-
1
-
-
33748686575
-
Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use
-
Bender AT, Beavo JA (2006) Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use. Pharmacol Rev 58(3):488-520.
-
(2006)
Pharmacol Rev
, vol.58
, Issue.3
, pp. 488-520
-
-
Bender, A.T.1
Beavo, J.A.2
-
2
-
-
34447265905
-
Biochemistry and physiology of cyclic nucleotide phosphodiesterases: Essential components in cyclic nucleotide signaling
-
Conti M, Beavo J (2007) Biochemistry and physiology of cyclic nucleotide phosphodiesterases: Essential components in cyclic nucleotide signaling. Annu Rev Biochem 76:481-511.
-
(2007)
Annu Rev Biochem
, vol.76
, pp. 481-511
-
-
Conti, M.1
Beavo, J.2
-
3
-
-
33847689816
-
Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity
-
Ke H, Wang H (2007) Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity. Curr Top Med Chem 7(4):391-403.
-
(2007)
Curr Top Med Chem
, vol.7
, Issue.4
, pp. 391-403
-
-
Ke, H.1
Wang, H.2
-
4
-
-
31144433061
-
Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents
-
Lugnier C (2006) Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents. Pharmacol Ther 109(3):366-398.
-
(2006)
Pharmacol Ther
, vol.109
, Issue.3
, pp. 366-398
-
-
Lugnier, C.1
-
5
-
-
0033783798
-
Cyclic 3', 5'-nucleotide phosphodiesterases: Potential targets for anticancer therapy
-
Marko D, Pahlke G, Merz KH, Eisenbrand G (2000) Cyclic 3', 5'-nucleotide phosphodiesterases: Potential targets for anticancer therapy. Chem Res Toxicol 13(10):944-948.
-
(2000)
Chem Res Toxicol
, vol.13
, Issue.10
, pp. 944-948
-
-
Marko, D.1
Pahlke, G.2
Merz, K.H.3
Eisenbrand, G.4
-
6
-
-
59449107942
-
Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression
-
Goldhoff P, et al. (2008) Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression. Clin Cancer Res 14(23):7717-7725.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.23
, pp. 7717-7725
-
-
Goldhoff, P.1
-
7
-
-
0034800269
-
Cyclic AMP specific phosphodiesterase activity and colon cancer cell motility
-
Murata K, et al. (2000) Cyclic AMP specific phosphodiesterase activity and colon cancer cell motility. Clin Exp Metastasis 18(7):599-604.
-
(2000)
Clin Exp Metastasis
, vol.18
, Issue.7
, pp. 599-604
-
-
Murata, K.1
-
8
-
-
0003226768
-
Type 4 cyclic adenosine monophosphate phosphodiesterase as a therapeutic target in chronic lymphocytic leukemia
-
Kim DH, Lerner A (1998) Type 4 cyclic adenosine monophosphate phosphodiesterase as a therapeutic target in chronic lymphocytic leukemia. Blood 92(7):2484-2494.
-
(1998)
Blood
, vol.92
, Issue.7
, pp. 2484-2494
-
-
Kim, D.H.1
Lerner, A.2
-
9
-
-
0036566204
-
Inhibition of PDE4 phosphodiesterase activity induces growth suppression, apoptosis, glucocorticoid sensitivity, p53, and p21 (WAF1/CIP1) proteins in human acute lymphoblastic leukemia cells
-
Ogawa R, Streiff MB, Bugayenko A, Kato GJ (2002) Inhibition of PDE4 phosphodiesterase activity induces growth suppression, apoptosis, glucocorticoid sensitivity, p53, and p21(WAF1/CIP1) proteins in human acute lymphoblastic leukemia cells. Blood 99 (9):3390-3397.
-
(2002)
Blood
, vol.99
, Issue.9
, pp. 3390-3397
-
-
Ogawa, R.1
Streiff, M.B.2
Bugayenko, A.3
Kato, G.J.4
-
10
-
-
0018863552
-
Humoral modulation of human acute myelogenous leukemia cell growth in vitro
-
Koeffler HP, Golde DW (1980) Humoral modulation of human acute myelogenous leukemia cell growth in vitro. Cancer Res 40(6):1858-1862.
