesterase as a therapeutic target in chronic lymphocytic leukemia
    • Kim DH, Lerner A (1998) Type 4 cyclic adenosine monophosphate phosphodiesterase as a therapeutic target in chronic lymphocytic leukemia. Blood 92(7):2484-2494.
    • (1998) Blood , vol.92 , Issue.7 , pp. 2484-2494
    • Kim, D.H.1    Lerner, A.2
  • 9
    • 0036566204 scopus 로고    scopus 로고
    • Inhibition of PDE4 phosphodiesterase activity induces growth suppression, apoptosis, glucocorticoid sensitivity, p53, and p21 (WAF1/CIP1) proteins in human acute lymphoblastic leukemia cells
    • Ogawa R, Streiff MB, Bugayenko A, Kato GJ (2002) Inhibition of PDE4 phosphodiesterase activity induces growth suppression, apoptosis, glucocorticoid sensitivity, p53, and p21(WAF1/CIP1) proteins in human acute lymphoblastic leukemia cells. Blood 99 (9):3390-3397.
    • (2002) Blood , vol.99 , Issue.9 , pp. 3390-3397
    • Ogawa, R.1    Streiff, M.B.2    Bugayenko, A.3    Kato, G.J.4
  • 10
    • 0018863552 scopus 로고
    • Humoral modulation of human acute myelogenous leukemia cell growth in vitro
    • Koeffler HP, Golde DW (1980) Humoral modulation of human acute myelogenous leukemia cell growth in vitro. Cancer Res 40(6):1858-1862.
    • (1980) Cancer Res , vol.40 , Issue.6 , pp. 1858-1862
    • Koeffler, H.P.1    Golde, D.W.2
  • 11
    • 0035224418 scopus 로고    scopus 로고
    • PDE4 cAMP-specific phosphodiesterases
    • Houslay MD (2001) PDE4 cAMP-specific phosphodiesterases. Prog Nucleic Acid Res Mol Biol 69:249-315.
    • (2001) Prog Nucleic Acid Res Mol Biol , vol.69 , pp. 249-315
    • Houslay, M.D.1
  • 12
    • 66249125722 scopus 로고    scopus 로고
    • Identification of PDE4D as a proliferation promoting factor in prostate cancer using a Sleeping Beauty transposon-based somatic mutagenesis screen
    • Rahrmann EP, et al. (2009) Identification of PDE4D as a proliferation promoting factor in prostate cancer using a Sleeping Beauty transposon-based somatic mutagenesis screen. Cancer Res 69(10):4388-4397.
    • (2009) Cancer Res , vol.69 , Issue.10 , pp. 4388-4397
    • Rahrmann, E.P.1
  • 13
    • 84874734378 scopus 로고    scopus 로고
    • Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF
    • Pullamsetti SS, et al. (2012) Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF. Oncogene 32(9):1121-1134.
    • (2012) Oncogene , vol.32 , Issue.9 , pp. 1121-1134
    • Pullamsetti, S.S.1
  • 14
    • 77249119762 scopus 로고    scopus 로고
    • The landscape of somatic copy-number alteration across human cancers
    • Beroukhim R, et al. (2010) The landscape of somatic copy-number alteration across human cancers. Nature 463(7283):899-905.
    • (2010) Nature , vol.463 , Issue.7283 , pp. 899-905
    • Beroukhim, R.1
  • 15
    • 80052992261 scopus 로고    scopus 로고
    • Increased expression of the proapoptotic protein BIM, a mechanism for cAMP/protein kinase A (PKA)-induced apoptosis of immature T cells
    • Zambon AC, Wilderman A, Ho A, Insel PA (2011) Increased expression of the proapoptotic protein BIM, a mechanism for cAMP/protein kinase A (PKA)-induced apoptosis of immature T cells. J Biol Chem 286(38):33260-33267.
    • (2011) J Biol Chem , vol.286 , Issue.38 , pp. 33260-33267
    • Zambon, A.C.1    Wilderman, A.2    Ho, A.3    Insel, P.A.4
  • 16
    • 21844478747 scopus 로고    scopus 로고
    • Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
    • Garraway LA, et al. (2005) Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 436(7047):117-122.
    • (2005) Nature , vol.436 , Issue.7047 , pp. 117-122
    • Garraway, L.A.1
  • 17
    • 79551623112 scopus 로고    scopus 로고
    • MITF-siRNA formulation is a safe and effective therapy for human melasma
    • Yi X, et al. (2011) MITF-siRNA formulation is a safe and effective therapy for human melasma. Mol Ther 19(2):362-371.
    • (2011) Mol Ther , vol.19 , Issue.2 , pp. 362-371
    • Yi, X.1
  • 18
    • 13944273767 scopus 로고    scopus 로고
    • Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression
    • Carreira S, et al. (2005) Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. Nature 433(7027):764-769.
    • (2005) Nature , vol.433 , Issue.7027 , pp. 764-769
    • Carreira, S.1
  • 19
    • 27144537768 scopus 로고    scopus 로고
    • Novel genes associated with malignant melanoma but not benign melanocytic lesions
    • Talantov D, et al. (2005) Novel genes associated with malignant melanoma but not benign melanocytic lesions. Clin Cancer Res 11(20):7234-7242.
