Amurensin G induces autophagy and attenuates cellular toxicities in a rotenone model of Parkinson's disease

Biochemical and Biophysical Research Communications

Volumn 433, Issue 1, 2013, Pages 121-126

  Ryu, Hyun Wook ^a   Oh, Won Keun ^b   Jang, Ik Soon ^c   Park, Junsoo ^a  

^a Yonsei University Wonju   (South Korea)

^b Seoul National University   (South Korea)

^c Korea Basic Science Institute (KBSI)   (South Korea)

Author keywords

Autophagy; Natural products; Parkinson's disease

Indexed keywords

AMURENSIN G; BECLIN 1; FLAVONOL; GREEN FLUORESCENT PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; ROTENONE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; G2 PHASE CELL CYCLE CHECKPOINT; GRAPE; HUMAN; HUMAN CELL; M PHASE CELL CYCLE CHECKPOINT; NEUROTOXICITY; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BASE SEQUENCE; DIBENZOCYCLOHEPTENES; G2 PHASE CELL CYCLE CHECKPOINTS; HEK293 CELLS; HUMANS; MEDICINE, KOREAN TRADITIONAL; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; NEUROTOXINS; PARKINSON DISEASE; PHYTOTHERAPY; PLANTS, MEDICINAL; RESORCINOLS; RNA, SMALL INTERFERING; ROTENONE; VITIS;

VITACEAE; VITIS AMURENSIS;

EID: 84875804963     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.02.053     Document Type: Article

References (23)

