Pregnancy-induced decrease in the relaxant effect of terbutaline in the late-pregnant rat myometrium: Role of G-protein activation and progesterone

Reproduction

Volumn 130, Issue 1, 2005, Pages 113-122

  Gáspár, Róbert ^a   Ducza, Eszter ^a   Mihályi, Attila ^a   Márki, Árpád ^a   Kolarovszki Sipiczki, Zoltán ^a   Páldy, Eszter ^b   Benyhe, Sándor ^b   Borsodi, Anna ^b   Földesi, Imre ^c   Falkay, George ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c UNIVERSITY OF SZEGED   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; MESSENGER RNA; PROGESTERONE; RADIOLIGAND; SEX HORMONE; TERBUTALINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG MECHANISM; DRUG PROTEIN BINDING; ELECTROSTIMULATION; FEMALE; GENE ACTIVATION; IN VITRO STUDY; LIGAND BINDING; MALE; MYOMETRIUM; NONHUMAN; PREMATURE LABOR; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; RADIOIMMUNOASSAY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THIRD TRIMESTER PREGNANCY; UTERUS CONTRACTION; UTERUS RELAXATION;

ANIMALS; ELECTRIC STIMULATION; ESTRADIOL; FEMALE; GTP-BINDING PROTEINS; MYOMETRIUM; PREGNANCY; PROGESTERONE; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TERBUTALINE; TOCOLYTIC AGENTS; UTERINE CONTRACTION;

EID: 22544470578     PISSN: 14701626     EISSN: None     Source Type: Journal    
DOI: 10.1530/rep.1.00490     Document Type: Article

References (43)

