메뉴 건너뛰기




Volumn 30, Issue 6, 2012, Pages 683-691

Reduced serum osteocalcin concentrations are associated with type 2 diabetes mellitus and the metabolic syndrome components in postmenopausal women: The crosstalk between bone and energy metabolism

Author keywords

Diabetes mellitus; Metabolic syndrome; Osteocalcin; Postmenopausal women

Indexed keywords

ALKALINE PHOSPHATASE; C REACTIVE PROTEIN; CARBOXY TERMINAL TELOPEPTIDE; GLUCOSE; HIGH SENSITIVITY C REACTIVE PROTEIN; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; UNCLASSIFIED DRUG;

EID: 84875807152     PISSN: 09148779     EISSN: 14355604     Source Type: Journal    
DOI: 10.1007/s00774-012-0367-z     Document Type: Article
Times cited : (67)

References (43)
  • 1
    • 69249205598 scopus 로고    scopus 로고
    • A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms
    • 19376193 10.1016/j.mce.2009.04.004 1:CAS:528:DC%2BD1MXhtVKlsr%2FK
    • Confavreux CB, Levine RL, Karsenty G (2009) A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms. Mol Cell Endocrinol 310:21-29
    • (2009) Mol Cell Endocrinol , vol.310 , pp. 21-29
    • Confavreux, C.B.1    Levine, R.L.2    Karsenty, G.3
  • 2
    • 77956555175 scopus 로고    scopus 로고
    • Integrative physiology: Defined novel metabolic roles of osteocalcin
    • 20592887 10.3346/jkms.2010.25.7.985 1:CAS:528:DC%2BC3cXhtVSlurjL
    • Kim YS, Paik IIY, Rhie YJ, Suh SH (2010) Integrative physiology: defined novel metabolic roles of osteocalcin. J Korean Med Sci 25:985-991
    • (2010) J Korean Med Sci , vol.25 , pp. 985-991
    • Kim, Y.S.1    Paik, I.I.Y.2    Rhie, Y.J.3    Suh, S.H.4
  • 4
    • 78651518046 scopus 로고    scopus 로고
    • Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus
    • 20165834 10.1007/s00198-010-1184-7 1:CAS:528:DC%2BC3MXjtVaqtg%3D%3D
    • Kanazawa I, Yamaguchi T, Yamauchi M, Yamamoto M, Kurioka S, Yano S, Sugimoto T (2011) Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus. Osteoporos Int 22:187-194
    • (2011) Osteoporos Int , vol.22 , pp. 187-194
    • Kanazawa, I.1    Yamaguchi, T.2    Yamauchi, M.3    Yamamoto, M.4    Kurioka, S.5    Yano, S.6    Sugimoto, T.7
  • 5
    • 79952698270 scopus 로고    scopus 로고
    • Serum osteocalcin level is positively associated with insulin sensitivity and secretion in patients with type 2 diabetes
    • 21185419 10.1016/j.bone.2010.12.020 1:CAS:528:DC%2BC3MXjs12jtb0%3D
    • Kanazawa I, Yamaguchi T, Tada Y, Yamauchi M, Yano S, Sugimoto T (2011) Serum osteocalcin level is positively associated with insulin sensitivity and secretion in patients with type 2 diabetes. Bone 48:720-725
    • (2011) Bone , vol.48 , pp. 720-725
    • Kanazawa, I.1    Yamaguchi, T.2    Tada, Y.3    Yamauchi, M.4    Yano, S.5    Sugimoto, T.6
  • 6
    • 58149377704 scopus 로고    scopus 로고
    • Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus
    • 18984661 10.1210/jc.2008-1455 1:CAS:528:DC%2BD1MXptVKmtA%3D%3D
    • Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Kurioka S, Yano S, Sugimoto T (2009) Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus. J Clin Endocrinol Metab 94:45-49
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 45-49
    • Kanazawa, I.1    Yamaguchi, T.2    Yamamoto, M.3    Yamauchi, M.4    Kurioka, S.5    Yano, S.6    Sugimoto, T.7
  • 8
    • 84861757484 scopus 로고    scopus 로고
    • Circulating osteocalcin level is associated with improved glucose tolerance, insulin secretion and sensitivity independent of the plasma adiponectin level
    • 21656264 10.1007/s00198-011-1679-x 1:CAS:528:DC%2BC38XjvVSnt7Y%3D
