The global spread of healthcare-associated multidrug-resistant bacteria: A perspective from Asia

Clinical Infectious Diseases

Volumn 56, Issue 9, 2013, Pages 1310-1318

  Molton, James S ^a,b   Tambyah, Paul A ^a,b   Ang, Brenda S P ^c   Ling, Moi Lin ^d   Fisher, Dale A ^a,b  

^a NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^b Dept Medicine Endocrinol Diabet   (Singapore)

^c TAN TOCK SENG HOSPITAL   (Singapore)

^d SINGAPORE GENERAL HOSPITAL   (Singapore)

Author keywords

bacterial drug resistance; carbapenem resistant Enterobacteriaceae; extended spectrum beta lactamase; methicillin resistant Staphylococcus aureus; vancomycin resistant Enterococcus

Indexed keywords

BETA LACTAMASE; BETA LACTAMASE AMPC; CARBAPENEMASE; CEFTAZIDIME; CEFTRIAXONE; CEPHALOSPORIN DERIVATIVE; CEPHALOSPORINASE; TEICOPLANIN; VANCOMYCIN;

ACINETOBACTER INFECTION; ANTIBIOTIC RESISTANCE; ARTICLE; ASIA; BACTEREMIA; BLOODSTREAM INFECTION; DISEASE TRANSMISSION; EPIDEMIC; ESCHERICHIA COLI; EXTENDED SPECTRUM BETA LACTAMASE PRODUCING ENTEROBACTERIACEAE; HIGH RISK PATIENT; INFECTION CONTROL; INFECTION RATE; KLEBSIELLA PNEUMONIAE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR CLONING; MULTIDRUG RESISTANCE; PLASMID; PRIORITY JOURNAL; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ASIA; BACTERIAL INFECTIONS; CROSS INFECTION; DISEASE TRANSMISSION, INFECTIOUS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; HUMANS; TIME FACTORS; TRAVEL;

EID: 84875971014     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cit020     Document Type: Article

References (62)

