Deposition of IgA in primary IgA nephropathy: It takes at least four to tango

Nephrology Dialysis Transplantation

Volumn 28, Issue 4, 2013, Pages 794-797

  Daha, Mohamed R ^a   Van Kooten, Cees ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

CD89; IgA nephropathy; mesangial deposits; TfR1; transglutaminase

Indexed keywords

CD71 ANTIGEN; CD89 ANTIGEN; ENZYME INHIBITOR; FC RECEPTOR; IMMUNOGLOBULIN A; IMMUNOGLOBULIN A1; IMMUNOGLOBULIN G ANTIBODY; LYMPHOCYTE ANTIGEN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2 INHIBITOR; RAG2 PROTEIN; UNCLASSIFIED DRUG;

ANTIGEN DETECTION; BIOACCUMULATION; HEMATURIA; HUMAN; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN DEPOSITION; KIDNEY FIBROSIS; MESANGIUM CELL; NEPHROLOGIST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN PROTEIN INTERACTION; REVIEW;

ANIMALS; GLOMERULONEPHRITIS, IGA; HUMANS; IMMUNOGLOBULIN A; MICE;

EID: 84875989103     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfs445     Document Type: Review

References (27)

1. Boyd JK, Cheung CK, Molyneux K et al. An update on the pathogenesis and treatment of IgA nephropathy. KIdney Int 2012; 81: 833-843
2. Suzuki H, Kiryluk K, Novak J et al. The pathophysiology of IgA nephropathy. J Am Soc Nephrol 2011; 22: 1795-1803
3. Monteiro RC, Halbwachs-Mecarelli L, Berger J et al. Characteristics of eluted IgA in primary IgA nephropathy. Contrib Nephrol 1984; 40: 107-111
4. Novak J, Julian BA, Tomana M et al. IgA glycosylation and IgA immune complexes in the pathogenesis of IgA nephropathy. Semin Nephrol 2008; 28: 78-87
5. Allen AC, Harper SJ, Feehally J. Galactosylation of N-and Olinked carbohydrate moieties of IgA1 and IgG in IgA nephropathy. Clin Exp Immunol 1995; 100: 470-474
6. Berger J, Yaneva H, Nabarra B et al. Recurrence of mesangial deposition of IgA after renal transplantation. KIdney Int 1975; 7: 232-241
7. van den Wall Bake AW, Daha MR, Haaijman JJ et al. Elevated production of polymeric and monomeric IgA1 by the bone marrow in IgA nephropathy. Kidney Int 1989; 35: 1400-1404 (Pubitemid 19167933)
8. Oortwijn BD, Rastaldi MP, Roos A et al. Demonstration of secretory IgA in kidneys of patients with IgA nephropathy. Nephrol Dial Transplant 2007; 22: 3191-3195 (Pubitemid 350202542)
9. Monteiro RC, van de Winkel JG. IgA Fc receptors. Annu Rev Immunol 2003; 21: 177-204 (Pubitemid 37174530)
10. Westerhuis R, Van Zandbergen G, Verhagen NAM et al. Human mesangial cells in culture and in kidney sections fail to express Fc alpha receptor (CD89). J Am Soc Nephrol 1999; 10: 770-778 (Pubitemid 29149527)
11. Leung JC, Tsang AW, Chan DT et al. Absence of CD89, polymeric immunoglobulin receptor, and asialoglycoprotein receptor on human mesangial cells. J Am Soc Nephrol 2000; 11: 241-249 (Pubitemid 30064847)
12. Launay P, Grossetete B, Arcos-Fajardo M et al. Fcalpha receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease). Evidence for pathogenic soluble receptor-iga complexes in patients and CD89 transgenic mice. J Exp Med 2000; 191: 1999-2010
13. van der Boog PJ, van Kooten C, Van Zandbergen G et al. Injection of recombinant FcalphaRI/CD89 in mice does not induce mesangial IgA deposition. Nephrol Dial Transplant 2004; 19: 2729-2736
14. Moura IC, Centelles MN, Arcos-Fajardo M et al. Identification of the transferrin receptor as a novel immunoglobulin (Ig)A1 receptor and its enhanced expression on mesangial cells in IgA nephropathy. J Exp Med 2001; 194: 417-425 (Pubitemid 32835038)
15. Moura IC, Arcos-Fajardo M, Gdoura A et al. Engagement of transferrin receptor by polymeric IgA1: evidence for a positive feedback loop involving increased receptor expression and mesangial cell proliferation in IgA nephropathy. J Am Soc Nephrol 2005; 16: 2667-2676
16. Pleass RJ, Dunlop JI, Anderson CM et al. Identification of residues in the CH2/CH3 domain interface of IgA essential for interaction with the human fcalpha receptor (FcalphaR) CD89. J Biol Chem 1999; 274: 23508-23514
17. Duchez S, Amin R, Cogne N et al. Premature replacement of mu with alpha immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturation. Proc Natl Acad Sci USA 2010; 107: 3064-3069
18. Fesus L, Piacentini M. Transglutaminase 2: an enigmatic enzyme with diverse functions. Trends Biochem Sci 2002; 27: 534-539 (Pubitemid 35279599)
19. Shweke N, Boulos N, Jouanneau C et al. Tissue transglutaminase contributes to interstitial renal fibrosis by favoring accumulation of fibrillar collagen through TGF-beta activation and cell infiltration. Am J Pathol 2008; 173: 631-642
20. Ikee R, Kobayashi S, Hemmi N et al. Involvement of transglutaminase-2 in pathological changes in renal disease. Nephron Clin Pract 2007; 105: c139-c146 (Pubitemid 46215208)
21. Berthelot L, Papista C, Maciel TT et al. Transglutaminase is essential for IgA nephropathy development acting through IgA receptors. J Exp Med 2012; 209: 793-806
22. Vuong MT, Hahn-Zoric M, Lundberg S et al. Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy. KIdney Int 2010; 78: 1281-1287
23. Tomana M, Matousovic K, Julian BA et al. Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG. Kidney Int 1997; 52: 509-516 (Pubitemid 27359597)
24. Suzuki H, Fan R, Zhang Z et al. Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity. J Clin Invest 2009; 119: 1668-1677
25. Roos A, Rastaldi MP, Calvaresi N et al. Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease. J Am Soc Nephrol 2006; 17: 1724-1734 (Pubitemid 43794676)
26. Cattran DC, Coppo R, Cook HT et al. The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification. KIdney Int 2009; 76: 534-545
27. Johnson TS, Fisher M, Haylor JL et al. Transglutaminase inhibition reduces fibrosis and preserves function in experimental chronic kidney disease. J Am Soc Nephrol 2007; 18: 3078-3088 (Pubitemid 350223968)