Metabolomic phenotyping validates the infant rhesus monkey as a model of human infant metabolism

Journal of Pediatric Gastroenterology and Nutrition

Volumn 56, Issue 4, 2013, Pages 355-363

  O'Sullivan, Aifric ^a   He, Xuan ^a   McNiven, Elizabeth M S ^a   Hinde, Katie ^b   Haggarty, Neill W ^c   Lönnerdal, Bo ^a   Slupsky, Carolyn M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HARVARD UNIVERSITY   (United States)

^c FONTERRA RESEARCH CENTRE   (New Zealand)

Author keywords

1H NMR spectroscopy; infant nutrition; metabolomics; milk microbiome; rhesus macaque

Indexed keywords

OLIGOSACCHARIDE; RNA 16S;

ANIMAL EXPERIMENT; ARTICLE; BLOOD ANALYSIS; BREAST FEEDING; BREAST MILK; COMMUNITY STRUCTURE; CONTROLLED STUDY; FEMALE; GENE SEQUENCE; HUMAN; INFANT; INFANT NUTRITION; LACTATION; METABOLISM; METABOLOMICS; MICROBIAL COMMUNITY; MICROBIOME; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RHESUS MONKEY; URINALYSIS;

ANIMALS; BLOOD; CHILD DEVELOPMENT; FEMALE; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; INFANT; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; MACACA MULATTA; MALE; METABOLOMICS; MILK; MILK, HUMAN; MODELS, ANIMAL; MOLECULAR TYPING; SPECIES SPECIFICITY; URINE;

MACACA MULATTA;

EID: 84875871901     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0b013e31827e1f07     Document Type: Article

References (44)

