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Volumn 8, Issue 4, 2013, Pages

Metabolomic Analysis Reveals Metabolic Disturbance in the Cortex and Hippocampus of Subchronic MK-801 Treated Rats

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ACETIC ACID; ALANINE; ASPARTIC ACID; CHOLINE; CITRIC ACID; CREATININE; DIZOCILPINE; GLUTAMIC ACID; GLUTAMINE; INOSITOL; LACTIC ACID; PHOSPHORYLCHOLINE; SERINE; SUCCINIC ACID; TAURINE;

EID: 84875946194     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060598     Document Type: Article
Times cited : (25)

References (48)
  • 2
    • 58149230876 scopus 로고    scopus 로고
    • Treatment of schizophrenia in the 21st Century: beyond the neurotransmitter hypothesis
    • Rogers DP, Goldsmith CA, (2009) Treatment of schizophrenia in the 21st Century: beyond the neurotransmitter hypothesis. Expert Rev Neurother 9: 47-54.
    • (2009) Expert Rev Neurother , vol.9 , pp. 47-54
    • Rogers, D.P.1    Goldsmith, C.A.2
  • 3
    • 0031575414 scopus 로고    scopus 로고
    • Time course of cerebral ventricular enlargement in schizophrenia supports the hypothesis of its neurodevelopmental nature
    • Vita A, Dieci M, Giobbio GM, Tenconi F, Invernizzi G, (1997) Time course of cerebral ventricular enlargement in schizophrenia supports the hypothesis of its neurodevelopmental nature. Schizophr Res 23: 25-30.
    • (1997) Schizophr Res , vol.23 , pp. 25-30
    • Vita, A.1    Dieci, M.2    Giobbio, G.M.3    Tenconi, F.4    Invernizzi, G.5
  • 4
    • 33749074397 scopus 로고    scopus 로고
    • Glutamate and schizophrenia: beyond the dopamine hypothesis
    • Coyle JT, (2006) Glutamate and schizophrenia: beyond the dopamine hypothesis. Cell Mol Neurobiol 26: 365-384.
    • (2006) Cell Mol Neurobiol , vol.26 , pp. 365-384
    • Coyle, J.T.1
  • 5
    • 44449158676 scopus 로고    scopus 로고
    • Models of schizophrenia in humans and animals based on inhibition of NMDA receptors
    • Bubenikova-Valesova V, Horacek J, Vrajova M, Hoschl C, (2008) Models of schizophrenia in humans and animals based on inhibition of NMDA receptors. Neurosci Biobehav Rev 32: 1014-1023.
    • (2008) Neurosci Biobehav Rev , vol.32 , pp. 1014-1023
    • Bubenikova-Valesova, V.1    Horacek, J.2    Vrajova, M.3    Hoschl, C.4
  • 7
    • 81455126243 scopus 로고    scopus 로고
    • NMDA Receptor Hypofunction Induces Dysfunctions of Energy Metabolism And Semaphorin Signaling in Rats: A Synaptic Proteome Study
    • Zhou K, Yang Y, Gao L, He G, Li W, et al. (2010) NMDA Receptor Hypofunction Induces Dysfunctions of Energy Metabolism And Semaphorin Signaling in Rats: A Synaptic Proteome Study. Schizophr Bull.
    • (2010) Schizophr Bull
    • Zhou, K.1    Yang, Y.2    Gao, L.3    He, G.4    Li, W.5
  • 8
    • 80051964408 scopus 로고    scopus 로고
    • The role of energy metabolism dysfunction and oxidative stress in schizophrenia revealed by proteomics
    • Martins-de-Souza D, Harris LW, Guest PC, Bahn S, (2011) The role of energy metabolism dysfunction and oxidative stress in schizophrenia revealed by proteomics. Antioxid Redox Signal 15: 2067-2079.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 2067-2079
    • Martins-de-Souza, D.1    Harris, L.W.2    Guest, P.C.3    Bahn, S.4
  • 10
    • 79952185414 scopus 로고    scopus 로고
    • Altered (13)C glucose metabolism in the cortico-striato-thalamo-cortical loop in the MK-801 rat model of schizophrenia
    • Eyjolfsson EM, Nilsen LH, Kondziella D, Brenner E, Haberg A, et al. (2010) Altered (13)C glucose metabolism in the cortico-striato-thalamo-cortical loop in the MK-801 rat model of schizophrenia. J Cereb Blood Flow Metab.
