Oral L-glutamine increases active GLP-1 (7-36) amide secretion and improves glycemic control in stretpozotocin-nicotinamide induced diabetic rats

Chemico-Biological Interactions

Volumn 203, Issue 2, 2013, Pages 530-541

  Badole, Sachin L ^a   Bagul, Pranita P ^a   Mahamuni, Sagar P ^a   Khose, Rekha D ^a   Joshi, Anuja C ^a   Jangam, Ganesh B ^a   Ghule, Arvindkumar E ^b   Raut, Chandrashekhar G ^c   Khedkar, Vijay M ^d   Coutinho, Evans C ^d  

^a Affiliated to Savitribai Phule Pune University   (India)

^b BHARATI VIDYAPEETH DEEMED UNIVERSITY   (India)

^c NATIONAL INSTITUTE OF VIROLOGY   (India)

^d BOMBAY COLLEGE OF PHARMACY   (India)

Author keywords

Antioxidant parameters; Docking; GLP 1 (7 36) amide; Insulin secretion; l glutamine; Proglucagon gene expression

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 [7-36] AMIDE; GLUTAMINE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; GLYCOSYLATED HEMOGLOBIN; INSULIN; MALONALDEHYDE; MESSENGER RNA; SITAGLIPTIN; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; FLUID INTAKE; FOOD INTAKE; GENE EXPRESSION REGULATION; GLUCAGON LIKE PEPTIDE 1 GENE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HORMONE BLOOD LEVEL; HORMONE RELEASE; INSULIN BLOOD LEVEL; LIPID ANALYSIS; MALE; MOLECULAR DOCKING; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET; RAT; STREPTOZOCIN DIABETES; TREATMENT DURATION;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; COLON; DIABETES MELLITUS, EXPERIMENTAL; DRINKING; GENE EXPRESSION REGULATION; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE TOLERANCE TEST; GLUTAMINE; HEMOGLOBIN A, GLYCOSYLATED; INSULIN; LIPID METABOLISM; MALE; MOLECULAR DOCKING SIMULATION; NIACINAMIDE; OXIDATIVE STRESS; PANCREAS; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCAGON; TRIAZOLES;

RATTUS;

EID: 84875969642     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2013.02.006     Document Type: Article

References (48)

