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Volumn 10, Issue 3, 2013, Pages 193-201

Is there benefit in dual renin- angiotensin-aldosterone system blockade? No, yes and maybe: A guide for the perplexed

Author keywords

blocks; combination; inhibitors; Renin angiotensin aldosterone system

Indexed keywords

ALDOSTERONE ANTAGONIST; ALISKIREN; ANGIOTENSIN RECEPTOR ANTAGONIST; CANDESARTAN; CAPTOPRIL; CREATININE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; LISINOPRIL; RAMIPRIL; RENIN INHIBITOR; TELMISARTAN; VALSARTAN;

EID: 84876018863     PISSN: 14791641     EISSN: 17528984     Source Type: Journal    
DOI: 10.1177/1479164112463710     Document Type: Review
Times cited : (19)

References (40)
  • 2
    • 70349771914 scopus 로고    scopus 로고
    • Retraction - Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): A randomised controlled trial
    • Retraction - combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial. Lancet. 2009 ; 374: 1226
    • (2009) Lancet , vol.374 , pp. 1226
  • 3
    • 58949097006 scopus 로고    scopus 로고
    • The sudden demise of dual renin-angiotensin system blockade or the soft science of the surrogate end point
    • Messerli FH. The sudden demise of dual renin-angiotensin system blockade or the soft science of the surrogate end point. J Am Coll Cardiol. 2009 ; 53: 468-470
    • (2009) J Am Coll Cardiol , vol.53 , pp. 468-470
    • Messerli, F.H.1
  • 4
    • 53249090182 scopus 로고    scopus 로고
    • ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008
    • Members ATF, Dickstein K, Cohen-Solal A, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008. Eur Heart J. 2008 ; 29: 2388-2442
    • (2008) Eur Heart J , vol.29 , pp. 2388-2442
    • Atf, M.1    Dickstein, K.2    Cohen-Solal, A.3
  • 5
    • 44849124747 scopus 로고    scopus 로고
    • Aliskiren and dual therapy in type 2 diabetes mellitus
    • DOI 10.1056/NEJMe0803375
    • Ingelfinger JR. Aliskiren and dual therapy in type 2 diabetes mellitus. N Engl J Med. 2008 ; 358: 2503-2505 (Pubitemid 351793025)
    • (2008) New England Journal of Medicine , vol.358 , Issue.23 , pp. 2503-2505
    • Ingelfinger, J.R.1
  • 6
    • 33745845825 scopus 로고    scopus 로고
    • Physiology of local renin-angiotensin systems
    • DOI 10.1152/physrev.00036.2005
    • Paul M, Poyan Mehr A, Kreutz R. Physiology of local renin-angiotensin systems. Physiol Rev. 2006 ; 86: 747-803 (Pubitemid 44033382)
    • (2006) Physiological Reviews , vol.86 , Issue.3 , pp. 747-803
    • Paul, M.1    Mehr, A.P.2    Kreutz, R.3
  • 7
    • 0026707841 scopus 로고
    • Partial escape of angiotensin converting enzyme (ACE) inhibition during prolonged ACE inhibitor treatment: Does it exist and does it affect the antihypertensive response?
    • Van den Meiracker AH, Man in't, Veld AJ, Admiraal PJJ, et al. Partial escape of angiotensin converting enzyme (ACE) inhibition during prolonged ACE inhibitor treatment: does it exist and does it affect the antihypertensive response?. J Hypertens. 1992 ; 10: 803-812
    • (1992) J Hypertens , vol.10 , pp. 803-812
    • Van Den Meiracker, A.H.1    In'T, M.2    Veld, A.J.3    Pjj, A.4
  • 8
    • 0342894669 scopus 로고    scopus 로고
    • Synergistic effects of ACE inhibition and Ang II antagonism on blood pressure, cardiac weight, and renin in spontaneously hypertensive rats
    • Ménard J, Campbell DJ, Azizi M, et al. Synergistic effects of ACE inhibition and Ang II antagonism on blood pressure, cardiac weight, and renin in spontaneously hypertensive rats. Circulation. 1997 ; 96: 3072-3078 (Pubitemid 27500110)
    • (1997) Circulation , vol.96 , Issue.9 , pp. 3072-3078
    • Menard, J.1    Campbell, D.J.2    Azizi, M.3    Gonzales, M.-F.4
  • 9
    • 18244406792 scopus 로고    scopus 로고
