The influence of folate supplementation on global gene expression in normal colonic mucosa of subjects with colorectal adenoma

Molecular Nutrition and Food Research

Volumn 57, Issue 4, 2013, Pages 709-720

  Pufulete, Maria ^a,b   Abbadi, Reyad Al Ghnaniem ^a   Arno, Matthew ^a   Ewins, Mark ^a   Green, Caroline ^a   Astarloa, Estibaliz Aldecoa Otalora ^a   Sanders, Tom ^a   Emery, Peter ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Adenoma; Colorectal cancer; Folate; Gene expression; Microarray

Indexed keywords

FOLIC ACID;

AGED; ARTICLE; BLOOD; CELL DIVISION; COLON; COLORECTAL TUMOR; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA MICROARRAY; DOWN REGULATION; DRUG EFFECT; FEMALE; GENE EXPRESSION; GENETICS; HUMAN; INTESTINE MUCOSA; MALE; METABOLISM; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; REAL TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY; UPREGULATION;

AGED; CELL DIVISION; COLON; COLORECTAL NEOPLASMS; DIETARY SUPPLEMENTS; DOWN-REGULATION; FEMALE; FOLIC ACID; GENE EXPRESSION; HUMANS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; UP-REGULATION;

EID: 84875848179     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201200617     Document Type: Article

References (47)

