-
1
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer
-
I. Vivanco, and C.L. Sawyers The phosphatidylinositol 3-kinase AKT pathway in human cancer Nat Rev Cancer 2 7 2002 489 501
-
(2002)
Nat Rev Cancer
, vol.2
, Issue.7
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
2
-
-
33846416534
-
Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice
-
I.G. Maroulakou, W. Oemler, S.P. Naber, and P.N. Tsichlis Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice Cancer Res 67 1 2007 167 177
-
(2007)
Cancer Res
, vol.67
, Issue.1
, pp. 167-177
-
-
Maroulakou, I.G.1
Oemler, W.2
Naber, S.P.3
Tsichlis, P.N.4
-
3
-
-
67449136114
-
Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression
-
R.L. Dillon, R. Marcotte, and B.T. Hennessy Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression Cancer Res 69 12 2009 5057 5064
-
(2009)
Cancer Res
, vol.69
, Issue.12
, pp. 5057-5064
-
-
Dillon, R.L.1
Marcotte, R.2
Hennessy, B.T.3
-
4
-
-
77953158079
-
Distinct biological roles for the akt family in mammary tumor progression
-
R.L. Dillon, and W.J. Muller Distinct biological roles for the akt family in mammary tumor progression Cancer Res 70 11 2010 4260 4264
-
(2010)
Cancer Res
, vol.70
, Issue.11
, pp. 4260-4264
-
-
Dillon, R.L.1
Muller, W.J.2
-
5
-
-
34347269181
-
Roles of AKT signal in breast cancer
-
W. Liu, J. Bagaitkar, and K. Watabe Roles of AKT signal in breast cancer Front Biosci 12 2007 4011 4019
-
(2007)
Front Biosci
, vol.12
, pp. 4011-4019
-
-
Liu, W.1
Bagaitkar, J.2
Watabe, K.3
-
6
-
-
33644797510
-
Increased level of phosphorylated akt measured by chemiluminescence- linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2
-
J. Cicenas, P. Urban, and V. Vuaroqueaux Increased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2 Breast Cancer Res 7 4 2005 R394 R401
-
(2005)
Breast Cancer Res
, vol.7
, Issue.4
-
-
Cicenas, J.1
Urban, P.2
Vuaroqueaux, V.3
-
7
-
-
28844433950
-
Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients
-
E. Tokunaga, Y. Kimura, and E. Oki Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients Int J Cancer 118 2 2006 284 289
-
(2006)
Int J Cancer
, vol.118
, Issue.2
, pp. 284-289
-
-
Tokunaga, E.1
Kimura, Y.2
Oki, E.3
-
8
-
-
44849124183
-
Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer
-
Y. Wu, H. Mohamed, and R. Chillar Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer Breast Cancer Res 10 1 2008 R3
-
(2008)
Breast Cancer Res
, vol.10
, Issue.1
, pp. 3
-
-
Wu, Y.1
Mohamed, H.2
Chillar, R.3
-
9
-
-
84863718081
-
Proximity ligation assays for isoform-specific Akt activation in breast cancer identify activated Akt1 as a driver of progression
-
M. Spears, C.A. Cunningham, and K.J. Taylor Proximity ligation assays for isoform-specific Akt activation in breast cancer identify activated Akt1 as a driver of progression J Pathol 227 4 2012 481 489
-
(2012)
J Pathol
, vol.227
, Issue.4
, pp. 481-489
-
-
Spears, M.1
Cunningham, C.A.2
Taylor, K.J.3
-
10
-
-
0038700565
-
Akt kinases in breast cancer and the results of adjuvant therapy
-
O. Stal, G. Perez-Tenorio, and L. Akerberg Akt kinases in breast cancer and the results of adjuvant therapy Breast Cancer Res 5 2 2003 R37 R44
-
(2003)
Breast Cancer Res
, vol.5
, Issue.2
-
-
Stal, O.1
Perez-Tenorio, G.2
Akerberg, L.3
-
11
-
-
26044443105
-
AKT activation predicts outcome in breast cancer patients treated with tamoxifen
-
T. Kirkegaard, C.J. Witton, and L.M. McGlynn AKT activation predicts outcome in breast cancer patients treated with tamoxifen J Pathol 207 2 2005 139 146
-
(2005)
J Pathol
, vol.207
, Issue.2
, pp. 139-146
-
-
Kirkegaard, T.1
Witton, C.J.2
McGlynn, L.M.3
-
12
-
-
0037118575
-
AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival
-
S.S. Bacus, D.A. Altomare, and L. Lyass AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival Oncogene 21 22 2002 3532 3540
-
(2002)
Oncogene
, vol.21
, Issue.22
, pp. 3532-3540
-
-
Bacus, S.S.1
Altomare, D.A.2
Lyass, L.3
-
13
-
-
59149094599
-
Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance
-
T. van Agthoven, A.M. Sieuwerts, and M.E. Meijer-van Gelder Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance J Clin Oncol 27 4 2009 542 549
