Metabolic improvement and abdominal fat redistribution in Werner syndrome by pioglitazone [2]

Journal of the American Geriatrics Society

Volumn 52, Issue 9, 2004, Pages 1582-1583

  Yokote, Koutaro ^a   Honjo, Satoshi ^a   Kobayashi, Kazuki ^a   Fujimoto, Masaki ^a   Kawamura, Harukiyo ^a   Mori, Seijiro ^a   Saito, Yasushi ^a  

^a CHIBA UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HELICASE; PIOGLITAZONE;

ABDOMEN; ABDOMINAL FAT; ADULT; BODY FAT; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; FEMALE; GENETIC ANALYSIS; GLUCOSE BLOOD LEVEL; HOMOZYGOTE; HUMAN; HYPERGLYCEMIA; HYPERLIPIDEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; LETTER; LIVER FUNCTION; METABOLIC REGULATION; NUCLEOTIDE SEQUENCE; PHENOTYPE; SUBCUTANEOUS FAT DISORDER; WEIGHT GAIN; WERNER SYNDROME;

ABDOMEN; ADIPOSE TISSUE; BODY CONSTITUTION; FEMALE; GLUCOSE; GLUCOSE TOLERANCE TEST; HUMANS; HYPERLIPIDEMIAS; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; MIDDLE AGED; THIAZOLIDINEDIONES; TREATMENT OUTCOME; WERNER SYNDROME;

EID: 4444242631     PISSN: 00028614     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2004.52430_4.x     Document Type: Letter

References (10)

1. Yu CE, Oshima J, Fu YH et al. Positional cloning of the Werner's syndrome gene. Science 1996;272:258-262.
2. Mori S, Murano S, Yokote K et al. Enhanced intra-abdominal visceral fat accumulation in patients with Werner's syndrome. Int J Obes Relat Metab Disord 2001;25:292-295.
3. Matsumoto T, Imamura O, Yamabe Y et al. Mutation and haplotype analyses of the Werner's syndrome gene based on its genomic structure: Genetic epidemiology in the Japanese population. Hum Genet 1997;100:123-130.
4. Yamashita S, Nakamura T, Shimomura I et al. Insulin resistance and body fat distribution. Diabetes Care 1996;19:287-291.
5. Harano Y, Kageyama A, Hirose J et al. Improvement of insulin sensitivity for glucose metabolism with the long-acting Ca-channel blocker amlodipine in essential hypertensive subjects. Metabolism 1995;44:315-319.
6. Adams M, Montague CT, Prins JB et al. Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation. J Clin Invest 1997;100:3149-3153.
7. Mori Y, Murakawa Y, Okada K et al. Effect of troglitazone on body fat distribution in type 2 diabetic patients. Diabetes Care 1999;22:908-912.
8. Gavrilova O, Marcus-Samuels B, Graham D et al. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J Clin Invest 2000; 105:271-278.
9. Oral EA, Simha V, Ruiz E et al. Leptin-replacement therapy for lipodystrophy. N Engl J Med 2002;346:570-578.
10. Dandona P, Alijada A. A rational approach to pathogenesis and treatment of type 2 diabetes mellitus, insulin resistance, inflammation, and atherosclerosis. Am J Cardiol 2002;90:27G-33G.