메뉴 건너뛰기




Volumn 8, Issue 4, 2013, Pages

Gain-of-Function of Stat5 Leads to Excessive Granulopoiesis and Lethal Extravasation of Granulocytes to the Lung

Author keywords

[No Author keywords available]

Indexed keywords

STAT5 PROTEIN;

EID: 84875669829     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060902     Document Type: Article
Times cited : (5)

References (55)
  • 1
    • 0031057929 scopus 로고    scopus 로고
    • Stat5a is mandatory for adult mammary gland development and lactogenesis
    • Liu X, Robinson GW, Wagner KU, Garrett L, Wynshaw-Boris A, et al. (1997) Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev 11: 179-186.
    • (1997) Genes Dev , vol.11 , pp. 179-186
    • Liu, X.1    Robinson, G.W.2    Wagner, K.U.3    Garrett, L.4    Wynshaw-Boris, A.5
  • 2
    • 0030833570 scopus 로고    scopus 로고
    • Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
    • Udy GB, Towers RP, Snell RG, Wilkins RJ, Park SH, et al. (1997) Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc Natl Acad Sci U S A 94: 7239-7244.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 7239-7244
    • Udy, G.B.1    Towers, R.P.2    Snell, R.G.3    Wilkins, R.J.4    Park, S.H.5
  • 3
    • 0000943469 scopus 로고    scopus 로고
    • Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
    • Teglund S, McKay C, Schuetz E, van Deursen JM, Stravopodis D, et al. (1998) Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93: 841-850.
    • (1998) Cell , vol.93 , pp. 841-850
    • Teglund, S.1    McKay, C.2    Schuetz, E.3    van Deursen, J.M.4    Stravopodis, D.5
  • 4
    • 0033597715 scopus 로고    scopus 로고
    • Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction
    • Socolovsky M, Fallon AE, Wang S, Brugnara C, Lodish HF, (1999) Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction. Cell 98: 181-191.
    • (1999) Cell , vol.98 , pp. 181-191
    • Socolovsky, M.1    Fallon, A.E.2    Wang, S.3    Brugnara, C.4    Lodish, H.F.5
  • 5
    • 0033082138 scopus 로고    scopus 로고
    • Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
    • Moriggl R, Topham DJ, Teglund S, Sexl V, McKay C, et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10: 249-259.
    • (1999) Immunity , vol.10 , pp. 249-259
    • Moriggl, R.1    Topham, D.J.2    Teglund, S.3    Sexl, V.4    McKay, C.5
  • 6
    • 4444268818 scopus 로고    scopus 로고
    • Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation
    • Cui Y, Riedlinger G, Miyoshi K, Tang W, Li C, et al. (2004) Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol 24: 8037-8047.
    • (2004) Mol Cell Biol , vol.24 , pp. 8037-8047
    • Cui, Y.1    Riedlinger, G.2    Miyoshi, K.3    Tang, W.4    Li, C.5
  • 7
    • 35448975099 scopus 로고    scopus 로고
    • STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output
    • S0301-472X(07)00535-8 [pii]; [doi]10.1016/j.exphem.2007.08.026
    • Li G, Wang Z, Zhang Y, Kang Z, Haviernikova E, et al. (2007) STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output. Exp Hematol 35: 1684-1694. S0301-472X(07)00535-8 [pii];10.1016/j.exphem.2007.08.026 [doi].
    • (2007) Exp Hematol , vol.35 , pp. 1684-1694
    • Li, G.1    Wang, Z.2    Zhang, Y.3    Kang, Z.4    Haviernikova, E.5
  • 8
    • 77958481136 scopus 로고    scopus 로고
    • The gene encoding the hematopoietic stem cell regulator CCN3/NOV is under direct cytokine control through the transcription factors STAT5A/B
    • 32704-.32709 M110.141804 [pii]; [doi]10.1074/jbc.M110.141804
    • Kimura A, Martin C, Robinson GW, Simone JM, Chen W, et al. (2010) The gene encoding the hematopoietic stem cell regulator CCN3/NOV is under direct cytokine control through the transcription factors STAT5A/B. J Biol Chem. 28532704-.32709 M110.141804 [pii];10.1074/jbc.M110.141804 [doi].
