Strategies for conducting ADME studies during lead generation in the drug discovery process

IDrugs

Volumn 13, Issue 12, 2010, Pages 857-861

  Cramer, Jeffrey W ^a   Mattioni, Brian E ^a   Savin, Kenneth A ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

ADME; in silico ADME; in silico in vitro in vivo; ISIVIV; lead generation; pharmacokinetic; SAR

Indexed keywords

DRUG;

COMPUTER MODEL; DECISION MAKING; DISTRIBUTION VOLUME; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG INDUSTRY; DRUG METABOLISM; DRUG RESEARCH; DRUG SCREENING; FIRST PASS EFFECT; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KNOWLEDGE; NONHUMAN; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; VALIDATION PROCESS;

ANIMALS; COMPUTATIONAL BIOLOGY; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; DRUG INDUSTRY; HUMANS; PHARMACOKINETICS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79952744346     PISSN: 13697056     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (8)

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