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Volumn 110, Issue 2, 2013, Pages 203-214

A4S: A user-friendly graphical tool for pharmacokinetic and pharmacodynamic (PK/PD) simulation

Author keywords

Compartmental analysis; Matlab; Model based drug development; NONMEM; Pharmacokinetic and pharmacodynamic; Tumor Growth Inhibition model

Indexed keywords

COMPARTMENTAL ANALYSIS; DRUG DEVELOPMENT; EFFECTIVE COMMUNICATION; LARGE-SCALE DISTRIBUTION; MATHEMATICAL PRINCIPLE; MODELING AND SIMULATION; NONMEM; TUMOR GROWTH INHIBITION MODELS;

EID: 84875896804     PISSN: 01692607     EISSN: 18727565     Source Type: Journal    
DOI: 10.1016/j.cmpb.2012.10.006     Document Type: Article
Times cited : (10)

References (36)
  • 4
    • 15844380596 scopus 로고    scopus 로고
    • Modelling and simulation to improve decision-making in clinical development
    • Burman C.F., Hamrèn B., Olsson P. Modelling and simulation to improve decision-making in clinical development. Pharmaceutical Statistics 2005, 4:47-58.
    • (2005) Pharmaceutical Statistics , vol.4 , pp. 47-58
    • Burman, C.F.1    Hamrèn, B.2    Olsson, P.3
  • 5
    • 0035693563 scopus 로고    scopus 로고
    • Utilization of pharmacokinetic-pharmacodynamic modelling and simulation in regulatory decision-making
    • Gobburu J.V.S., Marroum P.J. Utilization of pharmacokinetic-pharmacodynamic modelling and simulation in regulatory decision-making. Clinical Pharmacokinetics 2001, 40:883-892.
    • (2001) Clinical Pharmacokinetics , vol.40 , pp. 883-892
    • Gobburu, J.V.S.1    Marroum, P.J.2
  • 9
    • 78449281731 scopus 로고    scopus 로고
    • Interactive visualization and communication for increased impact of pharmacometrics
    • Krause A., Gieschke R. Interactive visualization and communication for increased impact of pharmacometrics. The Journal of Clinical Pharmacology 2010, 50:140S-145S.
    • (2010) The Journal of Clinical Pharmacology , vol.50
    • Krause, A.1    Gieschke, R.2
  • 12
    • 84875883577 scopus 로고    scopus 로고
    • Basic concepts in population modeling, simulation, and model-based drug development
    • Mould D.R., Upton R.N. Basic concepts in population modeling, simulation, and model-based drug development. Pharmacometrics & Systems Pharmacology 2012, 1:e6. 10.1038/psp.2012.4.
    • (2012) Pharmacometrics & Systems Pharmacology , vol.1
    • Mould, D.R.1    Upton, R.N.2
  • 15
    • 77950535995 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic reasoning in drug discovery and early development
    • Van Der Graaf P.H., Gabrielsson J. Pharmacokinetic-pharmacodynamic reasoning in drug discovery and early development. Future Medicinal Chemistry 2009, 1(8):1371-1374.
    • (2009) Future Medicinal Chemistry , vol.1 , Issue.8 , pp. 1371-1374
    • Van Der Graaf, P.H.1    Gabrielsson, J.2
  • 16
    • 18244382840 scopus 로고    scopus 로고
    • A spreadsheet program for modeling quantitative structure-pharmacokinetic relationships for inhaled volatile organics in humans
    • Beliveau M., Krishnan K. A spreadsheet program for modeling quantitative structure-pharmacokinetic relationships for inhaled volatile organics in humans. SAR and QSAR in Environmental Research 2005, 16:63-77.
    • (2005) SAR and QSAR in Environmental Research , vol.16 , pp. 63-77
    • Beliveau, M.1    Krishnan, K.2
  • 17
    • 14844342828 scopus 로고    scopus 로고
    • Estimation of pharmacokinetic parameters from non-compartmental variables using Microsoft Excel
    • Dansirikul A., Choi M., Duffull S.B. Estimation of pharmacokinetic parameters from non-compartmental variables using Microsoft Excel. Computers in Biology and Medicine 2005, 35:389-403.
    • (2005) Computers in Biology and Medicine , vol.35 , pp. 389-403
    • Dansirikul, A.1    Choi, M.2    Duffull, S.B.3
  • 18
    • 0028500485 scopus 로고
    • A non-linear fitting program in pharmacokinetics with Microsoft Excel spreadsheet
    • Delboy H. A non-linear fitting program in pharmacokinetics with Microsoft Excel spreadsheet. International Journal of Bio-Medical Computing 1994, 37:1-14.
    • (1994) International Journal of Bio-Medical Computing , vol.37 , pp. 1-14
    • Delboy, H.1
  • 19
    • 36148980068 scopus 로고    scopus 로고
    • Brockmoller Simulation of complex pharmacokinetic models in Microsoft Excel
    • Meineke J., Brockmoller Simulation of complex pharmacokinetic models in Microsoft Excel. Computer Methods and Programs in Biomedicine 2007, 88:239-245.