    • Systematic review of combined angiotensin-converting enzyme inhibition and angiotensin receptor blockade in hypertension
    • DOI 10.1161/01.HYP.0000161880.59963.da
    • Doulton TWR, He FJ, MacGregor GA. Systematic review of combined angiotensin-converting enzyme inhibition and angiotensin receptor blockade in hypertension. Hypertension. 2005 ; 45: 880-886 (Pubitemid 40628932)
    • (2005) Hypertension , vol.45 , Issue.5 , pp. 880-886
    • Doulton, T.W.R.1    He, F.J.2    MacGregor, G.A.3
  • 10
    • 0034627208 scopus 로고    scopus 로고
    • Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: The candesartan and lisinopril microalbuminuria (CALM) study
    • Mogensen CE, Neldam S, Tikkanen I, et al. Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) study. BMJ. 2000 ; 321: 1440-1444
    • (2000) BMJ , vol.321 , pp. 1440-1444
    • Mogensen, C.E.1    Neldam, S.2    Tikkanen, I.3
  • 11
    • 42049107348 scopus 로고    scopus 로고
    • Telmisartan, ramipril, or both in patients at high risk for vascular events
    • Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med. 2008 ; 358: 1547-1559
    • (2008) N Engl J Med , vol.358 , pp. 1547-1559
  • 12
    • 49149087718 scopus 로고    scopus 로고
    • Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): A multicentre, randomised, double-blind, controlled trial
    • Mann JFE, Schmieder RE, McQueen M, et al. Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial. Lancet. 372: 547-553
    • Lancet , vol.372 , pp. 547-553
    • Jfe, M.1    Schmieder, R.E.2    McQueen, M.3
  • 13
    • 65949089834 scopus 로고    scopus 로고
    • On behalf of the Canadian Hypertension Education Program. Canadian Hypertension Education Program recommendations: The scientific summary - An annual update
    • Campbell NRC, Khan NA, Hill MD, et al. On behalf of the Canadian Hypertension Education Program. Canadian Hypertension Education Program recommendations: the scientific summary - an annual update. Can J Cardiol. 2009 ; 25: 271-277
    • (2009) Can J Cardiol , vol.25 , pp. 271-277
    • Nrc, C.1    Khan, N.A.2    Hill, M.D.3
  • 15
    • 77958546021 scopus 로고    scopus 로고
    • Beyond ONTARGET: Angiotensin-converting enzyme inhibition and angiotensin II receptor blockade in combination, a lesser evil in some?
    • Wong J, Molyneaux L, Constantino M, et al. Beyond ONTARGET: angiotensin-converting enzyme inhibition and angiotensin II receptor blockade in combination, a lesser evil in some?. Diabetes Obes Metab. 2010 ; 12: 1072-1078
    • (2010) Diabetes Obes Metab , vol.12 , pp. 1072-1078
    • Wong, J.1    Molyneaux, L.2    Constantino, M.3
  • 16
    • 0035922441 scopus 로고    scopus 로고
    • Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    • Brenner BM, Cooper ME, De Zeeuw D, et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med. 2001 ; 345: 861-869
    • (2001) N Engl J Med , vol.345 , pp. 861-869
    • Brenner, B.M.1    Cooper, M.E.2    De Zeeuw, D.3
  • 17
    • 34247640280 scopus 로고    scopus 로고
    • Combination therapy with an ACE inhibitor and an angiotensin receptor blocker for diabetic nephropathy: A meta-analysis
    • DOI 10.1111/j.1464-5491.2007.02097.x
    • Jennings DL, Kalus JS, Coleman CI, et al. Combination therapy with an ACE inhibitor and an angiotensin receptor blocker for diabetic nephropathy: a meta-analysis. Diabet Med. 2007 ; 24: 486-493 (Pubitemid 46669317)
    • (2007) Diabetic Medicine , vol.24 , Issue.5 , pp. 486-493
    • Jennings, D.L.1    Kalus, J.S.2    Coleman, C.I.3    Manierski, C.4    Yee, J.5
  • 18
    • 38049139424 scopus 로고    scopus 로고
    • Meta-analysis: Effect of monotherapy and combination therapy with inhibitors of the renin-angiotensin system on proteinuria in renal disease
