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Volumn 60, Issue 1, 2013, Pages 101-110

Anisomycin induces apoptosis of glucocorticoid resistant acute lymphoblastic leukemia CEM-C1 cells via activation of mitogen-activated protein kinases p38 and JNK

Author keywords

Acute lymphoblastic leukemia (ALL); Anisomycin; Apoptosis; Glucocorticoid resistance; Jun N terminal kinase (JNK); P38 Mitogen Activated protein kinase (p38 MAPK)

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL) IMIDAZOLE; ANISOMYCIN; ANTHRA [1, 9 CD] PYRAZOL 6 (2H) ONE; APOPTOSIS REGULATORY PROTEIN; CASPASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAD; PROTEIN BCL 2; PROTEIN BIMEL; PROTEIN MCL 1; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; DEXAMETHASONE; MESSENGER RNA; NUCLEIC ACID SYNTHESIS INHIBITOR;

EID: 84876007972     PISSN: 00282685     EISSN: 13384317     Source Type: Journal    
DOI: 10.4149/neo_2013_014     Document Type: Article
Times cited : (22)

References (39)
  • 1
    • 0032619951 scopus 로고    scopus 로고
    • Glucocorticosteroid therapy in childhood acute lymphoblastic leukemia
    • GAYNON PS, CARREL AL. Glucocorticosteroid therapy in childhood acute lymphoblastic leukemia. Adv Exp Med Biol 1999; 457: 593-605. http://dx.doi.org/10.1007/978-1-4615-4811-9_66
    • (1999) Adv Exp Med Biol , vol.457 , pp. 593-605
    • Gaynon, P.S.1    Carrel, A.L.2
  • 2
    • 3042581215 scopus 로고    scopus 로고
    • Evolution of BFM trials for childhood ALL
    • SCHRAPPE M. Evolution of BFM trials for childhood ALL. Ann Hematol 2004; 83(suppl 1): S121-123.
    • (2004) Ann Hematol , vol.83 , Issue.SUPPL. 1
    • Schrappe, M.1
  • 4
    • 22344458207 scopus 로고    scopus 로고
    • p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: Correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211
    • MILLER L, WEBB MS, COPIK AJ, WANG Y, JOHNSON BH et al. p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211. Mol Endocrinol 2005; 19: 1569-1583. http://dx.doi.org/10.1210/me.2004-0528
    • (2005) Mol Endocrinol , vol.19 , pp. 1569-1583
    • Miller, L.1    Webb, M.S.2    Copik, A.J.3    Wang, Y.4    Johnson, B.H.5
  • 5
    • 33749640683 scopus 로고    scopus 로고
    • Modification of glucocorticoid sensitivity by MAP kinase signaling pathways in glucocorticoid-induced T-cell apoptosis
    • TANAKA T, OKABE T, GONDO S, FUKUDA M, YAMAMOTO M, et al. Modification of glucocorticoid sensitivity by MAP kinase signaling pathways in glucocorticoid-induced T-cell apoptosis. Exp Hematol 2006; 34: 1542-1552. http://dx.doi.org/10.1016/j.exphem.2006.06.018
    • (2006) Exp Hematol , vol.34 , pp. 1542-1552
    • Tanaka, T.1    Okabe, T.2    Gondo, S.3    Fukuda, M.4    Yamamoto, M.5
  • 6
    • 0030780732 scopus 로고    scopus 로고
    • Evidence of two mechanisms for the activation of the glucose transporter GLUT1 by anisomycin: P38(MAP kinase) activation and protein synthesis inhibition in mammalian cells
    • BARROS LF, YOUNG M, SAKLATVALA J, BALDWIN SA. Evidence of two mechanisms for the activation of the glucose transporter GLUT1 by anisomycin: p38(MAP kinase) activation and protein synthesis inhibition in mammalian cells. J Physiol 1997; 1; 504: 517-525.
