Transgenic overexpression of ribonucleotide reductase improves cardiac performance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 15, 2013, Pages 6187-6192

  Nowakowski, Sarah G ^a   Kolwicz, Stephen C ^b   Korte, Frederick Steven ^a,c   Luo, Zhaoxiong ^a   Robinson Hamm, Jacqueline N ^a   Page, Jennifer L ^d   Brozovich, Frank ^e   Weiss, Robert S ^d   Tian, Rong ^b   Murry, Charles E ^a,c   Regnier, Michael ^a,c  

^a University of Washington   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d Department of Obstetrics Gynecology   (United States)

^e MAYO CLINIC   (United States)

Author keywords

Cross bridge cycling; Inotropy; Metabolism

Indexed keywords

2 DEOXY ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE; BETA ADRENERGIC RECEPTOR; CALCIUM; CREATINE PHOSPHATE; DOBUTAMINE; RIBONUCLEOTIDE REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; CELL SIZE; CONTROLLED STUDY; GENE OVEREXPRESSION; HEART CONTRACTION; HEART FUNCTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEART MUSCLE RELAXATION; HEART PERFORMANCE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MYOFILAMENT; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SMOOTH MUSCLE CONTRACTION; SYSTOLIC DYSFUNCTION; WILD TYPE;

ADENOSINE TRIPHOSPHATE; ANIMALS; ECHOCARDIOGRAPHY; GENE EXPRESSION REGULATION; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, TRANSGENIC; MYOCARDIUM; MYOCYTES, CARDIAC; PHENOTYPE; RIBONUCLEOTIDE REDUCTASES; SARCOMERES; SYSTOLE; TRANSGENES;

MUS; MUS MUSCULUS;

EID: 84876016335     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1220693110     Document Type: Article

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