    • (2010) J Biol Chem , vol.285
    • Kimura, A.1    Martin, C.2    Robinson, G.W.3    Simone, J.M.4    Chen, W.5
  • 9
    • 32244444750 scopus 로고    scopus 로고
    • Stat5a/b are essential for normal lymphoid development and differentiation
    • 1000-1005. 0507350103 [pii]; [doi]10.1073/pnas.0507350103
    • Yao Z, Cui Y, Watford WT, Bream JH, Yamaoka K, et al. (2006) Stat5a/b are essential for normal lymphoid development and differentiation. Proc Natl Acad Sci U S A 1031000-1005. 0507350103 [pii];10.1073/pnas.0507350103 [doi].
    • (2006) Proc Natl Acad Sci U S A , vol.103
    • Yao, Z.1    Cui, Y.2    Watford, W.T.3    Bream, J.H.4    Yamaoka, K.5
  • 10
    • 33745111882 scopus 로고    scopus 로고
    • Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation
    • 4898-4906. 2005-09-3596 [pii]; [doi]10.1182/blood-2005-09-3596
    • Hoelbl A, Kovacic B, Kerenyi MA, Simma O, Warsch W, et al. (2006) Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation. Blood 1074898-4906. 2005-09-3596 [pii];10.1182/blood-2005-09-3596 [doi].
    • (2006) Blood , vol.107
    • Hoelbl, A.1    Kovacic, B.2    Kerenyi, M.A.3    Simma, O.4    Warsch, W.5
  • 11
    • 34548807675 scopus 로고    scopus 로고
    • Stat5 is essential for early B cell development but not for B cell maturation and function
    • Dai X, Chen Y, Di L, Podd A, Li G, et al. (2007) Stat5 is essential for early B cell development but not for B cell maturation and function. J Immunol 179: 1068-1079 179/2/1068 [pii].
    • (2007) J Immunol , vol.179 , pp. 1068-1079
    • Dai, X.1    Chen, Y.2    Di, L.3    Podd, A.4    Li, G.5
  • 12
    • 73949103238 scopus 로고    scopus 로고
    • The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis
    • 4721-4728.blood-2009-04-216390 [pii]; [doi]10.1182/blood-2009-04-216390
    • Kimura A, Rieger MA, Simone JM, Chen W, Wickre MC, et al. (2009) The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis. Blood 1144721-4728.blood-2009-04-216390 [pii];10.1182/blood-2009-04-216390 [doi].
    • (2009) Blood , vol.114
    • Kimura, A.1    Rieger, M.A.2    Simone, J.M.3    Chen, W.4    Wickre, M.C.5
  • 13
    • 0034650805 scopus 로고    scopus 로고
    • Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation
    • Kieslinger M, Woldman I, Moriggl R, Hofmann J, Marine JC, et al. (2000) Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation. Genes Dev 14: 232-244.
    • (2000) Genes Dev , vol.14 , pp. 232-244
    • Kieslinger, M.1    Woldman, I.2    Moriggl, R.3    Hofmann, J.4    Marine, J.C.5
  • 14
    • 0141567775 scopus 로고    scopus 로고
    • Growth hormone insensitivity associated with a STAT5b mutation
    • Kofoed EM, Hwa V, Little B, Woods KA, Buckway CK, et al. (2003) Growth hormone insensitivity associated with a STAT5b mutation. N Engl J Med 349: 1139-1147.