    • (1997) J Physiol , vol.1 , pp. 517-525
    • Barros, L.F.1    Young, M.2    Saklatvala, J.3    Baldwin, S.A.4
  • 7
    • 70249146121 scopus 로고    scopus 로고
    • Macrophage inhibitory cytokine-1 (MIC-1) and subsequent urokinase-type plasminogen activator mediate cell death responses by ribotoxic anisomycin in HCT-116 colon cancer cells
    • YANG H, CHOI HJ, PARK SH, KIM JS, MOON Y. Macrophage inhibitory cytokine-1 (MIC-1) and subsequent urokinase-type plasminogen activator mediate cell death responses by ribotoxic anisomycin in HCT-116 colon cancer cells. Biochem Pharmacol 2009; 78: 1205-1213. http://dx.doi.org/10.1016/j.bcp.2009.06.012
    • (2009) Biochem Pharmacol , vol.78 , pp. 1205-1213
    • Yang, H.1    Choi, H.J.2    Park, S.H.3    Kim, J.S.4    Moon, Y.5
  • 8
    • 35848937160 scopus 로고    scopus 로고
    • Malignant mesothelioma cells are rapidly sensitized to TRAIL-induced apoptosis by low-dose anisomycin via Bim
    • ABAYASIRIWARDANA KS, BARBONE D, KIM KU, VIVO C, LEE KK, et al. Malignant mesothelioma cells are rapidly sensitized to TRAIL-induced apoptosis by low-dose anisomycin via Bim. Mol Cancer Ther 2007; 6: 2766-2776. http://dx.doi.org/10.1158/1535-7163.MCT-07-0278
    • (2007) Mol Cancer Ther , vol.6 , pp. 2766-2776
    • Abayasiriwardana, K.S.1    Barbone, D.2    Kim, K.U.3    Vivo, C.4    Lee, K.K.5
  • 9
    • 40349083844 scopus 로고    scopus 로고
    • Involvement of proteolytic activation of protein kinase R in the apoptosis of PC12 pheochromocytoma cells
    • PAP M, SZEBERENYI J. Involvement of proteolytic activation of protein kinase R in the apoptosis of PC12 pheochromocytoma cells. Cell Mol Neurobiol 2008; 28: 443-456. http://dx.doi.org/10.1007/s10571-007-9245-y
    • (2008) Cell Mol Neurobiol , vol.28 , pp. 443-456
    • Pap, M.1    Szeberenyi, J.2
  • 10
    • 34548062851 scopus 로고    scopus 로고
    • Ribotoxic stress sensitizes glioblastoma cells to death receptor induced apoptosis: Requirements for c-Jun NH2-Terminal Kinase and Bim
    • XIA S, LI Y, ROSEN EM, LATERRA J. Ribotoxic stress sensitizes glioblastoma cells to death receptor induced apoptosis: requirements for c-Jun NH2-Terminal Kinase and Bim. Mol Cancer Res 2007; 5: 783-792. http://dx.doi.org/10.1158/1541-7786.MCR-06-0433
    • (2007) Mol Cancer Res , vol.5 , pp. 783-792
    • Xia, S.1    Li, Y.2    Rosen, E.M.3    Laterra, J.4
  • 11
    • 3142616426 scopus 로고    scopus 로고
    • Inhibition of MKP-1 expression potentiates JNK related apoptosis in renal cancer cells
    • MIZUNO R, OYA M, SHIOMI T, MARUMO K, OKADA Y, et al. Inhibition of MKP-1 expression potentiates JNK related apoptosis in renal cancer cells. J Urol 2004; 172: 723-727. http://dx.doi.org/10.1097/01.ju.0000124990.37563.00
    • (2004) J Urol , vol.172 , pp. 723-727
    • Mizuno, R.1    Oya, M.2    Shiomi, T.3    Marumo, K.4    Okada, Y.5
  • 12
    • 0037021256 scopus 로고    scopus 로고
    • Anisomycin activates JNK and sensitizes DU145 prostate carcinoma cells to Fas mediated apoptosis
