Uterus-relaxing effect of β2-agonists in combination with phosphodiesterase inhibitors: Studies on pregnant rat in vivo and on pregnant human myometrium in vitro

Journal of Obstetrics and Gynaecology Research

Volumn 39, Issue 1, 2013, Pages 31-39

  Verli, Judit ^a   Klukovits, Anna ^a   Kormányos, Zsolt ^b   Hajagos Tóth, Judit ^a   Ducza, Eszter ^a   Seres, Adrienn B ^a   Falkay, George ^a   Gáspár, Róbert ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

2 mimetics; Phosphodiesterase; Preterm labor; Rolipram; Terbutaline

Indexed keywords

CYCLIC AMP; OXYTOCIN; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV B; PHOSPHODIESTERASE IV D; ROLIPRAM; TERBUTALINE; THEOPHYLLINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DIAGNOSTIC TEST ACCURACY STUDY; DRUG EFFECT; ENZYME IMMUNOASSAY; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MYOMETRIUM; NONHUMAN; PREMATURE LABOR; PROTEIN EXPRESSION; RAT; UTERUS RELAXATION;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ANIMALS; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; FEMALE; HUMANS; MYOMETRIUM; OBSTETRIC LABOR, PREMATURE; PHOSPHODIESTERASE INHIBITORS; PREGNANCY; PREMATURE BIRTH; RATS; RATS, SPRAGUE-DAWLEY; ROLIPRAM; TERBUTALINE; THEOPHYLLINE; UTERINE CONTRACTION; UTERUS;

EID: 84875747213     PISSN: 13418076     EISSN: 14470756     Source Type: Journal    
DOI: 10.1111/j.1447-0756.2012.01929.x     Document Type: Article

References (35)

