Expression of orexin aand b in the porcine hypothalamus during the oestrous cycle

Journal of Physiology and Pharmacology

Volumn 64, Issue 1, 2013, Pages 55-63

  Maleszka, A ^a   Smolinska, N ^a   Nitkiewicz, A ^a   Kiezun, M ^a   Chojnowska, K ^a   Dobrzyn, K ^a   Jazowska, J ^a   Kaminski, T ^a  

^a UNIVERSITY OF WARMIA AND MAZURY IN OLSZTYN   (Poland)

Author keywords

Hypothalamus; Oestrous cycle; Orexin a; Orexin b; Orexin receptors; Preoptic area; Stalk median eminence

Indexed keywords

MESSENGER RNA; OREXIN A; OREXIN B; PREPROOREXIN; PROTEIN PRECURSOR; UNCLASSIFIED DRUG; NEUROPEPTIDE; OREXINS; SIGNAL PEPTIDE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ESTRUS CYCLE; FEMALE; HYPOTHALAMUS; MEDIAN EMINENCE; MEDIOBASAL HYPOTHALAMUS; NONHUMAN; PREOPTIC AREA; PROTEIN EXPRESSION; SWINE; ANIMAL; BIOSYNTHESIS; GENETICS; MALE; METABOLISM;

ANIMALS; ESTROUS CYCLE; FEMALE; HYPOTHALAMUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEDIAN EMINENCE; NEUROPEPTIDES; PREOPTIC AREA; RNA, MESSENGER; SWINE;