-
(1980)
Cancer Res
, vol.40
, Issue.6
, pp. 1858-1862
-
-
Koeffler, H.P.1
Golde, D.W.2
-
11
-
-
0035224418
-
PDE4 cAMP-specific phosphodiesterases
-
Houslay MD (2001) PDE4 cAMP-specific phosphodiesterases. Prog Nucleic Acid Res Mol Biol 69:249-315.
-
(2001)
Prog Nucleic Acid Res Mol Biol
, vol.69
, pp. 249-315
-
-
Houslay, M.D.1
-
12
-
-
66249125722
-
Identification of PDE4D as a proliferation promoting factor in prostate cancer using a Sleeping Beauty transposon-based somatic mutagenesis screen
-
Rahrmann EP, et al. (2009) Identification of PDE4D as a proliferation promoting factor in prostate cancer using a Sleeping Beauty transposon-based somatic mutagenesis screen. Cancer Res 69(10):4388-4397.
-
(2009)
Cancer Res
, vol.69
, Issue.10
, pp. 4388-4397
-
-
Rahrmann, E.P.1
-
13
-
-
84874734378
-
Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF
-
Pullamsetti SS, et al. (2012) Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF. Oncogene 32(9):1121-1134.
-
(2012)
Oncogene
, vol.32
, Issue.9
, pp. 1121-1134
-
-
Pullamsetti, S.S.1
-
14
-
-
77249119762
-
The landscape of somatic copy-number alteration across human cancers
-
Beroukhim R, et al. (2010) The landscape of somatic copy-number alteration across human cancers. Nature 463(7283):899-905.
-
(2010)
Nature
, vol.463
, Issue.7283
, pp. 899-905
-
-
Beroukhim, R.1
-
15
-
-
80052992261
-
Increased expression of the proapoptotic protein BIM, a mechanism for cAMP/protein kinase A (PKA)-induced apoptosis of immature T cells
-
Zambon AC, Wilderman A, Ho A, Insel PA (2011) Increased expression of the proapoptotic protein BIM, a mechanism for cAMP/protein kinase A (PKA)-induced apoptosis of immature T cells. J Biol Chem 286(38):33260-33267.
-
(2011)
J Biol Chem
, vol.286
, Issue.38
, pp. 33260-33267
-
-
Zambon, A.C.1
Wilderman, A.2
Ho, A.3
Insel, P.A.4
-
16
-
-
21844478747
-
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
-
Garraway LA, et al. (2005) Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 436(7047):117-122.
-
(2005)
Nature
, vol.436
, Issue.7047
, pp. 117-122
-
-
Garraway, L.A.1
-
17
-
-
79551623112
-
MITF-siRNA formulation is a safe and effective therapy for human melasma
-
Yi X, et al. (2011) MITF-siRNA formulation is a safe and effective therapy for human melasma. Mol Ther 19(2):362-371.
-
(2011)
Mol Ther
, vol.19
, Issue.2
, pp. 362-371
-
-
Yi, X.1
-
18
-
-
13944273767
-
Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression
-
Carreira S, et al. (2005) Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. Nature 433(7027):764-769.
-
(2005)
Nature
, vol.433
, Issue.7027
, pp. 764-769
-
-
Carreira, S.1
-
19
-
-
27144537768
-
Novel genes associated with malignant melanoma but not benign melanocytic lesions
-
Talantov D, et al. (2005) Novel genes associated with malignant melanoma but not benign melanocytic lesions. Clin Cancer Res 11(20):7234-7242.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.20
, pp. 7234-7242
-
-
Talantov, D.1
-
20
-
-
58149399847
-
Oncogenic NRAS has multiple effects on the malignant phenotype of human melanoma cells cultured in vitro
-
Eskandarpour M, Huang F, Reeves KA, Clark E, Hansson J (2009) Oncogenic NRAS has multiple effects on the malignant phenotype of human melanoma cells cultured in vitro. Int J Cancer 124(1):16-26.
-
(2009)
Int J Cancer
, vol.124
, Issue.1
, pp. 16-26
-
-
Eskandarpour, M.1
Huang, F.2
Reeves, K.A.3
Clark, E.4
Hansson, J.5
-
21
-
-
77956170810
-
The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors
-
Aspiotis R, et al. (2010) The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors. Bioorg Med Chem Lett 20(18):5502-5505.
