Scanning laser ophthalmoscope measurement of local fundus reflectance and autofluorescence changes arising from rhodopsin bleaching and regeneration

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 3, 2013, Pages 2048-2059

  Morgan, Jessica I W ^a   Pugh, Edward N ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RHODOPSIN;

ADULT; ARTICLE; AUTOFLUORESCENCE IMAGING; BLEACHING; EYE FUNDUS; FEMALE; HUMAN; HUMAN EXPERIMENT; KINETICS; MALE; NORMAL HUMAN; PHOTOSENSITIVITY; PRIORITY JOURNAL; RETINA IMAGE; SCANNING LASER OPHTHALMOSCOPY; SPECTRAL SENSITIVITY; VISUAL STIMULATION;

EID: 84875674681     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-11089     Document Type: Article

References (41)

1. Lamb TD, Pugh EN. Dark adaptation and the retinoid cycle of vision. Prog Retin Eye Res. 2004;23:307-380.
2. Hartong DT, Berson EL, Dryja TP. Retinitis pigmentosa. Lancet. 2006;368:1795-1809.
3. RetNet. Retinal information network. 2012. Available at https://sph.uth.tmc.edu/Retnet/.
4. Malanson KM, Lem J. Rhodopsin-mediated retinitis pigmentosa. Prog Mol Biol Trans Sci. 2009;88:1-31.
5. Rushton WAH. The difference spectrum and the photosensitivity of rhodopsin in the living human eye. J Physiol. 1956; 134:11-29.
6. Ripps H, Weale RA. Flash bleaching of rhodopsin in the human retina. J Physiol. 1969;200:151-159.
7. Alpern M. Rhodopsin kinetics in the human eye. J Physiol. 1971;217:447-471.
8. Van Norren D, Tiemeijer LF. Spectral reflectance of the human eye. Vision Res. 1986;26:313-320.
9. van de Kraats J, Berendschot TT, Van Norren D. The pathways of light measured in fundus reflectometry. Vision Res. 1996; 36:2229-2247.
10. Berendschot TT, DeLint PJ, van Norren D. Fundus reflectance-historical and present ideas. Prog Retin Eye Res. 2003;22:171-200.
11. Faulkner DJ, Kemp CM. Human rhodopsin measurements using a TV-based imaging fundus reflectometer. Vision Res. 1984;24:221-231.
12. Elsner AE, Burns SA, Hughes GW, Webb RH. Reflectometry with a scanning laser ophthalmoscope. Appl Opt. 1992;31: 3697-3710.
13. Van Norren D, Van de Kraats J. Imaging retinal densitometry with a confocal scanning laser ophthalmoscope. Vision Res. 1989;29:1825-1830.
14. Tornow RP, Stilling R, Zrenner E. Scanning laser densitometry and color perimetry demonstrate reduced photopigment density and sensitivity in two patients with retinal degeneration. Vision Res. 1999;39:3630-3641.
15. Sheorey UB. Clinical assessment of rhodopsin in the eye. Using a standard fundus camera and a photographic technique. Br J Ophthalmol. 1976;60:135-141.
16. Strauss O. The retinal pigment epithelium in visual function. Physiol Rev. 2005;85:845-881.
17. Thompson DA, Gal A. Vitamin A metabolism in the retinal pigment epithelium: genes mutations, and diseases. Prog Retin Eye Res. 2003;22:683-703.
18. Feeneyburns L, Hilderbrand ES, Eldridge S. Aging human RPE: Morphometric analysis of macular, equatorial, and peripheral cells. Invest Ophthalmol Vis Sci. 1984;25:195-200.
19. Delori FC, Goger DG, Dorey CK. Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects. Invest Ophthalmol Vis Sci. 2001;42:1855-1866.
20. Delori FC, Dorey CK, Staurenghi G, Arend O, Goger DG, Weiter JJ. In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol Vis Sci. 1995;36:718-729.
21. Bindewald A, Jorzik JJ, Loesch A, Schutt F, Holz FG. Visualization of retinal pigment epithelial cells in vivo using digital high-resolution confocal scanning laser ophthalmoscopy. Am J Ophthalmol. 2004;137:556-558.