    • Hwang YC, Jeong IK, Ahn KJ, Chung HY (2012) Circulating osteocalcin level is associated with improved glucose tolerance, insulin secretion and sensitivity independent of the plasma adiponectin level. Osteoporos Int 23:1337-1342
    • (2012) Osteoporos Int , vol.23 , pp. 1337-1342
    • Hwang, Y.C.1    Jeong, I.K.2    Ahn, K.J.3    Chung, H.Y.4
  • 9
    • 70449727666 scopus 로고    scopus 로고
    • Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals
    • 19671707 10.1530/EJE-09-0585 1:CAS:528:DC%2BD1MXhsFajt7fJ
    • Zhou M, Ma X, Li H, Pan X, Tang J, Gao Y, Hou X, Lu H, Bao Y, Jia W (2009) Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals. Eur J Endocrinol 161:723-729
    • (2009) Eur J Endocrinol , vol.161 , pp. 723-729
    • Zhou, M.1    Ma, X.2    Li, H.3    Pan, X.4    Tang, J.5    Gao, Y.6    Hou, X.7    Lu, H.8    Bao, Y.9    Jia, W.10
  • 10
    • 62349099001 scopus 로고    scopus 로고
    • Association between serum osteocalcin and markers of metabolic phenotype
    • 10.1210/jc.2008-1422 1:CAS:528:DC%2BD1MXjt1Wmsbk%3D
    • Pittas AG, Harris SS, Eliades M, Stark P, Dawson-Hughes B (2009) Association between serum osteocalcin and markers of metabolic phenotype. J Clin Endocrinol Met 94:827-832
    • (2009) J Clin Endocrinol Met , vol.94 , pp. 827-832
    • Pittas, A.G.1    Harris, S.S.2    Eliades, M.3    Stark, P.4    Dawson-Hughes, B.5
  • 11
    • 80755129059 scopus 로고    scopus 로고
    • The association between serum osteocalcin levels and metabolic syndrome in Koreans
    • 21153019 10.1007/s00198-010-1504-y 1:CAS:528:DC%2BC3MXht1Kmsb%2FI
    • Bae S, Choe J, Chung YE, Kim BJ, Lee S, Kim H, Koh JM, Kim G (2011) The association between serum osteocalcin levels and metabolic syndrome in Koreans. Osteoporos Int 22:2837-2846
    • (2011) Osteoporos Int , vol.22 , pp. 2837-2846
    • Bae, S.1    Choe, J.2    Chung, Y.E.3    Kim, B.J.4    Lee, S.5    Kim, H.6    Koh, J.M.7    Kim, G.8
  • 12
    • 79960554187 scopus 로고    scopus 로고
    • Low serum osteocalcin level is a potential marker for metabolic syndrome: Results from a Chinese male population survey
    • 21353261 10.1016/j.metabol.2011.01.002 1:CAS:528:DC%2BC3MXptlCntbg%3D
    • Tan A, Gao Y, Yang X, Zhang H, Qin X, Mo L, Peng T, Xia N, Mo Z (2011) Low serum osteocalcin level is a potential marker for metabolic syndrome: results from a Chinese male population survey. Metabolism 60:1186-1192
    • (2011) Metabolism , vol.60 , pp. 1186-1192
    • Tan, A.1    Gao, Y.2    Yang, X.3    Zhang, H.4    Qin, X.5    Mo, L.6    Peng, T.7    Xia, N.8    Mo, Z.9
  • 13
    • 77953921007 scopus 로고    scopus 로고
    • Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of metabolic syndrome
    • 20395593 10.1161/ATVBAHA.110.204859 1:CAS:528:DC%2BC3cXnsFGns74%3D
    • Saleem U, Mosley TH Jr, Kullo IJ (2010) Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of metabolic syndrome. Arterioscler Thromb Vasc Biol 30:1474-1478
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1474-1478
    • Saleem, U.1    Mosley, Jr.T.H.2    Kullo, I.J.3
  • 14
    • 79960194357 scopus 로고    scopus 로고
    • Serum levels of osteocalcin are inversely associated with the metabolic syndrome and the severity of coronary artery disease in Chinese men
    • 10.1111/j.1365-2265.2011.04065.x 1:CAS:528:DC%2BC3MXhtV2rurvP
    • Bao Y, Zhou M, Lu Z, Li H, Wang Y, Sun L, Gao M, Wei M, Jia W (2011) Serum levels of osteocalcin are inversely associated with the metabolic syndrome and the severity of coronary artery disease in Chinese men. Clin Endocrinol (Oxf) 75:196-201
