Antileishmanial activity of 5-methyl-2,2′: 5′,2′- terthiophene isolated from porophyllum ruderale is related to mitochondrial dysfunction in leishmania amazonensis

Planta Medica

Volumn 79, Issue 5, 2013, Pages 330-333

  Takahashi, Helena Teru ^a   Britta, Elizandra Aparecida ^a   Longhini, Renata ^a   Ueda Nakamura, Tânia ^a   Palazzo De Mello, João Carlos ^a   Nakamura, Celso Vataru ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

Author keywords

Asteraceae; mitochondrion dysfunction; Porophyllum ruderale; thiophene derivatives

Indexed keywords

5 METHYL 2,2' 5',2'' TERTHIOPHENE; 5' METHYL [5 (4 ACETOXY 1 BUTYNYL)] 2,2' BI THIOPHENE; AMPHOTERICIN B; ANTILEISHMANIAL AGENT; RHODAMINE 123; UNCLASSIFIED DRUG; 5-METHYL-2,2'-5',2''-TERTHIOPHENE; ANTIPROTOZOAL AGENT; THIOPHENE DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL LABELING; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG ISOLATION; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; LEISHMANIA; MEDICINAL PLANT; MITOCHONDRIAL MEMBRANE; POROPHYLLUM RUDERALE; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; ASTERACEAE; BAGG ALBINO MOUSE; CHEMISTRY; DRUG EFFECTS; HEMOLYSIS; ISOLATION AND PURIFICATION; MOUSE; TOXICITY TESTING; ULTRASTRUCTURE;

ASTERACEAE; LEISHMANIA AMAZONENSIS; POROPHYLLUM RUDERALE;

ANIMALS; ANTIPROTOZOAL AGENTS; ASTERACEAE; FLOW CYTOMETRY; HEMOLYSIS; HUMANS; LEISHMANIA; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIAL MEMBRANES; THIOPHENES; TOXICITY TESTS;

EID: 84875717212     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0032-1328258     Document Type: Article

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