1. Baker DH. Animal models in nutrition research. J Nutr 2008;138: 391-6.
2. Gardner MB, Luciw PA. Macaque models of human infectious disease. ILAR J 2008;49:220-55.
3. Gibbs RA, Rogers J, et al. Evolutionary and biomedical insights from the rhesus macaque genome. Science 2007;316:222-34.
4. Bodkin NL, Hannah JS, et al. Central obesity in rhesus monkeys: Association with hyperinsulinemia, insulin resistance and hypertrigly-ceridemia? Int J Obes Relat Metab Disord 1993;17:53-61.
5. Adams Waldorf KM, Rubens CE, et al. Use of nonhuman primate models to investigate mechanisms of infection-associated preterm birth. BJOG: Int J Ob Gynaecol 2011;118:136-44.
6. Hinde K, Capitanio JP. Lactational programming? Mother's milk energy predicts infant behavior and temperament in rhesus macaques (macaca mulatta). Am J Primatol 2010;72:522-9.
7. Golub MS, Hogrefe CE, et al. Neurobehavioral evaluation of rhesus monkey infants fed cow's milk formula, soy formula, or soy formula with added manganese. Neurotoxicol Teratol 2005;27:615-27.
8. Kelleher SL, Casas I, et al. Supplementation of infant formula with the probiotic lactobacillus reuteri and zinc: impact on enteric infection and nutrition in infant rhesus monkeys. J Pediatr Gastroenterol Nutr 2002;35:162-8.
9. Lonnerdal B. Preclinical assessment of infant formula. Annals Nutr Metabol 2012;60:196-9.
10. Slupsky CM, Steed H, et al. Urine metabolite analysis offers potential early diagnosis of ovarian and breast cancers. Clin Cancer Res 2010;16:5835-41.
11. O'Sullivan A, Gibney MJ, et al. Dietary intake patterns are reflected in metabolomic profiles: potential role in dietary assessment studies. Am J Clin Nutr 2011;93:314-21.
12. O'Sullivan A, Gibney MJ, et al. Biochemical and metabolomic phe-notyping in the identification of a vitamin D responsive metabotype for markers of the metabolic syndrome. Mol Nutr Food Res 2011;55: 679-90.
13. Patterson AD, Bonzo JA, et al. Metabolomics reveals attenuation of the slc6a20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus. J Biol Chem 2011;286:19511-22.
14. Salek RM, Maguire ML, et al. A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human. Physiol Genomics 2007;29:99-108.
15. van Doorn M, Vogels J, et al. Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in type 2 diabetes mellitus patients and healthy volunteers. BrJ Clin Pharmacol 2007;63:562-74.
16. Hinde K, Power ML, et al. Rhesus macaque milk: magnitude, sources, and consequences of individual variation over lactation. Am J Phys Anthropol 2009;138:148-57.
17. Slupsky CM, Rankin KN, et al. Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles. Anal Chem 2007;79:6995-7004.
18. Weljie AM, Newton J, et al. Targeted profiling: quantitative analysis of 1 h nmr metabolomics data. Anal Chem 2006;78:4430-42.
19. Bokulich NA, Joseph CML, et al. Next-generation sequencing reveals significant bacterial diversity of botrytized wine. PLoS ONE 2012;7: e36357.
20. Werner JJ, Zhou D, et al. Comparison of illumina paired-end and single-direction sequencing for microbial 16 s rrna gene amplicon surveys. ISME J 2012;6:1273-6.
21. Caporaso JG, Kuczynski J, et al. Qiime allows analysis of high-throughput community sequencing data. Nature Meth 2010;7:335-6.
22. Edgar RC. Search and clustering orders of magnitude faster than blast. Bioinformatics 2010;26:2460-1.
23. Yatsunenko T, Rey FE, et al. Human gut microbiome viewed across age and geography. Nature 2012;486:222-7.
24. Caporaso JG, Bittinger K, et al. Pynast: a flexible tool for aligning sequences to a template alignment. Bioinformatics 2010;26:266-7.
25. DeSantis TZ, Hugenholtz P, et al. Nast: a multiple sequence alignment server for comparative analysis of 16s rrna genes. Nucleic Acids Res 2006; 34(Web Server issue):W394-9.
26. Price MN, Dehal PS, et al. Fasttree: computing large minimum evolution trees with profiles instead of a distance matrix. Mol Biol Evol 2009;26:1641-50.
27. Hinde R, Bowell T, et al. Behaviour of socially living rhesus monkeys in their first six months. Proc Zool Soc London 1964;143:609-49.
28. Haberthur K, Engelman F, et al. Immune senescence in aged nonhuman primates. Exp Gerontol 2010;45:655-61.
29. Nelson EE, Winslow JT. Non-human primates: model animals for developmental psychopathology. Neuropsychopharmacol 2009;34: 90-105.
30. Walsh MC, Nugent A, et al. Understanding the metabolome-challenges for metabolomics. Nutr Bull 2008;33:316-23.
31. Younoszai MK, Andersen DW, et al. Urinary excretion of endogenous hydroxyproline by normal male infants. Pediatr Res 1967;1:266-70.
32. Walsh MC, Brennan L, et al. Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans. Am J Clin Nutr 2006;84:531-9.
33. Zeisel SH, da Costa K-A. Choline: An essential nutrient for public health. Nutr Rev 2009;67:615-23.
34. Ilcol YO, Ozbek R, et al. Choline status in newborns, infants, children, breast-feeding women, breast-fed infants and human breast milk. J Nutr Biochem 2005;16:489-99.
35. Braun LD, Cornford EM, et al. Newborn rabbit blood-brain barrier is selectively permeable and differs substantially from the adult. J Neu-rochem 1980;34:147-52.
36. Rassin DK, Sturman JA, et al. Taurine and other free amino acids in milk of man and other mammals. Early Hum Develop 1978;2:1-13.
37. Agostoni C, Carratù B, et al. Free glutamine and glutamic acid increase in human milk through a three-month lactation period. J Pediatr Gastroenterol Nutr 2000;31:508-12.
38. Balaban RS, Burg MB. Osmotically active organic solutes in the renal inner medulla. Kidney Int 1987;31:562-4.
39. Beck FX, Burger-Kentischer A, et al. Cellular response to osmotic stress in the renal medulla. Eur J Physiol 1998;436:814-27.
40. Sizeland P, Chambers S, et al. Organic osmolytes in human and other mammalian kidneys. Kidney Int 1993;43:448-53.
41. Kunz C, Rudloff S. Potential anti-inflammatory and anti-infectious effects of human milk oligosaccharides. Adv Exp Med Biol 2008; 606:455-66.
42. Goto K, Fukuda K, et al. Chemical characterization of oligosaccharides in the milk of six species of new and old world monkeys. Glycoconju-gate J 2010;27:703-15.
43. Tao N, Wu S, et al. Evolutionary glycomics: characterization of milk oligosaccharides in primates. J Proteome Res 2011;10:1548-57.
44. Zivkovic AM, German JB, et al. Human milk glycobiome and its impact on the infant gastrointestinal microbiota. Proc Natl Acad Sci USA 2011;108 (suppl 1):4653-8.