    • CURTIN JF, COTTER TG. Anisomycin activates JNK and sensitizes DU145 prostate carcinoma cells to Fas mediated apoptosis. Br J Cancer 2002; 87: 1188-1194. http://dx.doi.org/10.1038/sj.bjc.6600612
    • (2002) Br J Cancer , vol.87 , pp. 1188-1194
    • Curtin, J.F.1    Cotter, T.G.2
  • 13
    • 40149096346 scopus 로고    scopus 로고
    • Molecular mechanism of apoptosis and gene expressions in human lymphoma U937 cells treated with anisomycin
    • HORI T, KONDO T, TABUCHI Y, TAKASAKI I, ZHAO QL, et al. Molecular mechanism of apoptosis and gene expressions in human lymphoma U937 cells treated with anisomycin. Chem Biol Interact 2008; 172: 125-140. http://dx.doi.org/10.1016/j.cbi.2007.12.003
    • (2008) Chem Biol Interact , vol.172 , pp. 125-140
    • Hori, T.1    Kondo, T.2    Tabuchi, Y.3    Takasaki, I.4    Zhao, Q.L.5
  • 14
    • 0020626966 scopus 로고
    • Glucocorticoid-resistant human acute lymphoblastic leukemic cell line with functional receptor
    • ZAWYDIWSKI R, HARMON JM, THOMPSON EB. Glucocorticoid-resistant human acute lymphoblastic leukemic cell line with functional receptor. Cancer Res 1983; 43: 3865-3873.
    • (1983) Cancer Res , vol.43 , pp. 3865-3873
    • Zawydiwski, R.1    Harmon, J.M.2    Thompson, E.B.3
  • 15
    • 84655170249 scopus 로고    scopus 로고
    • Pro-apoptotic protein BIM in apoptosis of glucocorticoid-sensitive and-resistant acute lymphoblastic leukemia CEM cells
    • ZHAO YN, GUO X, MA ZG, GU L, GE J, et al. Pro-apoptotic protein BIM in apoptosis of glucocorticoid-sensitive and-resistant acute lymphoblastic leukemia CEM cells. Med Oncol 2011; 28: 1609-1617. http://dx.doi.org/10.1007/s12032-010-9641-x
    • (2011) Med Oncol , vol.28 , pp. 1609-1617
    • Zhao, Y.N.1    Guo, X.2    Ma, Z.G.3    Gu, L.4    Ge, J.5
  • 16
    • 77649213702 scopus 로고    scopus 로고
    • Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia
    • STAM RW, DEN BOER ML, SCHNEIDER P, DE BOER J, HAGELSTEIN J, et al. Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia. Blood 2010; 115: 1018-1025. http://dx.doi.org/10.1182/blood-2009-02-205963
    • (2010) Blood , vol.115 , pp. 1018-1025
    • Stam, R.W.1    Den Boer, M.L.2    Schneider, P.3    De Boer, J.4    Hagelstein, J.5
  • 17
    • 79951944939 scopus 로고    scopus 로고
    • BIM is a prognostic biomarker for early prednisolone response in pediatric acute lymphoblastic leukemia
    • JIANG N, KOH GS, LIM JY, KHAM SK, ARIFFIN H, et al. BIM is a prognostic biomarker for early prednisolone response in pediatric acute lymphoblastic leukemia. Exp Hematol 2011; 39: 321-329. http://dx.doi.org/10.1016/j.exphem.2010.11.009
    • (2011) Exp Hematol , vol.39 , pp. 321-329
    • Jiang, N.1    Koh, G.S.2    Lim, J.Y.3    Kham, S.K.4    Ariffin, H.5
  • 18
    • 0037592259 scopus 로고    scopus 로고
    • Microarray analysis uncovers the induction of the proapoptotic BH3-only protein BIM in multiple models of glucocorticoid induced apoptosis