    • (2003) N Engl J Med , vol.349 , pp. 1139-1147
    • Kofoed, E.M.1    Hwa, V.2    Little, B.3    Woods, K.A.4    Buckway, C.K.5
  • 15
    • 23044470651 scopus 로고    scopus 로고
    • Severe growth hormone insensitivity resulting from total absence of signal transducer and activator of transcription 5b
    • jc.2005-0515 [pii]; [doi]10.1210/jc.2005-0515
    • Hwa V, Little B, Adiyaman P, Kofoed EM, Pratt KL, et al. (2005) Severe growth hormone insensitivity resulting from total absence of signal transducer and activator of transcription 5b. J Clin Endocrinol Metab 90: 4260-4266 jc.2005-0515 [pii];10.1210/jc.2005-0515 [doi].
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4260-4266
    • Hwa, V.1    Little, B.2    Adiyaman, P.3    Kofoed, E.M.4    Pratt, K.L.5
  • 16
    • 33750952330 scopus 로고    scopus 로고
    • Characterization of immunodeficiency in a patient with growth hormone insensitivity secondary to a novel STAT5b gene mutation
    • peds.2005-2882 [pii]; [doi]10.1542/peds.2005-2882
    • Bernasconi A, Marino R, Ribas A, Rossi J, Ciaccio M, et al. (2006) Characterization of immunodeficiency in a patient with growth hormone insensitivity secondary to a novel STAT5b gene mutation. Pediatrics 118: e1584-e1592 peds.2005-2882 [pii];10.1542/peds.2005-2882 [doi].
    • (2006) Pediatrics , vol.118
    • Bernasconi, A.1    Marino, R.2    Ribas, A.3    Rossi, J.4    Ciaccio, M.5
  • 17
    • 79954419918 scopus 로고    scopus 로고
    • STAT5b deficiency: an unsuspected cause of growth failure, immunodeficiency, and severe pulmonary disease
    • S0022-3476(10)01154-6 [pii]; [doi]10.1016/j.jpeds.2010.12.042
    • Nadeau K, Hwa V, Rosenfeld RG, (2011) STAT5b deficiency: an unsuspected cause of growth failure, immunodeficiency, and severe pulmonary disease. J Pediatr 158: 701-708 S0022-3476(10)01154-6 [pii];10.1016/j.jpeds.2010.12.042 [doi].
    • (2011) J Pediatr , vol.158 , pp. 701-708
    • Nadeau, K.1    Hwa, V.2    Rosenfeld, R.G.3
  • 19
    • 32144453842 scopus 로고    scopus 로고
    • JAK/STAT signal transduction: regulators and implication in hematological malignancies
    • Valentino L, Pierre J, (2006) JAK/STAT signal transduction: regulators and implication in hematological malignancies. Biochem Pharmacol 71: 713-721.
    • (2006) Biochem Pharmacol , vol.71 , pp. 713-721
    • Valentino, L.1    Pierre, J.2
  • 20
  • 21
    • 20144363192 scopus 로고    scopus 로고
    • Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    • S0140-6736(05)71142-9 [pii]; [doi]10.1016/S0140-6736(05)71142-9
    • Baxter EJ, Scott LM, Campbell PJ, East C, Fourouclas N, et al. (2005) Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 365: 1054-1061 S0140-6736(05)71142-9 [pii];10.1016/S0140-6736(05)71142-9 [doi].
    • (2005) Lancet , vol.365 , pp. 1054-1061
    • Baxter, E.J.1    Scott, L.M.2    Campbell, P.J.3    East, C.4    Fourouclas, N.5
  • 22
    • 17844383458 scopus 로고    scopus 로고
    • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    • nature03546 [pii]; [doi]10.1038/nature03546
    • James C, Ugo V, Le Couedic JP, Staerk J, Delhommeau F, et al. (2005) A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 434: 1144-1148 nature03546 [pii];10.1038/nature03546 [doi].
    • (2005) Nature , vol.434 , pp. 1144-1148
    • James, C.1    Ugo, V.2    Le Couedic, J.P.3    Staerk, J.4    Delhommeau, F.5
  • 23
    • 20244369569 scopus 로고    scopus 로고
    • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
    • S1535-6108(05)00094-2 [pii]; [doi]10.1016/j.ccr.2005.03.023
    • Levine RL, Wadleigh M, Cools J, Ebert BL, Wernig G, et al. (2005) Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 7: 387-397 S1535-6108(05)00094-2 [pii];10.1016/j.ccr.2005.03.023 [doi].