    • (2010) J Cereb Blood Flow Metab
    • Eyjolfsson, E.M.1    Nilsen, L.H.2    Kondziella, D.3    Brenner, E.4    Haberg, A.5
  • 12
    • 33846238600 scopus 로고    scopus 로고
    • How do glial-neuronal interactions fit into current neurotransmitter hypotheses of schizophrenia?
    • Kondziella D, Brenner E, Eyjolfsson EM, Sonnewald U, (2007) How do glial-neuronal interactions fit into current neurotransmitter hypotheses of schizophrenia? Neurochem Int 50: 291-301.
    • (2007) Neurochem Int , vol.50 , pp. 291-301
    • Kondziella, D.1    Brenner, E.2    Eyjolfsson, E.M.3    Sonnewald, U.4
  • 13
    • 18244363880 scopus 로고    scopus 로고
    • Metabolic characterization of distinct neuroanatomical regions in rats by magic angle spinning 1H nuclear magnetic resonance spectroscopy
    • Tsang TM, Griffin JL, Haselden J, Fish C, Holmes E, (2005) Metabolic characterization of distinct neuroanatomical regions in rats by magic angle spinning 1H nuclear magnetic resonance spectroscopy. Magn Reson Med 53: 1018-1024.
    • (2005) Magn Reson Med , vol.53 , pp. 1018-1024
    • Tsang, T.M.1    Griffin, J.L.2    Haselden, J.3    Fish, C.4    Holmes, E.5
  • 14
    • 0001413420 scopus 로고    scopus 로고
    • Metabolite profiling by one- and two-dimensional NMR analysis of complex mixtures
    • Fan TWM, (1996) Metabolite profiling by one- and two-dimensional NMR analysis of complex mixtures. Progress in Nuclear Magnetic Resonance Spectroscopy 28: 161-219.
    • (1996) Progress in Nuclear Magnetic Resonance Spectroscopy , vol.28 , pp. 161-219
    • Fan, T.W.M.1
  • 15
    • 30044447943 scopus 로고    scopus 로고
    • High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease
    • Pears MR, Cooper JD, Mitchison HM, Mortishire-Smith RJ, Pearce DA, et al. (2005) High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease. J Biol Chem 280: 42508-42514.
    • (2005) J Biol Chem , vol.280 , pp. 42508-42514
    • Pears, M.R.1    Cooper, J.D.2    Mitchison, H.M.3    Mortishire-Smith, R.J.4    Pearce, D.A.5
  • 16
    • 67349196013 scopus 로고    scopus 로고
    • Metabonomic Characterization of the 3-Nitropropionic Acid Rat Model of Huntington's Disease
    • Tsang TM, Haselden JN, Holmes E (2009) Metabonomic Characterization of the 3-Nitropropionic Acid Rat Model of Huntington's Disease. Neurochemical Research: 1-11.
    • (2009) Neurochemical Research , pp. 1-11
    • Tsang, T.M.1    Haselden, J.N.2    Holmes, E.3
  • 17
    • 77953124257 scopus 로고    scopus 로고
    • A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease
    • Salek RM, Xia J, Innes A, Sweatman BC, Adalbert R, et al. (2010) A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease. Neurochem Int 56: 937-947.
    • (2010) Neurochem Int , vol.56 , pp. 937-947
    • Salek, R.M.1    Xia, J.2    Innes, A.3    Sweatman, B.C.4    Adalbert, R.5
  • 18
    • 71049189969 scopus 로고    scopus 로고
    • Normalization and statistical analysis of quantitative proteomics data generated by metabolic labeling
    • Ting L, Cowley MJ, Hoon SL, Guilhaus M, Raftery MJ, et al. (2009) Normalization and statistical analysis of quantitative proteomics data generated by metabolic labeling. Mol Cell Proteomics 8: 2227-2242.
    • (2009) Mol Cell Proteomics , vol.8 , pp. 2227-2242
    • Ting, L.1    Cowley, M.J.2    Hoon, S.L.3    Guilhaus, M.4    Raftery, M.J.5
  • 19
    • 0019293020 scopus 로고
    • Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia
    • Kim JS, Kornhuber HH, Schmid-Burgk W, Holzmuller B, (1980) Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neurosci Lett 20: 379-382.
    • (1980) Neurosci Lett , vol.20 , pp. 379-382
    • Kim, J.S.1    Kornhuber, H.H.2    Schmid-Burgk, W.3    Holzmuller, B.4
  • 20
    • 27544447486 scopus 로고    scopus 로고
    • Increased prefrontal and hippocampal glutamate concentration in schizophrenia: evidence from a magnetic resonance spectroscopy study
    • van Elst LT, Valerius G, Buchert M, Thiel T, Rusch N, et al. (2005) Increased prefrontal and hippocampal glutamate concentration in schizophrenia: evidence from a magnetic resonance spectroscopy study. Biol Psychiatry 58: 724-730.