    • Kunz R, Friedrich C, Wolbers M, Mann JF. Meta-analysis: effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal disease. Ann Intern Med. 2008 ; 148 (1). 30-48 (Pubitemid 351688350)
    • (2008) Annals of Internal Medicine , vol.148 , Issue.1 , pp. 30-48
    • Kunz, R.1    Friedrich, C.2    Wolbers, M.3    Mann, J.F.E.4
  • 19
    • 77956904820 scopus 로고    scopus 로고
    • Of fads, fashion, surrogate endpoints and dual RAS blockade
    • Messerli FH, Staessen JA, Zannad F. Of fads, fashion, surrogate endpoints and dual RAS blockade. Eur Heart J. 2010 ; 31: 2205-2208
    • (2010) Eur Heart J , vol.31 , pp. 2205-2208
    • Messerli, F.H.1    Staessen, J.A.2    Zannad, F.3
  • 20
    • 67649635807 scopus 로고    scopus 로고
    • Renal and retinal effects of enalapril and losartan in type 1 diabetes
    • Mauer M, Zinman B, Gardiner R, et al. Renal and retinal effects of enalapril and losartan in type 1 diabetes. N Engl J Med. 2009 ; 361: 40-51
    • (2009) N Engl J Med , vol.361 , pp. 40-51
    • Mauer, M.1    Zinman, B.2    Gardiner, R.3
  • 21
    • 77956231922 scopus 로고    scopus 로고
    • Have we fallen off target with concerns surrounding dual RAAS blockade
    • Lattanzio MR, Weir MR. Have we fallen off target with concerns surrounding dual RAAS blockade. Kidney Int. 2010 ; 78: 539-545
    • (2010) Kidney Int , vol.78 , pp. 539-545
    • Lattanzio, M.R.1    Weir, M.R.2
  • 22
    • 0028838569 scopus 로고
    • Blood pressure control, proteinuria, and the progression of renal disease
    • Peterson JC, Adler S, Burkart JM, et al. Blood pressure control, proteinuria, and the progression of renal disease. Ann Intern Med. 1995 ; 123: 754-762
    • (1995) Ann Intern Med , vol.123 , pp. 754-762
    • Peterson, J.C.1    Adler, S.2    Burkart, J.M.3
  • 23
    • 66849128220 scopus 로고    scopus 로고
    • Design of combination angiotensin receptor blocker and angiotensin-converting enzyme inhibitor for treatment of diabetic nephropathy (VA NEPHRON-D)
    • Fried LF, Duckworth W, Zhang JH, et al. Design of combination angiotensin receptor blocker and angiotensin-converting enzyme inhibitor for treatment of diabetic nephropathy (VA NEPHRON-D). Clin J Am Soc Nephrol. 2009 ; 4: 361-368
    • (2009) Clin J Am Soc Nephrol , vol.4 , pp. 361-368
    • Fried, L.F.1    Duckworth, W.2    Zhang, J.H.3
  • 27
    • 0041408235 scopus 로고    scopus 로고
    • Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: The CHARM-added trial
    • DOI 10.1016/S0140-6736(03)14283-3
    • McMurray JJV, Östergren J, Swedberg K, et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial. Lancet. 2003 ; 362: 767-771 (Pubitemid 37093916)
    • (2003) Lancet , vol.362 , Issue.9386 , pp. 767-771
    • McMurray, J.J.V.1    Ostergren, J.2    Swedberg, K.3    Granger, C.B.4    Held, P.5    Michelson, E.L.6    Olofsson, B.7    Yusuf, S.8    Pfeffer, M.A.9
  • 28
    • 69849114573 scopus 로고    scopus 로고
    • Aliskiren and valsartan in stage 2 hypertension: Subgroup analysis of a randomized, double-blind study
    • Yarows S, Oparil S, Patel S, et al. Aliskiren and valsartan in stage 2 hypertension: subgroup analysis of a randomized, double-blind study. Adv Ther. 2008 ; 25: 1288-1302
    • (2008) Adv Ther , vol.25 , pp. 1288-1302
    • Yarows, S.1    Oparil, S.2    Patel, S.3
  • 29
    • 79955463305 scopus 로고    scopus 로고
    • Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction
    • Solomon SD, Hee Shin S, Shah A, et al. Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction. Eur Heart J. 2011 ; 32: 1227-1234
    • (2011) Eur Heart J , vol.32 , pp. 1227-1234
    • Solomon, S.D.1    Hee Shin, S.2    Shah, A.3
  • 31
    • 65249182083 scopus 로고    scopus 로고
    • Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): Rationale and study design