    • (2005) Cancer Cell , vol.7 , pp. 387-397
    • Levine, R.L.1    Wadleigh, M.2    Cools, J.3    Ebert, B.L.4    Wernig, G.5
  • 24
    • 17644424955 scopus 로고    scopus 로고
    • A gain-of-function mutation of JAK2 in myeloproliferative disorders
    • 352/17/1779 [pii]; [doi]10.1056/NEJMoa051113
    • Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, et al. (2005) A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med 352: 1779-1790 352/17/1779 [pii];10.1056/NEJMoa051113 [doi].
    • (2005) N Engl J Med , vol.352 , pp. 1779-1790
    • Kralovics, R.1    Passamonti, F.2    Buser, A.S.3    Teo, S.S.4    Tiedt, R.5
  • 25
    • 0036554816 scopus 로고    scopus 로고
    • Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
    • Buettner R, Mora LB, Jove R, (2002) Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res 8: 945-954.
    • (2002) Clin Cancer Res , vol.8 , pp. 945-954
    • Buettner, R.1    Mora, L.B.2    Jove, R.3
  • 26
    • 0033546145 scopus 로고    scopus 로고
    • STAT protein recruitment and activation in c-Kit deletion mutants
    • Brizzi MF, Dentelli P, Rosso A, Yarden Y, Pegoraro L, (1999) STAT protein recruitment and activation in c-Kit deletion mutants. J Biol Chem 274: 16965-16972.
    • (1999) J Biol Chem , vol.274 , pp. 16965-16972
    • Brizzi, M.F.1    Dentelli, P.2    Rosso, A.3    Yarden, Y.4    Pegoraro, L.5
  • 27
    • 0037944120 scopus 로고    scopus 로고
    • Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations
    • [doi];2002-06-1677 [pii]10.1182/blood-2002-06-1677
    • Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, et al. (2003) Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations. Blood 101: 3164-3173 10.1182/blood-2002-06-1677 [doi];2002-06-1677 [pii].
    • (2003) Blood , vol.101 , pp. 3164-3173
    • Mizuki, M.1    Schwable, J.2    Steur, C.3    Choudhary, C.4    Agrawal, S.5
  • 28
    • 9144244169 scopus 로고    scopus 로고
    • FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy
    • [doi];2003-02-0418 [pii]10.1182/blood-2003-02-0418
    • Taketani T, Taki T, Sugita K, Furuichi Y, Ishii E, et al. (2004) FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy. Blood 103: 1085-1088 10.1182/blood-2003-02-0418 [doi];2003-02-0418 [pii].
    • (2004) Blood , vol.103 , pp. 1085-1088
    • Taketani, T.1    Taki, T.2    Sugita, K.3    Furuichi, Y.4    Ishii, E.5
  • 29
    • 19944431828 scopus 로고    scopus 로고
    • Stat5 tetramer formation is associated with leukemogenesis
    • Moriggl R, Sexl V, Kenner L, Duntsch C, Stangl K, et al. (2005) Stat5 tetramer formation is associated with leukemogenesis. Cancer Cell 7: 87-99.
    • (2005) Cancer Cell , vol.7 , pp. 87-99
    • Moriggl, R.1    Sexl, V.2    Kenner, L.3    Duntsch, C.4    Stangl, K.5
  • 30
    • 33746859330 scopus 로고    scopus 로고
    • Constitutive STAT5 activation specifically cooperates with the loss of p53 function in B-cell lymphomagenesis
    • 1209480 [pii]; [doi]10.1038/sj.onc.1209480
    • Joliot V, Cormier F, Medyouf H, Alcalde H, Ghysdael J, (2006) Constitutive STAT5 activation specifically cooperates with the loss of p53 function in B-cell lymphomagenesis. Oncogene 25: 4573-4584 1209480 [pii];10.1038/sj.onc.1209480 [doi].