-
(2010)
Bioorg Med Chem Lett
, vol.20
, Issue.18
, pp. 5502-5505
-
-
Aspiotis, R.1
-
22
-
-
0034766764
-
Phorbol 12-myristate 13-acetate triggers the protein kinase A-mediated phosphorylation and activation of the PDE4D5 cAMP phosphodiesterase in human aortic smooth muscle cells through a route involving extracellular signal regulated kinase (ERK)
-
Baillie G, MacKenzie SJ, Houslay MD (2001) Phorbol 12-myristate 13-acetate triggers the protein kinase A-mediated phosphorylation and activation of the PDE4D5 cAMP phosphodiesterase in human aortic smooth muscle cells through a route involving extracellular signal regulated kinase (ERK). Mol Pharmacol 60(5):1100-1111.
-
(2001)
Mol Pharmacol
, vol.60
, Issue.5
, pp. 1100-1111
-
-
Baillie, G.1
MacKenzie, S.J.2
Houslay, M.D.3
-
23
-
-
0035224063
-
Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases
-
Baillie GS, MacKenzie SJ, McPhee I, Houslay MD (2000) Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases. Br J Pharmacol 131(4):811-819.
-
(2000)
Br J Pharmacol
, vol.131
, Issue.4
, pp. 811-819
-
-
Baillie, G.S.1
MacKenzie, S.J.2
McPhee, I.3
Houslay, M.D.4
-
24
-
-
0034595707
-
ERK2 mitogenactivated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions
-
MacKenzie SJ, Baillie GS, McPhee I, Bolger GB, Houslay MD (2000) ERK2 mitogenactivated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions. J Biol Chem 275(22):16609-16617.
-
(2000)
J Biol Chem
, vol.275
, Issue.22
, pp. 16609-16617
-
-
MacKenzie, S.J.1
Baillie, G.S.2
McPhee, I.3
Bolger, G.B.4
Houslay, M.D.5
-
25
-
-
0026753496
-
Characterization of the structure of a low Km, rolipram-sensitive cAMP phosphodiesterase. Mapping of the catalytic domain
-
Jin SL, Swinnen JV, Conti M (1992) Characterization of the structure of a low Km, rolipram-sensitive cAMP phosphodiesterase. Mapping of the catalytic domain. J Biol Chem 267(26):18929-18939.
-
(1992)
J Biol Chem
, vol.267
, Issue.26
, pp. 18929-18939
-
-
Jin, S.L.1
Swinnen, J.V.2
Conti, M.3
-
26
-
-
0030964062
-
Recombinant expression of a type IV, cAMP-specific phosphodiesterase: Characterization and structure-function studies of deletion mutants
-
Kovala T, Sanwal BD, Ball EH (1997) Recombinant expression of a type IV, cAMP-specific phosphodiesterase: Characterization and structure-function studies of deletion mutants. Biochemistry 36(10):2968-2976.
-
(1997)
Biochemistry
, vol.36
, Issue.10
, pp. 2968-2976
-
-
Kovala, T.1
Sanwal, B.D.2
Ball, E.H.3
-
27
-
-
0033538486
-
Activation of the cAMP-specific phosphodiesterase PDE4D3 by phosphorylation. Identification and function of an inhibitory domain
-
Lim J, Pahlke G, Conti M (1999) Activation of the cAMP-specific phosphodiesterase PDE4D3 by phosphorylation. Identification and function of an inhibitory domain. J Biol Chem 274(28):19677-19685.
-
(1999)
J Biol Chem
, vol.274
, Issue.28
, pp. 19677-19685
-
-
Lim, J.1
Pahlke, G.2
Conti, M.3
-
28
-
-
0026563109
-
Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3
-
Bang YJ, et al. (1992) Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3. Proc Natl Acad Sci USA 89(8):3556-3560.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, Issue.8
, pp. 3556-3560
-
-
Bang, Y.J.1
-
29
-
-
0028356553
-
Terminal neuroendocrine differentiation of human prostate carcinoma cells in response to increased intracellular cyclic AMP
-
Bang YJ, et al. (1994) Terminal neuroendocrine differentiation of human prostate carcinoma cells in response to increased intracellular cyclic AMP. Proc Natl Acad Sci USA 91(12):5330-5334.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, Issue.12
, pp. 5330-5334
-
-
Bang, Y.J.1
-
30
-
-
84866002291
-
The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data
-
Cerami E, et al. (2012) The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov 2(5):401-404.
-
(2012)
Cancer Discov
, vol.2
, Issue.5
, pp. 401-404
-
-
Cerami, E.1
|