Potentiation of the uterus-relaxing effects of β-adrenergic agonists with nifedipine: Studies on rats and the human myometrium

Acta Obstetricia et Gynecologica Scandinavica

Volumn 89, Issue 10, 2010, Pages 1284-1289

  Hajagos Tth, Judit ^a   Kormnyos, Zsolt ^b   Falkay, George ^a   Pl, Attila ^b   Gspr, Rbert ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

2 Mimetics; Nifedipine; Preterm; Progesterone

Indexed keywords

MIFEPRISTONE; NIFEDIPINE; OXYTOCIN; PROGESTERONE; PROSTAGLANDIN E2; SALMETEROL; TERBUTALINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIRTH; CESAREAN SECTION; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; ISOLATED ORGAN; MALE; MYOMETRIUM; NONHUMAN; PREMATURE LABOR; PREMATURITY; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; UTERUS; UTERUS CONTRACTION; UTERUS RELAXATION;

ADRENERGIC BETA-AGONISTS; ALBUTEROL; ANIMALS; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MIFEPRISTONE; MODELS, ANIMAL; MYOMETRIUM; NIFEDIPINE; OXYTOCICS; PREGNANCY; PREMATURE BIRTH; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY; TOCOLYSIS; TOCOLYTIC AGENTS; UTERINE CONTRACTION;

EID: 77956835794     PISSN: 00016349     EISSN: 16000412     Source Type: Journal    
DOI: 10.3109/00016349.2010.512064     Document Type: Article

References (14)

1. Kim A, Shim JY. Emerging tocolytics for maintenance therapy of preterm labour: oxytocin antagonists and calcium channels blockers. Br J Pharmacol. 2006;113(Suppl 3):113-115
2. Gálik M, Gáspár R, Kolarovszki-Sipiczki Z, Falkay G. Gestagen treatment enhances the tocolytic effect of salmeterol in hormone-induced preterm labor in the rat in vivo. Am J Obstet Gynaecol. 2008;198:319.e1-5
3. Oei SG. Calcium channel blockers for tocolysis: a review of their role and safety following reports of serious adverse events. Eur J Obstet Gynaecol. 2006;126:137-145
4. Longo M, Jain V, Vedernikov YP, Hankins GDV, Garfield RE, Saade GR. Effects of L-type Ca2+-channel blockade,K+ATP-channel opening and nitric oxide on human uterine contractility in relation to gestational age and labor. Mol Hum Reprod. 2003;9:159-164
5. Wray S, Jones K, Kupittayanant S, Li Y, Matthew A, Monir-Bisthty E, et al. Calcium signaling and uterine contractility. J Soc Gynecol Investig. 2003;10:252-264
6. Kobayashi T, Yamada Y, Fukao M, Tsutsuura M, Tohse N. Regulation of Cav1.2 current: interaction with intracellular molecules. J Pharmacol Sci. 2007;103:347-353
7. Kamp TJ, Hell JW. Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C. Circ Res. 2000;87:1095-1102
8. Thirstrup S, Nielsen-Kudsk F, Dahl F. In vitro studies on the interactions of b2-adrenoreceptor agonists, methylxanthenes, Ca2+-channel blockers, K+-channel openers and other airway smooth muscle relaxants in isolated guinea-pig trachea. Eur J Pharmacol. 1997;326:191-200.
9. Hajagos-Tth J, Falkay G, Gáspár R. Modification of the effect of nifedipine in the pregnant rat myometrium: the influence of progesterone and terbutaline. Life Sci. 2009; 85:568-572
10. Helguera G, Olcese R, Song M, Toro L, Stefani E. Tissue-specific regulation of Ca2+ channel protein expression by sex hormones. Biochim Biophys Acta. 2002;1569: 59-66.
11. Rechberger T, Abramson SR, Woessner JF Jr. Onapristone and prostaglandin E2 induction of delivery in the rat in late pregnancy: a model for the analysis of cervical softening. Am J Obstet Gynecol. 1996;175:719-723
12. Hernandez F, Peluffo MC, Bas D, Stouffer RL, Tesone M. Local effects of the sphingosine 1-phosphate on prostaglandin F2alpha-induced luteolysis in the pregnant rat. Mol Reprod Dev. 2009;76(12):1153-1164
13. Farina M, Ribeiro ML, Weissmann C, Estevez A, Billi S, Vercelli C, et al. Biosynthesis and catabolism of prostaglandin F2alpha (PGF2alpha) are controlled by progesterone in the rat uterus during pregnancy. J Steroid Biochem Mol Biol. 2004; 91(4-5):211-218
14. Downing SJ, Hollingsworth M. Nifedipine kinetics in the rat and relationship between its serum concentrations and uterine and cardiovascular effects. Br J Pharmacol. 1998;95: 23-32.