A high-throughput screening campaign for detection of Ca 2+-activated K+ channel activators and inhibitors using a fluorometric imaging plate reader-based Tl+-influx assay

Assay and Drug Development Technologies

Volumn 11, Issue 3, 2013, Pages 163-172

  Jørgensen, Susanne ^a   Dyhring, Tino ^a   Brown, David T ^a   Strøbæk, Dorte ^a   Christophersen, Palle ^a   Demnitz, Joachim ^a  

^a NEUROSEARCH A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

1 [(2 CHLOROPHENYL)DIPHENYLMETHYL] 1H PYRAZOLE; 4 [[3 (TRIFLUOROMETHYL)PHENYL]METHYL] 2H 1,4 BENZOTHIAZIN 3 (4H)ONE; CALCIMYCIN; DIMETHYL SULFOXIDE; NS 6180; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; SENICAPOC; THALLIUM; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CELL ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG POTENCY; ERYTHROCYTE; FLUORESCENCE ANALYSIS; FLUOROMETRY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; NORMAL HUMAN; PERMEABILITY; PHARMACOPHORE; PROCESS OPTIMIZATION;

ACETAMIDES; ALGORITHMS; DATA INTERPRETATION, STATISTICAL; ERYTHROCYTES; FLUOROMETRY; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INFLAMMATORY BOWEL DISEASES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PYRAZOLES; SMALL MOLECULE LIBRARIES; THALLIUM; THIAZINES; TRITYL COMPOUNDS;

EID: 84875969060     PISSN: 1540658X     EISSN: 15578127     Source Type: Journal    
DOI: 10.1089/adt.2012.479     Document Type: Article

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