Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines

European Journal of Medicinal Chemistry

Volumn 62, Issue , 2013, Pages 728-737

  Burgy, Guillaume ^a,b   Tahtouh, Tania ^c   Durieu, Emilie ^c   Foll Josselin, Béatrice ^c   Limanton, Emmanuelle ^a   Meijer, Laurent ^b   Carreaux, François ^a   Bazureau, Jean Pierre ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

^b Centre de Perharidy   (France)

^c STATION BIOLOGIQUE   (France)

Author keywords

Alzheimer's disease; CLKs; DYRKs; GSK 3; Kinase; Kinase inhibitor; Leucettamine B; Leucettine; Pre mRNA splicing

Indexed keywords

2 [4 [2 [2 (2 AMINOETHOXY)ETHOXY]ETHOXY]ANILINO] 4 BENZYLIDENE 3,5 DIHYDRO IMIDAZOL 5 ONE; 2 [4 [2 [2 (2 AMINOETHOXY)ETHOXY]ETHOXY]PHENYLAMINO] 5 (BENZO[1,3]DIOXOL 5 YLMETHYLENE) 3,5 DIHYDRO IMIDAZOL 4 ONE; 2 [4 [2 [2 [2 (2 AMINOETHOXY)ETHOXY]ETHOXY]ETHOXY]PHENYLAMINO] 5 (BENZO[1,3]DIOXOL 5 YLMETHYLENE) 3,5 DIHYDRO IMIDAZOL 4 ONE; ALKALOID DERIVATIVE; DUAL SPECIFICITY TYROSINE PHOSPHORYLATION REGULATED KINASE; GLYCOGEN SYNTHASE KINASE 3; IMIDAZOLE DERIVATIVE; IMMOBILIZED PROTEIN; LEUCETTINE L41; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COVALENT BOND; CRYSTAL STRUCTURE; DRUG SYNTHESIS; HYDROPHOBICITY; IC 50; MASS SPECTROMETRY; MOUSE; NONHUMAN; PROTEIN INTERACTION; SUBSTITUTION REACTION; THERMOSTABILITY; THIN LAYER CHROMATOGRAPHY; WESTERN BLOTTING;

ANIMALS; DIOXOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMIDAZOLES; MICE; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 84875968245     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.01.035     Document Type: Article

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