    • (2006) Oncogene , vol.25 , pp. 4573-4584
    • Joliot, V.1    Cormier, F.2    Medyouf, H.3    Alcalde, H.4    Ghysdael, J.5
  • 31
    • 0029586870 scopus 로고
    • Conditional gene expression in secretory tissues and skin of transgenic mice using the MMTV-LTR and the tetracycline responsive system
    • Hennighausen L, Wall RJ, Tillmann U, Li M, Furth PA, (1995) Conditional gene expression in secretory tissues and skin of transgenic mice using the MMTV-LTR and the tetracycline responsive system. J Cell Biochem 59: 463-472.
    • (1995) J Cell Biochem , vol.59 , pp. 463-472
    • Hennighausen, L.1    Wall, R.J.2    Tillmann, U.3    Li, M.4    Furth, P.A.5
  • 32
    • 0033987718 scopus 로고    scopus 로고
    • Reversibility of acute B-cell leukaemia induced by BCR-ABL1
    • Huettner CS, Zhang P, Van Etten RA, Tenen DG, (2000) Reversibility of acute B-cell leukaemia induced by BCR-ABL1. Nat Genet 24: 57-60.
    • (2000) Nat Genet , vol.24 , pp. 57-60
    • Huettner, C.S.1    Zhang, P.2    Van Etten, R.A.3    Tenen, D.G.4
  • 33
    • 4544340539 scopus 로고    scopus 로고
    • Antiapoptotic BCL-2 is required for maintenance of a model leukemia
    • Letai A, Sorcinelli MD, Beard C, Korsmeyer SJ, (2004) Antiapoptotic BCL-2 is required for maintenance of a model leukemia. Cancer Cell 6: 241-249.
    • (2004) Cancer Cell , vol.6 , pp. 241-249
    • Letai, A.1    Sorcinelli, M.D.2    Beard, C.3    Korsmeyer, S.J.4
  • 34
    • 45849135641 scopus 로고    scopus 로고
    • The B cell antigen receptor and overexpression of MYC can cooperate in the genesis of B cell lymphomas
    • Refaeli Y, Young RM, Turner BC, Duda J, Field KA, et al. (2008) The B cell antigen receptor and overexpression of MYC can cooperate in the genesis of B cell lymphomas. PLoS Biol 6: e152.
    • (2008) PLoS Biol , vol.6
    • Refaeli, Y.1    Young, R.M.2    Turner, B.C.3    Duda, J.4    Field, K.A.5
  • 35
    • 43249084493 scopus 로고    scopus 로고
    • Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice
    • Tiedt R, Hao-Shen H, Sobas MA, Looser R, Dirnhofer S, et al. (2008) Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice. Blood 111: 3931-3940.
    • (2008) Blood , vol.111 , pp. 3931-3940
    • Tiedt, R.1    Hao-Shen, H.2    Sobas, M.A.3    Looser, R.4    Dirnhofer, S.5
  • 36
    • 77956578342 scopus 로고    scopus 로고
    • JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia
    • Li J, Spensberger D, Ahn JS, Anand S, Beer PA, et al. (2010) JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia. Blood 116: 1528-1538.
    • (2010) Blood , vol.116 , pp. 1528-1538
    • Li, J.1    Spensberger, D.2    Ahn, J.S.3    Anand, S.4    Beer, P.A.5
  • 38
    • 0033106168 scopus 로고    scopus 로고
    • Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells
    • Matsumura I, Kitamura T, Wakao H, Tanaka H, Hashimoto K, et al. (1999) Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells. EMBO J 18: 1367-1377.
    • (1999) EMBO J , vol.18 , pp. 1367-1377
    • Matsumura, I.1    Kitamura, T.2    Wakao, H.3    Tanaka, H.4    Hashimoto, K.5
  • 39
    • 66549086623 scopus 로고    scopus 로고
    • Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement
    • blood-2008-09-181107 [pii]; [doi]10.1182/blood-2008-09-181107
    • Wang Z, Li G, Tse W, Bunting KD, (2009) Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement. Blood 113: 4856-4865 blood-2008-09-181107 [pii];10.1182/blood-2008-09-181107 [doi].