1. Rolain JM, Canton R, Cornaglia G. Emergence of antibiotic resistance: need for a new paradigm. Clin Microbiol Infect 2012; 18:615-6.
2. The Nobel Committee. Fleming A. Penicillin. Available at: http://www. nobelprize.org/nobel-prizes/medicine/laureates/1945/fleming-lecture. pdf. Accessed 28 August 2012.
3. Barber M, Rozwadowska-Dowzenko M. Infection by penicillin-resistant staphylococci. Lancet 1948; 2:641-4.
4. Rosenthal VD, Bijie H, Maki DG, et al. International Nosocomial Infection Control Consortium (INICC) report, data summary of 36 countries, for 2004-2009. Am J Infect Control 2012; 40:396-407.
5. Barber M. Methicillin-resistant staphylococci. J Clin Pathol 1961; 14:385-93.
6. Teo J, Tan TY, Hon PY, et al. ST22 and ST239 MRSA duopoly in Singaporean hospitals: 2006-2010. Epidemiol Infect 2012; 7:1-5.
7. Stefani S, Chung DR, Lindsay JA, et al. Meticillin-resistant Staphylococcus aureus (MRSA): global epidemiology and harmonisation of typing methods. Int J Antimicrob Agents 2012; 39:273-82.
8. Song JH, Hsueh PR, Chung DR, et al. Spread of methicillin-resistant Staphylococcus aureus between the community and the hospitals in Asian countries: an ANSORP study. J Antimicrob Chemother 2011; 66:1061-9.
9. Livermore DM. Fourteen years in resistance. Int J Antimicrob Agents 2012; 39:283-94.
10. Johnson AP, Aucken HM, Cavendish S, et al. Dominance of EMRSA-15 and-16 among MRSA causing nosocomial bacteraemia in the UK: analysis of isolates from the European Antimicrobial Resistance Surveillance System (EARSS). J Antimicrob Chemother 2001; 48:143-4. (Pubitemid 32684742)
11. Pada SK, Ding Y, Ling ML, et al. Economic and clinical impact of nosocomial meticillin-resistant Staphylococcus aureus infections in Singapore: a matched case-control study. J Hosp Infect 2011; 78: 36-40.
12. Hiramatsu K, Hanaki H, Ino T, Yabuta K, Oguri T, Tenover FC. Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility. J Antimicrob Chemother 1997; 40:135-6. (Pubitemid 27341646)
13. Sng LH, Koh TH, Wang GC, Hsu LY, Kapi M, Hiramatsu K. Heterogeneous vancomycin-resistant Staphylococcus aureus (hetero-VISA) in Singapore. Int J Antimicrob Agents 2005; 25:177-9. (Pubitemid 40138957)
14. Fong RK, Low J, Koh TH, Kurup A. Clinical features and treatment outcomes of vancomycin-intermediate Staphylococcus aureus (VISA) and heteroresistant vancomycin-intermediate Staphylococcus aureus (hVISA) in a tertiary care institution in Singapore. Eur J Clin Microbiol Infect Dis 2009; 28:983-7.
15. Thati V, Shivannavar CT, Gaddad SM. Vancomycin resistance among methicillin resistant Staphylococcus aureus isolates from intensive care units of tertiary care hospitals in Hyderabad. Indian J Med Res 2011; 134:704-8.
16. Hsu LY, Leong M, Balm M, et al. Six cases of daptomycin-nonsusceptible Staphylococcus aureus bacteraemia in Singapore. J Med Microbiol 2010; 59(Pt 12):1509-13.
17. Ikeda-Dantsuji Y, Hanaki H, Sakai F, et al. Linezolid-resistant Staphylococcus aureus isolated from 2006 through 2008 at six hospitals in Japan. J Infect Chemother 2011; 17:45-51.
18. Sanchez Garcia M, De la Torre MA, Morales G, et al. Clinical outbreak of linezolid-resistant Staphylococcus aureus in an intensive care unit. JAMA 2010; 303:2260-4.
19. Chavers LS, Moser SA, Benjamin WH, et al. Vancomycin-resistant enterococci: 15 years and counting. J Hosp Infect 2003; 53:159-71. (Pubitemid 38002049)
20. Tacconelli E, Cataldo MA. Vancomycin-resistant enterococci (VRE): transmission and control. Int J Antimicrob Agents 2008; 31:99-106.
21. Hidron AI, Edwards JR, Patel J, et al. NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect Control Hosp Epidemiol 2008; 29:996-1011.
22. Ang SW, Seah CS, Lee ST. Vancomycin-resistant Enterococcus in the Singapore National Burns Centre: a case report. Ann Acad Med Singapore 1996; 25:270-2. (Pubitemid 26188975)
23. Oon LL, Ling ML, Chiew YF. Gastrointestinal colonisation of vancomycin-resistant enterococcus in a Singapore teaching hospital. Pathology 2001; 33:216-21. (Pubitemid 32453417)
24. Chlebicki MP, Ling ML, Koh TH, et al. First outbreak of colonization and infection with vancomycin-resistant Enterococcus faecium in a tertiary care hospital in Singapore. Infect Control Hosp Epidemiol 2006; 27:991-3. (Pubitemid 44449264)
25. Kurup A, Chlebicki MP, Ling ML, et al. Control of a hospital-wide vancomycin-resistant enterococci outbreak. Am J Infect Control 2008; 36:206-11. (Pubitemid 351417670)
26. Koh TH, Hsu LY, Chiu LL, Lin RV. Emergence of epidemic clones of vancomycin-resistant Enterococcus faecium in Singapore. J Hosp Infect 2006; 63:234-6.
27. Christiansen KJ, Tibbett PA, Beresford W, et al. Eradication of a large outbreak of a single strain of vanB vancomycin-resistant Enterococcus faecium at a major Australian teaching hospital. Infect Control Hosp Epidemiol 2004; 25:384-90. (Pubitemid 38621084)
28. Cai Y, Chan JP, Fisher DA, et al. Vancomycin-resistant enterococci in Singaporean hospitals: 5-year results of a multi-centre surveillance programme. Ann Acad Med Singapore 2012; 41:77-81.
29. Livermore DM. Current epidemiology and growing resistance of gram-negative pathogens. Korean J Intern Med 2012; 27:128-42.
30. Hanson ND. AmpC beta-lactamases: what do we need to know for the future? J Antimicrob Chemother 2003; 52:2-4. (Pubitemid 36850075)
31. Koh TH. Gram-negative resistance in Singapore: a historical perspective. Ann Acad Med Singapore 2008; 37:847-54.
