RFX Transcription Factor DAF-19 Regulates 5-HT and Innate Immune Responses to Pathogenic Bacteria in Caenorhabditis elegans

PLoS Genetics

Volumn 9, Issue 3, 2013, Pages

  Xie, Yusu ^a   Moussaif, Mustapha ^a   Choi, Sunju ^a   Xu, Lu ^a   Sze, Ji Ying ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATF 7 PROTEIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYSTEINE; DAF 19 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE D; SEROTONIN; TIR 1 PROTEIN; TRANSCRIPTION FACTOR; TYROSINE; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL INFECTION; BIOSYNTHESIS; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC SCREENING; IMMUNOREGULATION; INNATE IMMUNITY; INTESTINE; NONHUMAN; PROTEIN MOTIF; PSEUDOMONAS AERUGINOSA; SIGNAL TRANSDUCTION; TPH 1 GENE; UPREGULATION;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1; CYTOSKELETAL PROTEINS; HUMANS; IMMUNITY, INNATE; INTESTINES; NEURONS; PSEUDOMONAS AERUGINOSA; SEROTONIN; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRYPTOPHAN HYDROXYLASE;

CAENORHABDITIS ELEGANS; PSEUDOMONAS AERUGINOSA;

EID: 84875977306     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003324     Document Type: Article

References (64)