EID: 84875798680     PISSN: 08675910     EISSN: 18991505     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. De Lecea L, Kilduff TS, Peyron C, et al. The hypocretins: hypothalamus-specific peptides with neuroexicatory activity. Proc Natl Acad Sci USA 1998; 95: 322-327.
2. Sakurai T, Amemiya A, Ishii M, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998; 92: 573-585.
3. Kalra SP, Kalra PS. Nutritional infertility: the role of the interconnected hypothalamic neuropeptide Y-galanin-opioid network. Front Neuroendocrinol 1996; 17: 371-401.
4. Peyron C, Tighe DK, van den Pol AN, et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 1998; 18: 9996-10015.
5. Yamamoto Y, Ueta Y, Date Y, et al. Down regulation of the prepro-orexin gene expression in genetically obese mice. Brain Res Mol Brain Res 1999; 65: 14-22.
6. Lubkin M, Stricker-Krongrad A. Independent feeding and metabolic actions of orexins in mice. Biochem Biophys Res Commun 1998; 253: 241-245.
7. Samson WK, Gosnell B, Chang JK, Resch ZT, Murphy TC. Cardiovascular regulatory actions of the hypocretins in brain. Brain Res 1999; 831: 248-253.
8. Nakamura T, Uramura K, Nambu T, et al. Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system. Brain Res 2000; 873: 181-187.
9. Kilduff TS, Peyron C. The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. Tren ds Neurosci 2000; 23: 359-365.
10. Ida T, Nakahara K, Murakami T, Hanada R, Nakazato M, Murakami N. Possible involvement of orexin in the stress reaction in rats. Biochem Biophys Res Commun 2000; 270: 318-323.
11. Kuru M, Ueta Y, Serino R, et al. Centrally administered orexin/hypocretin activates HPA axis in rats. Neuroreport 2000; 11: 1977-1980.
12. Small CJ, Goubillon ML, Murray JF, et al. Central orexin A has site-specific effects on luteinizing hormone release in female rats. Endocrinology 2003; 144: 3225-3236.
13. Kohsaka A, Watanobe H, Kakizaki Y, Suda T, Schioth HB. A significant participation of orexin-A, a potent orexigenic peptide, in the preovulatory luteinizing hormone and prolactin surges in the rat. Brain Res 2001; 898: 166-170.
14. Date Y, Ueta Y, Yamashita H, et al. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc Natl Acad Sci USA 1999; 96: 748-753.
15. Tamura T, Irahara M, Tezuka M, Kiyokawa M, Aono T. Orexins, orexigenic hypothalamic neuropeptides, suppress the pulsatile secretion of luteinizing hormone in ovariectomized female rats. Biochem Biophys Res Commun 1999; 264: 759-762.
16. Bogacka I, Przala J, Siawrys G, Kaminski T, Smolinska N. The expression of short form of leptin receptor gene during early pregnancy in the pig examined by quantitative real time PCR. J Physiol Pharmacol 2006; 57: 479-489.
17. Rak-Mardyla A, Gregoraszczuk EL. Expression of ghrelin and its receptor in porcine ovarian follicles collected from prepubertal and estrous cycle animals. J Physiol Pharmacol 2012; 63: 195-199.
18. Silveyra P, Lux-Lantos V, Libertun C. Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation. Am J Physiol Endocrinol Metab 2007; 293: E977-E985.
19. Nitkiewicz A, Smolinska N, Przala J, Kaminski T. Expression of orexin receptors 1 (OX1R) and 2 (OX2R) in the porcine ovary during the oestrous cycle. Regul Pept 2010; 165: 186-190.
20. Nitkiewicz A, Smolinska N, Maleszka A, Kiezun M, Kaminski T. Localization of orexin A and orexin B in the porcine uterus. Reprod Biol 2012; 12: 135-155.
21. Kaminski T, Smolinska N, Nitkiewicz A, Przala J. Expression of orexin receptors 1 (OX1R) and 2 (OX2R) in the porcine pituitary during the oestrous cycle. Anim Reprod Sci 2010; 117: 111-118.
22. Barb CR, Matteri RL. Orexin-B modulates luteinizing hormone and growth hormone secretion from porcine pituitary cells in culture. Domest Anim Endocrinol 2005; 28: 331-337.
23. Molik E, Zieba DA, Misztal T, et al. The role of orexin A in the control of prolactin and growth hormone secretions in sheep - in vitro study. J Physiol Pharmacol 2008; 59: 91-100.
24. Fabris C, Cozzi B, Hay-Schmidt A, Naver B, Moller M. Demonstration of an orexinergic central innervation of the pineal gland of the pig. J Comp Neurol. 2004; 471: 113-127.
25. Li Q, Lei Z, Chen M, Deng B, Su J. Localization of orexin A in the pig hypothalamus. J Nanjing Agric Univ 2005; 28: 99-102.
26. Maeda KI, Adachi S, Inoue K, Ohkura S, Tsukamura H. Metastin/kisspeptin and control of estrous cycle in rats. Rev Endocr Metab Disord 2007; 8: 21-29.