    • (2011) Clin Endocrinol (Oxf) , vol.75 , pp. 196-201
    • Bao, Y.1    Zhou, M.2    Lu, Z.3    Li, H.4    Wang, Y.5    Sun, L.6    Gao, M.7    Wei, M.8    Jia, W.9
  • 15
    • 77955398568 scopus 로고    scopus 로고
    • Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels
    • 20501596 10.1530/EJE-10-0414 1:CAS:528:DC%2BC3cXhtFSksrjO
    • Yeap BB, Chubb SAP, Flicker L, McCaul KA, Ebeling PR, Beilby JP, Norman PE (2010) Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels. Eur J Endocrinol 163:265-272
    • (2010) Eur J Endocrinol , vol.163 , pp. 265-272
    • Yeap, B.B.1    Chubb, S.A.P.2    Flicker, L.3    McCaul, K.A.4    Ebeling, P.R.5    Beilby, J.P.6    Norman, P.E.7
  • 16
    • 79952732068 scopus 로고    scopus 로고
    • Association between bone mineral density and metabolic syndrome in pre- and postmenopausal women
    • 21242648 10.1507/endocrj.K10E-297
    • Jeon YK, Lee JG, Kim SS, Kim BH, Kim SJ, Kim YK, Kim IJ (2011) Association between bone mineral density and metabolic syndrome in pre- and postmenopausal women. Endocr J 58:87-93
    • (2011) Endocr J , vol.58 , pp. 87-93
    • Jeon, Y.K.1    Lee, J.G.2    Kim, S.S.3    Kim, B.H.4    Kim, S.J.5    Kim, Y.K.6    Kim, I.J.7
  • 17
    • 72149091430 scopus 로고    scopus 로고
    • Bone mineral density in men with and without the metabolic syndrome
    • 19639517 10.1080/13685530903150812 1:CAS:528:DC%2BD1MXhtlKqtL3J
    • Boyanov M, Bakalov D, Boneva Z (2009) Bone mineral density in men with and without the metabolic syndrome. Aging Male 12:62-65
    • (2009) Aging Male , vol.12 , pp. 62-65
    • Boyanov, M.1    Bakalov, D.2    Boneva, Z.3
  • 20
    • 50049111403 scopus 로고    scopus 로고
    • Relationship between osteocalcin and glucose metabolism in postmenopausal women
    • 18657532 10.1016/j.cca.2008.07.001 1:CAS:528:DC%2BD1cXhtVKmsrzE
    • Im JA, Yu BP, Jeon JY, Kim SH (2008) Relationship between osteocalcin and glucose metabolism in postmenopausal women. Clin Chim Acta 396:66-69
    • (2008) Clin Chim Acta , vol.396 , pp. 66-69
    • Im, J.A.1    Yu, B.P.2    Jeon, J.Y.3    Kim, S.H.4
  • 21
    • 58249093759 scopus 로고    scopus 로고
    • Relationship among insulinlike growth factor i concentrations, bone mineral density, and biochemical markers of bone turnover in postmenopausal women: A population-based study
    • 18451743 10.1097/gme.0b013e31816665a7
    • Nabipour I, Larijani B, Beigi S, Jafari SM, Amiri M, Assadi M, Pazoki R, Amiri Z, Sanjdideh Z (2008) Relationship among insulinlike growth factor I concentrations, bone mineral density, and biochemical markers of bone turnover in postmenopausal women: a population-based study. Menopause 15:934-939
    • (2008) Menopause , vol.15 , pp. 934-939
    • Nabipour, I.1    Larijani, B.2    Beigi, S.3    Jafari, S.M.4    Amiri, M.5    Assadi, M.6    Pazoki, R.7    Amiri, Z.8    Sanjdideh, Z.9
  • 22
    • 1842334456 scopus 로고    scopus 로고
    • Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
    • Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
    • Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20:1183-1197
    • (1997) Diabetes Care , vol.20 , pp. 1183-1197
  • 23
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults 10.1001/jama.285.19.2486
    • Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (2001) Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285:2486-2497
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 25
  • 26
    • 29044434138 scopus 로고    scopus 로고
