Postresuscitation cyclosporine treatment attenuates myocardial and cardiac mitochondrial injury in newborn piglets with asphyxia-reoxygenation

Critical Care Medicine

Volumn 41, Issue 4, 2013, Pages 1069-1074

  Gill, Richdeep S ^a   Lee, Tze Fun ^a   Manouchehri, Namdar ^a   Liu, Jiang Qin ^a   Lopaschuk, Gary ^a   Bigam, David L ^a   Cheung, Po Yin ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

asphyxia; cyclosporine A; mitochondria; myocardium; newborn; piglets

Indexed keywords

BETA ACTIN; CASPASE 3; CYCLOSPORIN A; CYTOCHROME C; LIPID HYDROPEROXIDE; TROPONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARDIOGENIC SHOCK; CLINICAL PROTOCOL; CONTROLLED STUDY; CYTOSOL; DISEASE MARKER; ENZYME ACTIVATION; ENZYME ACTIVITY; HEART MUSCLE INJURY; HEART OUTPUT; LIPID PEROXIDATION; NONHUMAN; PERINATAL ASPHYXIA; PIGLET; PRIORITY JOURNAL; REOXYGENATION; RESUSCITATION; SHAM PROCEDURE; SPECTROPHOTOMETRY; WESTERN BLOTTING;

ANIMALS; ASPHYXIA; CARDIOPULMONARY RESUSCITATION; CYCLOSPORINE; HEART; IMMUNOSUPPRESSIVE AGENTS; MYOCARDIAL REPERFUSION INJURY; OXIDATIVE STRESS; RESUSCITATION; SWINE; TROPONIN I;

EID: 84875812532     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3182746704     Document Type: Article

References (35)