    • WANG Z, MALONE MH, HH H, MCCOLL KS, DISTELHORST CW. Microarray analysis uncovers the induction of the proapoptotic BH3-only protein BIM in multiple models of glucocorticoid induced apoptosis. J Biol Chem 2003; 278: 23861-23867. http://dx.doi.org/10.1074/jbc.M301843200
    • (2003) J Biol Chem , vol.278 , pp. 23861-23867
    • Wang, Z.1    Malone, M.H.2    Hh, H.3    McColl, K.S.4    Distelhorst, C.W.5
  • 19
    • 11244305855 scopus 로고    scopus 로고
    • Inhibition of Glucocorticoid-induced apoptosis by targeting the major splice variants of BIM mRNA with small interfering RNA and short hairpin RNA
    • ABRAMS MT, ROBERTSON NM, YOON K, WICKSTROM E. Inhibition of Glucocorticoid-induced apoptosis by targeting the major splice variants of BIM mRNA with small interfering RNA and short hairpin RNA. J Biol Chem 2004; 279: 55809-55817. http://dx.doi.org/10.1074/jbc.M411767200
    • (2004) J Biol Chem , vol.279 , pp. 55809-55817
    • Abrams, M.T.1    Robertson, N.M.2    Yoon, K.3    Wickstrom, E.4
  • 20
    • 84863809812 scopus 로고    scopus 로고
    • Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression
    • doi: 10.1038/onc.2011.508
    • MERINO D, STRASSER A, BOUILLET P. Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression. Oncogene 2011; doi: 10.1038/onc.2011.508. http://dx.doi.org/10.1038/onc.2011.508
    • (2011) Oncogene
    • Merino, D.1    Strasser, A.2    Bouillet, P.3
  • 21
    • 74049125266 scopus 로고    scopus 로고
    • BH3-only proteins: The death-puppeteer's wires
    • GHIOTTO F, FAIS F, BRUNO S. BH3-only proteins: the death-puppeteer's wires. Cytometry A 2010; 77: 11-21.
    • (2010) Cytometry A , vol.77 , pp. 11-21
    • Ghiotto, F.1    Fais, F.2    Bruno, S.3
  • 23
    • 0033628853 scopus 로고    scopus 로고
    • Cellular mechanisms of multidrug resistance of tumor cells
    • STAVROVSKAYA AA. Cellular mechanisms of multidrug resistance of tumor cells. Biochemistry (Mosc) 2000; 65: 95-106.
    • (2000) Biochemistry (Mosc) , vol.65 , pp. 95-106
    • Stavrovskaya, A.A.1
  • 24
    • 38149111023 scopus 로고    scopus 로고
    • Staurosporine sensitizes T lymphoma cells to glucocorticoid-induced apoptosis: Role of Nur77 and Bcl-2
    • Kfir S, SIONOV RV, ZAFRIR E, ZILBERMAN Y, YEFENOF E. Staurosporine sensitizes T lymphoma cells to glucocorticoid-induced apoptosis: role of Nur77 and Bcl-2. Cell Cycle 2007; 6: 3086-3096. http://dx.doi.org/10.4161/cc.6.24.5023
    • (2007) Cell Cycle , vol.6 , pp. 3086-3096
    • Kfir, S.1    Sionov, R.V.2    Zafrir, E.3    Zilberman, Y.4    Yefenof, E.5
  • 25
    • 0031929376 scopus 로고    scopus 로고
    • Elevated Bcl-2/Bax are a consistent feature of apoptosis resistance in B-cell chronic lymphocytic leukaemia and are corre1ated with in vivo chemoresistance
    • PEPPER C, HOY T, BENTLEY P. Elevated Bcl-2/Bax are a consistent feature of apoptosis resistance in B-cell chronic lymphocytic leukaemia and are corre1ated with in vivo chemoresistance. Leuk Lymphoma 1998; 28: 355-361.