    • Increased bone density and decreased bone turnover, but no evident alteration of fracture susceptibility in elderly women with diabetes mellitus
    • 15824889 10.1007/s00198-005-1877-5 1:STN:280:DC%2BD2MnnsVCntg%3D%3D
    • Gerdhem P, Isaksson A, Akesson K, Obrant KJ (2005) Increased bone density and decreased bone turnover, but no evident alteration of fracture susceptibility in elderly women with diabetes mellitus. Osteoporos Int 16:1506-1512
    • (2005) Osteoporos Int , vol.16 , pp. 1506-1512
    • Gerdhem, P.1    Isaksson, A.2    Akesson, K.3    Obrant, K.J.4
  • 27
    • 0037300007 scopus 로고    scopus 로고
    • Evaluation of bone turnover in postmenopausal patients with type 2 diabetes mellitus using biochemical markers and bone mineral density measurements
    • 12724015 1:CAS:528:DC%2BD3sXjt1yrsrw%3D
    • Akin O, Göl K, Aktürk M, Erkaya S (2003) Evaluation of bone turnover in postmenopausal patients with type 2 diabetes mellitus using biochemical markers and bone mineral density measurements. Gynecol Endocrinol 17:19-29
    • (2003) Gynecol Endocrinol , vol.17 , pp. 19-29
    • Akin, O.1    Göl, K.2    Aktürk, M.3    Erkaya, S.4
  • 29
    • 29044434138 scopus 로고    scopus 로고
    • Increased bone density and decreased bone turnover, but no evident alteration of fracture susceptibility in elderly women with diabetes mellitus
    • 10.1007/s00198-005-1877-5
    • Gerdhem P, Isaksson A, Akesson K, Obrant KJ (2005) Increased bone density and decreased bone turnover, but no evident alteration of fracture susceptibility in elderly women with diabetes mellitus. Osteoporos Int 6:1506-1512
    • (2005) Osteoporos Int , vol.6 , pp. 1506-1512
    • Gerdhem, P.1    Isaksson, A.2    Akesson, K.3    Obrant, K.J.4
  • 30
    • 83155173116 scopus 로고    scopus 로고
    • Serum adiponectin, bone mineral density and bone turnover markers in post-menopausal women with newly diagnosed Type 2 diabetes: A 12-month follow-up
    • 21726281 10.1111/j.1464-5491.2011.03381.x 1:CAS:528:DC%2BC38XhvVChsb4%3D
    • Miazgowski T, Noworyta-Ziȩtara M, Safranow K, Ziemak J, Widecka K (2012) Serum adiponectin, bone mineral density and bone turnover markers in post-menopausal women with newly diagnosed Type 2 diabetes: a 12-month follow-up. Diabet Med 29:62-69
    • (2012) Diabet Med , vol.29 , pp. 62-69
    • Miazgowski, T.1    Noworyta-Ziȩtara, M.2    Safranow, K.3    Ziemak, J.4    Widecka, K.5
  • 31
    • 79960152609 scopus 로고    scopus 로고
    • Serum concentrations of osteocalcin, procollagen type 1 N-terminal propeptide and beta-CrossLaps in obese subjects with varying degrees of glucose tolerance
    • 10.1111/j.1365-2265.2011.04035.x 1:CAS:528:DC%2BC3MXhtV2rurrF
    • Iglesias P, Arrieta F, Piñera M, Botella-Carretero JI, Balsa JA, Zamarrón I, Menacho M, Díez JJ, Muñoz T, Vázquez C (2011) Serum concentrations of osteocalcin, procollagen type 1 N-terminal propeptide and beta-CrossLaps in obese subjects with varying degrees of glucose tolerance. Clin Endocrinol (Oxf) 75:184-188
    • (2011) Clin Endocrinol (Oxf) , vol.75 , pp. 184-188
    • Iglesias, P.1    Arrieta, F.2    Piñera, M.3    Botella-Carretero, J.I.4    Balsa, J.A.5    Zamarrón, I.6    Menacho, M.7    Díez, J.J.8    Muñoz, T.9    Vázquez, C.10
  • 32
    • 33748946364 scopus 로고    scopus 로고
    • Chronic hyperglycemia modulates osteoblast gene expression through osmotic and non-osmotic pathways
    • 16619259 10.1002/jcb.20842 1:CAS:528:DC%2BD28XhtVSktLzJ
    • Botolin S, McCabe LR (2006) Chronic hyperglycemia modulates osteoblast gene expression through osmotic and non-osmotic pathways. J Cell Biochem 99:411-424
