-
1
-
-
84861355868
-
Hepcidin and iron homeostasis
-
Ganz T, Nemeth E. Hepcidin and iron homeostasis. Biochim Biophys Acta. 2012;1823(9):1434-1443.
-
(2012)
Biochim Biophys Acta.
, vol.1823
, Issue.9
, pp. 1434-1443
-
-
Ganz, T.1
Nemeth, E.2
-
2
-
-
80054838641
-
Beta-thalassemia: A model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism
-
Ginzburg Y, Rivella S. beta-thalassemia: A model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism. Blood. 2011; 118(16):4321-4330.
-
(2011)
Blood.
, vol.118
, Issue.16
, pp. 4321-4330
-
-
Ginzburg, Y.1
Rivella, S.2
-
3
-
-
78649813036
-
Hepcidin as a therapeutic tool to limit iron overload and improve anemia in beta-thalassemic mice
-
Gardenghi S, et al. Hepcidin as a therapeutic tool to limit iron overload and improve anemia in beta-thalassemic mice. J Clin Invest. 2010; 120(12):4466-4477.
-
(2010)
J Clin Invest.
, vol.120
, Issue.12
, pp. 4466-4477
-
-
Gardenghi, S.1
-
4
-
-
0037847496
-
Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis
-
Nicolas G, et al. Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. Nat Genet. 2003;34(1):97-101.
-
(2003)
Nat Genet.
, vol.34
, Issue.1
, pp. 97-101
-
-
Nicolas, G.1
-
5
-
-
77952590062
-
Hepcidin treatment in hfe-/-mice diminishes plasma iron without affecting erythropoiesis
-
Moran-Jimenez MJ, et al. Hepcidin treatment in Hfe-/-mice diminishes plasma iron without affecting erythropoiesis. Eur J Clin Invest. 2010;40(6):511-517.
-
(2010)
Eur J Clin Invest.
, vol.40
, Issue.6
, pp. 511-517
-
-
Moran-Jimenez, M.J.1
-
6
-
-
84055190801
-
Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload
-
Preza GC, et al. Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload. J Clin Invest. 2011;121(12):4880-4888.
-
(2011)
J Clin Invest.
, vol.121
, Issue.12
, pp. 4880-4888
-
-
Preza, G.C.1
-
7
-
-
84875849962
-
Reducing TMPRSS6 ameliorates hemochromatosis and ®-thalassemia in mice
-
Guo S, et al. Reducing TMPRSS6 ameliorates hemochromatosis and ®-thalassemia in mice. J Clin Invest. 2013;123(4):1531-1541.
-
(2013)
J Clin Invest.
, vol.123
, Issue.4
, pp. 1531-1541
-
-
Guo, S.1
-
8
-
-
44449177930
-
The serine protease TMPRSS6 is required to sense iron deficiency
-
Du X, et al. The serine protease TMPRSS6 is required to sense iron deficiency. Science. 2008; 320(5879):1088-1092.
-
(2008)
Science.
, vol.320
, Issue.5879
, pp. 1088-1092
-
-
Du, X.1
-
9
-
-
56449096622
-
The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin
-
Silvestri L, et al. The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metab. 2008; 8(6):502-511.
-
(2008)
Cell Metab.
, vol.8
, Issue.6
, pp. 502-511
-
-
Silvestri, L.1
-
10
-
-
79955956398
-
Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice
-
Finberg KE, Whittlesey RL, Andrews NC. Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice. Blood. 2011;117(17):4590-4599.
-
(2011)
Blood.
, vol.117
, Issue.17
, pp. 4590-4599
-
-
Finberg, K.E.1
Whittlesey, R.L.2
Andrews, N.C.3
-
11
-
-
84861525631
-
Deletion of TMPRSS6 attenuates the phenotype in a mouse model of beta-thalassemia
-
Nai A, et al. Deletion of TMPRSS6 attenuates the phenotype in a mouse model of beta-thalassemia. Blood. 2012;119(21):5021-5029.
-
(2012)
Blood.
, vol.119
, Issue.21
, pp. 5021-5029
-
-
Nai, A.1
-
12
-
-
77949512140
-
RNA targeting therapeutics: Molecular mechanisms of antisense oligonucleotides as a therapeutic platform
-
Bennett CF, Swayze EE. RNA targeting therapeutics: Molecular mechanisms of antisense oligonucleotides as a therapeutic platform. Annu Rev Pharmacol Toxicol. 2010;50:259-293.
-
(2010)
Annu Rev Pharmacol Toxicol.
, vol.50
, pp. 259-293
-
-
Bennett, C.F.1
Swayze, E.E.2
-
13
-
-
76349118307
-
Transferrin therapy ameliorates disease in beta-thalassemic mice
-
Li H, et al. Transferrin therapy ameliorates disease in beta-thalassemic mice. Nat Med. 2010;16(2):177-182.
-
(2010)
Nat Med.
, vol.16
, Issue.2
, pp. 177-182
-
-
Li, H.1
-
14
-
-
84874066920
-
An RNAi therapeutic targeting tmprss6 decreases iron overload in hfe-/-mice and ameliorates anemia and iron overload in murine beta-thalassemia intermedia
-
Schmidt PJ, et al. An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe-/-mice and ameliorates anemia and iron overload in murine beta-thalassemia intermedia. Blood. 2013; 121(7):1200-1208.
-
(2013)
Blood.
, vol.121
, Issue.7
, pp. 1200-1208
-
-
Schmidt, P.J.1
-
15
-
-
77955383425
-
Identification of the first low-molecular-weight inhibitors of matriptase-2
-
Sisay MT, et al. Identification of the first low-molecular-weight inhibitors of matriptase-2. J Med Chem. 2010;53(15):5523-5535.
-
(2010)
J Med Chem.
, vol.53
, Issue.15
, pp. 5523-5535
-
-
Sisay, M.T.1
-
16
-
-
79959547265
-
Diagnosis and management of hemochromatosis: 2011 practice guideline by the American association for the study of liver diseases
-
Bacon BR, Adams PC, Kowdley KV, Powell LW, Tavill AS. Diagnosis and management of hemochromatosis: 2011 practice guideline by the American Association for the Study of Liver Diseases. Hepatology. 2011;54(1):328-343.
-
(2011)
Hepatology.
, vol.54
, Issue.1
, pp. 328-343
-
-
Bacon, B.R.1
Adams, P.C.2
Kowdley, K.V.3
Powell, L.W.4
Tavill, A.S.5
-
18
-
-
84861381296
-
The definition and epidemiology of non-transfusion-dependent thalassemia
-
Weatherall DJ. The definition and epidemiology of non-transfusion- dependent thalassemia. Blood Rev. 2012;26(suppl 1):S3-S6.
-
(2012)
Blood Rev.
, vol.26
, Issue.SUPPL. 1
-
-
Weatherall, D.J.1
|