1. Lawn J, Shibuya K, Stein C: No cry at birth: Global estimates of intrapartum stillbirths and intrapartum-related neonatal deaths. Bull World Health Organ 2005; 83:409-417
2. Leone TA, Finer NN: Shock: A common consequence of neonatal asphyxia. J Pediatr 2011; 158(2 Suppl):e9-12
3. Rowe RD, Hoffman T: Transient myocardial ischemia of the newborn infant: A form of severe cardiorespiratory distress in full-term infants. J Pediatr 1972; 81:243-250
4. Bucciarelli RL, Nelson RM, Egan EA, et al: Transient tricuspid insufficiency of the newborn: A form of myocardial dysfunction in stressed newborns. Pediatrics 1977; 59:330-337
5. Cabal LA, Devaskar U, Siassi B, et al: Cardiogenic shock associated with perinatal asphyxia in preterm infants. J Pediatr 1980; 96:705-710
6. Abdelwahid E, Pelliniemi LJ, Niinikoski H, et al: Apoptosis in the pattern formation of the ventricular wall during mouse heart organogenesis. Anat Rec (Hoboken) 1999; 256:208-217
7. Veldman A, Rupp S, Schranz D: New inotropic pharmacologic strategies targeting the failing myocardium in the newborn and infant. Mini Rev Med Chem 2006; 6:785-792
8. Crow MT, Mani K, Nam YJ, et al: The mitochondrial death pathway and cardiac myocyte apoptosis. Circ Res 2004; 95:957-970
9. Halestrap AP: What is the mitochondrial permeability transition pore? J Mol Cell Cardiol 2009; 46:821-831
10. Griffiths EJ, Halestrap AP: Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion. Biochem J 1995; 307(Pt 1):93-98
11. Lemasters JJ, Nieminen AL, Qian T, et al: The mitochondrial permeability transition in cell death: A common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta 1998; 1366:177-196
12. Halestrap AP, Clarke SJ, Javadov SA: Mitochondrial permeability transition pore opening during myocardial reperfusion-A target for cardioprotection. Cardiovasc Res 2004; 61:372-385
13. Crompton M, Ellinger H, Costi A: Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress. Biochem J 1988; 255:357-360
14. Crompton M: The mitochondrial permeability transition pore and its role in cell death. Biochem J 1999; 341(Pt 2):233-249
15. Halestrap AP: Calcium, mitochondria and reperfusion injury: A pore way to die. Biochem Soc Trans 2006; 34(Pt 2):232-237
16. Baines CP: The molecular composition of the mitochondrial permeability transition pore. J Mol Cell Cardiol 2009; 46:850-857
17. Argaud L, Gateau-Roesch O, Muntean D, et al: Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury. J Mol Cell Cardiol 2005; 38:367-374
18. Halestrap AP, Connern CP, Griffiths EJ, et al: Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury. Mol Cell Biochem 1997; 174:167-172
19. Argaud L, Gateau-Roesch O, Raisky O, et al: Postconditioning inhibits mitochondrial permeability transition. Circulation 2005; 111:194-197
20. Leshnower BG, Kanemoto S, Matsubara M, et al: Cyclosporine preserves mitochondrial morphology after myocardial ischemia/reperfusion independent of calcineurin inhibition. Ann Thorac Surg 2008; 86:1286-1292
21. Gill RS, Manouchehri N, Liu JQ, et al: Cyclosporine treatment improves cardiac function and systemic hemodynamics during resuscitation in a newborn piglet model of asphyxia: A dose-response study. Crit Care Med 2012; 40:1237-1244
22. Joynt C, Bigam DL, Charrois G, et al: Intestinal hemodynamic effects of milrinone in asphyxiated newborn pigs after reoxygenation with 100% oxygen: A dose-response study. Shock 2009; 31:292-299
23. Johnson ST, Bigam DL, Emara M, et al: N-acetylcysteine improves the hemodynamics and oxidative stress in hypoxic newborn pigs reoxygenated with 100% oxygen. Shock 2007; 28:484-490
24. Liu L, Zhu J, Brink PR, et al: Age-associated differences in the inhibition of mitochondrial permeability transition pore opening by cyclosporine A. Acta Anaesthesiol Scand 2011; 55:622-630
25. Rigoulet M, Yoboue ED, Devin A: Mitochondrial ROS generation and its regulation: Mechanisms involved in H(2)O(2) signaling. Antioxid Redox Signal 2011; 14:459-468
26. Jacobson J, Duchen MR: Mitochondrial oxidative stress and cell death in astrocytes-Requirement for stored Ca2+ and sustained opening of the permeability transition pore. J Cell Sci 2002; 115(Pt 6):1175-1188
27. Turrens JF: Mitochondrial formation of reactive oxygen species. J Physiol (Lond) 2003; 552(Pt 2):335-344
28. Xu M, Wang Y, Hirai K, et al: Calcium preconditioning inhibits mitochondrial permeability transition and apoptosis. Am J Physiol Heart Circ Physiol 2001; 280:H899-H908
29. Batandier C, Leverve X, Fontaine E: Opening of the mitochondrial permeability transition pore induces reactive oxygen species production at the level of the respiratory chain complex I. J Biol Chem 2004; 279:17197-17204
30. Knott EM, Sun J, Lei Y, et al: Pyruvate mitigates oxidative stress during reperfusion of cardioplegia-arrested myocardium. Ann Thorac Surg 2006; 81:928-934
31. Sadek HA, Humphries KM, Szweda PA, et al: Selective inactivation of redox-sensitive mitochondrial enzymes during cardiac reperfusion. Arch Biochem Biophys 2002; 406:222-228
32. Akhlaghi M, Bandy B: Dietary broccoli sprouts protect against myocardial oxidative damage and cell death during ischemia-reperfusion. Plant Foods Hum Nutr 2010; 65:193-199
33. Bulteau AL, Lundberg KC, Ikeda-Saito M, et al: Reversible redox-dependent modulation of mitochondrial aconitase and proteolytic activity during in vivo cardiac ischemia/reperfusion. Proc Natl Acad Sci USA 2005; 102:5987-5991
34. Lee TF, Liu JQ, Li YQ, et al: Improved renal recovery with postresuscitation N-acetylcysteine treatment in asphyxiated newborn pigs. Shock 2011; 35:428-433
35. Swindle MM, Smith AC: Comparative anatomy and physiology of the pig. Scan J Lab Anim Sci Suppl 1998; 25:11-22