    • (2005) Biol Psychiatry , vol.58 , pp. 724-730
    • van Elst, L.T.1    Valerius, G.2    Buchert, M.3    Thiel, T.4    Rusch, N.5
  • 21
    • 39149114402 scopus 로고    scopus 로고
    • Elevated 3T proton MRS glutamate levels associated with poor Continuous Performance Test (CPT-0X) scores and genetic risk for schizophrenia
    • Purdon SE, Valiakalayil A, Hanstock CC, Seres P, Tibbo P, (2008) Elevated 3T proton MRS glutamate levels associated with poor Continuous Performance Test (CPT-0X) scores and genetic risk for schizophrenia. Schizophr Res 99: 218-224.
    • (2008) Schizophr Res , vol.99 , pp. 218-224
    • Purdon, S.E.1    Valiakalayil, A.2    Hanstock, C.C.3    Seres, P.4    Tibbo, P.5
  • 23
    • 60549094588 scopus 로고    scopus 로고
    • Metabolite changes and gender differences in schizophrenia using 3-Tesla proton magnetic resonance spectroscopy (1H-MRS)
    • Tayoshi S, Sumitani S, Taniguchi K, Shibuya-Tayoshi S, Numata S, et al. (2009) Metabolite changes and gender differences in schizophrenia using 3-Tesla proton magnetic resonance spectroscopy (1H-MRS). Schizophr Res 108: 69-77.
    • (2009) Schizophr Res , vol.108 , pp. 69-77
    • Tayoshi, S.1    Sumitani, S.2    Taniguchi, K.3    Shibuya-Tayoshi, S.4    Numata, S.5
  • 24
    • 11844304922 scopus 로고    scopus 로고
    • Evidence for glutamatergic neuronal dysfunction in the prefrontal cortex in chronic but not in first-episode patients with schizophrenia: a proton magnetic resonance spectroscopy study
    • Ohrmann P, Siegmund A, Suslow T, Spitzberg K, Kersting A, et al. (2005) Evidence for glutamatergic neuronal dysfunction in the prefrontal cortex in chronic but not in first-episode patients with schizophrenia: a proton magnetic resonance spectroscopy study. Schizophr Res 73: 153-157.
    • (2005) Schizophr Res , vol.73 , pp. 153-157
    • Ohrmann, P.1    Siegmund, A.2    Suslow, T.3    Spitzberg, K.4    Kersting, A.5
  • 25
    • 0026089424 scopus 로고
    • Regional alterations in brain amino acids after administration of the N-methyl-D-aspartate receptor antagonists MK-801 and CGP 39551 in rats
    • Loscher W, Honack D, Fassbender CP, (1991) Regional alterations in brain amino acids after administration of the N-methyl-D-aspartate receptor antagonists MK-801 and CGP 39551 in rats. Neurosci Lett 124: 115-118.
    • (1991) Neurosci Lett , vol.124 , pp. 115-118
    • Loscher, W.1    Honack, D.2    Fassbender, C.P.3
  • 26
    • 24944532047 scopus 로고    scopus 로고
    • Impaired glutamine metabolism in NMDA receptor hypofunction induced by MK801
    • Brenner E, Kondziella D, Haberg A, Sonnewald U, (2005) Impaired glutamine metabolism in NMDA receptor hypofunction induced by MK801. J Neurochem 94: 1594-1603.
    • (2005) J Neurochem , vol.94 , pp. 1594-1603
    • Brenner, E.1    Kondziella, D.2    Haberg, A.3    Sonnewald, U.4
  • 27
    • 33645241866 scopus 로고    scopus 로고
    • Effect of acute and chronic MK-801 administration on extracellular glutamate and ascorbic acid release in the prefrontal cortex of freely moving mice on line with open-field behavior
    • Zuo DY, Zhang YH, Cao Y, Wu CF, Tanaka M, et al. (2006) Effect of acute and chronic MK-801 administration on extracellular glutamate and ascorbic acid release in the prefrontal cortex of freely moving mice on line with open-field behavior. Life Sci 78: 2172-2178.