27. Ma AY, Kelly MJ, Ronnekleiv OK. Pro-gonadotropin-releasing hormone (ProGnRH) and GnRH content in the preoptic area and the basal hypothalamus of anterior medial preoptic nucleus/suprachiasmatic nucleus-lesioned persistent estrous rats. Endocrinology 1990; 127: 2654-2664.
28. Weiling Y, Gore AC. The hypothalamic median eminence and its role in reproductive aging. Ann NY Acad Sci 2010; 1204: 113-122.
29. Akins EL, Morrissette MC. Gross ovarian changes during estrous cycle of swine. Am J Vet Res 1968; 29: 1953-1957.
30. Sesti LA, Britt JH. Relationship of secretion of GnRH in vitro to changes in pituitary concentrations of LH and FSH and serum concentrations of LH during lactation in sows. J Reprod Fertil 1993; 98: 393-400.
31. -DDCT method. Methods 2001; 25: 402-408.
32. Khan AQ, Bury JP, Brown SR, Riley SA, Corfe BM. Keratin 8 expression in colon cancer associates with low faecal butyrate levels. BMC Gastroenterol 2011; 11: 2. DOI: 10.1186/1471-230X-11-2.
33. Ning H, Lei Z, Zhang W, Su J, et al. Expression of preproorexin and OX1R mRNA in the hypothalamo-pituitary-ovary axis of Suzhong sows in the oestrous cycle. J Nanjing Agric Univ 2008; 30: 70-74.
34. Chen CT, Dun SL, Kwok EH, Dun NJ, Chang JK. Orexin Alike immunoreactivity in the rat brain. Neurosci Lett 1999; 260; 161-164.
35. Cutler DJ, Morris R, Scheridhar V, et al. Differential distribution of orexin-A and orexin-B immunoreactivity in the rat brain and spinal cord. Peptides 1999; 20: 1455-1470.
36. Li Q, Lei Z, Chen M, Deng B, Su J. Localization of orexin A in some porcine organs. Chin J Anat 2005; 28: 290-291.
37. Su J, Lei Z, Zhang W, Ning W, Ping J. Distribution of orexin B and its relationship with GnRH in the pig hypothalamus. Res Ve t Sci 2008; 85: 315-323.
38. Su J, Yao Y, Yang G, et al. Distribution of orexin B in porcine hypothalamus-pituitary-gonadal axis and the regulation of reproduction in vitro. Chin J Anim Vet Sci 2010; 41: 1460-1466.
39. Kaminski T, Smolinska N, Nitkiewicz A, Przala J. Expression of orexin receptors 1 (OX1R) and 2 (OX2R) in the porcine hypothalamus during the oestrous cycle. J Physiol Pharmacol 2010; 61: 363-371.
40. Johren O, Neidert SJ, Kummer M, Dendorfer A, Dominiak P. Prepro-orexin and orexin receptor mRNAs differentially expressed in peripheral tissues of male and female rats. Endocrinology 2001; 142: 3324-3331.
41. Johren O, Neidert SJ, Kummer M, Dominiak P. Sexually dimorphic expression of prepro-orexin mRNA in the rat hypothalamus. Peptides 2002; 23: 1177-1180.
42. Kanenishi K, Ueno M, Momose S, et al. Prepro-orexin mRNA expression in the rat brain is increase during pregnancy. Neurosci Lett 2004; 368: 73-77.
43. Garcia MC, Lopez M, Gualillo O, Seoane LM, Dieguez C, Senaris RM. Hypothalamic levels of NPY, MCH, and prepro-orexin mRNA during pregnancy and lactation in the rat: role of prolactin. FASEB J 2003; 17: 1392-1400.
44. Porkka-Heiskanen T, Kalinchuk A, Alanko L, Huhtaniemi I, Stenberg D. Orexin A and B levels in the hypothalamus of female rats: the effects of the oestrous cycle and age. Eur J Endocrinol 2004; 150: 737-742.
45. Russell SH, Small CJ, Kennedy AR, et al. Orexin A interactions in the hypothalamo-pituitary gonadal axis. Endocrinology 2001; 142: 5294-5302.
46. Campbell RE, Grove KL, Smith MS. Gonadotropin-releasing hormone neurons coexpress orexin 1 receptor immunoreactivity and receive direct contacts by orexins fibers. Endocrinology 2003; 144: 1542-1548.
47. Iqbal J, Pompolo S, Sakurai T, Clarke IJ. Evidence that orexin-containing neurones provide direct input to gonadotropin-releasing hormone neurones in the ovine hypothalamus. J Neuroendocrinol 2001; 13: 1033-1041.
48. Ning H, Ge Y, Su J, et al. Effects of orexin A on mRNA expression of various neuropeptides in the hypothalamus and pituitary, and on serum LH levels in ovariectomized gilts. Agric Sci Chin 2010; 9: 1362-1371.
49. Sasson R, Dearth RK, White RS, Chappell PE, Mellon PL. Orexin A induces GnRH gene expression and secretion from GT1-7 hypothalamic GnRH neurons. Neuroendocrinology 2006; 84: 353-363.
50. Irahara M, Tamura T, Matuzaki T, et al. Orexin-A suppresses the pulsatile secretion of luteinizing hormone via beta-endorphin. Biochem Biophys Res Commun 2001; 281: 232-236.
51. Iwasa T, Matsuzaki T, Kiyokawa M, et al. The type 2 corticotrophin-releasing hormone receptor mediates orexin A-induced luteinising hormone suppression in ovariectomised rats. J Neuroendocrinol 2007; 19: 732-728.
52. Pu S, Jain MR, Kalra PS, Kalra S P. Orexins, a novel family of hypothalamic neuropeptides, modulate pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner. Regul Pept 1998; 78: 133-136.