1. Andreassi S & Teso A 1992 Magnesium oxide and tocolysis. Our clinical experience and comparison with beta-mimetic (isoxusprine) therapy. Rivista Europea Per le Scienze Mediche E Farmacologiche 14 309-312.
2. Berkman ND, Thorp JM Jr, Lohr KN, Carey TS, Hartmann KE, Gavin NI, Hasselblad V & Idicula AE 2003 Tocolytic treatment for the management of preterm labor: a review of the evidence. American Journal of Obstetrics and Gynecology 188 1648-1659.
3. Bilski AJ, Halliday SE, Fitzgerald JD & Wale JL 1983 The pharmacology of a beta 2-selective adrenoceptor antagonist (ICI 118,551). Journal of Cardiovascular Pharmacology 5 430-437.
4. Caritis SN, Chiao JP, Moore JJ & Ward SM 1987 Myometrial desensitization after ritodrine infusion. American Journal of Physiology 253 E410-E417.
5. Cohen-Tannoudji J, Vivat V, Heilmann J, Legrand C & Maltier JP 1991 Regulation by progesterone of the high-affinity state of myometrial beta-adrenergic receptor and adenylate cyclase in the pregnant rat. Journal of Molecular Endocrinology 6 137-145.
6. Cohen-Tannoudji J, Mhaouty S, Elwardy-Merezak J, Lecrivain JL, Robin MT, Legrand C & Maltier JP 1995 Regulation of myometrial Gi2, Gi3, and Gq expression during pregnancy. Effects of progesterone and estradiol. Biology of Reproduction 53 55-64.
7. Chomczynski P & Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry 162 156-159.
8. Cruz MA, Sepulveda WH & Rudolph MI 1990 Changes in the response to adrenergic drugs on mouse uterine contractions during pregnancy. Life Sciences 46 99-104.
9. Dowell RT, Forsberg AL & Kauer CD 1994 Decreased ovarian blood flow may confound the tocolytic effect of ritodrine. Gynecologic and Obstetric Investigation 37 168-171.
10. Einstein FH & Bracero LA 2004 Progesterone and preterm birth. American Journal of Obstetrics and Gynecology 190 1798-1799.
11. Elwardy-Merezak J, Maltier JP, Cohen-Tannoudji J, Lecrivain JL, Vivat V & Legrand C 1994 Pregnancy-related modifications of rat myometrial Gs proteins: ADP ribosylation, immunoreactivity and gene expression studies. Journal of Molecular Endocrinology 13 23-37.
12. Engelhard S & Lohse JM 2000 Determination of adrenergic receptor mRNAs by quantitative reverse transcriptase-polymerase chain reactions. Methods in Molecular Biology 126 155-168.
13. 2-adrenoceptor function in non-pregnant rat myometrium is modulated by sex steroids. Journal of Endocrinology 170 147-155.
14. da Fonseca EB, Bittar RE, Carvalho MH & Zugaib M 2003 Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study. American Journal of Obstetrics and Gynecology 188 419-424.
15. Fuchs AR & Fields MJ 1998 Parturition, nonhuman mammals. In Encyclopedia of Reproduction, Vol 3, pp 703-716. Eds E Knobil & JD Neill. San Diego: Academic Press.
16. Gáspár R, Földesi I, Havass J, Márki A & Falkay G 2001 Characterization of late-pregnant rat uterine contraction via the contractility ratio in vitro: significance of alpha-1 adrenoceptors. Life Sciences 68 1119-1129.
17. Gyetvai K, Hannah ME, Hodnett ED & Ohlsson A 1999 Tocolytics for preterm labor: a systematic review. Obstetrics and Gynecology 94 869-877.
18. Haram K, Mortensen JH & Wollen AL 2003 Preterm delivery: an overview. Acta Obstetricia et Gynecologica Scandinavica 82 687-704.
19. 35S]GTPγS binding assay: approaches and applications in pharmacology. Life Sciences 74 489-508.
20. Hatjis CG, Koritnik DR & Crews A 1988 Up-regulation of guinea pig myometrial beta-adrenoceptors by systematic estradiol and progesterone. Endocrinology 122 1455-1459.
21. Higby K, Xenakis E & Paurstein C 1993 Do tocolytic agents stop preterm labour? A critical and comprehensive review of efficacy and safety. American Journal of Obstetrics and Gynecology 168 1247-1259.
22. Katz VL & Farmer RM 1999 Controversies in tocolytic therapy. Clinical Obstetrics and Gynecology 42 802-819.
23. Maeda K, Ohkura S & Tsukamura H 2000 Reproduction and breeding: Physiology of Reproduction. In The Handbook of Experimental Animals: The Laboratory Rat, pp 145-176. Ed. G Krinke. San Diego: Academic Press.
24. Maltier JP & Legrand C 1988 Characterization of beta-adrenoceptors in myometrium of preparturient rats. Fundamental Clinical Pharmacology 2 369-383.