    • (2009) Blood , vol.113 , pp. 4856-4865
    • Wang, Z.1    Li, G.2    Tse, W.3    Bunting, K.D.4
  • 40
    • 0033180211 scopus 로고    scopus 로고
    • Reversible tumorigenesis by MYC in hematopoietic lineages
    • Felsher DW, Bishop JM, (1999) Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell 4: 199-207.
    • (1999) Mol Cell , vol.4 , pp. 199-207
    • Felsher, D.W.1    Bishop, J.M.2
  • 41
    • 19944426030 scopus 로고    scopus 로고
    • Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis
    • [doi];2003-12-4369 [pii]10.1182/blood-2003-12-4369
    • Koschmieder S, Gottgens B, Zhang P, Iwasaki-Arai J, Akashi K, et al. (2005) Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis. Blood 105: 324-334 10.1182/blood-2003-12-4369 [doi];2003-12-4369 [pii].
    • (2005) Blood , vol.105 , pp. 324-334
    • Koschmieder, S.1    Gottgens, B.2    Zhang, P.3    Iwasaki-Arai, J.4    Akashi, K.5
  • 42
    • 0345700700 scopus 로고    scopus 로고
    • Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis
    • Iavnilovitch E, Groner B, Barash I, (2002) Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis. Mol Cancer Res 1: 32-47.
    • (2002) Mol Cancer Res , vol.1 , pp. 32-47
    • Iavnilovitch, E.1    Groner, B.2    Barash, I.3
  • 43
    • 7044272580 scopus 로고    scopus 로고
    • Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice
    • Iavnilovitch E, Cardiff RD, Groner B, Barash I, (2004) Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice. Int J Cancer 112: 607-619.
    • (2004) Int J Cancer , vol.112 , pp. 607-619
    • Iavnilovitch, E.1    Cardiff, R.D.2    Groner, B.3    Barash, I.4
  • 44
    • 40449135440 scopus 로고    scopus 로고
    • Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression
    • Wagner KU, Rui H, (2008) Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression. J Mammary Gland Biol Neoplasia 13: 93-103.
    • (2008) J Mammary Gland Biol Neoplasia , vol.13 , pp. 93-103
    • Wagner, K.U.1    Rui, H.2
  • 45
    • 0030930196 scopus 로고    scopus 로고
    • STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression
    • Feldman GM, Rosenthal LA, Liu X, Hayes MP, Wynshaw-Boris A, et al. (1997) STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression. Blood 90: 1768-1776.
    • (1997) Blood , vol.90 , pp. 1768-1776
    • Feldman, G.M.1    Rosenthal, L.A.2    Liu, X.3    Hayes, M.P.4    Wynshaw-Boris, A.5
  • 46
    • 0034845972 scopus 로고    scopus 로고
    • Enhanced survival of lung granulocytes in an animal model of asthma: evidence for a role of GM-CSF activated STAT5 signalling pathway
    • Turlej RK, Fievez L, Sandersen CF, Dogne S, Kirschvink N, et al. (2001) Enhanced survival of lung granulocytes in an animal model of asthma: evidence for a role of GM-CSF activated STAT5 signalling pathway. Thorax 56: 696-702.
    • (2001) Thorax , vol.56 , pp. 696-702
    • Turlej, R.K.1    Fievez, L.2    Sandersen, C.F.3    Dogne, S.4    Kirschvink, N.5
  • 47
    • 84865626916 scopus 로고    scopus 로고
    • Generation of a novel MMTV-tTA transgenic mouse strain for the targeted expression of genes in the embryonic and postnatal mammary gland
    • [doi];PONE-D-12-16928 [pii]10.1371/journal.pone.0043778
    • Sakamoto K, Schmidt JW, Wagner KU, (2012) Generation of a novel MMTV-tTA transgenic mouse strain for the targeted expression of genes in the embryonic and postnatal mammary gland. PLoS One 7: e43778 10.1371/journal.pone.0043778 [doi];PONE-D-12-16928 [pii].
