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Journal of Pharmacology and Experimental Therapeutics

Volumn 298, Issue 3, 2001, Pages 1252-1259

P-glycoprotein efflux at the blood-brain barrier mediates differences in brain disposition and pharmacodynamics between two structurally related neurokinin-1 receptor antagonists

(6) Smith, Bill J a Doran, Angela C a Mclean, Stafford a Tingley III, F David a O'Neill, Brian T a Kajiji, Shama M b

a PFIZER INC (United States)

b PFIZER GLOBAL RESEARCH AND DEVELOPMENT (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 METHOXY 5 TRIFLUOROMETHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; 5 AMINOVALERYLSUBSTANCE P [7-11][9 PROLINE 10 (N METHYLLEUCINE)]; ADENOSINE TRIPHOSPHATASE; CP 141938; GLYCOPROTEIN P; MS 073; MULTIDRUG RESISTANCE PROTEIN; NEUROKININ 1 RECEPTOR ANTAGONIST; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL STRAIN; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG STRUCTURE; DRUG TRANSPORT; ENZYME ACTIVITY; GERBIL; MALE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATASES; ANIMALS; BEHAVIOR, ANIMAL; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD-BRAIN BARRIER; BRAIN; GENES, MDR; GERBILLINAE; MALE; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; P-GLYCOPROTEIN; PIPERIDINES; RECEPTORS, NEUROKININ-1;

EID: 0034883081 PISSN: 00223565 EISSN: None Source Type: Journal
DOI: None Document Type: Article

Times cited : (40)

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