Expression of cyclin A in childhood acute lymphoblastic leukemia cells reveals undisturbed G1-S phase transition and passage through the S phase

Leukemia

Volumn 23, Issue 2, 2009, Pages 414-417

  Hirt, A ^a   Schmid, A M ^a   Julmy, F ^a   Schmitz, N M R ^a   Leibundgut, K ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; CYCLIN E; DNA; RNA;

ACUTE LYMPHOBLASTIC LEUKEMIA; B CELL LEUKEMIA; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL STRUCTURE; CHILDHOOD LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; DNA CONTENT; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LETTER; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 60149087741     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2008.200     Document Type: Letter

References (8)

1. Hirt A, Antic V, Wang E, Luthy AR, Leibundgut K, von der Weid N et al. Acute lymphoblastic leukemia in childhood: Cell proliferation without rest. Br J Haematol 1997; 96: 366-368.
2. Pardee AB. G1 events and regulation of cell proliferation. Science 1989; 246: 603-608.
3. Lundberg AS, Weinberg RA. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-CDK complexes. Mol Cell Biol 1998; 18: 753-761.
4. Schmitz NMR, Leibundgut K, Hirt A. CDK2 catalytic activity and loss of nuclear tethering of retinoblastoma protein in childhood acute lymphoblastic leukemia. Leukemia 2005; 19: 1783-1787.
5. Ji P, Agrawal S, Diederichs S, Bäumer N, Becker A, Cauvet T et al. Cyclin A1, the alternative A-type cyclin, contributes to G1/S cell cycle progression in somatic cells. Oncogene 2005; 24: 2739-2744.
6. Paterlini P, Suberville AM, Zindy F, Melle J, Sonnier M, Marie JP et al. Cyclin A expression in human haematological malignancies: A new marker of cell proliferation. Cancer Res 1993; 53: 235-238.
7. Zindy F, Lamas E, Chenivesse X, Sobczak J, Wang J, Fesquet D et al. Cyclin A is required in S phase in normal epithelial cells. Biochem Biophys Res Commun 1992; 182: 1144-1154.
8. Yao G, Lee JT, Mori S, Nevins JR, You L. A bistable Rb-E2F switch underlies the restriction point. Nat Cell Biol 2008; 10: 476-482.