    • (2006) J Cell Biochem , vol.99 , pp. 411-424
    • Botolin, S.1    McCabe, L.R.2
  • 33
    • 68549120751 scopus 로고    scopus 로고
    • Adiponectin is associated with changes in bone markers during glycemic control in type 2 diabetes mellitus
    • 19470634 10.1210/jc.2008-2187 1:CAS:528:DC%2BD1MXpvFGnurs%3D
    • Kanazawa I, Yamaguchi T, Yamauchi M, Yamamoto M, Kurioka S, Yano S, Sugimoto T (2009) Adiponectin is associated with changes in bone markers during glycemic control in type 2 diabetes mellitus. J Clin Endocrinol Metab 94:3031-3037
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 3031-3037
    • Kanazawa, I.1    Yamaguchi, T.2    Yamauchi, M.3    Yamamoto, M.4    Kurioka, S.5    Yano, S.6    Sugimoto, T.7
  • 34
  • 37
    • 0030003905 scopus 로고    scopus 로고
    • Relationship between body composition and bone mass in women
    • 8725184 10.1002/jbmr.5650110618 1:STN:280:DyaK28zmtl2msA%3D%3D
    • Khosla S, Atkinson EJ, Riggs BL, Melton LJ 3rd (1996) Relationship between body composition and bone mass in women. J Bone Miner Res 11:857-863
    • (1996) J Bone Miner Res , vol.11 , pp. 857-863
    • Khosla, S.1    Atkinson, E.J.2    Riggs, B.L.3    Melton III, L.J.4
  • 38
    • 42449096306 scopus 로고    scopus 로고
    • Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice
    • 18362359 10.1073/pnas.0711119105 1:CAS:528:DC%2BD1cXksVOns7Y%3D
    • Ferron M, Hinoi E, Karsenty G, Ducy P (2008) Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci U S A 105:5266-5270
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 5266-5270
    • Ferron, M.1    Hinoi, E.2    Karsenty, G.3    Ducy, P.4
  • 40
    • 33644856016 scopus 로고    scopus 로고
    • Vitamin K status of healthy Japanese women: Age-related vitamin K requirement for gamma-carboxylation of osteocalcin
    • 16469998 1:CAS:528:DC%2BD28Xhs1ehsbg%3D
    • Tsugawa N, Shiraki M, Suhara Y, Kamao M, Tanaka K, Okano T (2006) Vitamin K status of healthy Japanese women: age-related vitamin K requirement for gamma-carboxylation of osteocalcin. Am J Clin Nutr 83:380-386
    • (2006) Am J Clin Nutr , vol.83 , pp. 380-386
    • Tsugawa, N.1    Shiraki, M.2    Suhara, Y.3    Kamao, M.4    Tanaka, K.5    Okano, T.6
  • 41
    • 2442717405 scopus 로고    scopus 로고
    • Impaired gamma carboxylation of osteocalcin in elderly women with type II diabetes mellitus: Relationship between increase in undercarboxylated osteocalcin levels and low bone mineral density
    • 15108065 10.1007/s00774-003-0473-z 1:CAS:528:DC%2BD2cXjtlyjsbc%3D
    • Horiuchi T, Kazama H, Araki A, Inoue J, Hosoi T, Onouchi T, Mizuno S, Ito H, Orimo H (2004) Impaired gamma carboxylation of osteocalcin in elderly women with type II diabetes mellitus: relationship between increase in undercarboxylated osteocalcin levels and low bone mineral density. J Bone Miner Metab 22:236-240
    • (2004) J Bone Miner Metab , vol.22 , pp. 236-240
    • Horiuchi, T.1    Kazama, H.2    Araki, A.3    Inoue, J.4    Hosoi, T.5    Onouchi, T.6    Mizuno, S.7    Ito, H.8    Orimo, H.9
  • 43
    • 84855866319 scopus 로고    scopus 로고
    • Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice
    • 21550430 10.1016/j.bone.2011.04.017 1:CAS:528:DC%2BC38Xos12mug%3D%3D
    • Ferron M, McKee MD, Levine RL, Ducy P, Karsenty G (2012) Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice. Bone 50:568-575
    • (2012) Bone , vol.50 , pp. 568-575
    • Ferron, M.1    McKee, M.D.2    Levine, R.L.3    Ducy, P.4    Karsenty, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.