1. Boulanger LM, (2009) Immune proteins in brain development and synaptic plasticity. Neuron 64: 93-109.
2. Veerhuis R, Nielsen HM, Tenner AJ, (2011) Complement in the brain. Molecular immunology 48: 1592-1603.
3. Shatz CJ, (2009) MHC class I: an unexpected role in neuronal plasticity. Neuron 64: 40-45.
4. Zhang S, Sokolchik I, Blanco G, Sze JY, (2004) Caenorhabditis elegans TRPV ion channel regulates 5HT biosynthesis in chemosensory neurons. Development 131: 1629-1638.
5. Moussaif M, Sze JY, (2009) Intraflagellar transport/Hedgehog-related signaling components couple sensory cilium morphology and serotonin biosynthesis in Caenorhabditis elegans. The Journal of neuroscience: the official journal of the Society for Neuroscience 29: 4065-4075.
6. Sifri CD, Begun J, Ausubel FM, (2005) The worm has turned-microbial virulence modeled in Caenorhabditis elegans. Trends Microbiol 13: 119-127.
7. Zhang Y, Lu H, Bargmann CI, (2005) Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans. Nature 438: 179-184.
8. Liberati NT, Fitzgerald KA, Kim DH, Feinbaum R, Golenbock DT, et al. (2004) Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. Proceedings of the National Academy of Sciences of the United States of America 101: 6593-6598.
9. Shivers RP, Kooistra T, Chu SW, Pagano DJ, Kim DH, (2009) Tissue-specific activities of an immune signaling module regulate physiological responses to pathogenic and nutritional bacteria in C. elegans. Cell Host Microbe 6: 321-330.
10. Newton K, Dixit VM, (2012) Signaling in innate immunity and inflammation. Cold Spring Harb Perspect Biol 5doi: 10.1101/cshperspect.a011247.
11. Pujol N, Link EM, Liu LX, Kurz CL, Alloing G, et al. (2001) A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans. Current biology: CB 11: 809-821.
12. Reith W, Mach B, (2001) The bare lymphocyte syndrome and the regulation of MHC expression. Annu Rev Immunol 19: 331-373.
13. Reith W, LeibundGut-Landmann S, Waldburger JM, (2005) Regulation of MHC class II gene expression by the class II transactivator. Nat Rev Immunol 5: 793-806.
14. Reith W, Ucla C, Barras E, Gaud A, Durand B, et al. (1994) RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. Mol Cell Biol 14: 1230-1244.
15. Chu JS, Baillie DL, Chen N, (2010) Convergent evolution of RFX transcription factors and ciliary genes predated the origin of metazoans. BMC evolutionary biology 10: 130.
16. Piasecki BP, Burghoorn J, Swoboda P, (2010) Regulatory Factor X (RFX)-mediated transcriptional rewiring of ciliary genes in animals. Proceedings of the National Academy of Sciences of the United States of America 107: 12969-12974.
17. Swoboda P, Adler HT, Thomas JH, (2000) The RFX-type transcription factor DAF-19 regulates sensory neuron cilium formation in C. elegans. Mol Cell 5: 411-421.
18. Wang J, Schwartz HT, Barr MM, (2010) Functional specialization of sensory cilia by an RFX transcription factor isoform. Genetics 186: 1295-1307.
19. Dubruille R, Laurencon A, Vandaele C, Shishido E, Coulon-Bublex M, et al. (2002) Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation. Development 129: 5487-5498.
20. El Zein L, Ait-Lounis A, Morle L, Thomas J, Chhin B, et al. (2009) RFX3 governs growth and beating efficiency of motile cilia in mouse and controls the expression of genes involved in human ciliopathies. Journal of cell science 122: 3180-3189.
21. Sze JY, Victor M, Loer C, Shi Y, Ruvkun G, (2000) Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature 403: 560-564.
22. White JG, Southgate E, Thomson JN, Brenner S, (1986) The Structure of the Nervous-System of the Nematode Caenorhabditis-Elegans. Philosophical Transactions of the Royal Society of London Series B-Biological Sciences 314: 1-340.
23. Chuang CF, Bargmann CI, (2005) A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling. Genes Dev 19: 270-281.
24. Kurz CL, Shapira M, Chen K, Baillie DL, Tan MW, (2007) Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade. Biochemical and biophysical research communications 363: 438-443.
25. Hu PJ, (2007) Dauer. WormBook pp. 1-19 Available:http:///www.wormbase.org.
26. Perens EA, Shaham S, (2005) C. elegans daf-6 encodes a patched-related protein required for lumen formation. Dev Cell 8: 893-906.
27. Starich TA, Herman RK, Kari CK, Yeh WH, Schackwitz WS, et al. (1995) Mutations affecting the chemosensory neurons of Caenorhabditis elegans. Genetics 139: 171-188.
28. Duerr JS, Frisby DL, Gaskin J, Duke A, Asermely K, et al. (1999) The cat-1 gene of Caenorhabditis elegans encodes a vesicular monoamine transporter required for specific monoamine-dependent behaviors. The Journal of neuroscience: the official journal of the Society for Neuroscience 19: 72-84.
29. Amoutzias GD, Veron AS, Weiner J 3rd, Robinson-Rechavi M, Bornberg-Bauer E, et al. (2007) One billion years of bZIP transcription factor evolution: conservation and change in dimerization and DNA-binding site specificity. Molecular biology and evolution 24: 827-835.
30. Shivers RP, Pagano DJ, Kooistra T, Richardson CE, Reddy KC, et al. (2010) Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans. PLoS Genet 6: e1000892 doi:10.1371/journal.pgen.1000892.
31. Senti G, Swoboda P, (2008) Distinct isoforms of the RFX transcription factor DAF-19 regulate ciliogenesis and maintenance of synaptic activity. Mol Biol Cell 19: 5517-5528.