-
(2009)
J Clin Oncol
, vol.27
, Issue.4
, pp. 542-549
-
-
Van Agthoven, T.1
Sieuwerts, A.M.2
Meijer-Van Gelder, M.E.3
-
14
-
-
33746751444
-
Long-term follow-up of the Stockholm randomized trials of postoperative radiation therapy versus adjuvant chemotherapy among 'high risk' pre- and postmenopausal breast cancer patients
-
L.E. Rutqvist, and H. Johansson Long-term follow-up of the Stockholm randomized trials of postoperative radiation therapy versus adjuvant chemotherapy among 'high risk' pre- and postmenopausal breast cancer patients Acta Oncol 45 5 2006 517 527
-
(2006)
Acta Oncol
, vol.45
, Issue.5
, pp. 517-527
-
-
Rutqvist, L.E.1
Johansson, H.2
-
15
-
-
34250749822
-
PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer
-
G. Perez-Tenorio, L. Alkhori, and B. Olsson PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer Clin Cancer Res 13 12 2007 3577 3584
-
(2007)
Clin Cancer Res
, vol.13
, Issue.12
, pp. 3577-3584
-
-
Perez-Tenorio, G.1
Alkhori, L.2
Olsson, B.3
-
16
-
-
33750310901
-
REporting recommendations for tumor MARKer prognostic studies (REMARK)
-
L.M. McShane, D.G. Altman, and W. Sauerbrei REporting recommendations for tumor MARKer prognostic studies (REMARK) Breast Cancer Res Treat 100 2 2006 229 235
-
(2006)
Breast Cancer Res Treat
, vol.100
, Issue.2
, pp. 229-235
-
-
McShane, L.M.1
Altman, D.G.2
Sauerbrei, W.3
-
17
-
-
4944254361
-
Survival after treatment for breast cancer in a geographically defined population
-
G. Tejler, B. Norberg, M. Dufmats, and B. Nordenskjöld Survival after treatment for breast cancer in a geographically defined population Br J Surg 91 2004 1307 1312
-
(2004)
Br J Surg
, vol.91
, pp. 1307-1312
-
-
Tejler, G.1
Norberg, B.2
Dufmats, M.3
Nordenskjöld, B.4
-
18
-
-
38649109161
-
An overview of prognostic factors for long-term survivors of breast cancer
-
I. Soerjomataram, M.W. Louwman, J.G. Ribot, J.A. Roukema, and J.W. Coebergh An overview of prognostic factors for long-term survivors of breast cancer Breast Cancer Res Treat 107 3 2008 309 330
-
(2008)
Breast Cancer Res Treat
, vol.107
, Issue.3
, pp. 309-330
-
-
Soerjomataram, I.1
Louwman, M.W.2
Ribot, J.G.3
Roukema, J.A.4
Coebergh, J.W.5
-
19
-
-
75149198825
-
Akt2 inhibition enables the forkhead transcription factor FoxO3a to have a repressive role in estrogen receptor alpha transcriptional activity in breast cancer cells
-
C. Morelli, M. Lanzino, and C. Garofalo Akt2 inhibition enables the forkhead transcription factor FoxO3a to have a repressive role in estrogen receptor alpha transcriptional activity in breast cancer cells Mol Cell Biol 30 3 2010 857 870
-
(2010)
Mol Cell Biol
, vol.30
, Issue.3
, pp. 857-870
-
-
Morelli, C.1
Lanzino, M.2
Garofalo, C.3
-
20
-
-
4544369383
-
Forkhead box transcription factor FOXO3a regulates estrogen receptor alpha expression and is repressed by the Her-2/neu/phosphatidylinositol 3-kinase/Akt signaling pathway
-
S. Guo, and G.E. Sonenshein Forkhead box transcription factor FOXO3a regulates estrogen receptor alpha expression and is repressed by the Her-2/neu/phosphatidylinositol 3-kinase/Akt signaling pathway Mol Cell Biol 24 19 2004 8681 8690
-
(2004)
Mol Cell Biol
, vol.24
, Issue.19
, pp. 8681-8690
-
-
Guo, S.1
Sonenshein, G.E.2
-
21
-
-
18244391514
-
Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients
-
G. Perez-Tenorio, and O. Stal Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients Br J Cancer 86 4 2002 540 545
-
(2002)
Br J Cancer
, vol.86
, Issue.4
, pp. 540-545
-
-
Perez-Tenorio, G.1
Stal, O.2
-
22
-
-
79551631199
-
Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells
-
S.A. Santi, and H. Lee Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells PLoS One 6 1 2011 e14614
-
(2011)
PLoS One
, vol.6
, Issue.1
, pp. 14614
-
-
Santi, S.A.1
Lee, H.2
-
23
-
-
79953186071
-
Next generation Akt inhibitors provide greater specificity-effects on glucose metabolism in adipocytes
-
S.X. Tan, Y. Ng, and D.E. James Next generation Akt inhibitors provide greater specificity-effects on glucose metabolism in adipocytes Biochem J. 435 2011 539 544
-
(2011)
Biochem J.