25. Meis PJ, Klebanoff M, Thom E, Dombrowski MP, Sibai B, Moawad AH, Spong CY, Hauth JC, Miodovnik M, Varner MW, Leveno KJ, Caritis SN, Iams JD, Wapner RJ, Conway D, O'Sullivan MJ, Carpenter M, Mercer B, Ramin SM, Thorp JM, Peaceman AM & Gabbe S 2003 Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. New England Journal of Medicine 348 2379-2385.
26. Moutquin JM, Sherman D, Cohen H, Mohide PT, Hochner-Celnikier D, Fejgin M, Liston RM, Dansereau J, Mazor M, Shalev E, Boucher M, Glezerman M, Zimmer EZ & Rabinovici J 2000 Double blind, randomized, controlled trial of atosiban and ritodrine in the treatment of preterm labor: a multicenter effectiveness and safety study. American Journal of Obstetrics and Gynecology 182 1191-1199.
27. Nimmo AJ, Whitaker EM, Morrison JF & Carstairs JR 1995 Multiple mechanisms of heterologous beta-adrenoceptor regulation in rat uterus. Journal of Endrocrinology 147 303-309.
28. Papatsonis DN, Kok JH, van Geijn HP, Bleker OP, Ader HJ & Dekker GA 2000 Neonatal effects of nifedipine and ritodrine for preterm labor. Obstetrics and Gynecology 95 477-481.
29. Riemer RK, Goldfien A & Roberts JM 1987 Rabbit myometrial adrenergic sensitivity is increased by oestrogen but is independent of changes in alpha adrenoceptor concentration. Journal of Pharmacology and Experimental Therapeutics 240 44-50.
30. Riemer RK, Wu YY, Bottari SP, Jacobs MM, Goldfien A & Roberts JM 1988 Estrogen reduces beta-adrenoceptor-mediated cAMP production and the concentration of the guanyl nucleotide-regulatory protein, Gs, in rabbit myometrium. Molecular Pharmacology 33 389-395.
31. Roberts JM, Riemer RK, Bottari SP, Wu YY & Goldfien A 1989 Hormonal regulation myometrial adrenergic responses: the receptor and beyond. Journal of Developmental Physiology 11 125-134.
32. Ruzycky AL & DeLoia JA 1997 Expression of beta-adrenergic receptor kinase subtypes in the pregnant rat myometrium. American Journal of Obstetrics and Gynecology 176 1077-1083.
33. Simon V, Mhaouty-Kodja S, Legrand C & Cohen-Tannoudji J 2001 Concomitant increase of G-protein-coupled receptor kinase activity and uncoupling of β-adrenergic receptors in rat myometrium at parturition. Endocrinology 142 1899-1905.
34. Simon V, Robin MT, Legrand C & Cohen-Tannoudji J 2003 Endogenous G protein-coupled receptor kinase 6 triggers homologous β-adrenergic receptor desensitization in primary uterine smooth muscle cells. Endocrinology 144 3058-3066.
35. Smigaj D, Roman-Drago NM, Amini SB, Caritis SN, Kalhan SC & Catalano PM 1998 The effect of oral terbutaline on maternal glucose metabolism and energy expenditure in pregnancy. American Journal of Obstetrics and Gynecology 178 1041-1047.
36. Sciscione AC, Stamilio DM, Manley JS, Shlossman PA, Gorman RT & Colmorgen GH 1998 Tocolysis of preterm contractions does not improve preterm delivery or perinatal outcomes. American Journal of Perinatology 15 177-181.
37. Sim LJ, Selley DE & Childers SR 1995 In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5′-[gamma-[35S]thio]-triphosphate binding. PNAS 92 7242-7246.
38. Tita AT & O'Day MP 2004 Prophylactic progesterone to prevent preterm birth. American Journal of Obstetrics and Gynecology 190 1799-1800.
39. Traynor JR & Nahorski SR 1995 Modulation by mu-opioid agonists of guanosine-5′-O-(3-[35S]thio]triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells. Molecular Pharmacology 47 848-854.
40. Tso Ju, Sun Xh, Kao T, Reece KS & Wu R 1985 Isolation of rat and human glycerinaldehyde-3-phosphate dehydrogenase cDNA: genomic complexity and molecular evolution of the gene. Nucleic Acids Research 13 2485-2502.
41. Tucker J & McGuire W 2004 ABC of preterm birth. Epidemiology of preterm birth. British Medical Journal 329 675-678.
42. Vivat V, Cohen-Tannoudji J, Revelli JP, Muzzin P, Giacobino JP, Maltier JP & Legrand C 1992 Progesterone transcriptionally regulates the beta 2-adrenergic receptor gene in pregnant rat myometrium. Journal of Biological Chemistry 267 7975-7978.
43. Worldwide Atosiban versus Beta-agonists Study Group 2001 Effectiveness and safety of the oxytocin antagonist atosiban versus beta-adrenergic agonists in the treatment of preterm labour. The Worldwide Atosiban versus Beta-agonists Study Group. British Journal of Obstetrics and Gynecology 108 133-142.