Inhibition of human chondrosarcoma cell growth via apoptosis by peroxisome proliferator-activated receptor-γ

British Journal of Cancer

Volumn 86, Issue 8, 2002, Pages 1303-1309

  Nishida, K ^a   Furumatsu, T ^a   Takada, I ^a   Kawai, A ^a   Yoshida, A ^a   Kunisada, T ^a   Inoue, H ^a  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

15d PGJ2; Apoptosis; Chondrosarcoma; PPAR

Indexed keywords

DNA FRAGMENT; FLUORESCEIN; LIPOCORTIN 5; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROPIDIUM IODIDE; RETINOID; RETINOID X RECEPTOR;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CHONDROSARCOMA; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

APOPTOSIS; CELL CYCLE; CELL DIVISION; CELL SURVIVAL; CHONDROSARCOMA; FLOW CYTOMETRY; HUMANS; MALE; MICROSCOPY, ELECTRON; PROSTAGLANDIN D2; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THIAZOLES; THIAZOLIDINEDIONES; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0037156938     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600241     Document Type: Article

References (35)

1. Evidence for the presence of peroxisome proliferator-activated receptor (PPAR) alpha and gamma and retinoid Z receptor in cartilage. PPARγ activation modulates the effects of interleukin-1beta on rat chondrocytes
2. Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor gamma in non-small cell lung cancer
3. Peroxisome proliferator activated receptor (PPAR) gamma: Adipose-predominant expression and induction early in adipocyte differentiation
4. Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma
5. PPARγ ligand (thiazolidinedione) induces growth arrest and differentiation markers of human pancreatic cancer cells
6. Ligands for peroxisome proliferator-activated receptor-γ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice
7. Prognostic factors in chondrosarcoma of bone: A clinicopathologic analysis with emphasis on histologic grading
8. Transcriptional cross-talk, the second mode of steroid hormone receptor action
9. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
10. 15-Deoxy-Delta(12,14)-prostaglandin J(2), a ligand for peroxisome proliferator-activated receptor-gamma, induces apoptosis in JEG3 choriocarcinoma cells
11. Peroxisome proliferator-activated receptor gamma induces growth arrest and differentiation markers of human colon cancer cells
12. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
13. Involvement of p21(WAF1/Cip1), p27(Kip1), and p18(INK4c) in troglitazone-induced cell-cycle arrest in human hepatoma cell lines
14. Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo
15. A new human chondrosarcoma cell line (OUMS-27) that maintains chondrocytic differentiation
16. Evolutionary aspects of peroxisomes as cell organelles, and of genes encoding peroxisomal proteins
17. p53, the cellular gatekeeper for growth and division
18. Investigation of glucocorticoid-induced apoptotic pathway: Processing of caspase-6 but not caspase-3
19. Intramedullary cartilage- and chondroid-producing tumors
20. Role of PPARgamma in regulating a cascade expression of cyclin-dependent kinase inhibitors, p18(INK4c) and p21(Waf1/Cip1), during adipogenesis
21. Kip1 in human pancreatic carcinoma cells
22. Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer
23. Involvement of nitric oxide in chondrocyte cell death in chondro-osteophyte formation
24. Troglitazone induces apoptosis via the p53 and Gadd45 pathway in vascular smooth muscle cells
25. Influence of intralesional surgery on treatment outcome of chondrosarcoma
26. Differentiation and reversal of malignant changes in colon cancer through PPARgamma
27. Expression of peroxisome proliferator-activated receptor (PPAR)gamma in gastric cancer and inhibitory effects of PPARgamma agonists
28. Chondrosarcoma
29. Chondrosarcoma of the pelvis. Prognostic factors for 67 patients treated with definitive surgery
30. Nuclear integration of glucocorticoid receptor and nuclear factor-κB signaling by CREB-binding protein and steroid receptor coactivator-1
31. Activation of PPARgamma inhibits cell growth and induces apoptosis in human gastric cancer cells
32. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor
33. Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis
34. Chondrosarcoma (primary, secondary, de-differentiated, and clear-cell)
35. Peroxisome proliferator-activated receptor gamma activation in human breast cancer