    • Parving H-H, Brenner BM, McMurray JJV, et al. Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study design. Nephrol Dial Transplant. 2009 ; 24: 1663-1671
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 1663-1671
    • Parving, H.-H.1    Brenner, B.M.2    Jjv, M.3
  • 32
    • 78650380191 scopus 로고    scopus 로고
    • Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patients with chronic systolic heart failure: Rationale and design of the Aliskiren Trial to Minimize OutcomeS in Patients with HEart failuRE (ATMOSPHERE) study
    • Krum H, Massie B, Abraham WT, et al. Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patients with chronic systolic heart failure: rationale and design of the Aliskiren Trial to Minimize OutcomeS in Patients with HEart failuRE (ATMOSPHERE) study. Eur J Heart Fail. 2011 ; 13: 107-114
    • (2011) Eur J Heart Fail , vol.13 , pp. 107-114
    • Krum, H.1    Massie, B.2    Abraham, W.T.3
  • 33
    • 84858997658 scopus 로고    scopus 로고
    • The effect of combination treatment with aliskiren and blockers of the renin-angiotensin system on hyperkalaemia and acute kidney injury: Systematic review and meta-analysis
    • Harel Z, Gilbert C, Wald R, et al. The effect of combination treatment with aliskiren and blockers of the renin-angiotensin system on hyperkalaemia and acute kidney injury: systematic review and meta-analysis. BMJ. 2012 ; 344: e42
    • (2012) BMJ , vol.344 , pp. 42
    • Harel, Z.1    Gilbert, C.2    Wald, R.3
  • 34
    • 84859084617 scopus 로고    scopus 로고
    • Aliskiren, ALTITUDE, and the implications for ATMOSPHERE
    • McMurray JJV, Abraham WT, Dickstein K, et al. Aliskiren, ALTITUDE, and the implications for ATMOSPHERE. Eur J Heart Fail. 2012 ; 14: 341-343
    • (2012) Eur J Heart Fail , vol.14 , pp. 341-343
    • Jjv, M.1    Abraham, W.T.2    Dickstein, K.3
  • 35
    • 63849278544 scopus 로고    scopus 로고
    • Aldosterone-receptor antagonism in hypertension
    • Jansen PM, Danser AJ, Imholz BP, et al. Aldosterone-receptor antagonism in hypertension. J Hypertens. 2009 ; 27: 680-691
    • (2009) J Hypertens , vol.27 , pp. 680-691
    • Jansen, P.M.1    Danser, A.J.2    Imholz, B.P.3
  • 36
    • 38149030811 scopus 로고    scopus 로고
    • Change in proteinuria after adding aldosterone blockers to ACE inhibitors or angiotensin receptor blockers in CKD: A systematic review
    • Bomback AS, Kshirsagar AV, Amamoo MA, et al. Change in proteinuria after adding aldosterone blockers to ACE inhibitors or angiotensin receptor blockers in CKD: a systematic review. Am J Kidney Dis. 2008 ; 51: 199-211
    • (2008) Am J Kidney Dis , vol.51 , pp. 199-211
    • Bomback, A.S.1    Kshirsagar, A.V.2    Ma, A.3
  • 39
    • 53749100124 scopus 로고    scopus 로고
    • Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: Randomised, placebo-controlled trials
    • Chaturvedi N, Porta M, Klein R, et al. Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials. Lancet. 2008 ; 372: 1394-1402
    • (2008) Lancet , vol.372 , pp. 1394-1402
    • Chaturvedi, N.1    Porta, M.2    Klein, R.3
  • 40
    • 84876140745 scopus 로고    scopus 로고
    • Blockade of the renin-angiotensin-aldosterone system (RAAS) for primary prevention of non-valvular atrial fibrillation: A systematic review and meta analysis of randomized controlled trials
    • Epub ahead of print 16March2012 http://dx.doi.org/10.1016/j.ijcard.2012. 02.009.
    • KhatibRJosephPBrielM. Blockade of the renin-angiotensin-aldosterone system (RAAS) for primary prevention of non-valvular atrial fibrillation: a systematic review and meta analysis of randomized controlled trials. Int J Cardiol. Epub ahead of print 16March2012. http://dx.doi.org/10.1016/j.ijcard. 2012.02.009.
    • Int J Cardiol.
    • Khatib, R.1    Joseph, P.2    Briel, M.3


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