1. Levine B., Klionsky D.J. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev. Cell 2004, 6:463-477.
2. Klionsky D.J., Abdalla F.C., Abeliovich H., Abraham R.T., Acevedo-Arozena A., Adeli K., Agholme L., Agnello M., Agostinis P., Aguirre-Ghiso J.A., Ahn H.J., Ait-Mohamed O., Ait-Si-Ali S., Akematsu T., Akira S., Al-Younes H.M., Al-Zeer M.A., Albert M.L., Albin R.L., Alegre-Abarrategui J., Aleo M.F., Alirezaei M., Almasan A., Almonte-Becerril M., Amano A., Amaravadi R., Amarnath S., Amer A.O., Andrieu-Abadie N., Anantharam V., Ann D.K., Anoopkumar-Dukie S., Aoki H., Apostolova N., Arancia G., Aris J.P., Asanuma K., Asare N.Y., Ashida H., Askanas V., Askew D.S., Auberger P., Baba M., Backues S.K., Baehrecke E.H., Bahr B.A., Bai X.Y., Bailly Y., Baiocchi R., Baldini G., Balduini W., Ballabio A., Bamber B.A., Bampton E.T., Banhegyi G., Bartholomew C.R., Bassham D.C., Bast R.C., Batoko H., Bay B.H., Beau I., Bechet D.M., Begley T.J., Behl C., Behrends C., Bekri S., Bellaire B., Bendall L.J., Benetti L., Berliocchi L., Bernardi H., Bernassola F., Besteiro S., Bhatia-Kissova I., Bi X., Biard-Piechaczyk M., Blum J.S., Boise L.H., Bonaldo P., Boone D.L., Bornhauser B.C., Bortoluci K.R., Bossis I., Bost F., Bourquin J.P., Boya P., Boyer-Guittaut M., Bozhkov P.V., Brady N.R., Brancolini C., Brech A., Brenman J.E., Brennand A., Bresnick E.H., Brest P., Bridges D., Bristol M.L., Brookes P.S., Brown E.J., Brumell J.H., et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012, 8:445-544.
3. Yoon J.H., Her S., Kim M., Jang I.S., Park J. The expression of damage-regulated autophagy modulator 2 (DRAM2) contributes to autophagy induction. Mol. Biol. Rep. 2012, 39:1087-1093.
4. Goedert M., Spillantini M.G., Del Tredici K., Braak H. 100years of Lewy pathology. Nat. Rev. Neurol. 2012, 9:13-24.
5. Greenamyre J.T., MacKenzie G., Peng T.I., Stephans S.E. Mitochondrial dysfunction in Parkinson's disease. Biochem. Soc. Symp. 1999, 66:85-97.
6. Imamura K., Takeshima T., Kashiwaya Y., Nakaso K., Nakashima K. D-beta-hydroxybutyrate protects dopaminergic SH-SY5Y cells in a rotenone model of Parkinson's disease. J. Neurosci. Res. 2006, 84:1376-1384.
7. Dadakhujaev S., Noh H.S., Jung E.J., Cha J.Y., Baek S.M., Ha J.H., Kim D.R. Autophagy protects the rotenone-induced cell death in alpha-synuclein overexpressing SH-SY5Y cells. Neurosci. Lett. 2010, 472:47-52.
8. Sherer T.B., Betarbet R., Stout A.K., Lund S., Baptista M., Panov A.V., Cookson M.R., Greenamyre J.T. An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J. Neurosci. 2002, 22:7006-7015.
9. Webb J.L., Ravikumar B., Atkins J., Skepper J.N., Rubinsztein D.C. Alpha-synuclein is degraded by both autophagy and the proteasome. J. Biol. Chem. 2003, 278:25009-25013.
10. Sarkar S., Davies J.E., Huang Z., Tunnacliffe A., Rubinsztein D.C. Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J. Biol. Chem. 2007, 282:5641-5652.
11. Pan T., Kondo S., Zhu W., Xie W., Jankovic J., Le W. Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement. Neurobiol. Dis. 2008, 32:16-25.
12. Congdon E.E., Wu J.W., Myeku N., Figueroa Y.H., Herman M., Marinec P.S., Gestwicki J.E., Dickey C.A., Yu W.H., Duff K.E. Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo. Autophagy 2012, 8:609-622.
13. Pan T., Rawal P., Wu Y., Xie W., Jankovic J., Le W. Rapamycin protects against rotenone-induced apoptosis through autophagy induction. Neuroscience 2009, 164:541-551.
14. Jeong H.Y., Kim J.Y., Lee H.K., Ha do T., Song K.S., Bae K., Seong Y.H. Leaf and stem of Vitis amurensis and its active components protect against amyloid beta protein (25-35)-induced neurotoxicity. Arch. Pharm. Res. 2010, 33:1655-1664.
15. Huang K.S., Lin M. Oligostilbenes from the roots of Vitis amurensis. J. Asian Nat. Prod. Res. 1999, 2:21-28.
16. Huang K.S., Lin M., Cheng G.F. Anti-inflammatory tetramers of resveratrol from the roots of Vitis amurensis and the conformations of the seven-membered ring in some oligostilbenes. Phytochemistry 2001, 58:357-362.
17. Kim J.A., Kim M.R., Kim O., Phuong N.T., Yoon J., Oh W.K., Bae K., Kang K.W. Amurensin G inhibits angiogenesis and tumor growth of tamoxifen-resistant breast cancer via Pin1 inhibition. Food Chem. Toxicol. 2012, 50:3625-3634.
18. Oh W.K., Cho K.B., Hien T.T., Kim T.H., Kim H.S., Dao T.T., Han H.K., Kwon S.M., Ahn S.G., Yoon J.H., Kim Y.G., Kang K.W. Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1. Mol. Pharmacol. 2010, 78:855-864.
19. Kim H.B., Kim M.J., Lee S.H., Lee J.W., Bae J.H., Kim D.W., Dao T.T., Oh W.K., Kang C.D., Kim S.H. Amurensin G, a novel SIRT1 inhibitor, sensitizes TRAIL-resistant human leukemic K562 cells to TRAIL-induced apoptosis. Biochem. Pharmacol. 2012, 84:402-410.
20. Kabeya Y., Mizushima N., Ueno T., Yamamoto A., Kirisako T., Noda T., Kominami E., Ohsumi Y., Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000, 19:5720-5728.
21. Park H.J., Kim H.J., Park H.K., Chung J.H. Protective effect of histamine H2 receptor antagonist ranitidine against rotenone-induced apoptosis. Neurotoxicology 2009, 30:1114-1119.
22. Armstrong J.S., Hornung B., Lecane P., Jones D.P., Knox S.J. Rotenone-induced G2/M cell cycle arrest and apoptosis in a human B lymphoma cell line PW. Biochem. Biophys. Res. Commun. 2001, 289:973-978.
23. Glick D., Barth S., Macleod K.F. Autophagy: cellular and molecular mechanisms. J. Pathol. 2010, 221:3-12.