    • (2012) PLoS One , vol.7
    • Sakamoto, K.1    Schmidt, J.W.2    Wagner, K.U.3
  • 49
    • 66149101380 scopus 로고    scopus 로고
    • Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging
    • Creamer BA, Triplett AA, Wagner KU, (2009) Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging. Genesis 47: 234-245.
    • (2009) Genesis , vol.47 , pp. 234-245
    • Creamer, B.A.1    Triplett, A.A.2    Wagner, K.U.3
  • 50
    • 77952236062 scopus 로고    scopus 로고
    • Temporally and spatially controlled expression of transgenes in embryonic and adult tissues
    • Zhang Q, Triplett AA, Harms DW, Lin WC, Creamer BA, et al. (2010) Temporally and spatially controlled expression of transgenes in embryonic and adult tissues. Transgenic Res 19: 499-509.
    • (2010) Transgenic Res , vol.19 , pp. 499-509
    • Zhang, Q.1    Triplett, A.A.2    Harms, D.W.3    Lin, W.C.4    Creamer, B.A.5
  • 51
    • 34547441513 scopus 로고    scopus 로고
    • The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells
    • Sakamoto K, Creamer BA, Triplett AA, Wagner KU, (2007) The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells. Mol Endocrinol 21: 1877-1892.
    • (2007) Mol Endocrinol , vol.21 , pp. 1877-1892
    • Sakamoto, K.1    Creamer, B.A.2    Triplett, A.A.3    Wagner, K.U.4
  • 52
    • 0034624828 scopus 로고    scopus 로고
    • A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    • [doi]10.1038/35004599
    • Akashi K, Traver D, Miyamoto T, Weissman IL, (2000) A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404: 193-197 10.1038/35004599 [doi].
    • (2000) Nature , vol.404 , pp. 193-197
    • Akashi, K.1    Traver, D.2    Miyamoto, T.3    Weissman, I.L.4
  • 53
    • 56849127197 scopus 로고    scopus 로고
    • Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells
    • [doi]10.1371/journal.pone.0003776
    • Kalaitzidis D, Neel BG, (2008) Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells. PLoS One 3: e3776 10.1371/journal.pone.0003776 [doi].
    • (2008) PLoS One , vol.3
    • Kalaitzidis, D.1    Neel, B.G.2
  • 54
    • 33645729159 scopus 로고    scopus 로고
    • AML1-ETO rapidly induces acute myeloblastic leukemia in cooperation with the Wilms tumor gene, WT1
    • 2005-04-1656 [pii]; [doi]10.1182/blood-2005-04-1656
    • Nishida S, Hosen N, Shirakata T, Kanato K, Yanagihara M, et al. (2006) AML1-ETO rapidly induces acute myeloblastic leukemia in cooperation with the Wilms tumor gene, WT1. Blood 107: 3303-3312 2005-04-1656 [pii];10.1182/blood-2005-04-1656 [doi].
    • (2006) Blood , vol.107 , pp. 3303-3312
    • Nishida, S.1    Hosen, N.2    Shirakata, T.3    Kanato, K.4    Yanagihara, M.5
  • 55
    • 34347406119 scopus 로고    scopus 로고
    • Abnormal hematopoiesis in Gab2 mutant mice
    • blood-2006-11-060707 [pii]; [doi]10.1182/blood-2006-11-060707
    • Zhang Y, Diaz-Flores E, Li G, Wang Z, Kang Z, et al. (2007) Abnormal hematopoiesis in Gab2 mutant mice. Blood 110: 116-124 blood-2006-11-060707 [pii];10.1182/blood-2006-11-060707 [doi].
    • (2007) Blood , vol.110 , pp. 116-124
    • Zhang, Y.1    Diaz-Flores, E.2    Li, G.3    Wang, Z.4    Kang, Z.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.