32. Reece-Hoyes JS, Shingles J, Dupuy D, Grove CA, Walhout AJ, et al. (2007) Insight into transcription factor gene duplication from Caenorhabditis elegans Promoterome-driven expression patterns. BMC genomics 8: 27.
33. Kurz CL, Tan MW, (2004) Regulation of aging and innate immunity in C. elegans. Aging Cell 3: 185-193.
34. Mallo GV, Kurz CL, Couillault C, Pujol N, Granjeaud S, et al. (2002) Inducible antibacterial defense system in C. elegans. Current biology: CB 12: 1209-1214.
35. Styer KL, Singh V, Macosko E, Steele SE, Bargmann CI, et al. (2008) Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1/GPCR. Science 322: 460-464.
36. Troemel ER, Chu SW, Reinke V, Lee SS, Ausubel FM, et al. (2006) p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet 2: e183 doi:10.1371/journal.pgen.0020183.
37. Ren M, Feng H, Fu Y, Land M, Rubin CS, (2009) Protein kinase D is an essential regulator of C. elegans innate immunity. Immunity 30: 521-532.
38. Wayman GA, Tokumitsu H, Davare MA, Soderling TR, (2011) Analysis of CaM-kinase signaling in cells. Cell calcium 50: 1-8.
39. Rongo C, Whitfield CW, Rodal A, Kim SK, Kaplan JM, (1998) LIN-10 is a shared component of the polarized protein localization pathways in neurons and epithelia. Cell 94: 751-759.
40. Matsuzawa A, Saegusa K, Noguchi T, Sadamitsu C, Nishitoh H, et al. (2005) ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat Immunol 6: 587-592.
41. Wu SY, McLeod M, (1995) The sak1+ gene of Schizosaccharomyces pombe encodes an RFX family DNA-binding protein that positively regulates cyclic AMP-dependent protein kinase-mediated exit from the mitotic cell cycle. Mol Cell Biol 15: 1479-1488.
42. Huang M, Zhou Z, Elledge SJ, (1998) The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Cell 94: 595-605.
43. Maijgren S, Sur I, Nilsson M, Toftgard R, (2004) Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element. Archives of dermatological research 295: 482-489.
44. Azmitia EC, (2007) Serotonin and brain: evolution, neuroplasticity, and homeostasis. International review of neurobiology 77: 31-56.
45. Chaouloff F, Berton O, Mormede P, (1999) Serotonin and stress. Neuropsychopharmacology 21: 28S-32S.
46. Chen GL, Miller GM, (2012) Advances in tryptophan hydroxylase-2 gene expression regulation: new insights into serotonin-stress interaction and clinical implications. Am J Med Genet B Neuropsychiatr Genet 159B: 152-171.
47. Seguin-Estevez Q, De Palma R, Krawczyk M, Leimgruber E, Villard J, et al. (2009) The transcription factor RFX protects MHC class II genes against epigenetic silencing by DNA methylation. Journal of immunology 183: 2545-2553.
48. Efimenko E, Bubb K, Mak HY, Holzman T, Leroux MR, et al. (2005) Analysis of xbx genes in C. elegans. Development 132: 1923-1934.
49. Chen N, Mah A, Blacque OE, Chu J, Phgora K, et al. (2006) Identification of ciliary and ciliopathy genes in Caenorhabditis elegans through comparative genomics. Genome biology 7: R126.
50. Phirke P, Efimenko E, Mohan S, Burghoorn J, Crona F, et al. (2011) Transcriptional profiling of C. elegans DAF-19 uncovers a ciliary base-associated protein and a CDK/CCRK/LF2p-related kinase required for intraflagellar transport. Developmental biology 357: 235-247.
51. Blacque OE, Perens EA, Boroevich KA, Inglis PN, Li C, et al. (2005) Functional genomics of the cilium, a sensory organelle. Current biology: CB 15: 935-941.
52. McAllister AK, van de Water J, (2009) Breaking boundaries in neural-immune interactions. Neuron 64: 9-12.
53. Sternberg EM, (2006) Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens. Nat Rev Immunol 6: 318-328.
54. Irwin MR, Cole SW, (2011) Reciprocal regulation of the neural and innate immune systems. Nat Rev Immunol 11: 625-632.
55. Kim Y, Zhou P, Qian L, Chuang JZ, Lee J, et al. (2007) MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. The Journal of experimental medicine 204: 2063-2074.
56. O'Neill LA, Bowie AG, (2007) The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nature reviews Immunology 7: 353-364.
57. Troemel ER, Sagasti A, Bargmann CI, (1999) Lateral signaling mediated by axon contact and calcium entry regulates asymmetric odorant receptor expression in C. elegans. Cell 99: 387-398.
58. Sze JY, Zhang S, Li J, Ruvkun G, (2002) The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons. Development 129: 3901-3911.
59. Zheng X, Chung S, Tanabe T, Sze JY, (2005) Cell-type specific regulation of serotonergic identity by the C. elegans LIM-homeodomain factor LIM-4. Dev Biol 286: 618-628.
60. Jansen G, Thijssen KL, Werner P, van der Horst M, Hazendonk E, et al. (1999) The complete family of genes encoding G proteins of Caenorhabditis elegans. Nature genetics 21: 414-419.
61. Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, et al. (2005) Systematic analysis of genes required for synapse structure and function. Nature 436: 510-517.
62. Tan MW, Mahajan-Miklos S, Ausubel FM, (1999) Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis. Proceedings of the National Academy of Sciences of the United States of America 96: 715-720.
63. Vowels JJ, Thomas JH, (1994) Multiple chemosensory defects in daf-11 and daf-21 mutants of Caenorhabditis elegans. Genetics 138: 303-316.
64. Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.