    • (1998) Leuk Lymphoma , vol.28 , pp. 355-361
    • Pepper, C.1    Hoy, T.2    Bentley, P.3
  • 26
    • 0028518750 scopus 로고
    • Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases
    • STRAUSFELD UP, HOWELL M, REMPEL R, MALLER JL, HUNT T, et al. Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases. Curr Biol 1994; 4: 876-883. http://dx.doi.org/10.1016/S0960-9822(00)00196-2
    • (1994) Curr Biol , vol.4 , pp. 876-883
    • Strausfeld, U.P.1    Howell, M.2    Rempel, R.3    Maller, J.L.4    Hunt, T.5
  • 27
    • 0034011051 scopus 로고    scopus 로고
    • Multiple functions of p27 (Kip1) and its alterations in tumor cells: A review
    • 1<18::AIDJCP3>3.0.CO;2-S
    • SGAMBATO A, CITTADINI A, FARAGLIA B, WEINSTEIN IB. Multiple functions of p27 (Kip1) and its alterations in tumor cells: a review. J Cell Physiol 2000; 183: 18-27. http://dx.doi.org/10.1002/(SICI)1097-4652(200004)183:1<18::AIDJCP3>3.0.CO;2-S
    • (2000) J Cell Physiol , vol.183 , pp. 18-27
    • Sgambato, A.1    Cittadini, A.2    Faraglia, B.3    Weinstein, I.B.4
  • 28
    • 60149087741 scopus 로고    scopus 로고
    • Expression of cyclin A in childhood acute lymphoblastic leukemia cells reveals undisturbed G1-S phase transition and passage through the S phase
    • HIRT A, SCHMID AM, JULMY F, SCHMITZ NM, LEIBUNDGUT K. Expression of cyclin A in childhood acute lymphoblastic leukemia cells reveals undisturbed G1-S phase transition and passage through the S phase. Leukemia 2009; 23: 414-417. http://dx.doi.org/10.1038/leu.2008.200
    • (2009) Leukemia , vol.23 , pp. 414-417
    • Hirt, A.1    Schmid, A.M.2    Julmy, F.3    Schmitz, N.M.4    Leibundgut, K.5
  • 29
  • 30
    • 33644818889 scopus 로고    scopus 로고
    • Relationship between cyclins and prognosis of acute leukemia
    • WU SJ, DU X, CHEN YX, JIANG WL, ZHONG LY, et al. Relationship between cyclins and prognosis of acute leukemia. Ai Zheng 2003; 22: 852-855.
    • (2003) Ai Zheng , vol.22 , pp. 852-855
    • Wu, S.J.1    Du, X.2    Chen, Y.X.3    Jiang, W.L.4    Zhong, L.Y.5
  • 31
    • 84862925835 scopus 로고    scopus 로고
    • A112, a tamibarotene dimethylaminoethyl ester, may inhibit human leukemia cell growth more potently than tamibarotene
    • YUAN C, ZHANG YS, CHENG YN, XUE X, XU WF, et al. A112, a tamibarotene dimethylaminoethyl ester, may inhibit human leukemia cell growth more potently than tamibarotene. Leuk Lymphoma 2012; 53: 295-304. http://dx.doi.org/10.3109/10428194.2011.614707
    • (2012) Leuk Lymphoma , vol.53 , pp. 295-304
    • Yuan, C.1    Zhang, Y.S.2    Cheng, Y.N.3    Xue, X.4    Xu, W.F.5
  • 32
    • 79958254560 scopus 로고    scopus 로고
    • A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers
    • JIRAWATNOTAI S, HU Y, MICHOWSKI W, ELIAS JE, BECKS L, et al. A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature 2011; 474: 230-234. http://dx.doi.org/10.1038/nature10155
    • (2011) Nature , vol.474 , pp. 230-234
    • Jirawatnotai, S.1    Hu, Y.2    Michowski, W.3    Elias, J.E.4    Becks, L.5
  • 33
    • 84856136186 scopus 로고    scopus 로고
    • The critical role of JNK in the ER-mitochondrial crosstalk during apoptotic cell death