    • (2005) Clin Cancer Res , vol.11 , Issue.20 , pp. 7234-7242
    • Talantov, D.1
  • 20
    • 58149399847 scopus 로고    scopus 로고
    • Oncogenic NRAS has multiple effects on the malignant phenotype of human melanoma cells cultured in vitro
    • Eskandarpour M, Huang F, Reeves KA, Clark E, Hansson J (2009) Oncogenic NRAS has multiple effects on the malignant phenotype of human melanoma cells cultured in vitro. Int J Cancer 124(1):16-26.
    • (2009) Int J Cancer , vol.124 , Issue.1 , pp. 16-26
    • Eskandarpour, M.1    Huang, F.2    Reeves, K.A.3    Clark, E.4    Hansson, J.5
  • 21
    • 77956170810 scopus 로고    scopus 로고
    • The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors
    • Aspiotis R, et al. (2010) The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors. Bioorg Med Chem Lett 20(18):5502-5505.
    • (2010) Bioorg Med Chem Lett , vol.20 , Issue.18 , pp. 5502-5505
    • Aspiotis, R.1
  • 22
    • 0034766764 scopus 로고    scopus 로고
    • Phorbol 12-myristate 13-acetate triggers the protein kinase A-mediated phosphorylation and activation of the PDE4D5 cAMP phosphodiesterase in human aortic smooth muscle cells through a route involving extracellular signal regulated kinase (ERK)
    • Baillie G, MacKenzie SJ, Houslay MD (2001) Phorbol 12-myristate 13-acetate triggers the protein kinase A-mediated phosphorylation and activation of the PDE4D5 cAMP phosphodiesterase in human aortic smooth muscle cells through a route involving extracellular signal regulated kinase (ERK). Mol Pharmacol 60(5):1100-1111.
    • (2001) Mol Pharmacol , vol.60 , Issue.5 , pp. 1100-1111
    • Baillie, G.1    MacKenzie, S.J.2    Houslay, M.D.3
  • 23
    • 0035224063 scopus 로고    scopus 로고
    • Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases
    • Baillie GS, MacKenzie SJ, McPhee I, Houslay MD (2000) Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases. Br J Pharmacol 131(4):811-819.
    • (2000) Br J Pharmacol , vol.131 , Issue.4 , pp. 811-819
    • Baillie, G.S.1    MacKenzie, S.J.2    McPhee, I.3    Houslay, M.D.4
  • 24
    • 0034595707 scopus 로고    scopus 로고
    • ERK2 mitogenactivated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions
    • MacKenzie SJ, Baillie GS, McPhee I, Bolger GB, Houslay MD (2000) ERK2 mitogenactivated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions. J Biol Chem 275(22):16609-16617.
    • (2000) J Biol Chem , vol.275 , Issue.22 , pp. 16609-16617
    • MacKenzie, S.J.1    Baillie, G.S.2    McPhee, I.3    Bolger, G.B.4    Houslay, M.D.5
  • 25
    • 0026753496 scopus 로고
    • Characterization of the structure of a low Km, rolipram-sensitive cAMP phosphodiesterase. Mapping of the catalytic domain
    • Jin SL, Swinnen JV, Conti M (1992) Characterization of the structure of a low Km, rolipram-sensitive cAMP phosphodiesterase. Mapping of the catalytic domain. J Biol Chem 267(26):18929-18939.
    • (1992) J Biol Chem , vol.267 , Issue.26 , pp. 18929-18939
    • Jin, S.L.1    Swinnen, J.V.2    Conti, M.3
  • 26
    • 0030964062 scopus 로고    scopus 로고
    • Recombinant expression of a type IV, cAMP-specific phosphodiesterase: Characterization and structure-function studies of deletion mutants
    • Kovala T, Sanwal BD, Ball EH (1997) Recombinant expression of a type IV, cAMP-specific phosphodiesterase: Characterization and structure-function studies of deletion mutants. Biochemistry 36(10):2968-2976.
    • (1997) Biochemistry , vol.36 , Issue.10 , pp. 2968-2976
    • Kovala, T.1    Sanwal, B.D.2    Ball, E.H.3
  • 27
    • 0033538486 scopus 로고    scopus 로고
    • Activation of the cAMP-specific phosphodiesterase PDE4D3 by phosphorylation. Identification and function of an inhibitory domain
    • Lim J, Pahlke G, Conti M (1999) Activation of the cAMP-specific phosphodiesterase PDE4D3 by phosphorylation. Identification and function of an inhibitory domain. J Biol Chem 274(28):19677-19685.
    • (1999) J Biol Chem , vol.274 , Issue.28 , pp. 19677-19685
    • Lim, J.1    Pahlke, G.2    Conti, M.3
  • 28
    • 0026563109 scopus 로고
    • Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3
    • Bang YJ, et al. (1992) Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3. Proc Natl Acad Sci USA 89(8):3556-3560.
    • (1992) Proc Natl Acad Sci USA , vol.89 , Issue.8 , pp. 3556-3560
    • Bang, Y.J.1
  • 29
    • 0028356553 scopus 로고
    • Terminal neuroendocrine differentiation of human prostate carcinoma cells in response to increased intracellular cyclic AMP
    • Bang YJ, et al. (1994) Terminal neuroendocrine differentiation of human prostate carcinoma cells in response to increased intracellular cyclic AMP. Proc Natl Acad Sci USA 91(12):5330-5334.
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.12 , pp. 5330-5334
    • Bang, Y.J.1
  • 30
    • 84866002291 scopus 로고    scopus 로고
    • The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data
    • Cerami E, et al. (2012) The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov 2(5):401-404.
    • (2012) Cancer Discov , vol.2 , Issue.5 , pp. 401-404
    • Cerami, E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.