Platinum compounds sensitize ovarian carcinoma cells to ABT-737 by modulation of the Mcl-1/Noxa axis

Apoptosis

Volumn 18, Issue 4, 2013, Pages 492-508

  Simonin, Karin ^a   N'Diaye, Monique ^a   Lheureux, Stéphanie ^a,b   Loussouarn, Claire ^a   Dutoit, Soizic ^a   Briand, Mélanie ^a   Giffard, Florence ^a   Brotin, Emilie ^a   Blanc Fournier, Cécile ^a,b   Poulain, Laurent ^a  

^a UNIVERSITÉ DE CAEN   (France)

^b CLCC Centre de Lutte Contre le Cancer François Baclesse   (France)

Author keywords

ABT 737; Apoptosis; Mcl 1; Noxa; Ovarian cancer

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; BIM PROTEIN; PLATINUM DERIVATIVE; PROTEIN MCL 1; PROTEIN NOXA; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CHEMOSENSITIVITY; CHEMOSENSITIZATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; EX VIVO STUDY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; RNA INTERFERENCE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-X PROTEIN; BIPHENYL COMPOUNDS; CARBOPLATIN; CELL LINE, TUMOR; CISPLATIN; DRUG SYNERGISM; FEMALE; HUMANS; MEMBRANE PROTEINS; MICE; MICE, NUDE; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; NEOPLASM TRANSPLANTATION; NITROPHENOLS; OVARIAN NEOPLASMS; PIPERAZINES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA INTERFERENCE; RNA, SMALL INTERFERING; SULFONAMIDES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84876049405     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-012-0799-x     Document Type: Article

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