    • (2007) Computer Methods and Programs in Biomedicine , vol.88 , pp. 239-245
    • Meineke, J.1
  • 23
    • 0035730322 scopus 로고    scopus 로고
    • General pharmacokinetic model for drugs exhibiting target-mediated drug disposition
    • Mager D.E., Jusko W.J. General pharmacokinetic model for drugs exhibiting target-mediated drug disposition. Journal of Pharmacokinetics and Pharmacodynamics 2001, 28:507-532.
    • (2001) Journal of Pharmacokinetics and Pharmacodynamics , vol.28 , pp. 507-532
    • Mager, D.E.1    Jusko, W.J.2
  • 27
    • 67649306822 scopus 로고    scopus 로고
    • Incorporating receptor theory in mechanism-based pharmacokinetic-pharmacodynamic (PK-PD modeling)
    • Ploeger B.A., van der Graaf P.H., Danhof M. Incorporating receptor theory in mechanism-based pharmacokinetic-pharmacodynamic (PK-PD modeling). Drug Metabolism and Pharmacokinetics 2009, 24(1):3-15.
    • (2009) Drug Metabolism and Pharmacokinetics , vol.24 , Issue.1 , pp. 3-15
    • Ploeger, B.A.1    van der Graaf, P.H.2    Danhof, M.3
  • 28
    • 80052569232 scopus 로고    scopus 로고
    • Quantitative pharmacological analysis of antagonist binding kinetics at CRF1 receptors in vitro and in vivo
    • Ramsey S.J., Attkins N.J., Fish R., van der Graaf P.H. Quantitative pharmacological analysis of antagonist binding kinetics at CRF1 receptors in vitro and in vivo. British Journal of Pharmacology 2011, 164(3):992-1007.
    • (2011) British Journal of Pharmacology , vol.164 , Issue.3 , pp. 992-1007
    • Ramsey, S.J.1    Attkins, N.J.2    Fish, R.3    van der Graaf, P.H.4
  • 30
    • 0842282616 scopus 로고    scopus 로고
    • Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents
    • Simeoni M., Magni P., Cammia C., De Nicolao G., Croci V., Pesenti E., Germani M., Poggesi I., Rocchetti M. Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents. Cancer Research 2004, 64:1094-1101.
    • (2004) Cancer Research , vol.64 , pp. 1094-1101
    • Simeoni, M.1    Magni, P.2    Cammia, C.3    De Nicolao, G.4    Croci, V.5    Pesenti, E.6    Germani, M.7    Poggesi, I.8    Rocchetti, M.9
  • 31
    • 79956201217 scopus 로고    scopus 로고
    • Mathematical analysis of the pharmacokinetic-pharmacodynamic (PKPD) behaviour of monoclonal antibodies: predicting in vivo potency
    • Aston P.J., Derks G., Raji A., Agoram B.M., van der Graaf P.H. Mathematical analysis of the pharmacokinetic-pharmacodynamic (PKPD) behaviour of monoclonal antibodies: predicting in vivo potency. Journal of Theoretical Biology 2011, 281(1):113-121.
    • (2011) Journal of Theoretical Biology , vol.281 , Issue.1 , pp. 113-121
    • Aston, P.J.1    Derks, G.2    Raji, A.3    Agoram, B.M.4    van der Graaf, P.H.5
  • 32
    • 0032777107 scopus 로고    scopus 로고
    • Qualitative and quantitative assessment of relative agonist efficacy
    • Christopoulos A., El-Fakahany E.E. Qualitative and quantitative assessment of relative agonist efficacy. Biochemical Pharmacology 1999, 58(5):735-748.
    • (1999) Biochemical Pharmacology , vol.58 , Issue.5 , pp. 735-748
    • Christopoulos, A.1    El-Fakahany, E.E.2
  • 35
    • 0002762924 scopus 로고    scopus 로고
    • Pharmacodynamics. Mechanisms of drug action and the relationship between drug concentration and effect
    • McGraw-Hill, New York, J.G. Hardman, L.E. Limbird (Eds.)
    • Ross E.M., Kenakin T.P. Pharmacodynamics. Mechanisms of drug action and the relationship between drug concentration and effect. Goodman & Gilman's The Pharmacological Basis of Therapeutics, vol. Tenth 2001, McGraw-Hill, New York. J.G. Hardman, L.E. Limbird (Eds.).
    • (2001) Goodman & Gilman's The Pharmacological Basis of Therapeutics, vol. Tenth
    • Ross, E.M.1    Kenakin, T.P.2
  • 36
    • 84856090378 scopus 로고    scopus 로고
    • TGI-Simulator: a visual tool to support the preclinical phase of the drug discovery process by assessing in silico the effect of an anticancer drug
    • Terranova N., Magni P. TGI-Simulator: a visual tool to support the preclinical phase of the drug discovery process by assessing in silico the effect of an anticancer drug. Computer Methods and Programs in Biomedicine 2012, 105:162-174.
    • (2012) Computer Methods and Programs in Biomedicine , vol.105 , pp. 162-174
    • Terranova, N.1    Magni, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.