, vol.435
, pp. 539-544
-
-
Tan, S.X.1
Ng, Y.2
James, D.E.3
-
24
-
-
0346220278
-
Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex
-
C. Figueroa, S. Tarras, J. Taylor, and A.B. Vojtek Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex J Biol Chem 278 48 2003 47922 47927
-
(2003)
J Biol Chem
, vol.278
, Issue.48
, pp. 47922-47927
-
-
Figueroa, C.1
Tarras, S.2
Taylor, J.3
Vojtek, A.B.4
-
25
-
-
34547567539
-
Regulation of the pro-apoptotic scaffolding protein POSH by Akt
-
T.R. Lyons, J. Thorburn, and P.W. Ryan Regulation of the pro-apoptotic scaffolding protein POSH by Akt J Biol Chem 282 30 2007 21987 21997
-
(2007)
J Biol Chem
, vol.282
, Issue.30
, pp. 21987-21997
-
-
Lyons, T.R.1
Thorburn, J.2
Ryan, P.W.3
-
26
-
-
33845975305
-
Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration
-
G.L. Zhou, D.F. Tucker, and S.S. Bae Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration J Biol Chem 281 47 2006 36443 36453
-
(2006)
J Biol Chem
, vol.281
, Issue.47
, pp. 36443-36453
-
-
Zhou, G.L.1
Tucker, D.F.2
Bae, S.S.3
-
27
-
-
35549002845
-
Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer
-
J. Bostner, M. Ahnstrom Waltersson, and T. Fornander Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer Oncogene 26 49 2007 6997 7005
-
(2007)
Oncogene
, vol.26
, Issue.49
, pp. 6997-7005
-
-
Bostner, J.1
Waltersson, M.A.2
Fornander, T.3
-
28
-
-
79955568142
-
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells
-
C.C. Ong, A.M. Jubb, and P.M. Haverty Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells Proc Natl Acad Sci U S A 108 17 2011 7177 7182
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.17
, pp. 7177-7182
-
-
Ong, C.C.1
Jubb, A.M.2
Haverty, P.M.3
-
29
-
-
77954789824
-
Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition
-
M.M. Caffarel, C. Andradas, and E. Mira Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition Mol Cancer 9 2010 196
-
(2010)
Mol Cancer
, vol.9
, pp. 196
-
-
Caffarel, M.M.1
Andradas, C.2
Mira, E.3
-
30
-
-
6944235337
-
Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity
-
L.A. deGraffenried, W.E. Friedrichs, and D.H. Russell Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity Clin Cancer Res 10 23 2004 8059 8067
-
(2004)
Clin Cancer Res
, vol.10
, Issue.23
, pp. 8059-8067
-
-
Degraffenried, L.A.1
Friedrichs, W.E.2
Russell, D.H.3
-
31
-
-
0142227019
-
Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
-
J. Luo, B.D. Manning, and L.C. Cantley Targeting the PI3K-Akt pathway in human cancer: rationale and promise Cancer Cell 4 4 2003 257 262
-
(2003)
Cancer Cell
, vol.4
, Issue.4
, pp. 257-262
-
-
Luo, J.1
Manning, B.D.2
Cantley, L.C.3
-
32
-
-
84863078767
-
Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
-
J. Baselga, M. Campone, and M. Piccart Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer N Eng J Med. 366 2012 520 529
-
(2012)
N Eng J Med.
, vol.366
, pp. 520-529
-
-
Baselga, J.1
Campone, M.2
Piccart, M.3
-
33
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
-
H. Cho, J. Mu, and J.K. Kim Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta) Science 292 5522 2001 1728 1731
-
(2001)
Science
, vol.292
, Issue.5522
, pp. 1728-1731
-
-
Cho, H.1
Mu, J.2
Kim, J.K.3
-
34
-
-
2542528670
-
A family with severe insulin resistance and diabetes due to a mutation in AKT2
-
S. George, J.J. Rochford, and C. Wolfrum A family with severe insulin resistance and diabetes due to a mutation in AKT2 Science 304 5675 2004 1325 1328
-
(2004)
Science
, vol.304
, Issue.5675
, pp. 1325-1328
-
-
George, S.1
Rochford, J.J.2
Wolfrum, C.3
|