    • (2006) Life Sci , vol.78 , pp. 2172-2178
    • Zuo, D.Y.1    Zhang, Y.H.2    Cao, Y.3    Wu, C.F.4    Tanaka, M.5
  • 28
    • 7244220611 scopus 로고    scopus 로고
    • Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy comparison subjects measured with 4.0-T proton MRS
    • Theberge J, Al-Semaan Y, Williamson PC, Menon RS, Neufeld RW, et al. (2003) Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy comparison subjects measured with 4.0-T proton MRS. Am J Psychiatry 160: 2231-2233.
    • (2003) Am J Psychiatry , vol.160 , pp. 2231-2233
    • Theberge, J.1    Al-Semaan, Y.2    Williamson, P.C.3    Menon, R.S.4    Neufeld, R.W.5
  • 29
    • 54149109208 scopus 로고    scopus 로고
    • GABA neurons and the mechanisms of network oscillations: implications for understanding cortical dysfunction in schizophrenia
    • Gonzalez-Burgos G, Lewis DA, (2008) GABA neurons and the mechanisms of network oscillations: implications for understanding cortical dysfunction in schizophrenia. Schizophr Bull 34: 944-961.
    • (2008) Schizophr Bull , vol.34 , pp. 944-961
    • Gonzalez-Burgos, G.1    Lewis, D.A.2
  • 31
    • 0036501099 scopus 로고    scopus 로고
    • The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia
    • Cotter D, Landau S, Beasley C, Stevenson R, Chana G, et al. (2002) The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia. Biol Psychiatry 51: 377-386.
    • (2002) Biol Psychiatry , vol.51 , pp. 377-386
    • Cotter, D.1    Landau, S.2    Beasley, C.3    Stevenson, R.4    Chana, G.5
  • 32
    • 79955916792 scopus 로고    scopus 로고
    • Exploring metabolic pathway disruption in the subchronic phencyclidine model of schizophrenia with the Generalized Singular Value Decomposition
    • Xiao X, Dawson N, Macintyre L, Morris BJ, Pratt JA, et al. (2011) Exploring metabolic pathway disruption in the subchronic phencyclidine model of schizophrenia with the Generalized Singular Value Decomposition. BMC Syst Biol 5: 72.
    • (2011) BMC Syst Biol , vol.5 , pp. 72
    • Xiao, X.1    Dawson, N.2    Macintyre, L.3    Morris, B.J.4    Pratt, J.A.5
  • 33
    • 76749151747 scopus 로고    scopus 로고
    • Effect of subchronic phencyclidine administration on sucrose preference and hippocampal parvalbumin immunoreactivity in the rat
    • Jenkins TA, Harte MK, Reynolds GP, (2010) Effect of subchronic phencyclidine administration on sucrose preference and hippocampal parvalbumin immunoreactivity in the rat. Neurosci Lett 471: 144-147.
    • (2010) Neurosci Lett , vol.471 , pp. 144-147
    • Jenkins, T.A.1    Harte, M.K.2    Reynolds, G.P.3
  • 34
    • 0034940329 scopus 로고    scopus 로고
    • GABAergic neuronal subtypes in the human frontal cortex-development and deficits in schizophrenia
    • Reynolds GP, Beasley CL, (2001) GABAergic neuronal subtypes in the human frontal cortex-development and deficits in schizophrenia. J Chem Neuroanat 22: 95-100.
    • (2001) J Chem Neuroanat , vol.22 , pp. 95-100
    • Reynolds, G.P.1    Beasley, C.L.2
  • 35
    • 29544439968 scopus 로고    scopus 로고
    • Proteome analysis of cortical neuronal cultures following cycloheximide, heat stress and MK801 preconditioning
    • Meloni BP, Van Dyk D, Cole R, Knuckey NW, (2005) Proteome analysis of cortical neuronal cultures following cycloheximide, heat stress and MK801 preconditioning. Proteomics 5: 4743-4753.
    • (2005) Proteomics , vol.5 , pp. 4743-4753
    • Meloni, B.P.1    Van Dyk, D.2    Cole, R.3    Knuckey, N.W.4
  • 37
    • 0036550998 scopus 로고    scopus 로고
    • Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia
    • Middleton FA, Mirnics K, Pierri JN, Lewis DA, Levitt P, (2002) Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia. J Neurosci 22: 2718-2729.
    • (2002) J Neurosci , vol.22 , pp. 2718-2729
    • Middleton, F.A.1    Mirnics, K.2    Pierri, J.N.3    Lewis, D.A.4    Levitt, P.5
  • 38
    • 0038403903 scopus 로고    scopus 로고
    • Differential roles of alanine in GABAergic and glutamatergic neurons
    • Schousboe A, Sonnewald U, Waagepetersen HS, (2003) Differential roles of alanine in GABAergic and glutamatergic neurons. Neurochem Int 43: 311-315.