1. Kennedy, D. A., Stern, S. J., Moretti, M., Matok, I. et al., Folate intake and the risk of colorectal cancer: a systematic review and meta-analysis. Cancer Epidemiol. 2011, 35, 2-10.
2. Mason, J. B., Unraveling the complex relationship between folate and cancer risk. Biofactors 2011, 37, 253-260.
3. Basten, G. P., Duthie, S. J., Pirie, L., Vaughan, N. et al., Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers. Br. J. Cancer 2006, 94, 1942-1947.
4. Cravo, M. L., Pinto, A. G., Chaves, P., Cruz, J. A. et al., Effect of folate supplementation on DNA methylation of rectal mucosa in patients with colonic adenomas: correlation with nutrient intake. Clin. Nutr. 1998, 17, 45-49.
5. Kim, Y. I., Baik, H. W., Fawaz, K., Knox, T. et al., Effects of folate supplementation on two provisional molecular markers of colon cancer: a prospective, randomized trial. Am. J. Gastroenterol. 2001, 96, 184-195.
6. Pufulete, M., Al-Ghnaniem, R., Khushal, A., Appleby, P., et al., Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma. Gut 2005, 54, 648-653.
7. van den Donk, M., Pellis, L., Crott, J. W., van Engeland, M. et al., Folic acid and vitamin B-12 supplementation does not favorably influence uracil incorporation and promoter methylation in rectal mucosa DNA of subjects with previous colorectal adenomas. J. Nutr. 2007, 137, 2114-2120.
8. Courtemanche, C., Huang, A. C., Elson-Schwab, I., Kerry, N. et al., Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison. FASEB J. 2004, 18, 209-211.
9. Crott, J. W., Choi, S. W., Ordovas, J. M., Ditelberg, J. S. et al., Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: implications for carcinogenesis. Carcinogenesis 2004, 25, 69-76.
10. Jhaveri, M. S., Wagner, C., Trepel, J. B., Impact of extracellular folate levels on global gene expression. Mol. Pharmacol. 2001, 60, 1288-1295.
11. Junaid, M. A., Kuizon, S., Cardona, J., Azher, T., et al., Folic acid supplementation dysregulates gene expression in lymphoblastoid cells-implications in nutrition. Biochem. Biophys. Res. Commun. 2011, 412, 688-692.
12. Katula, K. S., Heinloth, A. N., Paules, R. S., Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J. Nutr. Biochem. 2007, 18, 541-552.
13. Knock, E., Deng, L., Wu, Q., Leclerc, D. et al., Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c. Cancer Res. 2006, 66, 10349-10356.
14. Pufulete, M., Emery, P. W., Nelson, M., Sanders, T. A., Validation of a short food frequency questionnaire to assess folate intake. Br. J. Nutr. 2002, 87, 383-390.
15. Barbaux, S., Kluijtmans, L. A., Whitehead, A. S., Accurate and rapid "multiplex heteroduplexing" method for genotyping key enzymes involved in folate/homocysteine metabolism. Clin. Chem. 2000, 46, 907-912.
16. Balaghi, M., Wagner, C., DNA methylation in folate deficiency: use of CpG methylase. Biochem. Biophys. Res. Commun. 1993, 193, 1184-1190.
17. Livak, K. J., Schmittgen, T. D., Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25, 402-408.
18. Wolfinger, R. D., Gibson, G., Wolfinger, E. D., Bennett, L. et al., Assessing gene significance from cDNA microarray expression data via mixed models. J. Comput. Biol. 2001, 8, 625-637.
19. Benjamini, Y., Hochberg, Y., Controlling the false discovery rate: a practical and powerful apporach to multiple testing. J. R. Stat. Soc. 1995, 57, 289-300.
20. Draghici, S., Khatri, P., Bhavsar, P., Shah, A. et al., Onto-Tools, the toolkit of the modern biologist: Onto-Express, Onto-Compare, Onto-Design and Onto-Translate. Nucleic Acids Res. 2003, 31, 3775-3781.
21. Khatri, P., Draghici, S., Ostermeier, G. C., Krawetz, S. A., Profiling gene expression using onto-express. Genomics 2002, 79, 266-270.
22. Kapitanovic, S., Cacev, T., Berkovic, M., Popovic-Hadzija, M. et al., nm23-H1 expression and loss of heterozygosity in colon adenocarcinoma. J. Clin. Pathol. 2004, 57, 1312-1318.
23. Saha, S., Bardelli, A., Buckhaults, P., Velculescu, V. E. et al., A phosphatase associated with metastasis of colorectal cancer. Science 2001, 294, 1343-1346.
24. Furuta, K., Zahurak, M., Yang, X. L., Rosada, C. et al., Relationship between CD44 expression and cell proliferation in epithelium and stroma of colorectal neoplasms. Am. J. Pathol. 1996, 149, 1147-1155.
25. Koshida, S., Kobayashi, D., Moriai, R., Tsuji, N. et al., Specific overexpression of OLFM4(GW112/HGC-1) mRNA in colon, breast and lung cancer tissues detected using quantitative analysis. Cancer Sci. 2007, 98, 315-320.
26. Friedman, J. B., Brunschwig, E. B., Platzer, P., Wilson, K. et al., C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer. Int. J. Cancer 2004, 111, 72-75.
27. Chew, E. H., Matthews, C. S., Zhang, J., McCarroll, A. J. et al., Antitumor quinols: role of glutathione in modulating quinol-induced apoptosis and identification of putative cellular protein targets. Biochem. Biophys. Res. Commun. 2006, 346, 242-251.
28. Kim, J. S., Lee, Y. C., Nam, H. T., Li, G. et al., Apicularen A induces cell death through Fas ligand up-regulation and microtubule disruption by tubulin down-regulation in HM7 human colon cancer cells. Clin. Cancer Res. 2007, 13, 6509-6517.
29. Grant, K., Knowles, J., Dawas, K., Burnstock, G. et al., Mechanisms of endothelin 1-stimulated proliferation in colorectal cancer cell lines. Br. J. Surg. 2007, 94, 106-112.
30. Fernandez, J. C., Vizoso, F. J., Corte, M. D., Gava, R. R. et al., CD44s expression in resectable colorectal carcinomas and surrounding mucosa. Cancer Invest. 2004, 22, 878-885.
31. Liu, Y. J., Yan, P. S., Li, J., Jia, J. F., Expression and significance of CD44s, CD44v6, and nm23 mRNA in human cancer. World J. Gastroenterol. 2005, 11, 6601-6606.
32. Aviram, R., Deutsch, A., Patya, M., Nordenberg, J. et al., Biochemical tissue markers of human colorectal carcinoma. Dis. Colon Rectum 1988, 31, 176-180.
33. Nordenberg, J., Aviram, R., Beery, E., Stenzel, K. H. et al., Inhibition of 6-phosphogluconate dehydrogenase by glucose 1, 6-diphosphate in human normal and malignant colon extracts. Cancer Lett. 1984, 23, 193-199.
34. Park, H. J., Yoon, S. H., Han, L. S., Zheng, L. T. et al., Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells. World J. Gastroenterol. 2005, 11, 5156-5161.
35. Xu, Z., Liang, L., Wang, H., Li, T., Zhao, M., HCRP1, a novel gene that is downregulated in hepatocellular carcinoma, encodes a growth-inhibitory protein. Biochem. Biophys. Res. Commun. 2003, 311, 1057-1066.
36. Protiva, P., Mason, J. B., Liu, Z., Hopkins, M. E. et al., Altered folate availability modifies the molecular environment of the human colorectum: implications for colorectal carcinogenesis. Cancer Prev. Res. 2011, 4, 530-543.
37. Smith-Beckerman, D. M., Fung, K. W., Williams, K. E., Auersperg, N. et al., Proteome changes in ovarian epithelial cells derived from women with BRCA1 mutations and family histories of cancer. Mol. Cell. Proteomics 2004, 4, 156-168.
38. Arun, C., London, N. J., Hemingway, D. M., Prognostic significance of elevated endothelin-1 levels in patients with colorectal cancer. Int. J. Biol. Markers 2004, 19, 32-37.
39. Huh, J. W., Kim, H. R., Kim, Y. J., Lee, J. H. et al., Expression of standard CD44 in human colorectal carcinoma: association with prognosis. Pathol. Int. 2009, 59, 241-246.
40. Nishimura, S., Tsuda, H., Ito, K., Jobo, T. et al., Differential expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of different organs. Hum. Pathol. 2006, 38, 134-139.
41. Hao, C. Y., Moore, D.H., Chiu, Y. S., Wong, P. et al., Altered gene expression in normal colonic mucosa of individuals with polyps of the colon. Dis. Colon Rectum 2005, 48, 2329-2335.
42. Hutchins, J. T., Reading, C. L., Giavazzi, R., Hoaglund, J. et al., Distribution of mono-, di, and tri-O-acetylated sialic acids in normal and neoplastic colon. Cancer Res. 1988, 48, 483-489.
43. Hao, C. Y., Moore, D. H., Wong, P., Bennington, J. L. et al., Alteration of gene expression in macroscopically normal colonic mucosa from individuals with a family history of sporadic colon cancer. Clin. Cancer Res. 2005, 11, 1400-1407.
44. Anti, M., Armuzzi, A., Morini, S., Iascone, E. et al., Severe imbalance of cell proliferation and apoptosis in the left colon and in the rectosigmoid tract in subjects with a history of large adenomas. Gut 2001, 48, 238-246.
45. Cole, B. F., Baron, J. A., Sandler, R. S., Haile, R. W. et al., Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 2007, 297, 2351-2359.
46. Thal, D., Xavier, C. P., Rosentreter, A., Linder, S. et al., Expression of coronin-3 (coronin-1C) in diffuse gliomas is related to malignancy. J. Pathol. 2008, 214, 415-424.
47. Pellis, L., Franssen-van Hal, N. L., Burema, J., Keijer, J., The intraclass correlation coefficient applied for evaluation of data correction, labeling methods, and rectal biopsy sampling in DNA microarray experiments. Physiol. Genom. 2003, 16, 99-106.