1. Gracie SK, Lyon AW, Kehler HL et al. All our babies cohort study: Recruitment of a cohort to predict women at risk of preterm birth through the examination of gene expression profiles and the environment. BMC Pregnancy Childbirth 2010; 10: 87-95.
2. Vinken MP, Rabotti C, Mischi M, van Laar JO, Oei SG. Nifedipine-induced changes in the electrohysterogram of preterm contractions: Feasibility in clinical practice. Obstet Gynecol Int 2010; 2010: 325635, doi: 10.1155/2010/325635.
3. López Bernal A. The regulation of uterine relaxation. Semin Cell Dev Biol 2007; 18: 340-347.
4. Engelhardt S, Zieger W, Kassubek J, Michel MC, Lohse MJ, Brodde OE. Tocolytic therapy with fenoterol induces selective down-regulation of beta-Adrenergic receptors in human myometrium. J Clin Endocrinol Metab 1997; 82: 1235-1242.
5. Houslay MD, Adams DR. PDE4 cAMP phosphodiesterases: Modular enzymes that orchestrate signalling cross-Talk, desensitization and compartmentalization. Biochem J 2003; 370: 1-18.
6. Leroy MJ, Lugnier C, Merezak J et al. Isolation and characterization of the rolipram-sensitive cyclic AMP-specific phosphodiesterase (type IV PDE) in human term myometrium. Cell Signal 1994; 6: 405-412.
7. Boswell-Smith V, Spina D, Page CP. Phosphodiesterase inhibitors. Br J Pharmacol 2006; 147: S252-S257.
8. Lugnier C. Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents. Pharmacol Ther 2006; 109: 366-398.
9. Robichaud A, Stamatiou PB, Jin SL et al. Deletion of phosphodiesterase 4D in mice shortens alpha(2)-Adrenoceptormediated anesthesia, a behavioral correlate of emesis. J Clin Invest 2002; 110: 1045-1052.
10. Salminen A, Paananen R, Vuolteenaho R et al. Maternal endotoxin-induced preterm birth in mice: Fetal responses in toll-like receptors, collectins, and cytokines. Pediatr Res 2008; 63: 80-86.
11. Farmer P, Pugin J. Beta-Adrenergic agonists exert their 'anti-inflammatory' effects in monocytic cells through the IkappaB/NF-kappaB pathway. Am J Physiol Lung Cell Mol Physiol 2000; 279: L675-L682.
12. Elovitz MA, Mrinalini C. Animal models of preterm birth. Trends Endocrinol Metab 2004; 15: 79-87.
13. Jansson L, Sandler S. Alloxan, but not streptozotocin, increases blood perfusion of pancreatic islets in rats. Am J Physiol 1992; 263: E57-E63.
14. Lourenco CM, Houle S, Wilson AA, DaSilva JN. Characterization of r-(11)C] rolipram for PET imaging of phosphodiesterase-4: In vitro binding, metabolism, and dosimetry studies in rats. Nucl Med Biol 2001; 28: 347-358.
15. Gáspár R, Gál A, Gálik M et al. Different roles of alpha2-Adrenoceptor subtypes in non-pregnant and late-pregnant uterine contractility in vitro in the rat. Neurochem Int 2007; 51: 311-318.
16. Chiossi G, Costantine MM, Betancourt A et al. Does sildenafil citrate affect myometrial contractile response to nifedipine in vitro? Am J Obstet Gynecol 2010; 203: 252e1-5.
17. Meloni A, Melis M, Alba E et al. Medical therapy in the management of preterm birth. J Matern Fetal Neonatal Med 2009; 22 (Suppl 3): 72-76.
18. Hajagos-Tóth J, Kormányos Z, Falkay G, Pál A, Gáspár R. Potentiation of the uterus-relaxing effects of b-Adrenergic agonists with nifedipine: Studies on rats and the human myometrium. Acta Obstet Gynecol Scand 2010; 89: 1284-1289.
19. Gálik M, Gáspár R, Kolarovszki-Sipiczki Z, Falkay G. Gestagen treatment enhances the tocolytic effect of salmeterol in hormone-induced preterm labor in the rat in vivo. Am J Obstet Gynecol 2008; 198: 19.e1-19.e5.
20. de Heus R, Mulder EJ, Derks JB, Visser GH. Acute tocolysis for uterine activity reduction in term labor -A review. Obstet Gynecol Surv 2008; 63: 383-388.
21. Gáspár R, Ducza E, Mihályi A et al. Pregnancy-induced decrease in the relaxant effect of terbutaline in the latepregnant rat myometrium: Role of G-protein activation and progesterone. Reproduction 2005; 130: 113-122.
22. Giembycz MA. Phosphodiesterase 4 and tolerance to beta 2-Adrenoceptor agonists in asthma. Trends Pharmacol Sci 1996; 17: 331-336.
23. Iams JD, Romero R, Culhane JF, Goldenberg RL. Primary, secondary, and tertiary interventions to reduce the morbidity and mortality of preterm birth. Lancet 2008; 371: 164-175.
24. Withworth M, Quenby S. Prophylactic oral betamimetics for preventing preterm labour in singleton pregnancies. Cochrane Database Syst Rev 2008; (1): CD006395.
25. Klukovits A, Verli J, Falkay G, Gáspár R. Improving the relaxing effect of terbutaline with phosphodiesterase inhibitors: Studies on pregnant rat uteri in vitro. Life Sci 2010; 87: 733-737.
26. Collis MG. Integrative pharmacology and drug discovery: is the tide finally turninǧ Nat Rev Drug Discov 2006; 5: 377-380.
27. Wang K, Chen JQ, Chen Z, Chen JC. Inhibition of human phosphodiesterase 4A expressed in yeast cell GL62 by theophylline, rolipram, and acetamide-45. Acta Pharmacol Sin 2002; 23: 1013-1017.
28. Bardou M, Cortijo J, Loustalot C et al. Pharmacological and biochemical study on the effects of selective phosphodiesterase inhibitors on human term myometrium. Naunyn Schmiedebergs Arch Pharmacol 1999; 360: 457-463.
29. Leroy MJ, Cedrin I, Breuiller M, Giovagrandi Y, Ferre F. Correlation between selective inhibition of the cyclic nucleotide phosphodiesterases and the contractile activity in human pregnant myometrium near term. Biochem Pharmacol 1989; 38: 9-15.
30. Slater DM, Astle S,Woodcock N et al. Anti-inflammatory and relaxatory effects of prostaglandin E2 in myometrial smooth muscle. Mol Hum Reprod 2006; 12: 89-97.
31. Oger S, Méhats C, Barnette MS, Ferré F, Cabrol D, Leroy MJ. Anti-inflammatory and utero-relaxant effects in human myometrium of new generation phosphodiesterase 4 inhibitors. Biol Reprod 2004; 70: 458-464.
32. Franova S, Janicek F, Visnovsky J et al. Utero-relaxant effect of PDE4-selective inhibitor alone and in simultaneous administration with beta2-mimetic on oxytocin-induced contractions in pregnant myometrium. J Obstet Gynaecol Res 2009; 35: 20-25.
33. Schmitz T, Souil E, Hervé R et al. PDE4 inhibition prevents preterm delivery induced by an intrauterine inflammation. J Immunol 2007; 178: 1115-1121.
34. Méhats C, Tanguy G, Paris B et al. Pregnancy induces a modulation of the cAMP phosphodiesterase 4-conformers ratio in human myometrium: Consequences for the utero-relaxant effect of PDE4-selective inhibitors. J Pharmacol Exp Ther 2000; 292: 817-823.
35. Muller B, Lugnier C, Stoclet JC. Involvement of rolipramsensitive cyclic AMP phosphodiesterase in the regulation of cardiac contraction. J Cardiovasc Pharmacol 1990; 16: 796-803.