32. Hsu LY, Tan TY, Tam VH, Kwa A, Fisher DA, Koh TH. Surveillance and correlation of antibiotic prescription and resistance of gram-negative bacteria in Singaporean hospitals. Antimicrob Agents Chemother 2010; 54:1173-8.
33. Tan TY, Hsu LY, Koh TH, et al. Antibiotic resistance in gram-negative bacilli: a Singapore perspective. Ann Acad Med Singapore 2008; 37:819-25.
34. Tan TY, Ng LS, He J, Hsu LY. CTX-M and ampC beta-lactamases contributing to increased prevalence of ceftriaxone-resistant Escherichia coli in Changi General Hospital, Singapore. Diagn Microbiol Infect Dis 2010; 66:210-3.
35. Chaudhuri BN, Rodrigues C, Balaji V, et al. Incidence of ESBL producers amongst gram-negative bacilli isolated from intra-abdominal infections across India (based on SMART study, 2007 data). J Assoc Physicians India 2011; 59:287-92.
36. Nordmann P, Cuzon G, Naas T. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 2009; 9:228-36.
37. Venkatachalam I, Teo J, Balm MN, Fisher DA, Jureen R, Lin RT. Klebsiella pneumoniae carbapenemase-producing enterobacteria in hospital, Singapore. Emerg Infect Dis 2012; 18:1381-3.
38. Balm MN, Ngan G, Jureen R, Lin RT, Teo J. Molecular characterization of newly emerged blaKPC-2-producing Klebsiella pneumoniae in Singapore. J Clin Microbiol 2012; 50:475-6.
39. Watanabe M, Iyobe S, Inoue M, Mitsuhashi S. Transferable imipenem resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother 1991; 35:147-51.
40. Koh TH, Babini GS, Woodford N, Sng LH, Hall LM, Livermore DM. Carbapenem-hydrolysing IMP-1 beta-lactamase in Klebsiella pneumoniae from Singapore. Lancet 1999; 353:2162. (Pubitemid 29278505)
41. Nordmann P, Poirel L, Walsh TR, Livermore DM. The emerging NDM carbapenemases. Trends Microbiol 2011; 19:588-95.
42. Yong D, Toleman MA, Giske CG, et al. Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother 2009; 53:5046-54.
43. Kumarasamy KK, Toleman MA, Walsh TR, et al. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis 2010; 10:597-602.
44. Isozumi R, Yoshimatsu K, Yamashiro T, et al. bla(NDM-1)-positive Klebsiella pneumoniae from environment, Vietnam. Emerg Infect Dis 2012; 18:1383-5.
45. Walsh TR, Weeks J, Livermore DM, Toleman MA. Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study. Lancet Infect Dis 2011; 11:355-62.
46. Wilson ME, Chen LH. NDM-1 and the role of travel in its dissemination. Curr Infect Dis Rep 2012; 14:213-26.
47. Teo J, Ngan G, Balm M, Jureen R, Krishnan P, Lin R. Molecular characterization of NDM-1 producing Enterobacteriaceae isolates in Singapore hospitals. West Pacific Surveill Response 2012; 3:1-6.
48. Marimuthu K, Teo J, Gan VC, Ng WK, Krishnan P, Ang B, Lye D. Risk factors for locally acquired New Delhi metallo-beta-lactamase-1 Enterobacteriaceae in Singapore. In: European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 2011.
49. Nordmann P, Dortet L, Poirel L. Carbapenem resistance in Enterobacteriaceae: here is the storm! Trends Mol Med 2012; 18:263-72.
50. Castanheira M, Deshpande LM, Mathai D, Bell JM, Jones RN, Mendes RE. Early dissemination of NDM-1-and OXA-181-producing Enterobacteriaceae in Indian hospitals: report from the SENTRY Antimicrobial Surveillance Program, 2006-2007. Antimicrob Agents Chemother 2011; 55:1274-8.
51. Koh TH, Cao DY, Chan KS, et al. bla(OXA-181)-positive Klebsiella pneumoniae, Singapore. Emerg Infect Dis 2012; 18:1524-5.
52. Deshpande P, Shetty A, Kapadia F, Hedge A, Soman R, Rodrigues C. New Delhi metallo 1: have carbapenems met their doom? Clin Infect Dis 2010; 51:1222.
53. Falagas ME, Karveli EA, Kelesidis I, Kelesidis T. Community-acquired Acinetobacter infections. Eur J Clin Microbiol Infect Dis 2007; 26: 857-68. (Pubitemid 350077206)
54. Bouchillon SK, Iredell JR, Barkham T, Lee K, Dowzicky MJ. Comparative in vitro activity of tigecycline and other antimicrobials against gram-negative and gram-positive organisms collected from the Asia-Pacific Rim as part of the Tigecycline Evaluation and Surveillance Trial (TEST). Int J Antimicrob Agents 2009; 33:130-6.
55. Apisarnthanarak A, Li Yang H, Warren DK. Termination of an extreme-drug resistant Acinetobacter baumannii outbreak in a hospital after flooding: lessons learned. Clin Infect Dis 2012; 55:1589-90.
56. Tambyah PA, Kumarasinghe G. Methicillin-resistant Staphylococcus aureus control at the National University Hospital, Singapore: a historical perspective. Ann Acad Med Singapore 2008; 37:855-60.
57. Liew YX, Krishnan P, Yeo CL, et al. Surveillance of broad-spectrum antibiotic prescription in Singaporean hospitals: a 5-year longitudinal study. PLoS One 2011; 6:e28751.
58. Liew YX, Lee W, Kwa AL, Lye DC, Yeo CL, Hsu LY. Inappropriate carbapenem use in Singapore public hospitals: opportunities for antimicrobial stewardship. Int J Antimicrob Agents 2011; 37:87-8.
59. Liew YX, Lee W, Loh JC, et al. Impact of an antimicrobial stewardship programme on patient safety in Singapore General Hospital. Int J Antimicrob Agents 2012; 40:55-60.
60. World Health Organization. The evolving threat of antimicrobial resistance: options for action. 2012. Available at: http://whqlibdoc.who. int/publications/2012/9789241503181-eng.pdf. Accessed 7 August 2012.
61. Marshall BM, Levy SB. Food animals and antimicrobials: impacts on human health. Clin Microbiol Rev 2011; 24:718-33.
62. Antibiotic Resistance 2012: The antibiotics development pipeline and strategies to combat antibiotic resistance. Available at: http://www.bio pharmreports.co.uk/Report-description.asp?id=66. Accessed 7 August 12.