1. E. Diakogiannaki, F.M. Gribble, and F. Reimaann Nutrient detection by incretin hormone secreting cells Physiol. Behav. 106 2012 387 393
2. E. Verspohl Novel therapeutics for type 2 diabetes: incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors Pharmacol. Ther. 124 2009 113 138
3. J.J. Meier, and M.A. Nauck Glucagon-like peptide-1(GLP-1) in biology and pathology Diabetes Metab. Res. Rev. 21 2 2005 91 117
4. E. Roth Nonnutritive effects of glutamine J. Nutr. 138 10 2008 2025 2031
5. A. Bonet, and T. Grau l-glutamine, un aminoácido casi indispensable en elenfermo crítico Med. Intensiva 31 2007 402 406
6. P. Newsholme, L. Brennan, and K. Bender Amino acid metabolism, β-cell function and diabetes Diabetes 55 2006 39 47
7. B.A. Menge, H. Schrader, P.R. Ritter, M. Ellrichmann, W. Uhl, W.E. Schmidt, and J.J. Meie Selective amino acid deficiency in patients with impaired glucose tolerance and type 2 diabetes Regul. Pept. 160 2010 75 80
8. E.C. Opara, A.W. Petro, A. Tevrizian, Feihglo, and R.S. Surwit l-glutamine supplementation of a high fat diet reduces body weight and attenuates hyperglycemia and hyperinsulinemia in c57bl/6j mice 1′2′3 J. Nutr. 126 1996 273 279
9. P. Tsai, J. Liu, W. Chiu, M. Pai, and S. Yeh Effects of dietary glutamine on adhesion molecule expression and oxidative stress in mice with streptozotocin-induced type 1 diabetes Clin. Nutr. 30 2011 124 129
10. D. Bonet, O. Wong, and E. Synnott Glutamine reduces postprandial glycemia and augments the glucagon-like peptide-1 response in type 2 diabetes patients J. Nutr. 141 2011 1233 1238
11. J. Greenfield, S. Farooqi, and M. Keogh Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects Am. J. Clin. Nutr. 89 2009 106 113
12. P. Masiello, C. Broca, and R. Gross Experimental NIDDM: development of a new model in rats administered streptozotocin and nicotinamide Diabetes 47 1998 224 229
13. R.A. Friesner, J.L. Banks, and R.B. Murphy Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy J. Med. Chem. 47 7 2004 1739 1749
14. T.A. Halgren, R.B. Murphy, R.A. Friesner, H.S. Beard, L.L. Frye, W.T. Pollard, and J.L. Banks Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening J. Med. Chem. 47 2004 1750 1759
15. S.L. Badole, S.P. Mahamuni, P.P. Bagul, R.D. Khose, A.C. Joshi, A.E. Ghule, S.L. Bodhankar, C.G. Raut, V.M. Khedkar, E.C. Coutinho, and N.K. Wagh Cycloart-23-ene-3β, 25-diol stimulates GLP-1 (7-36) amide secretion in streptozotocin-nicotinamide induced diabetic Sprague Dawley rats: a mechanistic approach Eur. J. Pharmacol. 698 2012 470 479
16. T.M. Dao, A. Waget, and P. Klopp Resveratrol increases glucose Induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control Plos One 6 2011 1 9
17. G.L. Gomori Gomori's aldehyde fuschin stain (special stain for β cells) Am. J. Clin. Pathol. 20 1950 665 666
18. T.F. Slater, and B.C. Sawyer The stimulatory effects of carbon tetrachloride and other halogenoalkanes or peroxidative reactions in rat liver fractions in vitro Biochem. J. 123 1971 805 814
19. M.S. Moron, J.W. Depierre, and B. Mannervik Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver Biochim. Biophys. Acta 582 1979 67 78
20. H.P. Misra, and I. Fridovich The role of superoxide anion in the auto-oxidation of epinephrine and a simple assay for SOD J. Biol. Chem. 247 1972 3170 3175
21. W.H. Habig, and W.B. Jakoby Assay of differentiation of glutathione S-transferases Methods Enzymol. 77 1981 398 405
22. J.T. Rotruck, A.L. Pope, H.E. Canther, A.B. Swanson, D.C. Hafeman, and W.C. Hoekstra Selenium: biochemical role as a component of glutathione peroxidase Science 179 1979 588 590
23. O.H. Lowry, N.J. Rosenbrough, A.C. Farr, and R.J. Randell Protein measurement with folin-phenol reagent J. Biol. Chem. 193 1951 265 275
24. B.F. Burkey, X. Li, and L. Bolognese Acute and chronic effects of the incretin enhancer vildagliptin in insulin-resistant rats J. Pharmacol. Exp. Ther. 315 2005 688 695
25. 2+ and cAMP Endocrinol 152 2 2011 405 413
26. S. Swanston-Flat, C. Day, C. Bailey, and P. Flatt Traditional plant treatments for diabetes: studies in normal and streptozotocin diabetic mice Diabetol 33 1990 462 464
27. A. Akarte, B. Srinivasan, and S. Gandhi A novel long acting DPP-IV inhibitor PKF-275-055 stimulates b-cell proliferation resulting in improved glucose homeostasis in diabetic rats Biochim. Pharmacol. 83 2012 241 252
28. P. Bansal, P. Paul, and J. Mudgul Exp. Toxicol. Pathol. 2011
29. A.J. Krentz Lipoprotien abnormalities and their consequences for patients with type 2 diabetes Diabetes Obes. Metab. 5 2003 19 27
30. R. Saxena, V. Madhu, R. Shukla, K.M. Prabhu, and J.K. Gambhir Postprandial hypertriglyceridemia and oxidative stress in patients of type 2 diabetes mellitus with macrovascular complications Clin. Chim. Acta 359 2005 101 108
31. D.W. Morel, and G.M. Chisolm Antidoxidant treatment of diabetic rats inhibits lipoprotein oxidation and cytotoxicity J. Lipid Res. 30 1989 1827 1834
32. C. Apparao, B. Kameswararao, and M.M. Kesavulu Evaluation of antidiabetic effect of momordica cymbalaria fruit in alloxan-diabetic rats Fitoterapia 74 2003 7 13
33. X. Qin, H. Shen, M. Liu, Q. Yang, S. Zheng, and M. Sabo GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats Am. J. Physiol. Gastrointest. Liver Physiol. 288 2005 943 949
34. D.J. Drucker, and M.A. Nauck The incretin system: glucagon-like peptide-1 receptor (GLP-1R) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors in type 2 diabetes Lancet 368 2006 1696 1705
35. T. Hira, T. Mochida, K. Miyashita, and H. Hara GLP-1 secretion is enhanced directly in the ileum but indirectly in the duodenum by a newly identified potent stimulator, zein hydrolysate in rats Am. J. Physiol. Gastrointest. Liver Physiol. 297 2006 663 671
36. T. Kieffer, and J. Habener The glucagon-like peptides Endocrine Rev. 20 1999 876 913
37. M. Punjabi, M. Arnold, N. Geary, W. Langhans, and G. Pacheco-López Peripheral glucagon-like peptide-1 (GLP-1) and satiation Physiol. Behav. 105 2011 71 76
38. P.L. Brubaker, and D.J. Drucker Minireview: glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system Endocrinology 145 2004 2653 2659
39. J.J. Holst On the physiology of GIP and GLP-1 Horm. Metab. Res. 36 2004 747 754
40. C. Knauf, P.D. Cani, C. Perrin, M.A. Iglesias, J.F. Maury, and E. Bernard Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage J. Clin. Invest. 115 2005 3554 3563
41. E. Verspohl Novel therapeutics for type 2 diabetes: incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors Pharmacol. Ther. 124 2009 113 138
42. G. Holz Epac: a new cAMP-binding protein in support of glucagon like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell Diabetes 53 2004 513
43. G. Holz, G. Kang, M. Harbeck, M. Roe, and O. Chepurny Cell physiology of cAMP sensor Epac J. Physiol. 577 2006 5 15
44. E.P. Rafferty, A.P. Wylie, C.T. Elliott, O.P. Chevallier, D.J. Grieve, and B.D. Green In vitro and in vivo effects of natural putative secretagogues of glucagon-like peptide-1 (GLP-1) Sci. Pharm. 79 2011 615 621
45. I. Gulcin Antioxidant activity of food constituents-an overview Arch. Toxicol. 86 2012 345 396
46. E. Roth, R. Oehler, N. Manhart, R. Exner, B. Wessner, E. Strasser, and A. Spittler Regulative potential of glutamine-relation to glutathione metabolism Nutrition 18 3 2002 217 221
47. G. De Mattia, M.C. Bravi, O. Laurenti, M. Cassone-Faldetta, A. Armiento, C. Ferri, and F. Balsano Influence of reduced glutathione infusion on glucose metabolism in patients with non-insulin-dependent diabetes mellitus Metabolism 47 1998 993 997
48. R.W. Hong, J.D. Rounds, W.S. Helton, M.K. Robinson, and D.W. Wilmore Glutamine preserves liver glutathione after lethal hepatic injury Ann. Surg. 215 1992 114 119