    • (2003) Neurochem Int , vol.43 , pp. 311-315
    • Schousboe, A.1    Sonnewald, U.2    Waagepetersen, H.S.3
  • 39
    • 0033929168 scopus 로고    scopus 로고
    • A possible role of alanine for ammonia transfer between astrocytes and glutamatergic neurons
    • Waagepetersen HS, Sonnewald U, Larsson OM, Schousboe A, (2000) A possible role of alanine for ammonia transfer between astrocytes and glutamatergic neurons. J Neurochem 75: 471-479.
    • (2000) J Neurochem , vol.75 , pp. 471-479
    • Waagepetersen, H.S.1    Sonnewald, U.2    Larsson, O.M.3    Schousboe, A.4
  • 40
    • 78650307890 scopus 로고    scopus 로고
    • A novel balanced chromosomal translocation found in subjects with schizophrenia and schizotypal personality disorder: altered l-serine level associated with disruption of PSAT1 gene expression
    • Ozeki Y, Pickard BS, Kano S, Malloy MP, Zeledon M, et al. (2011) A novel balanced chromosomal translocation found in subjects with schizophrenia and schizotypal personality disorder: altered l-serine level associated with disruption of PSAT1 gene expression. Neurosci Res 69: 154-160.
    • (2011) Neurosci Res , vol.69 , pp. 154-160
    • Ozeki, Y.1    Pickard, B.S.2    Kano, S.3    Malloy, M.P.4    Zeledon, M.5
  • 41
    • 56449112094 scopus 로고    scopus 로고
    • Changes in plasma glycine, L-serine, and D-serine levels in patients with schizophrenia as their clinical symptoms improve: results from the Juntendo University Schizophrenia Projects (JUSP)
    • Ohnuma T, Sakai Y, Maeshima H, Hatano T, Hanzawa R, et al. (2008) Changes in plasma glycine, L-serine, and D-serine levels in patients with schizophrenia as their clinical symptoms improve: results from the Juntendo University Schizophrenia Projects (JUSP). Prog Neuropsychopharmacol Biol Psychiatry 32: 1905-1912.
    • (2008) Prog Neuropsychopharmacol Biol Psychiatry , vol.32 , pp. 1905-1912
    • Ohnuma, T.1    Sakai, Y.2    Maeshima, H.3    Hatano, T.4    Hanzawa, R.5
  • 42
    • 77952240030 scopus 로고    scopus 로고
    • Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS
    • Ariyannur PS, Moffett JR, Manickam P, Pattabiraman N, Arun P, et al. (2010) Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS. Brain Res 1335: 1-13.
    • (2010) Brain Res , vol.1335 , pp. 1-13
    • Ariyannur, P.S.1    Moffett, J.R.2    Manickam, P.3    Pattabiraman, N.4    Arun, P.5
  • 45
    • 0035816627 scopus 로고    scopus 로고
    • Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95
    • Sun Y, Savanenin A, Reddy PH, Liu YF, (2001) Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95. J Biol Chem 276: 24713-24718.
    • (2001) J Biol Chem , vol.276 , pp. 24713-24718
    • Sun, Y.1    Savanenin, A.2    Reddy, P.H.3    Liu, Y.F.4
  • 46
    • 77958156339 scopus 로고    scopus 로고
    • In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects
    • Faideau M, Kim J, Cormier K, Gilmore R, Welch M, et al. (2010) In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects. Hum Mol Genet 19: 3053-3067.
    • (2010) Hum Mol Genet , vol.19 , pp. 3053-3067
    • Faideau, M.1    Kim, J.2    Cormier, K.3    Gilmore, R.4    Welch, M.5
  • 47
    • 80051964408 scopus 로고    scopus 로고
    • The role of energy metabolism dysfunction and oxidative stress in schizophrenia revealed by proteomics
    • Martins-de-Souza D, Harris LW, Guest PC, Bahn S, (2011) The role of energy metabolism dysfunction and oxidative stress in schizophrenia revealed by proteomics. Antioxid Redox Signal 15: 2067-2079.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 2067-2079
    • Martins-de-Souza, D.1    Harris, L.W.2    Guest, P.C.3    Bahn, S.4
  • 48
    • 84856120944 scopus 로고    scopus 로고
    • From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment
    • Moghaddam B, Javitt D, (2012) From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment. Neuropsychopharmacology 37: 4-15.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 4-15
    • Moghaddam, B.1    Javitt, D.2


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