    • VERMA G, DATTA M. The critical role of JNK in the ER-mitochondrial crosstalk during apoptotic cell death. J Cell Physiol 2012; 227: 1791-1795. http://dx.doi.org/10.1002/jcp.22903
    • (2012) J Cell Physiol , vol.227 , pp. 1791-1795
    • Verma, G.1    Datta, M.2
  • 34
    • 73149095394 scopus 로고    scopus 로고
    • Basal c-Jun NH2-terminal protein kinase activity is essential for survival and proliferation of T-cell acute lymphoblastic leukemia cells
    • CUI J, WANG Q, WANG J, LV M, ZHU N, et al. Basal c-Jun NH2-terminal protein kinase activity is essential for survival and proliferation of T-cell acute lymphoblastic leukemia cells. Mol Cancer Ther 2009; 8: 3214-3222. http://dx.doi.org/10.1158/1535-7163.MCT-09-0408
    • (2009) Mol Cancer Ther , vol.8 , pp. 3214-3222
    • Cui, J.1    Wang, Q.2    Wang, J.3    Lv, M.4    Zhu, N.5
  • 35
    • 40949152993 scopus 로고    scopus 로고
    • Activation of the JNK pathway promotes phosphorylation and degradation of BimEL--a novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia
    • LEUNG KT, LI KK, SUN SS, CHAN PK, OOI VE, et al. Activation of the JNK pathway promotes phosphorylation and degradation of BimEL--a novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia. Carcinogenesis 2008; 29: 544-551.
    • (2008) Carcinogenesis , vol.29 , pp. 544-551
    • Leung, K.T.1    Li, K.K.2    Sun, S.S.3    Chan, P.K.4    Ooi, V.E.5
  • 36
    • 45149121372 scopus 로고    scopus 로고
    • The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates Pglycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism
    • CHIARINI F, DEL SOLE M, MONGIORGI S, GABOARDI GC, CAPPELLINI A, et al. The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates Pglycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism. Leukemia 2008; 22: 1106-1116. http://dx.doi.org/10.1038/leu.2008.79
    • (2008) Leukemia , vol.22 , pp. 1106-1116
    • Chiarini, F.1    Del Sole, M.2    Mongiorgi, S.3    Gaboardi, G.C.4    Cappellini, A.5
  • 37
    • 16844387124 scopus 로고    scopus 로고
    • Role of JNK activation in apoptosis: A double-edged sword
    • LIU J, LIN A. Role of JNK activation in apoptosis: a double-edged sword. Cell Res 2005; 15: 36-42. http://dx.doi.org/10.1038/sj.cr.7290262
    • (2005) Cell Res , vol.15 , pp. 36-42
    • Liu, J.1    Lin, A.2
  • 38
    • 0034653850 scopus 로고    scopus 로고
    • Molecular determinants that mediate selective activation of p38 MAP kinase isoforms
    • ENSLEN H, BRANCHO DM, DAVIS RJ. Molecular determinants that mediate selective activation of p38 MAP kinase isoforms. EMBO J 2000; 19: 1301-1311. http://dx.doi.org/10.1093/emboj/19.6.1301
    • (2000) EMBO J , vol.19 , pp. 1301-1311
    • Enslen, H.1    Brancho, D.M.2    Davis, R.J.3
  • 39
    • 33746391136 scopus 로고    scopus 로고
    • p38-MAP kinase activation followed by BIM induction is essential for glucocorticoidinduced apoptosis in lymphoblastic leukemia cells
    • LU J, QUEARRY B, HARADA H. p38-MAP kinase activation followed by BIM induction is essential for glucocorticoidinduced apoptosis in lymphoblastic leukemia cells. FEBS Lett 2006; 580: 3539-3544. http://dx.doi.org/10.1016/j.febslet.2006.05.031
    • (2006) FEBS Lett , vol.580 , pp. 3539-3544
    • Lu, J.1    Quearry, B.2    Harada, H.3


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