Testing of novel brain-penetrating oxime reactivators of acetylcholinesterase inhibited by nerve agent surrogates

Chemico-Biological Interactions

Volumn 203, Issue 1, 2013, Pages 135-138

  Chambers, Janice E ^a   Chambers, Howard W ^b   Meek, Edward C ^a   Pringle, Ronald B ^a  

^a MISSISSIPPI STATE UNIVERSITY   (United States)

^b MISSISSIPPI STATE UNIVERSITY   (United States)

Author keywords

Acetylcholinesterase reactivators; Blood brain barrier; Oxime reactivator; Sarin surrogate; VX surrogate

Indexed keywords

CHOLINESTERASE INHIBITOR; CHOLINESTERASE REACTIVATOR; NITROPHENYL ETHYL METHYLPHOSPHONATE; PHENOXYALKYL PYRIDINIUM OXIME DERIVATIVE; SARIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BLOOD BRAIN BARRIER; BRAIN HOMOGENATE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME REACTIVATION; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; MALE; NONHUMAN; RAT;

ACETYLCHOLINESTERASE; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; DRUG EVALUATION, PRECLINICAL; GPI-LINKED PROTEINS; MALE; ORGANOPHOSPHATES; ORGANOTHIOPHOSPHORUS COMPOUNDS; OXIMES; RATS; RATS, SPRAGUE-DAWLEY; SARIN; SEIZURES;

RATTUS;

EID: 84875804495     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.10.017     Document Type: Conference Paper

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