22. Holz FG, Bellman C, Staudt S, Schutt F, Volcker HE. Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2001;42:1051-1056.
23. Lois N, Halfyard AS, Bird AC, Fitzke FW. Quantitative evaluation of fundus autofluorescence imaged "in vivo" in eyes with retinal disease. Br J Ophthalmol. 2000;84:741-745.
24. von Ruckmann A, Fitzke FW, Bird AC. Distribution of fundus autofluorescence with a scanning laser ophthalmoscope. Br J Ophthalmol. 1995;79:407-412.
25. Morgan JIW, Dubra A, Wolfe R, Merigan WH, Williams DR. In vivo autofluorescence imaging of the human and macaque retinal pigment epithelial cell mosaic. Invest Ophthalmol Vis Sci. 2009;50:1350-1359.
26. Lois N, Halfyard AS, Bird AC, Holder GE, Fitzke FW. Fundus autofluorescence in Stargardt macular dystrophy-fundus flavimaculatus. Am J Ophthalmol. 2004;138:55-63.
27. von Ruckmann A, Fitzke FW, Bird AC. Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope. Invest Ophthalmol Vis Sci. 1997; 38:478-486.
28. Holz FG, Bellmann C, Margaritidis M, Schutt F, Otto TP, Volcker HE. Patterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with age-related macular degeneration. Graefe's Arch Clin Exp Ophthalmol. 1999; 237:145-152.
29. Prieto PM, McLellan JS, Burns SA. Investigating the light absorption in a single pass through the photoreceptor layer by means of the lipofuscin fluorescence. Vision Res. 2005;45: 1957-1965.
30. Delori F, Greenberg JP, Woods RL, et al. Quantitative measurements of autofluorescence with the scanning laser ophthalmoscope. Invest Ophthalmol Vis Sci. 2011;52:9379-9390.
31. Morgan JIW, Hunter JJ, Merigan WH, Williams DR. The reduction of retinal autofluorescence caused by light exposure. Invest Ophthalmol Vis Sci. 2009;50:6015-6022.
32. Morgan JIW, Hunter JJ, Masella B, et al. Light-induced retinal changes observed using high-resolution autofluorescence imaging of the retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2008;49:3715-3729.
33. Wyszecki G, Stiles WS. Color Science: Concepts and Methods, Quantitative Data and Formulae. 2nd ed. New York, NY: John Wiley & Sons; 1982.
34. Alpern M, Pugh EN Jr. The density and photosensitivity of human rhodopsin in the living retina. J Physiol. 1974;237: 341-370.
35. Mahroo OA, Lamb TD. Recovery of the human photopic electroretinogram after bleaching exposures: estimation of pigment regeneration kinetics. J Physiol. 2004;554:417-437.
36. Pircher M, Zawadzki RJ, Evans JW, Werner JS, Hitzenberger CK. Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high-speed transversal scanning optical coherence tomography. Opt Lett. 2008;33:22-24.
37. Baylor DA, Nunn BJ, Schnapf JL. The photocurrent, noise, and spectral sensitivity of rods of the monkey Macaca fascicularis. J Physiol. 1984;357:575-607.
38. Curcio CA, Sloan KR, Kalina RE, Hendrickson AE. Human photoreceptor topography. J Comp Neurol. 1990;292:497-523.
39. Radu RA, Mata NL, Nusinowitz S, Liu XR, Sieving PA, Travis GH. Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration. Proc Natl Acad Sci U S A. 2003;100:4742-4747.
40. Delori FC, Goger DG, Hammond BR, Snodderly DM, Burns SA. Macular pigment density measured by autofluorescence spectrometry: comparison with reflectometry and heterochromatic flicker photometry. J Opt Soc Am A Opt Image Sci Vis. 2001;18:1212-1230.
41. Cideciyan AV, Aleman TS, Swider M, et al. Mutations in ABCA4 result in accumulation of lipofuscin before slowing of the retinoid cycle: a reappraisal of the human disease sequence. Hum Mol Genet. 2004;13:525-534.