Interactive visualization and communication for increased impact of pharmacometrics

Journal of Clinical Pharmacology

Volumn 50, Issue 9, 2010, Pages

  Krause, Andreas ^a   Gieschke, Ronald ^b  

^a ACTELION PHARMACEUTICALS LTD   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

communication; decision making; Interactive visualization; model based drug development; modeling and simulation; pharmacokinetics pharmacodynamics; pharmacometrics

Indexed keywords

DATA ANALYSIS SOFTWARE; DECISION SUPPORT SYSTEM; DRUG RESEARCH; MATHEMATICAL MODEL; PHARMACOMETRY; QUANTITATIVE ANALYSIS; REVIEW; SIMULATION;

CLINICAL TRIALS AS TOPIC; COMMUNICATION; COMPUTER SIMULATION; DECISION MAKING; DRUG DESIGN; HUMANS; MODELS, THEORETICAL; PHARMACEUTICAL PREPARATIONS; SOFTWARE;

EID: 78449281731     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270010376964     Document Type: Review

References (19)

1. Lalonde RL, Kowalski KG, Hutmacher MM et al. Model-based drug development. Clinical Pharmacology & Therapeutics. 2007 ; 82: 21-32.
2. Dingemanse J., Appel-Dingemanse S. Integrated pharmacokinetics and pharmacodynamics in drug development. Clinical Pharmacokinetics. 2007 ; 46: 713-737.
3. Zhang L., Pfister M., Meibohm B. Concepts and challenges in quantitative pharmacology and model-based drug development. AAPS Journal. 2008 ; 10: 552-559.
4. Orloff J., Douglas F., Pinheiro J., et al. The future of drug development: advancing clinical trial design. Nature Reviews. Drug Discovery. 2009 ; 8: 949-957.
5. Boxenbaum H. Pharmacokinetics: philosophy of modeling. Drug Metabolism Reviews. 1992 ; 24: 89-120.
6. Keener J., Sneyd J. Mathematical Physiology. New York, NY: Springer ; 2008.
7. Yao L., Evans JA, Rzhetsky A. Novel opportunities for computational biology and sociology in drug discovery. Trends in Biotechnology. 2010 ; 28: 161-170.
8. Macey R., Oster G., Zahnley T. Berkeley Madonna user's guide, version 8.0.1. University of California ; 2006. http://www.berkeleymadonna.com/. Accessed June 30, 2010.
9. Beal S., Sheiner LB, Boeckmann A., Bauer RJ NONMEM User's Guides (1989-2009). Ellicott City, MD: Icon Development Solutions ; 2009.
10. R Development Core Team: R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria; 2009. http://www.R-project.org/. Accessed June 30, 2010.
11. Trial Simulator, version 2.2.1. Mountain View, CA: Pharsight Corporation ; 2006.
12. Tukey JW Exploratory Data Analysis. Reading, MA: Addison Wesley ; 1977.
13. Cleveland WS Visualizing Data. Summit, NJ: Hobart Press ; 1993.
14. Tufte ER Visual Explanations: Images and Quantities, Evidence and Narrative. Cheshire, CT: Graphics Press ; 1997.
15. Tufte ER The Visual Display of Quantitative Information. 2 nd ed. Cheshire, CT: Graphics Press ; 2001.
16. Stone J. Model-Based Drug Development PhRMA Initiative: mapping the current status and future state for modeling and simulation in the pharmaceutical industry. Paper presented at: American Conference on Pharmacometrics ; October 4-7, 2009 ; Mashantucket, CT.
17. Fitzharris A. Mathematical modelling and communication skills. Mathematics Support Association Newsletter. 1997 ; 7: 21-22.
18. Mathematica, version 7. Champaign, IL: Wolfram Research ; 2009.
19. Simulink and SimBiology, R2009b. Natick, MA: TheMathworks ; 2009.